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Wikipedia

Flugestone acetate

Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.[1][2][3][4][5][6]

Flugestone acetate
Clinical data
Trade namesCronolone, others
Other namesFlurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone
Routes of
administration
Intravaginal
Drug classProgestogen; Progestin; Progestogen ester
Identifiers
  • [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number
  • 2529-45-5
PubChem CID
  • 10476437
ChemSpider
  • 8651847
UNII
  • X60881643X
KEGG
  • D04235
ChEMBL
  • ChEMBL2106773
CompTox Dashboard (EPA)
  • DTXSID6046210
ECHA InfoCard100.017.979
Chemical and physical data
FormulaC23H31FO5
Molar mass406.494 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(C)=O
  • InChI=1S/C23H31FO5/c1-13(25)22(29-14(2)26)10-8-17-18-6-5-15-11-16(27)7-9-20(15,3)23(18,24)19(28)12-21(17,22)4/h11,17-19,28H,5-10,12H2,1-4H3/t17-,18-,19-,20-,21-,22-,23-/m0/s1
  • Key:JKQQZJHNUVDHKP-FQJIPJFPSA-N

Uses edit

Veterinary edit

FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.[2][4][5][6]

Chemistry edit

FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1][3] It is the C17α acetate ester of flugestone.[1][3][2]

History edit

FGA was developed and marketed by G.D. Searle & Company in the 1960s.[7][8]

Society and culture edit

Generic names edit

Flugestone acetate is the generic name of the drug and its INNTooltip International Nonproprietary Name and BANMTooltip British Approved Name, while flurogestone acetate is its USANTooltip United States Adopted Name.[1][3][2][9] Flugestone is the BANTooltip British Approved Name and DCITTooltip Denominazione Comune Italiana of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code names NSC-65411 and SC-9880.[1][3][2][9]

Brand names edit

FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]

Availability edit

FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.[3][9]

References edit

  1. ^ a b c d e f g Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 559. ISBN 978-1-4757-2085-3.
  2. ^ a b c d e f g Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 122–. ISBN 978-0-7514-0499-9.
  3. ^ a b c d e f g h Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 451–. ISBN 978-3-88763-075-1.
  4. ^ a b Office of the Federal Register (US) (29 May 2012). Code of Federal Regulations Title 21: Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359–. ISBN 978-0-16-090718-0.
  5. ^ a b Youngquist RS, Threlfall WR (23 November 2006). Current Therapy in Large Animal Theriogenology. Elsevier Health Sciences. pp. 2640–. ISBN 1-4377-1340-8.
  6. ^ a b Studdert VP, Gay CC, Blood DC (9 December 2011). Saunders Comprehensive Veterinary Dictionary. Elsevier Health Sciences. pp. 2673–. ISBN 978-0-7020-4744-2.
  7. ^ Animal Husbandry Research: Reports on Agricultural Industry. 1967. p. 60.
  8. ^ Dairy Science Handbook. Agriservices Foundation. 1971. p. 10.
  9. ^ a b c d e "Flugestone". Drugs.com.


flugestone, acetate, sold, under, brand, name, cronolone, among, others, progestin, medication, which, used, veterinary, medicine, clinical, datatrade, namescronolone, othersother, namesflurogestone, acetate, fluorogestone, acetate, 65411, 9880, 17α, acetoxy, . Flugestone acetate FGA sold under the brand name Cronolone among others is a progestin medication which is used in veterinary medicine 1 2 3 4 5 6 Flugestone acetateClinical dataTrade namesCronolone othersOther namesFlurogestone acetate Fluorogestone acetate FGA NSC 65411 SC 9880 17a Acetoxy 9a fluoro 11b hydroxyprogesteroneRoutes ofadministrationIntravaginalDrug classProgestogen Progestin Progestogen esterIdentifiersIUPAC name 8S 9R 10S 11S 13S 14S 17R 17 acetyl 9 fluoro 11 hydroxy 10 13 dimethyl 3 oxo 1 2 6 7 8 11 12 14 15 16 decahydrocyclopenta a phenanthren 17 yl acetateCAS Number2529 45 5PubChem CID10476437ChemSpider8651847UNIIX60881643XKEGGD04235ChEMBLChEMBL2106773CompTox Dashboard EPA DTXSID6046210ECHA InfoCard100 017 979Chemical and physical dataFormulaC 23H 31F O 5Molar mass406 494 g mol 13D model JSmol Interactive imageSMILES CC O O C 1 CC C H 2 C H 3CCC4 CC O CC C 4 C C 3 F C H O C C 12C C C OInChI InChI 1S C23H31FO5 c1 13 25 22 29 14 2 26 10 8 17 18 6 5 15 11 16 27 7 9 20 15 3 23 18 24 19 28 12 21 17 22 4 h11 17 19 28H 5 10 12H2 1 4H3 t17 18 19 20 21 22 23 m0 s1Key JKQQZJHNUVDHKP FQJIPJFPSA N Contents 1 Uses 1 1 Veterinary 2 Chemistry 3 History 4 Society and culture 4 1 Generic names 4 2 Brand names 4 3 Availability 5 ReferencesUses editVeterinary edit FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats 2 4 5 6 Chemistry editSee also List of progestogens Progestogen ester and List of progestogen esters FGA also known as 17a acetoxy 9a fluoro 11b hydroxyprogesterone or as 17a acetoxy 9a fluoro 11b hydroxypregn 4 ene 3 20 dione is a synthetic pregnane steroid and a derivative of progesterone and 17a hydroxyprogesterone 1 3 It is the C17a acetate ester of flugestone 1 3 2 History editFGA was developed and marketed by G D Searle amp Company in the 1960s 7 8 Society and culture editGeneric names edit Flugestone acetate is the generic name of the drug and its INNTooltip International Nonproprietary Name and BANMTooltip British Approved Name while flurogestone acetate is its USANTooltip United States Adopted Name 1 3 2 9 Flugestone is the BANTooltip British Approved Name and DCITTooltip Denominazione Comune Italiana of the unesterified free alcohol form 1 3 2 9 FGA is also known by its developmental code names NSC 65411 and SC 9880 1 3 2 9 Brand names edit FGA is or has been marketed under the brand names Chronogest Chrono Gest Crono Gest Cronolone Gyncro Mate Ova Gest Ovakron Synchro Mate Syncro Part and Syncropart 1 3 2 9 Availability edit FGA is marketed for veterinary use in Australia France Ireland Israel Italy the Netherlands South Africa and the United Kingdom 3 9 References edit a b c d e f g Elks J 14 November 2014 The Dictionary of Drugs Chemical Data Chemical Data Structures and Bibliographies Springer p 559 ISBN 978 1 4757 2085 3 a b c d e f g Morton IK Hall JM 31 October 1999 Concise Dictionary of Pharmacological Agents Properties and Synonyms Springer Science amp Business Media pp 122 ISBN 978 0 7514 0499 9 a b c d e f g h Index Nominum 2000 International Drug Directory Taylor amp Francis January 2000 pp 451 ISBN 978 3 88763 075 1 a b Office of the Federal Register US 29 May 2012 Code of Federal Regulations Title 21 Food and Drug Administration Parts 500 599 Revised April 1 2012 Government Printing Office pp 359 ISBN 978 0 16 090718 0 a b Youngquist RS Threlfall WR 23 November 2006 Current Therapy in Large Animal Theriogenology Elsevier Health Sciences pp 2640 ISBN 1 4377 1340 8 a b Studdert VP Gay CC Blood DC 9 December 2011 Saunders Comprehensive Veterinary Dictionary Elsevier Health Sciences pp 2673 ISBN 978 0 7020 4744 2 Animal Husbandry Research Reports on Agricultural Industry 1967 p 60 Dairy Science Handbook Agriservices Foundation 1971 p 10 a b c d e Flugestone Drugs com Retrieved from https en wikipedia org w index php title Flugestone acetate amp oldid 1162374130, wikipedia, wiki, book, books, library,

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