FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2gene.[5]
Salehi AH, Xanthoudakis S, Barker PA (2002). "NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway". J. Biol. Chem. 277 (50): 48043–50. doi:10.1074/jbc.M205324200. PMID 12376548.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Hattori A, Okumura K, Nagase T, et al. (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Pasteris NG, Gorski JL (1999). "Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues". Genomics. 60 (1): 57–66. doi:10.1006/geno.1999.5903. PMID 10458911.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J. Neurosci. 22 (1): 156–66. doi:10.1523/JNEUROSCI.22-01-00156.2002. PMC6757583. PMID 11756498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Rabizadeh S, Bredesen DE (2003). "Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)". Cytokine Growth Factor Rev. 14 (3–4): 225–39. doi:10.1016/S1359-6101(03)00018-2. PMID 12787561.
Huber C, Mårtensson A, Bokoch GM, et al. (2008). "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles". J. Biol. Chem. 283 (49): 34002–12. doi:10.1074/jbc.M803957200. PMC2590680. PMID 18838382.
Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC1950914. PMID 17564959.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
fgd2, fyve, rhogef, domain, containing, protein, also, known, zinc, finger, fyve, domain, containing, protein, zfyve4, protein, that, humans, encoded, gene, identifiersaliases, zfyve4, fyve, rhogef, domain, containing, 2external, idsomim, 605091, 1347084, homo. FYVE RhoGEF and PH domain containing protein 2 FGD2 also known as zinc finger FYVE domain containing protein 4 ZFYVE4 is a protein that in humans is encoded by the FGD2 gene 5 FGD2IdentifiersAliasesFGD2 ZFYVE4 FYVE RhoGEF and PH domain containing 2External IDsOMIM 605091 MGI 1347084 HomoloGene 8438 GeneCards FGD2Gene location Human Chr Chromosome 6 human 1 Band6p21 2Start37 005 646 bp 1 End37 029 069 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 15 26 cM 17 A3 3Start29 360 914 bp 2 End29 379 661 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytespleeninternal globus palliduslymph nodebloodspongy bonecardiatrigeminal ganglionsubthalamic nucleusinferior ganglion of vagus nerveTop expressed insacculespleenbloodotic placodeislet of Langerhanslipsubcutaneous adipose tissuepituitary glandseminiferous tubulethymusMore reference expression dataBioGPSn aGene ontologyMolecular functionphosphatidylinositol phosphate binding metal ion binding small GTPase binding protein binding guanyl nucleotide exchange factor activityCellular componentcytoplasm cytosol endosome Golgi apparatus cell projection early endosome membrane membrane ruffle plasma membrane ruffle membrane early endosome cytoskeleton nucleus lamellipodiumBiological processpositive regulation of JUN kinase activity regulation of GTPase activity filopodium assembly cytoskeleton organization regulation of cell shape positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction actin cytoskeleton organization G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez22147226382EnsemblENSG00000146192ENSMUSG00000024013UniProtQ7Z6J4Q8BY35RefSeq mRNA NM 173558NM 001159538NM 013710RefSeq protein NP 775829NP 001153010NP 038738Location UCSC Chr 6 37 01 37 03 MbChr 17 29 36 29 38 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseIt is a member of the FYVE RhoGEF and PH domain containing family References edit a b c GRCh38 Ensembl release 89 ENSG00000146192 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024013 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene FYVE Further reading editSalehi AH Xanthoudakis S Barker PA 2002 NRAGE a p75 neurotrophin receptor interacting protein induces caspase activation and cell death through a JNK dependent mitochondrial pathway J Biol Chem 277 50 48043 50 doi 10 1074 jbc M205324200 PMID 12376548 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Hattori A Okumura K Nagase T et al 2000 Characterization of long cDNA clones from human adult spleen DNA Res 7 6 357 66 doi 10 1093 dnares 7 6 357 PMID 11214971 Pasteris NG Gorski JL 1999 Isolation characterization and mapping of the mouse and human Fgd2 genes faciogenital dysplasia FGD1 Aarskog syndrome gene homologues Genomics 60 1 57 66 doi 10 1006 geno 1999 5903 PMID 10458911 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Harrington AW Kim JY Yoon SO 2002 Activation of Rac GTPase by p75 is necessary for c jun N terminal kinase mediated apoptosis J Neurosci 22 1 156 66 doi 10 1523 JNEUROSCI 22 01 00156 2002 PMC 6757583 PMID 11756498 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Rabizadeh S Bredesen DE 2003 Ten years on mediation of cell death by the common neurotrophin receptor p75 NTR Cytokine Growth Factor Rev 14 3 4 225 39 doi 10 1016 S1359 6101 03 00018 2 PMID 12787561 Huber C Martensson A Bokoch GM et al 2008 FGD2 a CDC42 specific exchange factor expressed by antigen presenting cells localizes to early endosomes and active membrane ruffles J Biol Chem 283 49 34002 12 doi 10 1074 jbc M803957200 PMC 2590680 PMID 18838382 Delague V Jacquier A Hamadouche T et al 2007 Mutations in FGD4 encoding the Rho GDP GTP exchange factor FRABIN cause autosomal recessive Charcot Marie Tooth type 4H Am J Hum Genet 81 1 1 16 doi 10 1086 518428 PMC 1950914 PMID 17564959 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FGD2 amp oldid 1142703254, wikipedia, wiki, book, books, library,
