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Endocarditis

February 16, 2024

Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices. Endocarditis is characterized by lesions, known as vegetations, which are masses of platelets, fibrin, microcolonies of microorganisms, and scant inflammatory cells.[1] In the subacute form of infective endocarditis, a vegetation may also include a center of granulomatous tissue, which may fibrose or calcify.[2]

Endocarditis
Bartonella henselae bacilli in cardiac valve of a patient with blood culture-negative endocarditis. The bacilli appear as black granulations.
SpecialtyCardiology, Infectious disease

There are several ways to classify endocarditis. The simplest classification is based on cause: either infective or non-infective, depending on whether a microorganism is the source of the inflammation or not. Regardless, the diagnosis of endocarditis is based on clinical features, investigations such as an echocardiogram, and blood cultures demonstrating the presence of endocarditis-causing microorganisms.

Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red spots on the skin), Osler's nodes (subcutaneous nodules found on hands and feet), Janeway lesions (nodular lesions on palms and soles), and Roth's spots (retinal hemorrhages).

Infective endocarditis edit

Main article: Infective endocarditis

Infective endocarditis is an infection of the inner surface of the heart, usually the valves.[3] Symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cells.[3] Complications may include valvular insufficiency, heart failure, stroke, and kidney failure.[4][3]

The cause is typically a bacterial infection and less commonly a fungal infection.[3] Risk factors include valvular heart disease including rheumatic disease, congenital heart disease, artificial valves, hemodialysis, intravenous drug use, and electronic pacemakers.[5] The bacterial most commonly involved are streptococci or staphylococci.[3]

The diagnosis of infective endocarditis relies on the Duke criteria, which were originally described in 1994 and modified in 2000. Clinical features and microbiological examinations are the first steps to diagnose an infective endocarditis. The imaging is also crucial. Echocardiography is the cornerstone of imaging modality in the diagnosis of infective endocarditis. Alternative imaging modalities as computer tomography, magnetic resonance imaging, and positron emission tomography/computer tomography (PET/CT) with 2-[18F]fluorodeoxyglucose (FDG) are playing an increasing role in the diagnosis and management of infective endocarditis.[6]

The usefulness of antibiotics following dental procedures has changed over time.[7] Prevention is recommended in patients at high risk.[3] Treatment is generally with intravenous antibiotics.[3] The choice of antibiotics is based on the blood cultures.[3] Occasionally heart surgery is required.[3][8] Populations at high risk of infective endocarditis include patients with previous infective endocarditis, patients with surgical or transcatheter prosthetic valves or post-cardiac valve repair, and patients with untreated CHD and surgically corrected congenital heart disease.[9][10]

The number of people affected is about 5 per 100,000 per year.[5] Rates, however, vary between regions of the world.[5] Males are affected more often than females.[3] The risk of death among those infected is about 25%.[5] Without treatment it is almost universally fatal.[3]

Non-infective endocarditis edit

Main article: Noninfective endocarditis

Nonbacterial thrombotic endocarditis (NBTE) is most commonly found on previously undamaged valves.[2] As opposed to infective endocarditis, the vegetations in NBTE are small, sterile, and tend to aggregate along the edges of the valve or the cusps.[2] Also unlike infective endocarditis, NBTE does not cause an inflammation response from the body.[2] NBTE usually occurs during a hypercoagulable state such as system-wide bacterial infection, or pregnancy, though it is also sometimes seen in patients with venous catheters.[2] NBTE may also occur in patients with cancer, particularly mucinous adenocarcinoma[2] where Trousseau syndrome can be encountered. Typically NBTE does not cause many problems on its own, but parts of the vegetations may break off and embolize to the heart or brain, or they may serve as a focus where bacteria can lodge, thus causing infective endocarditis.[2]

Another form of sterile endocarditis is termed Libman–Sacks endocarditis; this form occurs more often in patients with lupus erythematosus and is thought to be due to the deposition of immune complexes.[2] Like NBTE, Libman-Sacks endocarditis involves small vegetations, while infective endocarditis is composed of large vegetations.[2] These immune complexes precipitate an inflammation reaction, which helps to differentiate it from NBTE. Also unlike NBTE, Libman-Sacks endocarditis does not seem to have a preferred location of deposition and may form on the undersurfaces of the valves or even on the endocardium.[2]

References edit

  1. ^ Kasper DL, Braunwald E, Fauci AS, Hauser S, Longo DL, Jameson JL (May 2005). Harrison's Principles of Internal Medicine. McGraw-Hill. pp. 731–740. ISBN 978-0-07-139140-5. OCLC 54501403.
  2. ^ a b c d e f g h i j Mitchell RS, Kumar V, Robbins SL, Abbas AK, Fausto N (2007). Robbins Basic Pathology (8th ed.). Saunders/Elsevier. pp. 406–408. ISBN 978-1-4160-2973-1.
  3. ^ a b c d e f g h i j k "Infective Endocarditis - Cardiovascular Disorders". Merck Manuals Professional Edition. September 2017. Retrieved 11 December 2017.
  4. ^ Njuguna, B; Gardner, A; Karwa, R; Delahaye, F (February 2017). "Infective Endocarditis in Low- and Middle-Income Countries". Cardiology Clinics. 35 (1): 153–163. doi:10.1016/j.ccl.2016.08.011. hdl:1805/14046. PMID 27886786.
  5. ^ a b c d Ambrosioni, J; Hernandez-Meneses, M; Téllez, A; Pericàs, J; Falces, C; Tolosana, JM; Vidal, B; Almela, M; Quintana, E; Llopis, J; Moreno, A; Miro, JM; Hospital Clinic Infective Endocarditis, Investigators (May 2017). "The Changing Epidemiology of Infective Endocarditis in the Twenty-First Century". Current Infectious Disease Reports. 19 (5): 21. doi:10.1007/s11908-017-0574-9. PMID 28401448. S2CID 24935834.
  6. ^ Hubers, Scott A.; DeSimone, Daniel C.; Gersh, Bernard J.; Anavekar, Nandan S. (May 2020). "Infective Endocarditis: A Contemporary Review". Mayo Clinic Proceedings. 95 (5): 982–997. doi:10.1016/j.mayocp.2019.12.008. PMID 32299668. S2CID 215803991.
  7. ^ Cahill, TJ; Harrison, JL; Jewell, P; Onakpoya, I; Chambers, JB; Dayer, M; Lockhart, P; Roberts, N; Shanson, D; Thornhill, M; Heneghan, CJ; Prendergast, BD (June 2017). "Antibiotic prophylaxis for infective endocarditis: a systematic review and meta-analysis" (PDF). Heart. 103 (12): 937–944. doi:10.1136/heartjnl-2015-309102. PMID 28213367. S2CID 25918810.
  8. ^ Delgado, V; Ajmone Marsan, N; de Waha, S; Bonaros, N; Brida, M; Burri, H; Caselli, S; Doenst, T; Ederhy, S; Erba, PA; Foldager, D; Fosbøl, EL; Kovac, J; Mestres, CA; Miller, OI; Miro, JM; Pazdernik, M; Pizzi, MN; Quintana, E; Rasmussen, TB; Ristić, AD; Rodés-Cabau, J; Sionis, A; Zühlke, LJ; Borger, MA; ESC Scientific Document, Group (14 October 2023). "2023 ESC Guidelines for the management of endocarditis". European Heart Journal. 44 (39): 3948–4042. doi:10.1093/eurheartj/ehad193. hdl:10281/436142. PMID 37622656.
  9. ^ Delgado, V; Ajmone Marsan, N; de Waha, S; Bonaros, N; Brida, M; Burri, H; Caselli, S; Doenst, T; Ederhy, S; Erba, PA; Foldager, D; Fosbøl, EL; Kovac, J; Mestres, CA; Miller, OI; Miro, JM; Pazdernik, M; Pizzi, MN; Quintana, E; Rasmussen, TB; Ristić, AD; Rodés-Cabau, J; Sionis, A; Zühlke, LJ; Borger, MA; ESC Scientific Document, Group (14 October 2023). "2023 ESC Guidelines for the management of endocarditis". European Heart Journal. 44 (39): 3948–4042. doi:10.1093/eurheartj/ehad193. hdl:10281/436142. PMID 37622656.
  10. ^ Verzelloni Sef, A; Jaggar, SI; Trkulja, V; Alonso-Gonzalez, R; Sef, D; Turina, MI (2 May 2023). "Factors associated with long-term outcomes in adult congenital heart disease patients with infective endocarditis: a 16-year tertiary single-centre experience". European Journal of Cardio-Thoracic Surgery. 63 (5). doi:10.1093/ejcts/ezad105. PMID 36946284.

Further reading edit

  • Meine TJ, Nettles RE, Anderson DJ, Cabell CH, Corey GR, Sexton DJ, Wang A (2001). "Cardiac conduction abnormalities in endocarditis defined by the Duke criteria". American Heart Journal. 142 (2): 280–285. doi:10.1067/mhj.2001.116964. PMID 11479467.
  • Tissières P, Gervaix A, Beghetti M, Jaeggi ET (2003). "Value and limitations of the von Reyn, Duke, and modified Duke criteria for the diagnosis of infective endocarditis in children". Pediatrics. 112 (6 Pt 1): e467–e471. doi:10.1542/peds.112.6.e467. PMID 14654647.

External links edit

 
Scholia has a topic profile for Endocarditis.

February 16, 2024
endocarditis, inflammation, inner, layer, heart, endocardium, usually, involves, heart, valves, other, structures, that, involved, include, interventricular, septum, chordae, tendineae, mural, endocardium, surfaces, intracardiac, devices, characterized, lesion. Endocarditis is an inflammation of the inner layer of the heart the endocardium It usually involves the heart valves Other structures that may be involved include the interventricular septum the chordae tendineae the mural endocardium or the surfaces of intracardiac devices Endocarditis is characterized by lesions known as vegetations which are masses of platelets fibrin microcolonies of microorganisms and scant inflammatory cells 1 In the subacute form of infective endocarditis a vegetation may also include a center of granulomatous tissue which may fibrose or calcify 2 EndocarditisBartonella henselae bacilli in cardiac valve of a patient with blood culture negative endocarditis The bacilli appear as black granulations SpecialtyCardiology Infectious diseaseThere are several ways to classify endocarditis The simplest classification is based on cause either infective or non infective depending on whether a microorganism is the source of the inflammation or not Regardless the diagnosis of endocarditis is based on clinical features investigations such as an echocardiogram and blood cultures demonstrating the presence of endocarditis causing microorganisms Signs and symptoms include fever chills sweating malaise weakness anorexia weight loss splenomegaly flu like feeling cardiac murmur heart failure petechia red spots on the skin Osler s nodes subcutaneous nodules found on hands and feet Janeway lesions nodular lesions on palms and soles and Roth s spots retinal hemorrhages Contents 1 Infective endocarditis 2 Non infective endocarditis 3 References 4 Further reading 5 External linksInfective endocarditis editMain article Infective endocarditis Infective endocarditis is an infection of the inner surface of the heart usually the valves 3 Symptoms may include fever small areas of bleeding into the skin heart murmur feeling tired and low red blood cells 3 Complications may include valvular insufficiency heart failure stroke and kidney failure 4 3 The cause is typically a bacterial infection and less commonly a fungal infection 3 Risk factors include valvular heart disease including rheumatic disease congenital heart disease artificial valves hemodialysis intravenous drug use and electronic pacemakers 5 The bacterial most commonly involved are streptococci or staphylococci 3 The diagnosis of infective endocarditis relies on the Duke criteria which were originally described in 1994 and modified in 2000 Clinical features and microbiological examinations are the first steps to diagnose an infective endocarditis The imaging is also crucial Echocardiography is the cornerstone of imaging modality in the diagnosis of infective endocarditis Alternative imaging modalities as computer tomography magnetic resonance imaging and positron emission tomography computer tomography PET CT with 2 18F fluorodeoxyglucose FDG are playing an increasing role in the diagnosis and management of infective endocarditis 6 The usefulness of antibiotics following dental procedures has changed over time 7 Prevention is recommended in patients at high risk 3 Treatment is generally with intravenous antibiotics 3 The choice of antibiotics is based on the blood cultures 3 Occasionally heart surgery is required 3 8 Populations at high risk of infective endocarditis include patients with previous infective endocarditis patients with surgical or transcatheter prosthetic valves or post cardiac valve repair and patients with untreated CHD and surgically corrected congenital heart disease 9 10 The number of people affected is about 5 per 100 000 per year 5 Rates however vary between regions of the world 5 Males are affected more often than females 3 The risk of death among those infected is about 25 5 Without treatment it is almost universally fatal 3 Non infective endocarditis editMain article Noninfective endocarditis Nonbacterial thrombotic endocarditis NBTE is most commonly found on previously undamaged valves 2 As opposed to infective endocarditis the vegetations in NBTE are small sterile and tend to aggregate along the edges of the valve or the cusps 2 Also unlike infective endocarditis NBTE does not cause an inflammation response from the body 2 NBTE usually occurs during a hypercoagulable state such as system wide bacterial infection or pregnancy though it is also sometimes seen in patients with venous catheters 2 NBTE may also occur in patients with cancer particularly mucinous adenocarcinoma 2 where Trousseau syndrome can be encountered Typically NBTE does not cause many problems on its own but parts of the vegetations may break off and embolize to the heart or brain or they may serve as a focus where bacteria can lodge thus causing infective endocarditis 2 Another form of sterile endocarditis is termed Libman Sacks endocarditis this form occurs more often in patients with lupus erythematosus and is thought to be due to the deposition of immune complexes 2 Like NBTE Libman Sacks endocarditis involves small vegetations while infective endocarditis is composed of large vegetations 2 These immune complexes precipitate an inflammation reaction which helps to differentiate it from NBTE Also unlike NBTE Libman Sacks endocarditis does not seem to have a preferred location of deposition and may form on the undersurfaces of the valves or even on the endocardium 2 References edit Kasper DL Braunwald E Fauci AS Hauser S Longo DL Jameson JL May 2005 Harrison s Principles of Internal Medicine McGraw Hill pp 731 740 ISBN 978 0 07 139140 5 OCLC 54501403 a b c d e f g h i j Mitchell RS Kumar V Robbins SL Abbas AK Fausto N 2007 Robbins Basic Pathology 8th ed Saunders Elsevier pp 406 408 ISBN 978 1 4160 2973 1 a b c d e f g h i j k Infective Endocarditis Cardiovascular Disorders Merck Manuals Professional Edition September 2017 Retrieved 11 December 2017 Njuguna B Gardner A Karwa R Delahaye F February 2017 Infective Endocarditis in Low and Middle Income Countries Cardiology Clinics 35 1 153 163 doi 10 1016 j ccl 2016 08 011 hdl 1805 14046 PMID 27886786 a b c d Ambrosioni J Hernandez Meneses M Tellez A Pericas J Falces C Tolosana JM Vidal B Almela M Quintana E Llopis J Moreno A Miro JM Hospital Clinic Infective Endocarditis Investigators May 2017 The Changing Epidemiology of Infective Endocarditis in the Twenty First Century Current Infectious Disease Reports 19 5 21 doi 10 1007 s11908 017 0574 9 PMID 28401448 S2CID 24935834 Hubers Scott A DeSimone Daniel C Gersh Bernard J Anavekar Nandan S May 2020 Infective Endocarditis A Contemporary Review Mayo Clinic Proceedings 95 5 982 997 doi 10 1016 j mayocp 2019 12 008 PMID 32299668 S2CID 215803991 Cahill TJ Harrison JL Jewell P Onakpoya I Chambers JB Dayer M Lockhart P Roberts N Shanson D Thornhill M Heneghan CJ Prendergast BD June 2017 Antibiotic prophylaxis for infective endocarditis a systematic review and meta analysis PDF Heart 103 12 937 944 doi 10 1136 heartjnl 2015 309102 PMID 28213367 S2CID 25918810 Delgado V Ajmone Marsan N de Waha S Bonaros N Brida M Burri H Caselli S Doenst T Ederhy S Erba PA Foldager D Fosbol EL Kovac J Mestres CA Miller OI Miro JM Pazdernik M Pizzi MN Quintana E Rasmussen TB Ristic AD Rodes Cabau J Sionis A Zuhlke LJ Borger MA ESC Scientific Document Group 14 October 2023 2023 ESC Guidelines for the management of endocarditis European Heart Journal 44 39 3948 4042 doi 10 1093 eurheartj ehad193 hdl 10281 436142 PMID 37622656 Delgado V Ajmone Marsan N de Waha S Bonaros N Brida M Burri H Caselli S Doenst T Ederhy S Erba PA Foldager D Fosbol EL Kovac J Mestres CA Miller OI Miro JM Pazdernik M Pizzi MN Quintana E Rasmussen TB Ristic AD Rodes Cabau J Sionis A Zuhlke LJ Borger MA ESC Scientific Document Group 14 October 2023 2023 ESC Guidelines for the management of endocarditis European Heart Journal 44 39 3948 4042 doi 10 1093 eurheartj ehad193 hdl 10281 436142 PMID 37622656 Verzelloni Sef A Jaggar SI Trkulja V Alonso Gonzalez R Sef D Turina MI 2 May 2023 Factors associated with long term outcomes in adult congenital heart disease patients with infective endocarditis a 16 year tertiary single centre experience European Journal of Cardio Thoracic Surgery 63 5 doi 10 1093 ejcts ezad105 PMID 36946284 Further reading editMeine TJ Nettles RE Anderson DJ Cabell CH Corey GR Sexton DJ Wang A 2001 Cardiac conduction abnormalities in endocarditis defined by the Duke criteria American Heart Journal 142 2 280 285 doi 10 1067 mhj 2001 116964 PMID 11479467 Tissieres P Gervaix A Beghetti M Jaeggi ET 2003 Value and limitations of the von Reyn Duke and modified Duke criteria for the diagnosis of infective endocarditis in children Pediatrics 112 6 Pt 1 e467 e471 doi 10 1542 peds 112 6 e467 PMID 14654647 External links edit nbsp Scholia has a topic profile for Endocarditis Endocarditis at Curlie Retrieved from https en wikipedia org w index php title Endocarditis amp oldid 1202796276, wikipedia, wiki, book, books, library,

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