Red and white retinal spots were first observed in 1872 by Swiss physician Moritz Roth, and named "Roth spots" six years later by Moritz Litten. They are typically observed via fundoscopy (using an ophthalmoscope to view inside the eye) or slit lamp exam.[2][3]
The original retinal spots identified in 1872 were attributed to nerve-fibres that had burst. Present-day analysis shows that they can be composed of coagulatedfibrin including platelets, focal ischaemia, inflammatory infiltrate, infectious organisms, or neoplastic cells.[4]
Roth's spots occur in conditions that predispose to endothelial damage of retinal capillaries, that is when there is dysfunction and disruption of the endothelium of retinal capillaries. Looking through the microscope reveals lesions with white centers made mainly of fibrin, depicting a fibrin-platelet plug at the site of vessel damage.[2]
Associated conditions
Conditions associated with Roth's spots include:[2][1]
^Lepore, Frederick (1995). "Roth's Spots in Leukemic Retinopathy". New England Journal of Medicine. 332 (5): 335. doi:10.1056/NEJM199502023320515. PMID 7816078.
^"What are the classic signs of infective endocarditis (IE)?". www.medscape.com. Retrieved 12 August 2019.
External links
Image from the New England Journal of Medicine: Endocarditis
Image from the New England Journal of Medicine: CML
This medical sign article is a stub. You can help Wikipedia by expanding it.
roth, spot, also, known, litten, spots, litten, sign, specific, spots, with, white, pale, centres, seen, retina, although, traditionally, associated, with, infective, endocarditis, occur, number, other, conditions, including, hypertension, diabetes, collagen, . Roth s spots also known as Litten spots or the Litten sign 1 are non specific red spots with white or pale centres seen on the retina and although traditionally associated with infective endocarditis can occur in a number of other conditions including hypertension diabetes collagen vascular disease extreme hypoxia leukemia and HIV 2 3 Roth s spotOther namesLitten signSpecialtyOphthalmologyCausesConditions that predispose to endothelial damage of retinal capillariesDiagnostic methodFundoscopyRed and white retinal spots were first observed in 1872 by Swiss physician Moritz Roth and named Roth spots six years later by Moritz Litten They are typically observed via fundoscopy using an ophthalmoscope to view inside the eye or slit lamp exam 2 3 The original retinal spots identified in 1872 were attributed to nerve fibres that had burst Present day analysis shows that they can be composed of coagulated fibrin including platelets focal ischaemia inflammatory infiltrate infectious organisms or neoplastic cells 4 Contents 1 Cause 2 Associated conditions 3 Prevalence 4 See also 5 References 6 External linksCause EditRoth s spots occur in conditions that predispose to endothelial damage of retinal capillaries that is when there is dysfunction and disruption of the endothelium of retinal capillaries Looking through the microscope reveals lesions with white centers made mainly of fibrin depicting a fibrin platelet plug at the site of vessel damage 2 Associated conditions EditConditions associated with Roth s spots include 2 1 Infective endocarditis Anaemia thrombocytopenia Collagen vascular disease Leukemia Hypertensive retinopathy Diabetic retinopathy Pre eclampsia Human Immunodeficiency Virus HIV Extreme hypoxia Shaken baby syndromeand also 3 Candida albicans infection vascular diseases kala azarPrevalence EditRoth s spots occur in only 5 of people with infective endocarditis 5 Litten however reported a figure of 80 2 See also EditOsler s nodes Janeway lesion Splinter haemorrhageReferences Edit a b What is a roth spot Stanford Medicine 25 24 March 2016 Retrieved 11 August 2019 a b c d e Ruddy Stephanie M Bergstrom Reece Tivakaran Vijai S 2019 Roth Spots StatPearls StatPearls Publishing PMID 29494053 retrieved 11 August 2019 a b c Blumenthal Eytan Z Ehud Zamir 9 March 1999 Roth s Spots Circulation 99 9 1271 doi 10 1161 01 CIR 99 9 1271 PMID 10069798 Lepore Frederick 1995 Roth s Spots in Leukemic Retinopathy New England Journal of Medicine 332 5 335 doi 10 1056 NEJM199502023320515 PMID 7816078 What are the classic signs of infective endocarditis IE www medscape com Retrieved 12 August 2019 External links EditImage from the New England Journal of Medicine Endocarditis Image from the New England Journal of Medicine CML This medical sign article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Roth 27s spot amp oldid 1136248325, wikipedia, wiki, book, books, library,
