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Eileen Furlong

December 15, 2023

Eileen E. M. Furlong FRS MAE is an Irish molecular biologist working in the fields of transcription, chromatin biology, developmental biology and genomics.[3] She is known for her work in understanding how the genome is regulated, in particular to how developmental enhancers function, how they interact within three dimensional chromatin topologies and how they drive cell fate decisions during embryogenesis.[1][4][5] She is Head of the Department of Genome Biology at the European Molecular Biology Laboratory (EMBL). Furlong was elected a member of the European Molecular Biology Organization (EMBO) in 2013,[6] the Academia Europaea in 2016[7] and to EMBO’s research council in 2018.[8]

Eileen Furlong

FRS MAE
Furlong in 2017
Born
Eileen E.M. Furlong
NationalityIrish
Alma materUniversity College Dublin (BSc, PhD)
AwardsMember of the Academia Europaea (2016)
EMBO Membership (2013)
Scientific career
FieldsEnhancers
Chromatin topology
Embryonic development
Single cell genomics
Transcription factors[1]
InstitutionsEuropean Molecular Biology Laboratory
Stanford University
ThesisTissue-specific regulation of gene expression by the transcription factors Ying-Yang 1 and nuclear factor 1 (1996)
Doctoral advisorFinian Martin[2]
Websitefurlonglab.embl.de

Education edit

Eileen Furlong obtained a Bachelor of Science degree at University College Dublin, and a PhD at the Conway institute at UCD, studying transcriptional regulation of immediate early response genes in the lab of Finian Martin.[2]

Career and research edit

After her PhD, Furlong was a postdoctoral researcher at Stanford University, in Matthew P. Scott's lab,[9] developing genomics tools to functionally dissect developmental programmes during embryogenesis. Furlong started her independent lab at EMBL in 2002,[10] and was appointed head of department [11] in 2009. Her research integrates genomics, genetics and computational biology approaches to functionally dissect the role of non-coding cis-regulatory elements in the regulation of gene expression.[12][13] In particular, using mesoderm specification into different muscle primordia as a model system. Her group’s research has uncovered a number of properties of enhancers[14][15][16][17] and enhancer-promoter communication, including pre-formed enhancer-promoter ‘loops’[18][19] and the ability of many enhancer’s to function even when larger chromatin topologies are perturbed,[20][21][22] in addition to mechanisms that allow enhancers to withstand the effects of genetic variation, including collective transcription factor recruitment,[23][24] genetic epistasis within enhancers[25] and promoters,[26] and extensive redundancy,[27] which together contribute to canalization in developmental patterning.[citation needed]

Furlong’s work was credited in the development and application of genomic approaches to understand embryonic development,[28][29] including the development of Drosophila microarrays,[30][31] an automatic transgenic embryo sorter,[32][33] Chromatin immunoprecipitation (ChIP) in embryos,[34][35][36] tissue specific[37][38][39] and single cell approaches[40] - which combined with genetic manipulations provided insight into developmental programmes during embryogenesis at a genome-wide scale.[41][42]

Furlong serves on the editorial boards of the scientific journals Developmental Cell,[43] Development,[44] Molecular Systems Biology,[45] Current Opinion in Genetics Development,[46] Current Opinion in Cell Biology,[47][48] a European Research Council (ERC) panel member[49][50] and an organiser of the international Conferences From Functional Genomics to Systems Biology,[51] EMBL Transcription and Chromatin[52] meeting, and a keynote speaker at national and international conferences including Intelligent Systems for Molecular Biology (ISMB).[53][54][55][56][57][58][59][excessive citations]

Awards and honors edit

Furlong was elected a member of the European Molecular Biology Organization (EMBO) in 2013,[6] and a Member of the Academia Europaea (MAE) in 2016.[7] Furlong was awarded ERC advanced investigator funding CisRegVar 2013-2018[60] and DeCRypT 2019-2023.[61] She was elected a Fellow of the Royal Society in May 2022.[62]

References edit

  1. ^ a b Eileen Furlong publications indexed by Google Scholar  
  2. ^ a b Furlong, Eileen E. M. (1996). Tissue-specific regulation of gene expression by the transcription factors Ying-Yang 1 and nuclear factor 1 (PhD thesis). OCLC 605563938. ProQuest 301522152.
  3. ^ Eileen Furlong publications from Europe PubMed Central
  4. ^ "Deciphering the regulatory code". EMBL. 4 November 2009.
  5. ^ Niemitz, Emily (2014). "Synthetic modeling of developmental enhancers". Nature Genetics. 46 (2): 99. doi:10.1038/ng.2888. ISSN 1546-1718. S2CID 38520086.
  6. ^ a b "Find people in the EMBO Communities". people.embo.org.
  7. ^ a b "Academy of Europe: Furlong Eileen". ae-info.org.
  8. ^ "Council". EMBO. 22 March 2021.
  9. ^ Furlong, Eileen E.M.; Profitt, David; Scott, Matthew P. (2001). "Automated sorting of live transgenic embryos". Nature Biotechnology. 19 (2): 153–156. doi:10.1038/84422. ISSN 1087-0156. PMID 11175730. S2CID 14228050.
  10. ^ "Furlong Group - Genome regulation and topology during embryonic development - EMBL". embl.de.
  11. ^ "Genome Biology".
  12. ^ Furlong, EEM; Levine, M (28 September 2018). "Developmental enhancers and chromosome topology". Science. 361 (6409): 1341–1345. Bibcode:2018Sci...361.1341F. doi:10.1126/science.aau0320. PMC 6986801. PMID 30262496.
  13. ^ Spitz, F; Furlong, EE (September 2012). "Transcription factors: from enhancer binding to developmental control". Nature Reviews. Genetics. 13 (9): 613–26. doi:10.1038/nrg3207. PMID 22868264. S2CID 205485256.
  14. ^ Zinzen, RP; Girardot, C; Gagneur, J; Braun, M; Furlong, EE (5 November 2009). "Combinatorial binding predicts spatio-temporal cis-regulatory activity". Nature. 462 (7269): 65–70. Bibcode:2009Natur.462...65Z. doi:10.1038/nature08531. PMID 19890324. S2CID 4320071.
  15. ^ He, Xin; Sinha, Saurabh (February 2010). "ChIPs and regulatory bits". Nature Biotechnology. 28 (2): 142–143. doi:10.1038/nbt0210-142. ISSN 1546-1696. PMID 20139950. S2CID 30471127.
  16. ^ Stark, Alexander (1 January 2009). "Learning the transcriptional regulatory code". Molecular Systems Biology. 5 (1): 329. doi:10.1038/msb.2009.88. ISSN 1744-4292. PMC 2795480. PMID 19920814.
  17. ^ Rister, Jens; Desplan, Claude (2010). "Deciphering the genome's regulatory code: The many languages of DNA". BioEssays. 32 (5): 381–384. doi:10.1002/bies.200900197. ISSN 1521-1878. PMC 3024831. PMID 20394065.
  18. ^ Ghavi-Helm, Y; Klein, FA; Pakozdi, T; Ciglar, L; Noordermeer, D; Huber, W; Furlong, EE (7 August 2014). "Enhancer loops appear stable during development and are associated with paused polymerase". Nature. 512 (7512): 96–100. Bibcode:2014Natur.512...96G. doi:10.1038/nature13417. PMID 25043061. S2CID 4464054.
  19. ^ "Unexpected stability and complexity in transcriptional enhancers' interactions". phys.org.
  20. ^ Ghavi-Helm, Y; Jankowski, A; Meiers, S; Viales, RR; Korbel, JO; Furlong, EEM (August 2019). "Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression". Nature Genetics. 51 (8): 1272–1282. doi:10.1038/s41588-019-0462-3. PMC 7116017. PMID 31308546.
  21. ^ Finn, Elizabeth H.; Misteli, Tom (August 2019). "A genome disconnect". Nature Genetics. 51 (8): 1205–1206. doi:10.1038/s41588-019-0476-x. ISSN 1546-1718. PMC 7418859. PMID 31332379.
  22. ^ Koch, Linda (October 2019). "Toppling TAD tenets". Nature Reviews Genetics. 20 (10): 565. doi:10.1038/s41576-019-0164-9. ISSN 1471-0064. PMID 31367009. S2CID 199056689.
  23. ^ Junion, G; Spivakov, M; Girardot, C; Braun, M; Gustafson, EH; Birney, E; Furlong, EE (3 February 2012). "A transcription factor collective defines cardiac cell fate and reflects lineage history". Cell. 148 (3): 473–86. doi:10.1016/j.cell.2012.01.030. PMID 22304916. S2CID 7990140.
  24. ^ Khoueiry, P; Girardot, C; Ciglar, L; Peng, PC; Gustafson, EH; Sinha, S; Furlong, EE (9 August 2017). "Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity". eLife. 6. doi:10.7554/eLife.28440. PMC 5550276. PMID 28792889.
  25. ^ Cannavò, E; Koelling, N; Harnett, D; Garfield, D; Casale, FP; Ciglar, L; Gustafson, HE; Viales, RR; Marco-Ferreres, R; Degner, JF; Zhao, B; Stegle, O; Birney, E; Furlong, EE (19 January 2017). "Genetic variants regulating expression levels and isoform diversity during embryogenesis". Nature. 541 (7637): 402–406. Bibcode:2017Natur.541..402C. doi:10.1038/nature20802. PMID 28024300. S2CID 205252947.
  26. ^ Schor, IE; Degner, JF; Harnett, D; Cannavò, E; Casale, FP; Shim, H; Garfield, DA; Birney, E; Stephens, M; Stegle, O; Furlong, EE (April 2017). "Promoter shape varies across populations and affects promoter evolution and expression noise". Nature Genetics. 49 (4): 550–558. doi:10.1038/ng.3791. PMID 28191888. S2CID 3331476.
  27. ^ Cannavò, E; Khoueiry, P; Garfield, DA; Geeleher, P; Zichner, T; Gustafson, EH; Ciglar, L; Korbel, JO; Furlong, EE (11 January 2016). "Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks". Current Biology. 26 (1): 38–51. doi:10.1016/j.cub.2015.11.034. PMC 4712172. PMID 26687625.
  28. ^ McGuire, AL; Gabriel, S; Tishkoff, SA; Wonkam, A; Chakravarti, A; Furlong, EEM; Treutlein, B; Meissner, A; Chang, HY; López-Bigas, N; Segal, E; Kim, JS (October 2020). "The road ahead in genetics and genomics". Nature Reviews. Genetics. 21 (10): 581–596. doi:10.1038/s41576-020-0272-6. PMC 7444682. PMID 32839576.
  29. ^ Flintoft, Louisa (February 2013). "Predictions across space and time". Nature Reviews Genetics. 14 (2): 78–79. doi:10.1038/nrg3411. ISSN 1471-0064. PMID 23269464. S2CID 41780530.
  30. ^ Arbeitman, MN; Furlong, EE; Imam, F; Johnson, E; Null, BH; Baker, BS; Krasnow, MA; Scott, MP; Davis, RW; White, KP (2002). "Gene expression during the life cycle of Drosophila melanogaster". Science. 297 (5590): 2270–5. Bibcode:2002Sci...297.2270A. doi:10.1126/science.1072152. PMID 12351791. S2CID 15639586.
  31. ^ Science, American Association for the Advancement of (27 September 2002). "This Week in Science: Editor summaries of this week's papers". Science. 297 (5590): 2165. doi:10.1126/science.2002.297.5590.twis. ISSN 0036-8075. S2CID 239597164.
  32. ^ Furlong, EE; Profitt, D; Scott, MP (February 2001). "Automated sorting of live transgenic embryos". Nature Biotechnology. 19 (2): 153–6. doi:10.1038/84422. PMID 11175730. S2CID 14228050.
  33. ^ "Biological particle sorter". Google Patents. 21 March 2001.
  34. ^ Sandmann, T; Jensen, LJ; Jakobsen, JS; Karzynski, MM; Eichenlaub, MP; Bork, P; Furlong, EE (June 2006). "A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development". Developmental Cell. 10 (6): 797–807. doi:10.1016/j.devcel.2006.04.009. PMID 16740481.
  35. ^ Sandmann, T; Girardot, C; Brehme, M; Tongprasit, W; Stolc, V; Furlong, EE (15 February 2007). "A core transcriptional network for early mesoderm development in Drosophila melanogaster". Genes & Development. 21 (4): 436–49. doi:10.1101/gad.1509007. PMC 1804332. PMID 17322403.
  36. ^ Skipper, Magdalena (April 2007). "Chipping away at developmental networks". Nature Reviews Genetics. 8 (4): 249. doi:10.1038/nrg2077. ISSN 1471-0064. S2CID 38908110.
  37. ^ Bonn, S; Zinzen, RP; Girardot, C; Gustafson, EH; Perez-Gonzalez, A; Delhomme, N; Ghavi-Helm, Y; Wilczyński, B; Riddell, A; Furlong, EE (8 January 2012). "Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development". Nature Genetics. 44 (2): 148–56. doi:10.1038/ng.1064. PMID 22231485. S2CID 143727.
  38. ^ Bonn, S; Zinzen, RP; Perez-Gonzalez, A; Riddell, A; Gavin, AC; Furlong, EE (26 April 2012). "Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP". Nature Protocols. 7 (5): 978–94. doi:10.1038/nprot.2012.049. PMID 22538849. S2CID 20098167.
  39. ^ Reddington, JP; Garfield, DA; Sigalova, OM; Karabacak Calviello, A; Marco-Ferreres, R; Girardot, C; Viales, RR; Degner, JF; Ohler, U; Furlong, EEM (7 December 2020). "Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis". Developmental Cell. 55 (5): 648–664.e9. doi:10.1016/j.devcel.2020.10.009. PMID 33171098. S2CID 226302320.
  40. ^ Cusanovich, DA; Reddington, JP; Garfield, DA; Daza, RM; Aghamirzaie, D; Marco-Ferreres, R; Pliner, HA; Christiansen, L; Qiu, X; Steemers, FJ; Trapnell, C; Shendure, J; Furlong, EEM (2018). "The cis-regulatory dynamics of embryonic development at single-cell resolution". Nature. 555 (7697): 538–542. Bibcode:2018Natur.555..538C. doi:10.1038/nature25981. PMC 5866720. PMID 29539636.
  41. ^ Furlong, EE; Andersen, EC; Null, B; White, KP; Scott, MP (31 August 2001). "Patterns of gene expression during Drosophila mesoderm development". Science. 293 (5535): 1629–33. Bibcode:2001Sci...293.1629F. doi:10.1126/science.1062660. PMID 11486054. S2CID 13826608.
  42. ^ Science, American Association for the Advancement of (31 August 2001). "This Week in Science: Research in Science journals". Science. 293 (5535): 1553. doi:10.1126/science.2001.293.5535.twis. ISSN 0036-8075.
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  49. ^ "ERC Investigators - EMBL". embl.de.
  50. ^ "Futures: Genome regulation - ERC grantee Eileen Furlong". EMBL. 13 March 2017.
  51. ^ "EMBL Conference - from Functional Genomics to Systems Biology -".
  52. ^ "14th EMBL Conference - Transcription and Chromatin - Virtual - Speakers".
  53. ^ "Evolutionary Systems Biology". Wellcome Connecting Science Courses and Conferences.
  54. ^ "CSH Asia 2020 Conference Systems Biology of Gene Regulation and Genome Editing". cshl.csh-asia.org.
  55. ^ "Flyer Online Symposium Minerva-Gentner Symposium 2020" (PDF).
  56. ^ "Speaker - Cell Symposia: Transcriptional Regulation". cell-symposia.com.
  57. ^ "Eileen Furlong". iscb.org.
  58. ^ "EMBL professor Eileen Furlong: keynote on Genome Regulation". UBC. 4 October 2017.
  59. ^ Pathology, Research Institute of Molecular. "Eileen Furlong to give Max Birnstiel Lecture". The Research Institute of Molecular Pathology.
  60. ^ "ERC grant CisRegVar".
  61. ^ "ERC grant DeCRypT".
  62. ^ "Outstanding scientists elected as Fellows and Foreign Members of the Royal Society". Royal Society. 10 May 2022. Retrieved 11 May 2022.

December 15, 2023
eileen, furlong, eileen, furlong, irish, molecular, biologist, working, fields, transcription, chromatin, biology, developmental, biology, genomics, known, work, understanding, genome, regulated, particular, developmental, enhancers, function, they, interact, . Eileen E M Furlong FRS MAE is an Irish molecular biologist working in the fields of transcription chromatin biology developmental biology and genomics 3 She is known for her work in understanding how the genome is regulated in particular to how developmental enhancers function how they interact within three dimensional chromatin topologies and how they drive cell fate decisions during embryogenesis 1 4 5 She is Head of the Department of Genome Biology at the European Molecular Biology Laboratory EMBL Furlong was elected a member of the European Molecular Biology Organization EMBO in 2013 6 the Academia Europaea in 2016 7 and to EMBO s research council in 2018 8 Eileen FurlongFRS MAEFurlong in 2017BornEileen E M FurlongNationalityIrishAlma materUniversity College Dublin BSc PhD AwardsMember of the Academia Europaea 2016 EMBO Membership 2013 Scientific careerFieldsEnhancersChromatin topologyEmbryonic developmentSingle cell genomicsTranscription factors 1 InstitutionsEuropean Molecular Biology LaboratoryStanford UniversityThesisTissue specific regulation of gene expression by the transcription factors Ying Yang 1 and nuclear factor 1 1996 Doctoral advisorFinian Martin 2 Websitefurlonglab wbr embl wbr de Contents 1 Education 2 Career and research 2 1 Awards and honors 3 ReferencesEducation editEileen Furlong obtained a Bachelor of Science degree at University College Dublin and a PhD at the Conway institute at UCD studying transcriptional regulation of immediate early response genes in the lab of Finian Martin 2 Career and research editAfter her PhD Furlong was a postdoctoral researcher at Stanford University in Matthew P Scott s lab 9 developing genomics tools to functionally dissect developmental programmes during embryogenesis Furlong started her independent lab at EMBL in 2002 10 and was appointed head of department 11 in 2009 Her research integrates genomics genetics and computational biology approaches to functionally dissect the role of non coding cis regulatory elements in the regulation of gene expression 12 13 In particular using mesoderm specification into different muscle primordia as a model system Her group s research has uncovered a number of properties of enhancers 14 15 16 17 and enhancer promoter communication including pre formed enhancer promoter loops 18 19 and the ability of many enhancer s to function even when larger chromatin topologies are perturbed 20 21 22 in addition to mechanisms that allow enhancers to withstand the effects of genetic variation including collective transcription factor recruitment 23 24 genetic epistasis within enhancers 25 and promoters 26 and extensive redundancy 27 which together contribute to canalization in developmental patterning citation needed Furlong s work was credited in the development and application of genomic approaches to understand embryonic development 28 29 including the development of Drosophila microarrays 30 31 an automatic transgenic embryo sorter 32 33 Chromatin immunoprecipitation ChIP in embryos 34 35 36 tissue specific 37 38 39 and single cell approaches 40 which combined with genetic manipulations provided insight into developmental programmes during embryogenesis at a genome wide scale 41 42 Furlong serves on the editorial boards of the scientific journals Developmental Cell 43 Development 44 Molecular Systems Biology 45 Current Opinion in Genetics Development 46 Current Opinion in Cell Biology 47 48 a European Research Council ERC panel member 49 50 and an organiser of the international Conferences From Functional Genomics to Systems Biology 51 EMBL Transcription and Chromatin 52 meeting and a keynote speaker at national and international conferences including Intelligent Systems for Molecular Biology ISMB 53 54 55 56 57 58 59 excessive citations Awards and honors edit Furlong was elected a member of the European Molecular Biology Organization EMBO in 2013 6 and a Member of the Academia Europaea MAE in 2016 7 Furlong was awarded ERC advanced investigator funding CisRegVar 2013 2018 60 and DeCRypT 2019 2023 61 She was elected a Fellow of the Royal Society in May 2022 62 References edit a b Eileen Furlong publications indexed by Google Scholar nbsp a b Furlong Eileen E M 1996 Tissue specific regulation of gene expression by the transcription factors Ying Yang 1 and nuclear factor 1 PhD thesis OCLC 605563938 ProQuest 301522152 Eileen Furlong publications from Europe PubMed Central Deciphering the regulatory code EMBL 4 November 2009 Niemitz Emily 2014 Synthetic modeling of developmental enhancers Nature Genetics 46 2 99 doi 10 1038 ng 2888 ISSN 1546 1718 S2CID 38520086 a b Find people in the EMBO Communities people embo org a b Academy of Europe Furlong Eileen ae info org Council EMBO 22 March 2021 Furlong Eileen E M Profitt David Scott Matthew P 2001 Automated sorting of live transgenic embryos Nature Biotechnology 19 2 153 156 doi 10 1038 84422 ISSN 1087 0156 PMID 11175730 S2CID 14228050 Furlong Group Genome regulation and topology during embryonic development EMBL embl de Genome Biology Furlong EEM Levine M 28 September 2018 Developmental enhancers and chromosome topology Science 361 6409 1341 1345 Bibcode 2018Sci 361 1341F doi 10 1126 science aau0320 PMC 6986801 PMID 30262496 Spitz F Furlong EE September 2012 Transcription factors from enhancer binding to developmental control Nature Reviews Genetics 13 9 613 26 doi 10 1038 nrg3207 PMID 22868264 S2CID 205485256 Zinzen RP Girardot C Gagneur J Braun M Furlong EE 5 November 2009 Combinatorial binding predicts spatio temporal cis regulatory activity Nature 462 7269 65 70 Bibcode 2009Natur 462 65Z doi 10 1038 nature08531 PMID 19890324 S2CID 4320071 He Xin Sinha Saurabh February 2010 ChIPs and regulatory bits Nature Biotechnology 28 2 142 143 doi 10 1038 nbt0210 142 ISSN 1546 1696 PMID 20139950 S2CID 30471127 Stark Alexander 1 January 2009 Learning the transcriptional regulatory code Molecular Systems Biology 5 1 329 doi 10 1038 msb 2009 88 ISSN 1744 4292 PMC 2795480 PMID 19920814 Rister Jens Desplan Claude 2010 Deciphering the genome s regulatory code The many languages of DNA BioEssays 32 5 381 384 doi 10 1002 bies 200900197 ISSN 1521 1878 PMC 3024831 PMID 20394065 Ghavi Helm Y Klein FA Pakozdi T Ciglar L Noordermeer D Huber W Furlong EE 7 August 2014 Enhancer loops appear stable during development and are associated with paused polymerase Nature 512 7512 96 100 Bibcode 2014Natur 512 96G doi 10 1038 nature13417 PMID 25043061 S2CID 4464054 Unexpected stability and complexity in transcriptional enhancers interactions phys org Ghavi Helm Y Jankowski A Meiers S Viales RR Korbel JO Furlong EEM August 2019 Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression Nature Genetics 51 8 1272 1282 doi 10 1038 s41588 019 0462 3 PMC 7116017 PMID 31308546 Finn Elizabeth H Misteli Tom August 2019 A genome disconnect Nature Genetics 51 8 1205 1206 doi 10 1038 s41588 019 0476 x ISSN 1546 1718 PMC 7418859 PMID 31332379 Koch Linda October 2019 Toppling TAD tenets Nature Reviews Genetics 20 10 565 doi 10 1038 s41576 019 0164 9 ISSN 1471 0064 PMID 31367009 S2CID 199056689 Junion G Spivakov M Girardot C Braun M Gustafson EH Birney E Furlong EE 3 February 2012 A transcription factor collective defines cardiac cell fate and reflects lineage history Cell 148 3 473 86 doi 10 1016 j cell 2012 01 030 PMID 22304916 S2CID 7990140 Khoueiry P Girardot C Ciglar L Peng PC Gustafson EH Sinha S Furlong EE 9 August 2017 Uncoupling evolutionary changes in DNA sequence transcription factor occupancy and enhancer activity eLife 6 doi 10 7554 eLife 28440 PMC 5550276 PMID 28792889 Cannavo E Koelling N Harnett D Garfield D Casale FP Ciglar L Gustafson HE Viales RR Marco Ferreres R Degner JF Zhao B Stegle O Birney E Furlong EE 19 January 2017 Genetic variants regulating expression levels and isoform diversity during embryogenesis Nature 541 7637 402 406 Bibcode 2017Natur 541 402C doi 10 1038 nature20802 PMID 28024300 S2CID 205252947 Schor IE Degner JF Harnett D Cannavo E Casale FP Shim H Garfield DA Birney E Stephens M Stegle O Furlong EE April 2017 Promoter shape varies across populations and affects promoter evolution and expression noise Nature Genetics 49 4 550 558 doi 10 1038 ng 3791 PMID 28191888 S2CID 3331476 Cannavo E Khoueiry P Garfield DA Geeleher P Zichner T Gustafson EH Ciglar L Korbel JO Furlong EE 11 January 2016 Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks Current Biology 26 1 38 51 doi 10 1016 j cub 2015 11 034 PMC 4712172 PMID 26687625 McGuire AL Gabriel S Tishkoff SA Wonkam A Chakravarti A Furlong EEM Treutlein B Meissner A Chang HY Lopez Bigas N Segal E Kim JS October 2020 The road ahead in genetics and genomics Nature Reviews Genetics 21 10 581 596 doi 10 1038 s41576 020 0272 6 PMC 7444682 PMID 32839576 Flintoft Louisa February 2013 Predictions across space and time Nature Reviews Genetics 14 2 78 79 doi 10 1038 nrg3411 ISSN 1471 0064 PMID 23269464 S2CID 41780530 Arbeitman MN Furlong EE Imam F Johnson E Null BH Baker BS Krasnow MA Scott MP Davis RW White KP 2002 Gene expression during the life cycle of Drosophila melanogaster Science 297 5590 2270 5 Bibcode 2002Sci 297 2270A doi 10 1126 science 1072152 PMID 12351791 S2CID 15639586 Science American Association for the Advancement of 27 September 2002 This Week in Science Editor summaries of this week s papers Science 297 5590 2165 doi 10 1126 science 2002 297 5590 twis ISSN 0036 8075 S2CID 239597164 Furlong EE Profitt D Scott MP February 2001 Automated sorting of live transgenic embryos Nature Biotechnology 19 2 153 6 doi 10 1038 84422 PMID 11175730 S2CID 14228050 Biological particle sorter Google Patents 21 March 2001 Sandmann T Jensen LJ Jakobsen JS Karzynski MM Eichenlaub MP Bork P Furlong EE June 2006 A temporal map of transcription factor activity mef2 directly regulates target genes at all stages of muscle development Developmental Cell 10 6 797 807 doi 10 1016 j devcel 2006 04 009 PMID 16740481 Sandmann T Girardot C Brehme M Tongprasit W Stolc V Furlong EE 15 February 2007 A core transcriptional network for early mesoderm development in Drosophila melanogaster Genes amp Development 21 4 436 49 doi 10 1101 gad 1509007 PMC 1804332 PMID 17322403 Skipper Magdalena April 2007 Chipping away at developmental networks Nature Reviews Genetics 8 4 249 doi 10 1038 nrg2077 ISSN 1471 0064 S2CID 38908110 Bonn S Zinzen RP Girardot C Gustafson EH Perez Gonzalez A Delhomme N Ghavi Helm Y Wilczynski B Riddell A Furlong EE 8 January 2012 Tissue specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development Nature Genetics 44 2 148 56 doi 10 1038 ng 1064 PMID 22231485 S2CID 143727 Bonn S Zinzen RP Perez Gonzalez A Riddell A Gavin AC Furlong EE 26 April 2012 Cell type specific chromatin immunoprecipitation from multicellular complex samples using BiTS ChIP Nature Protocols 7 5 978 94 doi 10 1038 nprot 2012 049 PMID 22538849 S2CID 20098167 Reddington JP Garfield DA Sigalova OM Karabacak Calviello A Marco Ferreres R Girardot C Viales RR Degner JF Ohler U Furlong EEM 7 December 2020 Lineage Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis Developmental Cell 55 5 648 664 e9 doi 10 1016 j devcel 2020 10 009 PMID 33171098 S2CID 226302320 Cusanovich DA Reddington JP Garfield DA Daza RM Aghamirzaie D Marco Ferreres R Pliner HA Christiansen L Qiu X Steemers FJ Trapnell C Shendure J Furlong EEM 2018 The cis regulatory dynamics of embryonic development at single cell resolution Nature 555 7697 538 542 Bibcode 2018Natur 555 538C doi 10 1038 nature25981 PMC 5866720 PMID 29539636 Furlong EE Andersen EC Null B White KP Scott MP 31 August 2001 Patterns of gene expression during Drosophila mesoderm development Science 293 5535 1629 33 Bibcode 2001Sci 293 1629F doi 10 1126 science 1062660 PMID 11486054 S2CID 13826608 Science American Association for the Advancement of 31 August 2001 This Week in Science Research in Science journals Science 293 5535 1553 doi 10 1126 science 2001 293 5535 twis ISSN 0036 8075 Editorial Board Developmental Cell cell com Editors and Board Development dev biologists org Editors amp Board Molecular Systems Biology embopress org Current Opinion in Genetics amp Development Editorial Board Current Opinion in Cell Biology Journal Elsevier Current Opinion in Cell Biology Editorial Board ERC Investigators EMBL embl de Futures Genome regulation ERC grantee Eileen Furlong EMBL 13 March 2017 EMBL Conference from Functional Genomics to Systems Biology 14th EMBL Conference Transcription and Chromatin Virtual Speakers Evolutionary Systems Biology Wellcome Connecting Science Courses and Conferences CSH Asia 2020 Conference Systems Biology of Gene Regulation and Genome Editing cshl csh asia org Flyer Online Symposium Minerva Gentner Symposium 2020 PDF Speaker Cell Symposia Transcriptional Regulation cell symposia com Eileen Furlong iscb org EMBL professor Eileen Furlong keynote on Genome Regulation UBC 4 October 2017 Pathology Research Institute of Molecular Eileen Furlong to give Max Birnstiel Lecture The Research Institute of Molecular Pathology ERC grant CisRegVar ERC grant DeCRypT Outstanding scientists elected as Fellows and Foreign Members of the Royal Society Royal Society 10 May 2022 Retrieved 11 May 2022 Retrieved from https en wikipedia org w index php title Eileen Furlong amp oldid 1179850116, wikipedia, wiki, book, books, library,

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