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Wikipedia

EIF2C2

February 11, 2024

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.[5][6][7]

AGO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGO2, EIF2C2, Q10, argonaute 2, RISC catalytic component, PPD, CASC7, LINC00980, argonaute RISC catalytic component 2, LESKRES
External IDsOMIM: 606229 MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2
Orthologs
SpeciesHumanMouse
Entrez

27161

239528

Ensembl

ENSG00000123908

ENSMUSG00000036698

UniProt

Q9UKV8

Q8CJG0

RefSeq (mRNA)

NM_001164623
NM_012154

NM_153178

RefSeq (protein)

NP_001158095
NP_036286

NP_694818

Location (UCSC)Chr 8: 140.52 – 140.64 MbChr 15: 72.97 – 73.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[7]

Interactions edit

EIF2C2 has been shown to interact with

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123908 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036698 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406. S2CID 24461432.
  6. ^ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
  7. ^ a b "Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2".
  8. ^ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA. 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384.
  9. ^ a b Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
  10. ^ Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (January 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. S2CID 14650075.
  11. ^ Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7. doi:10.1038/nn1174. PMID 14703574. S2CID 1146182.
  12. ^ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. S2CID 8136380.

Further reading edit

  • Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (2002). "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis". Genes Dev. 16 (21): 2733–42. doi:10.1101/gad.1026102. PMID 12414724.
  • Mourelatos Z, Dostie J, Paushkin S, et al. (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
  • Martinez J, Patkaniowska A, Urlaub H, et al. (2003). "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi". Cell. 110 (5): 563–74. doi:10.1016/S0092-8674(02)00908-X. hdl:11858/00-001M-0000-0012-F2FD-2. PMID 12230974. S2CID 10616773.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Doi N, Zenno S, Ueda R, et al. (2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. S2CID 14650075.
  • Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189–94. doi:10.1038/sj.embor.7400070. PMC 1298981. PMID 14749716.
  • Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA. 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384.
  • Liu J, Carmell MA, Rivas FV, et al. (2004). "Argonaute2 is the catalytic engine of mammalian RNAi". Science. 305 (5689): 1437–41. Bibcode:2004Sci...305.1437L. doi:10.1126/science.1102513. PMID 15284456. S2CID 2778088.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rivas FV, Tolia NH, Song JJ, et al. (2005). "Purified Argonaute2 and an siRNA form recombinant human RISC". Nat. Struct. Mol. Biol. 12 (4): 340–9. doi:10.1038/nsmb918. PMID 15800637. S2CID 2021813.
  • Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nat. Cell Biol. 7 (6): 633–6. doi:10.1038/ncb1265. PMID 15908945. S2CID 6085169.
  • Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nat. Cell Biol. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kraynack BA, Baker BF (2006). "Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity". RNA. 12 (1): 163–76. doi:10.1261/rna.2150806. PMC 1370895. PMID 16301602.
  • Maniataki E, Mourelatos Z (2006). "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA". Genes Dev. 19 (24): 2979–90. doi:10.1101/gad.1384005. PMC 1315402. PMID 16357216.
  • Shi H, Tschudi C, Ullu E (2006). "Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2". RNA. 12 (6): 943–7. doi:10.1261/rna.20806. PMC 1464859. PMID 16611939.
  • Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLOS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.


 

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

February 11, 2024
eif2c2, protein, argonaute, protein, that, humans, encoded, gene, ago2available, structurespdbortholog, search, pdbe, rcsblist, codes3luc, 3lud, 3lug, 3luh, 3luj, 3luk, 3qx8, 3qx9, 4f3t, 4ola, 4olb, 4w5n, 4w5o, 4w5q, 4w5r, 4w5t, 4z4c, 4z4d, 4z4e, 4z4f, 4z4g, 4. Protein argonaute 2 is a protein that in humans is encoded by the EIF2C2 gene 5 6 7 AGO2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2IdentifiersAliasesAGO2 EIF2C2 Q10 argonaute 2 RISC catalytic component PPD CASC7 LINC00980 argonaute RISC catalytic component 2 LESKRESExternal IDsOMIM 606229 MGI 2446632 HomoloGene 81825 GeneCards AGO2Gene location Human Chr Chromosome 8 human 1 Band8q24 3Start140 520 156 bp 1 End140 635 633 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 D3Start72 967 693 bp 2 End73 056 784 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insuperficial temporal arteryspongy bonecorpus epididymislower lobe of lungtendonAchilles tendoncaput epididymiscorpus callosumparietal pleurabloodTop expressed inascending aortahandaortic valvesupraoptic nucleusventromedial nucleussuprachiasmatic nucleusfootparaventricular nucleus of hypothalamusarcuate nucleusbloodMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding protein C terminus binding metal ion binding nuclease activity endoribonuclease activity cleaving miRNA paired mRNA hydrolase activity translation initiation factor activity endonuclease activity endoribonuclease activity cleaving siRNA paired mRNA single stranded RNA binding double stranded RNA binding RNA polymerase II complex binding nucleic acid binding mRNA binding miRNA binding endoribonuclease activity RNA 7 methylguanosine cap binding siRNA binding mRNA cap binding RNA binding endoribonuclease activity producing 5 phosphomonoestersCellular componentcytoplasm polysome membrane P body dendrite RISC loading complex RISC complex cytosol nucleus nucleoplasm mRNA cap binding complex cell junction extracellular exosome ribonucleoprotein complexBiological processmRNA destabilization mediated gene silencing by miRNA RNA secondary structure unwinding transcription DNA templated regulation of translation RNA interference protein biosynthesis positive regulation of nuclear transcribed mRNA catabolic process deadenylation dependent decay positive regulation of gene expression production of miRNAs involved in gene silencing by miRNA mRNA destabilization mediated gene silencing by siRNA positive regulation of nuclear transcribed mRNA poly A tail shortening pre miRNA processing regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II post embryonic development RNA phosphodiester bond hydrolysis endonucleolytic translational initiation Wnt signaling pathway calcium modulating pathway miRNA mediated gene silencing by inhibition of translation negative regulation of translational initiation miRNA metabolic process production of siRNA involved in RNA interference gene silencing regulation of gene silencing by miRNA negative regulation of gene expression positive regulation of angiogenesis positive regulation of trophoblast cell migration negative regulation of amyloid precursor protein biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez27161239528EnsemblENSG00000123908ENSMUSG00000036698UniProtQ9UKV8Q8CJG0RefSeq mRNA NM 001164623NM 012154NM 153178RefSeq protein NP 001158095NP 036286NP 694818Location UCSC Chr 8 140 52 140 64 MbChr 15 72 97 73 06 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the Argonaute family of proteins which play a role in RNA interference The encoded protein is highly basic and contains a PAZ domain and a PIWI domain It may interact with Dicer1 and play a role in short interfering RNA mediated gene silencing 7 Interactions editEIF2C2 has been shown to interact with DDX20 8 9 DICER1 9 10 FMRP FXR1P FXR2P 11 and TNRC6B 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000123908 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036698 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Koesters R Adams V Betts D Moos R Schmid M Siermann A Hassam S Weitz S Lichter P Heitz PU von Knebel Doeberitz M Briner J Dec 1999 Human eukaryotic initiation factor EIF2C1 gene cDNA sequence genomic organization localization to chromosomal bands 1p34 p35 and expression Genomics 61 2 210 8 doi 10 1006 geno 1999 5951 PMID 10534406 S2CID 24461432 Sasaki T Shiohama A Minoshima S Shimizu N Aug 2003 Identification of eight members of the Argonaute family in the human genome small star filled Genomics 82 3 323 30 doi 10 1016 S0888 7543 03 00129 0 PMID 12906857 a b Entrez Gene EIF2C2 eukaryotic translation initiation factor 2C 2 Nelson PT Hatzigeorgiou AG Mourelatos Z March 2004 miRNP mRNA association in polyribosomes in a human neuronal cell line RNA 10 3 387 94 doi 10 1261 rna 5181104 PMC 1370934 PMID 14970384 a b Mourelatos Z Dostie J Paushkin S Sharma A Charroux B Abel L Rappsilber J Mann M Dreyfuss G March 2002 miRNPs a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 16 6 720 8 doi 10 1101 gad 974702 PMC 155365 PMID 11914277 Doi N Zenno S Ueda R Ohki Hamazaki H Ui Tei K Saigo K January 2003 Short interfering RNA mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors Curr Biol 13 1 41 6 doi 10 1016 S0960 9822 02 01394 5 PMID 12526743 S2CID 14650075 Jin P Zarnescu DC Ceman S Nakamoto M Mowrey J Jongens TA Nelson DL Moses K Warren ST February 2004 Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway Nat Neurosci 7 2 113 7 doi 10 1038 nn1174 PMID 14703574 S2CID 1146182 Till S Lejeune E Thermann R Bortfeld M Hothorn M Enderle D Heinrich C Hentze MW Ladurner AG October 2007 A conserved motif in Argonaute interacting proteins mediates functional interactions through the Argonaute PIWI domain Nat Struct Mol Biol 14 10 897 903 doi 10 1038 nsmb1302 PMID 17891150 S2CID 8136380 Further reading editCarmell MA Xuan Z Zhang MQ Hannon GJ 2002 The Argonaute family tentacles that reach into RNAi developmental control stem cell maintenance and tumorigenesis Genes Dev 16 21 2733 42 doi 10 1101 gad 1026102 PMID 12414724 Mourelatos Z Dostie J Paushkin S et al 2002 miRNPs a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 16 6 720 8 doi 10 1101 gad 974702 PMC 155365 PMID 11914277 Martinez J Patkaniowska A Urlaub H et al 2003 Single stranded antisense siRNAs guide target RNA cleavage in RNAi Cell 110 5 563 74 doi 10 1016 S0092 8674 02 00908 X hdl 11858 00 001M 0000 0012 F2FD 2 PMID 12230974 S2CID 10616773 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Doi N Zenno S Ueda R et al 2003 Short interfering RNA mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors Curr Biol 13 1 41 6 doi 10 1016 S0960 9822 02 01394 5 PMID 12526743 S2CID 14650075 Tahbaz N Kolb FA Zhang H et al 2004 Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer EMBO Rep 5 2 189 94 doi 10 1038 sj embor 7400070 PMC 1298981 PMID 14749716 Nelson PT Hatzigeorgiou AG Mourelatos Z 2004 miRNP mRNA association in polyribosomes in a human neuronal cell line RNA 10 3 387 94 doi 10 1261 rna 5181104 PMC 1370934 PMID 14970384 Liu J Carmell MA Rivas FV et al 2004 Argonaute2 is the catalytic engine of mammalian RNAi Science 305 5689 1437 41 Bibcode 2004Sci 305 1437L doi 10 1126 science 1102513 PMID 15284456 S2CID 2778088 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rivas FV Tolia NH Song JJ et al 2005 Purified Argonaute2 and an siRNA form recombinant human RISC Nat Struct Mol Biol 12 4 340 9 doi 10 1038 nsmb918 PMID 15800637 S2CID 2021813 Sen GL Blau HM 2005 Argonaute 2 RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies Nat Cell Biol 7 6 633 6 doi 10 1038 ncb1265 PMID 15908945 S2CID 6085169 Liu J Valencia Sanchez MA Hannon GJ Parker R 2005 MicroRNA dependent localization of targeted mRNAs to mammalian P bodies Nat Cell Biol 7 7 719 23 doi 10 1038 ncb1274 PMC 1855297 PMID 15937477 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Kraynack BA Baker BF 2006 Small interfering RNAs containing full 2 O methylribonucleotide modified sense strands display Argonaute2 eIF2C2 dependent activity RNA 12 1 163 76 doi 10 1261 rna 2150806 PMC 1370895 PMID 16301602 Maniataki E Mourelatos Z 2006 A human ATP independent RISC assembly machine fueled by pre miRNA Genes Dev 19 24 2979 90 doi 10 1101 gad 1384005 PMC 1315402 PMID 16357216 Shi H Tschudi C Ullu E 2006 Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2 RNA 12 6 943 7 doi 10 1261 rna 20806 PMC 1464859 PMID 16611939 Wichroski MJ Robb GB Rana TM 2006 Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies PLOS Pathog 2 5 e41 doi 10 1371 journal ppat 0020041 PMC 1458959 PMID 16699599 nbsp This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title EIF2C2 amp oldid 1188029039, wikipedia, wiki, book, books, library,

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