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Wikipedia

EDEM3


ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.[5][6][7]

EDEM3
Identifiers
AliasesEDEM3, C1orf22, ER degradation enhancing alpha-mannosidase like protein 3, CDG2V
External IDsOMIM: 610214 MGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025191
NM_001319960

NM_001039644
NM_001311165
NM_001311166

RefSeq (protein)

NP_001306889
NP_079467

NP_001034733
NP_001298094
NP_001298095

Location (UCSC)Chr 1: 184.69 – 184.75 MbChr 1: 151.63 – 151.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116406 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043019 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
  6. ^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
  7. ^ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

Further reading edit

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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ER degradation enhancing alpha mannosidase like 3 is an enzyme that in humans is encoded by the EDEM3 gene 5 6 7 EDEM3IdentifiersAliasesEDEM3 C1orf22 ER degradation enhancing alpha mannosidase like protein 3 CDG2VExternal IDsOMIM 610214 MGI 1914217 HomoloGene 11866 GeneCards EDEM3Gene location Human Chr Chromosome 1 human 1 Band1q25 3Start184 690 237 bp 1 End184 754 907 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 G2Start151 631 122 bp 2 End151 697 802 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpylorusjejunal mucosatrabecular boneislet of Langerhansstromal cell of endometriumcardiabody of pancreasrectumbronchial epithelial celllower lobe of lungTop expressed inlacrimal glandseminal vesiculasalivary glandparotid glandsubmandibular glandcumulus cellleft lung lobepineal glandepithelium of stomachcrypt of lieberkuhn of small intestineMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding hydrolase activity metal ion binding mannosyl oligosaccharide 1 2 alpha mannosidase activity catalytic activityCellular componentendoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartmentBiological processendoplasmic reticulum unfolded protein response protein glycosylation N glycan processing response to unfolded protein glycoprotein catabolic process proteasome mediated ubiquitin dependent protein catabolic process mannose trimming involved in glycoprotein ERAD pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8026766967EnsemblENSG00000116406ENSMUSG00000043019UniProtQ9BZQ6Q2HXL6RefSeq mRNA NM 025191NM 001319960NM 001039644NM 001311165NM 001311166RefSeq protein NP 001306889NP 079467NP 001034733NP 001298094NP 001298095Location UCSC Chr 1 184 69 184 75 MbChr 1 151 63 151 7 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000116406 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000043019 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mast SW Diekman K Karaveg K Davis A Sifers RN Moremen KW Mar 2005 Human EDEM2 a novel homolog of family 47 glycosidases is involved in ER associated degradation of glycoproteins Glycobiology 15 4 421 36 doi 10 1093 glycob cwi014 PMID 15537790 Olivari S Galli C Alanen H Ruddock L Molinari M Jan 2005 A novel stress induced EDEM variant regulating endoplasmic reticulum associated glycoprotein degradation J Biol Chem 280 4 2424 8 doi 10 1074 jbc C400534200 PMID 15579471 Entrez Gene EDEM3 ER degradation enhancer mannosidase alpha like 3 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Sood R Bonner TI Makalowska I et al 2001 Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer HPC1 locus Genomics 73 2 211 22 doi 10 1006 geno 2001 6500 PMID 11318611 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Hirao K Natsuka Y Tamura T et al 2006 EDEM3 a soluble EDEM homolog enhances glycoprotein endoplasmic reticulum associated degradation and mannose trimming J Biol Chem 281 14 9650 8 doi 10 1074 jbc M512191200 PMID 16431915 Gregory SG Barlow KF McLay KE et al 2006 The DNA sequence and biological annotation of human chromosome 1 Nature 441 7091 315 21 Bibcode 2006Natur 441 315G doi 10 1038 nature04727 PMID 16710414 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title EDEM3 amp oldid 1195317142, wikipedia, wiki, book, books, library,

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