fbpx
Wikipedia

Douglas R. Green

May 04, 2024

Douglas Green (born 1955), is an American biologist. He holds the Peter C. Doherty Endowed Chair of Immunology in St. Jude Children's Research Hospital. His research has focused on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the molecular events directing the death of the cell. Green was editor in chief of the journal Oncogene from 2009-2016, is a Deputy Editor of the journal "Science Advances" and the author of the book Cell Death, Means To An End.

Douglas R. Green
Born
Douglas R Green

February 1955 (age 69)
United States
NationalityAmerican
Known forApoptosis research
Scientific career
FieldsCell Death, Cancer Biology, Immunology
InstitutionsSt. Jude Children's Research Hospital
ThesisContrasuppression: An Immunoregulatory T Cell Activity (1981)
Doctoral advisorRichard K. Gershon
Websitewww.stjude.org/green

Education edit

Green attended Ashland High School in 1973.[1] He then graduated magna cum laude from the Yale University with a Bachelor of Science in Biology in 1977. After training at the Massachusetts Institute of Technology for the next two years, Green graduated from Yale with a PhD in 1981, where he studied immunology with Richard K. Gershon.

Green joined the faculty at the University of Alberta in 1985.[2] In 1990, Green moved to the La Jolla Institute for Allergy and Immunology, where he became Head of the Division of Cellular Immunology.[2] In 2005, he moved to St. Jude Children's Research Hospital to become the Peter C. Doherty Endowed Chair of the Department of Immunology.[2][3]

Research edit

After many studies on immunological tolerance, Green's work on cell death began with his discovery of activation-induced apoptosis in T lymphocytes,[4][5] the role of c-Myc in this process[6] and the finding that Bcl-2 cooperates with Myc in oncogenesis by blocking apoptosis.[7] More recently, he discovered the process of LC3-associated phagocytosis, which links the autophagy pathway to phagosome maturation.[8] Other areas of interest include regulated necrosis,[9] metabolic reprogramming in T lymphocytes,[10] and the function of the tumor suppressor, p53.[11] As of 2014 he had published many chapters and books and over 500 papers, making him one of the world's most cited molecular biologists.[12] He is listed in:

  • ISI "highly cited" (Immunology 2003)
  • ISI "highly cited" (Molecular Biology/Genetics 2014)

Recognition edit

Green has received many awards, among these the E.J. Boell Award (Biology) (Yale, 1977), the J.S. Nicholas Award (Zoology) (Yale, 1981), Alberta Heritage Scholar (AHFMR 1985-1990), the Outstanding Teacher Award (Alberta, 1990), Ashland Public School System Hall of Fame[13] (Ashland, MA 1998), MERIT Award, NIGMS (2002), the International Cell Death Society Prize[14] (2009), Einstein Professorship (China, 2011). He is an Honorary Fellow of Trinity College, Dublin (2010)[15] and Dottore Honoris Causa of Rome University Tor Vergata (2016).[16] Green was elected to the Royal Society of Canada in 2018, the United States National Academy of Sciences in 2020,[17] and the American Association for the Advancement of Science (AAAS) Fellow in 2021.[18] In 1998, he was inducted into the Ashland High School Hall of Fame.

References edit

  1. ^ "Ashland plans salute".
  2. ^ a b c "Major Symposium Speaker: Douglas Green". International Congress of Immunology. Retrieved 11 July 2019.
  3. ^ "Douglas R. Green, PhD". St Jude Children's Research Hospital. Retrieved 11 July 2019.
  4. ^ Shi, Y. F.; Sahai, B. M.; Green, D. R. (1989). "Cyclosporin a inhibits activation-induced cell death in T-cell hybridomas and thymocytes". Nature. 339 (6226): 625–6. Bibcode:1989Natur.339..625S. doi:10.1038/339625a0. PMID 2786609. S2CID 13603645.
  5. ^ Shi, Y. F.; Szalay, M. G.; Paskar, L; Sahai, B. M.; Boyer, M; Singh, B; Green, D. R. (1990). "Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation". Journal of Immunology. 144 (9): 3326–33. PMID 1691753.
  6. ^ Shi, Y; Glynn, J. M.; Guilbert, L. J.; Cotter, T. G.; Bissonnette, R. P.; Green, D. R. (1992). "Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas". Science. 257 (5067): 212–4. Bibcode:1992Sci...257..212S. doi:10.1126/science.1378649. PMID 1378649.
  7. ^ Bissonnette, R. P.; Echeverri, F; Mahboubi, A; Green, D. R. (1992). "Apoptotic cell death induced by c-myc is inhibited by bcl-2". Nature. 359 (6395): 552–4. Bibcode:1992Natur.359..552B. doi:10.1038/359552a0. PMID 1406975. S2CID 4276740.
  8. ^ Sanjuan, M. A.; Dillon, C. P.; Tait, S. W.; Moshiach, S; Dorsey, F; Connell, S; Komatsu, M; Tanaka, K; Cleveland, J. L.; Withoff, S; Green, D. R. (2007). "Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis". Nature. 450 (7173): 1253–7. Bibcode:2007Natur.450.1253S. doi:10.1038/nature06421. PMID 18097414. S2CID 4406473.
  9. ^ Dillon, C. P.; Weinlich, R; Rodriguez, D. A.; Cripps, J. G.; Quarato, G; Gurung, P; Verbist, K. C.; Brewer, T. L.; Llambi, F; Gong, Y. N.; Janke, L. J.; Kelliher, M. A.; Kanneganti, T. D.; Green, D. R. (2014). "RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3". Cell. 157 (5): 1189–202. doi:10.1016/j.cell.2014.04.018. PMC 4068710. PMID 24813850.
  10. ^ Wang, R; Dillon, C. P.; Shi, L. Z.; Milasta, S; Carter, R; Finkelstein, D; McCormick, L. L.; Fitzgerald, P; Chi, H; Munger, J; Green, D. R. (2011). "The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation". Immunity. 35 (6): 871–82. doi:10.1016/j.immuni.2011.09.021. PMC 3248798. PMID 22195744.
  11. ^ Chipuk, J. E.; Kuwana, T; Bouchier-Hayes, L; Droin, N. M.; Newmeyer, D. D.; Schuler, M; Green, D. R. (2004). "Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis". Science. 303 (5660): 1010–4. Bibcode:2004Sci...303.1010C. doi:10.1126/science.1092734. PMID 14963330. S2CID 9793389.
  12. ^ "ISI - highlycited.com". Retrieved 2015-02-06.[permanent dead link]
  13. ^ Hall of Fame
  14. ^ International Cell Death Society Prize February 25, 2015, at the Wayback Machine
  15. ^ Trinity College Fellows Scholars 2010
  16. ^ Dottorato Honoris Causa in 'Biochimica e Biologia Molecolare' a Douglas R. Green
  17. ^ News from the National Academy of Sciences
  18. ^ 2021 AAAS Fellows

External links edit

  • Official website
  • Identifying 1996's Most-Cited Articles And Hottest Authors

May 04, 2024
douglas, green, douglas, green, born, 1955, american, biologist, holds, peter, doherty, endowed, chair, immunology, jude, children, research, hospital, research, focused, process, active, cell, death, cell, survival, extending, from, role, cell, death, cancer,. Douglas Green born 1955 is an American biologist He holds the Peter C Doherty Endowed Chair of Immunology in St Jude Children s Research Hospital His research has focused on the process of active cell death and cell survival extending from the role of cell death in cancer regulation and immune responses in the whole organism to the molecular events directing the death of the cell Green was editor in chief of the journal Oncogene from 2009 2016 is a Deputy Editor of the journal Science Advances and the author of the book Cell Death Means To An End Douglas R GreenBornDouglas R GreenFebruary 1955 age 69 United StatesNationalityAmericanKnown forApoptosis researchScientific careerFieldsCell Death Cancer Biology ImmunologyInstitutionsSt Jude Children s Research HospitalThesisContrasuppression An Immunoregulatory T Cell Activity 1981 Doctoral advisorRichard K GershonWebsitewww wbr stjude wbr org wbr green Contents 1 Education 2 Research 3 Recognition 4 References 5 External linksEducation editGreen attended Ashland High School in 1973 1 He then graduated magna cum laude from the Yale University with a Bachelor of Science in Biology in 1977 After training at the Massachusetts Institute of Technology for the next two years Green graduated from Yale with a PhD in 1981 where he studied immunology with Richard K Gershon Green joined the faculty at the University of Alberta in 1985 2 In 1990 Green moved to the La Jolla Institute for Allergy and Immunology where he became Head of the Division of Cellular Immunology 2 In 2005 he moved to St Jude Children s Research Hospital to become the Peter C Doherty Endowed Chair of the Department of Immunology 2 3 Research editAfter many studies on immunological tolerance Green s work on cell death began with his discovery of activation induced apoptosis in T lymphocytes 4 5 the role of c Myc in this process 6 and the finding that Bcl 2 cooperates with Myc in oncogenesis by blocking apoptosis 7 More recently he discovered the process of LC3 associated phagocytosis which links the autophagy pathway to phagosome maturation 8 Other areas of interest include regulated necrosis 9 metabolic reprogramming in T lymphocytes 10 and the function of the tumor suppressor p53 11 As of 2014 he had published many chapters and books and over 500 papers making him one of the world s most cited molecular biologists 12 He is listed in ISI highly cited Immunology 2003 ISI highly cited Molecular Biology Genetics 2014 Recognition editGreen has received many awards among these the E J Boell Award Biology Yale 1977 the J S Nicholas Award Zoology Yale 1981 Alberta Heritage Scholar AHFMR 1985 1990 the Outstanding Teacher Award Alberta 1990 Ashland Public School System Hall of Fame 13 Ashland MA 1998 MERIT Award NIGMS 2002 the International Cell Death Society Prize 14 2009 Einstein Professorship China 2011 He is an Honorary Fellow of Trinity College Dublin 2010 15 and Dottore Honoris Causa of Rome University Tor Vergata 2016 16 Green was elected to the Royal Society of Canada in 2018 the United States National Academy of Sciences in 2020 17 and the American Association for the Advancement of Science AAAS Fellow in 2021 18 In 1998 he was inducted into the Ashland High School Hall of Fame References edit Ashland plans salute a b c Major Symposium Speaker Douglas Green International Congress of Immunology Retrieved 11 July 2019 Douglas R Green PhD St Jude Children s Research Hospital Retrieved 11 July 2019 Shi Y F Sahai B M Green D R 1989 Cyclosporin a inhibits activation induced cell death in T cell hybridomas and thymocytes Nature 339 6226 625 6 Bibcode 1989Natur 339 625S doi 10 1038 339625a0 PMID 2786609 S2CID 13603645 Shi Y F Szalay M G Paskar L Sahai B M Boyer M Singh B Green D R 1990 Activation induced cell death in T cell hybridomas is due to apoptosis Morphologic aspects and DNA fragmentation Journal of Immunology 144 9 3326 33 PMID 1691753 Shi Y Glynn J M Guilbert L J Cotter T G Bissonnette R P Green D R 1992 Role for c myc in activation induced apoptotic cell death in T cell hybridomas Science 257 5067 212 4 Bibcode 1992Sci 257 212S doi 10 1126 science 1378649 PMID 1378649 Bissonnette R P Echeverri F Mahboubi A Green D R 1992 Apoptotic cell death induced by c myc is inhibited by bcl 2 Nature 359 6395 552 4 Bibcode 1992Natur 359 552B doi 10 1038 359552a0 PMID 1406975 S2CID 4276740 Sanjuan M A Dillon C P Tait S W Moshiach S Dorsey F Connell S Komatsu M Tanaka K Cleveland J L Withoff S Green D R 2007 Toll like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 450 7173 1253 7 Bibcode 2007Natur 450 1253S doi 10 1038 nature06421 PMID 18097414 S2CID 4406473 Dillon C P Weinlich R Rodriguez D A Cripps J G Quarato G Gurung P Verbist K C Brewer T L Llambi F Gong Y N Janke L J Kelliher M A Kanneganti T D Green D R 2014 RIPK1 blocks early postnatal lethality mediated by caspase 8 and RIPK3 Cell 157 5 1189 202 doi 10 1016 j cell 2014 04 018 PMC 4068710 PMID 24813850 Wang R Dillon C P Shi L Z Milasta S Carter R Finkelstein D McCormick L L Fitzgerald P Chi H Munger J Green D R 2011 The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation Immunity 35 6 871 82 doi 10 1016 j immuni 2011 09 021 PMC 3248798 PMID 22195744 Chipuk J E Kuwana T Bouchier Hayes L Droin N M Newmeyer D D Schuler M Green D R 2004 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 303 5660 1010 4 Bibcode 2004Sci 303 1010C doi 10 1126 science 1092734 PMID 14963330 S2CID 9793389 ISI highlycited com Retrieved 2015 02 06 permanent dead link Hall of Fame International Cell Death Society Prize Archived February 25 2015 at the Wayback Machine Trinity College Fellows Scholars 2010 Dottorato Honoris Causa in Biochimica e Biologia Molecolare a Douglas R Green News from the National Academy of Sciences 2021 AAAS FellowsExternal links editOfficial website Identifying 1996 s Most Cited Articles And Hottest Authors Retrieved from https en wikipedia org w index php title Douglas R Green amp oldid 1217698773, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.