Hopwood served as an assistant lecturer in genetics at Cambridge until he became a Lecturer in Genetics at the University of Glasgow in 1961.[10] He later became John Innes Professor of Genetics at the University of East Anglia. He is now an Emeritus Fellow in the Department of Molecular Microbiology at the John Innes Centre.[10]
Awards and honoursedit
Hopwood was awarded the Gabor Medal in 1995 "in recognition of his pioneering and leading the growing field of the genetics of Streptomyces coelicolor A3(2), and for developing the programming of the pervasive process of polyketide synthesis".[11] In 2002, he co-authored the sequencing of the S. coelicolor A3(2) genome.[7] During more than forty years he has been studying the genetics and molecular biology of the model actinomycete S. coelicolor.[12]
Professor Hopwood has done outstanding work on the genetics of actinomycetes. He discovered genetic recombination of Streptomyces and developed original systems of genetic mapping which led him to the demonstration of a circular linkage group. This mapping work was important both in strengthening the generalization that the prokaryotes in general have circular chromosomes and in showing a tendency towards symmetry in the map suggestive of evolution by genome doubling. His electron microscope studies (with A. Glauert) showed beyond doubt the prokaryotic affinities of Streptomyces and demonstrated for the first time the existence of membranous "organelles" in continuity with plasma membrane. He has shown that the fertility system of Streptomyces coelicolor involves a sex factor associated with a plasmid. In the course of these studies he has discovered the first clear example of a plasmid-encoded antibiotics synthesis. Hopwood and his group have also extended the genetic analysis to other species of Streptomyces and Nocardia and demonstrated efficient DNA-mediated transformation to Thermoactinomyces. Current studies are directed towards the genetic analysis of development in S. coelicolor. While G. Semonti made some of the basic observations on recombination independently, Hopwood has been the prime mover in most of the advances. He now has an established international reputation as the leading pioneer and authority in what has become a very important aspect of microbial genetics.[14]
^Bibb, M. J.; Ward, J. M.; Hopwood, D. A. (1978). "Transformation of plasmid DNA into Streptomyces at high frequency". Nature. 274 (5669): 398–400. Bibcode:1978Natur.274..398B. doi:10.1038/274398a0. PMID 672966. S2CID 4221380.
^Freeman, R. F.; Bibb, M. J.; Hopwood, D. A. (1977). "Chloramphenicol acetylransferase-independent chloramphenicol resistance in Streptomyces coelicolor A3(2)". Journal of General Microbiology. 98 (2): 453–65. doi:10.1099/00221287-98-2-453. PMID 856941.
^ abc"HOPWOOD, Sir David (Alan)". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
^ abBentley, S. D.; Chater, K. F.; Cerdeño-Tárraga, A. -M.; Challis, G. L.; Thomson, N. R.; James, K. D.; Harris, D. E.; Quail, M. A.; Kieser, H.; Harper, D.; Bateman, A.; Brown, S.; Chandra, G.; Chen, C. W.; Collins, M.; Cronin, A.; Fraser, A.; Goble, A.; Hidalgo, J.; Hornsby, T.; Howarth, S.; Huang, C. -H.; Kieser, T.; Larke, L.; Murphy, L.; Oliver, K.; O'Neil, S.; Rabbinowitsch, E.; Rajandream, M. -A.; et al. (2002). "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)". Nature. 417 (6885): 141–7. Bibcode:2002Natur.417..141B. doi:10.1038/417141a. PMID 12000953. S2CID 4430218.
^Hopwood, D. A. (1997). "Genetic Contributions to Understanding Polyketide Synthases". Chemical Reviews. 97 (7): 2465–2498. doi:10.1021/cr960034i. PMID 11851466.
^Hopwood, David Alan (1973). Genetical and Cytological Studies on Actinomycetes (PhD thesis). University of Glasgow.
^ ab"Sir David Hopwood". John Innes Centre. from the original on 21 September 2020. Retrieved 5 February 2009.
^"Gabor previous winners 2005 - 1989". The Royal Society. Retrieved 5 February 2009.
^Hopwood, D. A. (1999). "Forty years of genetics with Streptomyces: From in vivo through in vitro to in silico". Microbiology. 145 (9): 2183–202. doi:10.1099/00221287-145-9-2183. PMID 10517572.
^"Fellows". Royal Society. Retrieved 28 January 2011.
^. London: The Royal Society. Archived from the original on 10 July 2019. Retrieved 7 April 2014.
December 15, 2023
david, hopwood, david, alan, hopwood, born, august, 1933, british, microbiologist, geneticist, born, 1933, august, 1933, alma, materst, john, college, cambridge, university, glasgow, awardsfrs, 1979, knight, bachelor, 1994, gabor, medal, 1995, mendel, medal, 1. Sir David Alan Hopwood FRS born 19 August 1933 is a British microbiologist and geneticist 6 1 7 8 David HopwoodBorn 1933 08 19 19 August 1933 age 90 6 Alma materSt John s College Cambridge BA University of Glasgow PhD AwardsFRS 1979 Knight bachelor 1994 Gabor Medal 1995 Mendel Medal 1998 Scientific careerFieldsMicrobial genetics Antibiotics Genomics Actinomycetota 1 InstitutionsUniversity of Glasgow John Innes Centre University of East AngliaThesisGenetical and Cytological Studies on Actinomycetes 1973 Doctoral studentsJohn Beringer 2 Mervyn Bibb 3 4 Deng Zixin 5 Websitewww wbr jic wbr ac wbr uk wbr people wbr david hopwood wbr www wbr jic wbr ac wbr uk wbr STAFF wbr david hopwood Contents 1 Education 2 Career 3 Awards and honours 4 ReferencesEducation editEducated at Purbrook Park County High School and Lymm Grammar School Hopwood gained his Bachelor of Arts degree from St John s College Cambridge 6 and his PhD from the University of Glasgow in 1973 9 Career editHopwood served as an assistant lecturer in genetics at Cambridge until he became a Lecturer in Genetics at the University of Glasgow in 1961 10 He later became John Innes Professor of Genetics at the University of East Anglia He is now an Emeritus Fellow in the Department of Molecular Microbiology at the John Innes Centre 10 Awards and honours editHopwood was awarded the Gabor Medal in 1995 in recognition of his pioneering and leading the growing field of the genetics of Streptomyces coelicolor A3 2 and for developing the programming of the pervasive process of polyketide synthesis 11 In 2002 he co authored the sequencing of the S coelicolor A3 2 genome 7 During more than forty years he has been studying the genetics and molecular biology of the model actinomycete S coelicolor 12 Hopwood was elected a Fellow of the Royal Society in 1979 13 and delivered their Leeuwenhoek Lecture in 1987 He is also the author of Streptomyces in Nature and Medicine The Antibiotic Makers His nomination for the Royal Society reads Professor Hopwood has done outstanding work on the genetics of actinomycetes He discovered genetic recombination of Streptomyces and developed original systems of genetic mapping which led him to the demonstration of a circular linkage group This mapping work was important both in strengthening the generalization that the prokaryotes in general have circular chromosomes and in showing a tendency towards symmetry in the map suggestive of evolution by genome doubling His electron microscope studies with A Glauert showed beyond doubt the prokaryotic affinities of Streptomyces and demonstrated for the first time the existence of membranous organelles in continuity with plasma membrane He has shown that the fertility system of Streptomyces coelicolor involves a sex factor associated with a plasmid In the course of these studies he has discovered the first clear example of a plasmid encoded antibiotics synthesis Hopwood and his group have also extended the genetic analysis to other species of Streptomyces and Nocardia and demonstrated efficient DNA mediated transformation to Thermoactinomyces Current studies are directed towards the genetic analysis of development in S coelicolor While G Semonti made some of the basic observations on recombination independently Hopwood has been the prime mover in most of the advances He now has an established international reputation as the leading pioneer and authority in what has become a very important aspect of microbial genetics 14 References edit a b David Hopwood publications indexed by Google Scholar About us Bibb M J Ward J M Hopwood D A 1978 Transformation of plasmid DNA into Streptomyces at high frequency Nature 274 5669 398 400 Bibcode 1978Natur 274 398B doi 10 1038 274398a0 PMID 672966 S2CID 4221380 Freeman R F Bibb M J Hopwood D A 1977 Chloramphenicol acetylransferase independent chloramphenicol resistance in Streptomyces coelicolor A3 2 Journal of General Microbiology 98 2 453 65 doi 10 1099 00221287 98 2 453 PMID 856941 Deng Zixin Shanghai Jiao Tong University Retrieved 8 October 2016 a b c HOPWOOD Sir David Alan Who s Who 2014 A amp C Black an imprint of Bloomsbury Publishing plc 2014 online edn Oxford University Press subscription required a b Bentley S D Chater K F Cerdeno Tarraga A M Challis G L Thomson N R James K D Harris D E Quail M A Kieser H Harper D Bateman A Brown S Chandra G Chen C W Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang C H Kieser T Larke L Murphy L Oliver K O Neil S Rabbinowitsch E Rajandream M A et al 2002 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3 2 Nature 417 6885 141 7 Bibcode 2002Natur 417 141B doi 10 1038 417141a PMID 12000953 S2CID 4430218 Hopwood D A 1997 Genetic Contributions to Understanding Polyketide Synthases Chemical Reviews 97 7 2465 2498 doi 10 1021 cr960034i PMID 11851466 Hopwood David Alan 1973 Genetical and Cytological Studies on Actinomycetes PhD thesis University of Glasgow a b Sir David Hopwood John Innes Centre Archived from the original on 21 September 2020 Retrieved 5 February 2009 Gabor previous winners 2005 1989 The Royal Society Retrieved 5 February 2009 Hopwood D A 1999 Forty years of genetics with Streptomyces From in vivo through in vitro to in silico Microbiology 145 9 2183 202 doi 10 1099 00221287 145 9 2183 PMID 10517572 Fellows Royal Society Retrieved 28 January 2011 Library and Archive Catalogue EC 1979 16 Hopwood Sir David Alan London The Royal Society Archived from the original on 10 July 2019 Retrieved 7 April 2014 Retrieved from https en wikipedia org w index php title David Hopwood amp oldid 1113101882, wikipedia, wiki, book, books, library,
