David Glover
David Moore Glover FRS FRSE (born 28 March 1948) is a British geneticist and Research Professor of Biology and Biological Engineering at the California Institute of Technology.[4] He served as Balfour Professor of Genetics at the University of Cambridge, a Wellcome Trust investigator in the Department of Genetics at the University of Cambridge, and Fellow of Fitzwilliam College, Cambridge. He serves as the first editor-in-chief of the open-access journal Open Biology published by the Royal Society.[5][6][7][3][2][8]
David Glover | |
|---|---|
| Born | David Moore Glover March 28, 1948[3] |
| Nationality | British |
| Education | Broadway Technical Grammar School, Barnsley[3] |
| Alma mater | University of Cambridge (BA, ScD) University of London (PhD) |
| Spouse | |
| Awards | EMBO Member (1978)[1] |
| Scientific career | |
| Fields | Mitosis Meiosis Centrosomes[2] |
| Institutions | Imperial Cancer Research Fund University College London Stanford University Imperial College University of Dundee University of Cambridge California Institute of Technology |
| Thesis | The synthesis of polyoma virus specific RNA in mouse cells |
Education edit
Glover was educated at Broadway Technical Grammar School, Barnsley[3] and the University of Cambridge.[3] He undertook his PhD research in the Imperial Cancer Research Fund laboratories as a student of University College London.[9]
Career and research edit
As a Damon Runyon Fellow at Stanford University he participated in the Recombinant DNA revolution and discovered sequences that interrupted the ribosomal genes of Drosophila. On establishing his independent laboratory at Imperial College London in 1975, he later showed that these were ancient transposable elements. Together with Peter Rigby, Jean Beggs and David Lane, he co-directed a combined research group exploiting the new techniques of recombinant DNA research. In 1978 he was elected Member of the European Molecular Biology Organization (EMBO).[1]
While at Imperial, Glover was awarded a 10-year personal fellowship from the UK's Cancer Research Campaign that allowed him open up a new area of research pioneering the use of Drosophila as a model in which to study cell cycle regulation. He began by characterising the duplication cycles of centrosomes in the rapid nuclear division cycles of Drosophila embryos. This led to genetic studies that allowed him to discover and name the Polo and Aurora protein kinases, required for the function of centrosomes at the poles of mitotic spindles.[10]
In 1989, he relinquished his position as Head of the Department of Biochemistry at Imperial to move to the University of Dundee, where with David and Birgitte Lane he established the Cancer Research Campaign Laboratories, Dundee. Here his work demonstrated Polo not only to be required at centrosomes in Drosophila but also for cytokinesis. In parallel studies, Glover found that in an organism as distant as fission yeast, Polo's counterpart, that he named Plo1, was also required to establish functional spindle pole bodies and cytokinesis rings. Remarkably, the localisation and function of Polo kinase at the centrosome, the kinetochore and the central spindle in cytokinesis was highly conserved in human cells where its expression was elevated in tumours. This led Glover to collaborations with Biotechnological and Pharmaceutical industries in developing small molecule inhibitors of Polo for use in cancer therapy.[citation needed]
In Dundee he continued to use Drosophila as a means to uncover new components of the mitotic apparatus and its regulatory circuits. These studies uncovered spindle pole molecules whose functions were regulated by Polo kinase; a germ line specific Cdc25 phosphatase that regulates meiotic entry; and demonstrated the roles of PP1 and PP2A protein phosphatases as negative mitotic regulators. His contribution to science in Scotland was recognised by his election to Fellow of the Royal Society of Edinburgh (FRSE).[citation needed]
In 1999, Glover moved to the University of Cambridge to become the 6th Arthur Balfour Professor of Genetics and Head of Department. In Cambridge he discovered the second main Aurora B kinase required for cells to progress through metaphase and used genetic approaches to identify and demonstrate the roles of the Greatwall kinase in inhibiting protein phosphase 2A during mitotic entry and progression. Over the past decade he has uncovered the major steps of centriole duplication by demonstrating that Polo-like-kinase 4 (Plk4) is its master regulator; Plk4 expression can drive the de novo formation of centrioles in unfertilised Drosophila eggs. In searching for Plk4's partners, his group identified Asterless (Cep152 in human cells) as required for bringing Plk4 to centrioles and an F-box protein, Slimb – a component of the SCF ubiquitin protein ligase, as responsible for targeting excess Plk4 for destruction. They showed that Plk4 phosphorylates the centriole protein Ana2/STIL to enable it to bind the "cartwheel protein" Sas6 and thus initiate procentriole formation, the first step of centriole duplication.[citation needed]
In 2019, the Glover Lab moved to the California Institute of Technology in USA. [11]
Glover's group are now[when?] studying the consequences of supernumerary centrosomes in a variety of mammalian tissues and their consequences for the balance of cell proliferation and differentiation in the skin and pancreas.
Personal life edit
Glover married Magdalena Żernicka-Goetz in 2000.[3]
References edit
- ^ a b "David M. Glover". people.embo.org.
- ^ a b David Glover publications indexed by Google Scholar
- ^ a b c d e f Anon (2017). "Glover, Prof. David Moore". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U17298. (Subscription or UK public library membership required.)
- ^ Glover DM; Leibowitz MH; McLean DA; Parry H (7 April 1995). "Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles". Cell. 81 (1): 95–105. doi:10.1016/0092-8674(95)90374-7. ISSN 0092-8674. PMID 7720077. Wikidata Q29617537.
- ^ Press release by the Royal Society on the launch of the journal, 17 October 2011 ()
- ^ . Archived from the original on 15 June 2011. Retrieved 11 June 2011.
- ^ . debretts.com. Archived from the original on 8 September 2012.
- ^ David Glover publications from Europe PubMed Central
- ^ Glover, David Moore (1972). The synthesis of polyoma virus specific RNA in mouse cells (PhD thesis). University College London (University of London). OCLC 857995843. EThOS uk.bl.ethos.574633.
- ^ R Giet; David Glover (1 February 2001). "Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis". Journal of Cell Biology. 152 (4): 669–682. doi:10.1083/JCB.152.4.669. ISSN 0021-9525. PMC 2195771. PMID 11266459. Wikidata Q28206511.
- ^ "David Glover, Division of Biology and Biological Engineering, California Institute of Technology". Retrieved 19 October 2022.