Delta cells (δ-cells or D cells) are somatostatin-producing cells. They can be found in the stomach, intestine and the pancreatic islets. Delta cells comprise ca 5% of the cells in the islets[1] but may interact with many more islet cells than suggested by their low numbers. In rodents, delta-cells are located in the periphery of the islets; in humans the islet architecture is generally less organized and delta-cells are frequently observed inside the islets as well.[2] In both species, the peptide hormone Urocortin III (Ucn3) is a major local signal that is released from beta cells (and alpha cells in primates) to induce the local secretion of somatostatin.[3] It has also been suggested that somatostatin may be implicated in insulin-induced hypoglycaemia through a mechanism involving SGLT-2 receptors. [4]Ghrelin can also strongly stimulate somatostatin secretion, thus indirectly inhibiting insulin release.[5] Viewed under an electron microscope, delta-cells can be identified as cells with smaller and slightly more compact granules than beta cells.[6]
The δ-cells in the stomach contain CCKBR (which respond to gastrin) and M3 receptors (which respond to Ach). Respectively, these receptors will increase somatostatin output and decrease somatostatin output from the δ-cells. VIP, vasoactive intestinal peptide, acts positively on δ-cells resulting in more somatostatin being released.
In the stomach, somatostatin acts directly on the acid-producing parietal cells via a G-protein coupled receptor (which inhibits adenylate cyclase, thus effectively antagonising the stimulatory effect of histamine) to reduce acid secretion. Somatostatin can also indirectly decrease stomach acid production by preventing the release of other hormones, including gastrin, secretin and histamine which effectively slows down the digestive process.
When a person is infected with H. pylori the lower region of the stomach, the antrum, is predominantly inflamed. This is where most of the δ-cells in the stomach are. The bacteria produce a cloud of ammonia around themselves using urease to protect them from the stomach acid; however, this reacts with the acid producing ammonium which is toxic to cells. This leads to many of the δ-cells dying, an effect that is further compounded by the low PD-L1 expression on the δ-cells as compared to gastric G cells (resulting in higher susceptibility of δ-cells to inflammatory responses).[7] In turn, this results in a lower level of somatostatin being secreted and consequently higher release of gastrin and stomach acid. This, combined with the damage from ammonium, leads to ulceration of the stomach wall.[8]
^Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A (February 2006). "The unique cytoarchitecture of human pancreatic islets has implications for islet cell function". Proceedings of the National Academy of Sciences of the United States of America. 103 (7): 2334–2339. Bibcode:2006PNAS..103.2334C. doi:10.1073/pnas.0510790103. PMC1413730. PMID 16461897.
^Brereton MF, Vergari E, Zhang Q, Clark A (August 2015). "Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?". The Journal of Histochemistry and Cytochemistry. 63 (8): 575–591. doi:10.1369/0022155415583535. PMC4530398. PMID 26216135.
^van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, et al. (July 2015). "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion". Nature Medicine. 21 (7): 769–776. doi:10.1038/nm.3872. PMC4496282. PMID 26076035.
^Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, et al. (January 2019). "Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion". Nature Communications. 10 (1): 139. Bibcode:2019NatCo..10..139V. doi:10.1038/s41467-018-08193-8. PMC6329806. PMID 30635569.
^DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, et al. (July 2016). "Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets". Molecular Metabolism. 5 (7): 449–458. doi:10.1016/j.molmet.2016.04.007. PMC4921781. PMID 27408771.
^Rorsman P, Huising MO (July 2018). "The somatostatin-secreting pancreatic δ-cell in health and disease". Nature Reviews. Endocrinology. 14 (7): 404–414. doi:10.1038/s41574-018-0020-6. PMC5997567. PMID 29773871.
^Mommersteeg MC, Yu BT, van den Bosch TP, von der Thüsen JH, Kuipers EJ, Doukas M, Spaander MC, Peppelenbosch MP, Fuhler GM (October 2022). "Constitutive programmed death ligand 1 expression protects gastric G-cells from Helicobacter pylori-induced inflammation". Helicobacter. 27 (5): e12917. doi:10.1111/hel.12917. PMC9542424. PMID 35899973.
^Liu Y, Vosmaer GD, Tytgat GN, Xiao SD, Ten Kate FJ (September 2005). "Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis". Journal of Clinical Pathology. 58 (9): 927–931. doi:10.1136/jcp.2003.010710. PMC1770830. PMID 16126872.
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Not to be confused with D battery Delta cells d cells or D cells are somatostatin producing cells They can be found in the stomach intestine and the pancreatic islets Delta cells comprise ca 5 of the cells in the islets 1 but may interact with many more islet cells than suggested by their low numbers In rodents delta cells are located in the periphery of the islets in humans the islet architecture is generally less organized and delta cells are frequently observed inside the islets as well 2 In both species the peptide hormone Urocortin III Ucn3 is a major local signal that is released from beta cells and alpha cells in primates to induce the local secretion of somatostatin 3 It has also been suggested that somatostatin may be implicated in insulin induced hypoglycaemia through a mechanism involving SGLT 2 receptors 4 Ghrelin can also strongly stimulate somatostatin secretion thus indirectly inhibiting insulin release 5 Viewed under an electron microscope delta cells can be identified as cells with smaller and slightly more compact granules than beta cells 6 Delta cellControl of stomach acidDetailsLocationstomach intestine and the pancreatic isletsFunctionSomatostatin productionIdentifiersLatinendocrinocytus DTHH3 04 02 0 00027FMA62935Anatomical terms of microanatomy edit on Wikidata The d cells in the stomach contain CCKBR which respond to gastrin and M3 receptors which respond to Ach Respectively these receptors will increase somatostatin output and decrease somatostatin output from the d cells VIP vasoactive intestinal peptide acts positively on d cells resulting in more somatostatin being released In the stomach somatostatin acts directly on the acid producing parietal cells via a G protein coupled receptor which inhibits adenylate cyclase thus effectively antagonising the stimulatory effect of histamine to reduce acid secretion Somatostatin can also indirectly decrease stomach acid production by preventing the release of other hormones including gastrin secretin and histamine which effectively slows down the digestive process Clinical significance editA tumor of the delta cells is called a somatostatinoma When a person is infected with H pylori the lower region of the stomach the antrum is predominantly inflamed This is where most of the d cells in the stomach are The bacteria produce a cloud of ammonia around themselves using urease to protect them from the stomach acid however this reacts with the acid producing ammonium which is toxic to cells This leads to many of the d cells dying an effect that is further compounded by the low PD L1 expression on the d cells as compared to gastric G cells resulting in higher susceptibility of d cells to inflammatory responses 7 In turn this results in a lower level of somatostatin being secreted and consequently higher release of gastrin and stomach acid This combined with the damage from ammonium leads to ulceration of the stomach wall 8 See also editList of human cell types derived from the germ layers List of distinct cell types in the adult human bodyReferences edit Cabrera O Berman DM Kenyon NS Ricordi C Berggren PO Caicedo A February 2006 The unique cytoarchitecture of human pancreatic islets has implications for islet cell function Proceedings of the National Academy of Sciences of the United States of America 103 7 2334 2339 Bibcode 2006PNAS 103 2334C doi 10 1073 pnas 0510790103 PMC 1413730 PMID 16461897 Brereton MF Vergari E Zhang Q Clark A August 2015 Alpha Delta and PP cells Are They the Architectural Cornerstones of Islet Structure and Co ordination The Journal of Histochemistry and Cytochemistry 63 8 575 591 doi 10 1369 0022155415583535 PMC 4530398 PMID 26216135 van der Meulen T Donaldson CJ Caceres E Hunter AE Cowing Zitron C Pound LD et al July 2015 Urocortin3 mediates somatostatin dependent negative feedback control of insulin secretion Nature Medicine 21 7 769 776 doi 10 1038 nm 3872 PMC 4496282 PMID 26076035 Vergari E Knudsen JG Ramracheya R Salehi A Zhang Q Adam J et al January 2019 Insulin inhibits glucagon release by SGLT2 induced stimulation of somatostatin secretion Nature Communications 10 1 139 Bibcode 2019NatCo 10 139V doi 10 1038 s41467 018 08193 8 PMC 6329806 PMID 30635569 DiGruccio MR Mawla AM Donaldson CJ Noguchi GM Vaughan J Cowing Zitron C et al July 2016 Comprehensive alpha beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets Molecular Metabolism 5 7 449 458 doi 10 1016 j molmet 2016 04 007 PMC 4921781 PMID 27408771 Rorsman P Huising MO July 2018 The somatostatin secreting pancreatic d cell in health and disease Nature Reviews Endocrinology 14 7 404 414 doi 10 1038 s41574 018 0020 6 PMC 5997567 PMID 29773871 Mommersteeg MC Yu BT van den Bosch TP von der Thusen JH Kuipers EJ Doukas M Spaander MC Peppelenbosch MP Fuhler GM October 2022 Constitutive programmed death ligand 1 expression protects gastric G cells from Helicobacter pylori induced inflammation Helicobacter 27 5 e12917 doi 10 1111 hel 12917 PMC 9542424 PMID 35899973 Liu Y Vosmaer GD Tytgat GN Xiao SD Ten Kate FJ September 2005 Gastrin G cells and somatostatin D cells in patients with dyspeptic symptoms Helicobacter pylori associated and non associated gastritis Journal of Clinical Pathology 58 9 927 931 doi 10 1136 jcp 2003 010710 PMC 1770830 PMID 16126872 nbsp This human digestive system article is a stub You can help Wikipedia by expanding it vte nbsp This cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Delta cell amp oldid 1206102794, wikipedia, wiki, book, books, library,
