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Dentin sialophosphoprotein

January 01, 1970

Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth. It is produced by cells (odontoblasts) inside the teeth (dental pulp), and in smaller quantities by bone tissues (osteoblasts and osteocytes). It is required for normal hardening (mineralisation) of teeth. During teeth development, it is broken down into three proteins such as dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP).[1] These proteins become the major non-collagenous components of teeth. Their distribution in the collagen matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including type III dentinogenesis imperfecta.[2][3]

Dentin sialophosphoprotein
Identifiers
SymbolDSPP
Alt. namesDentin Phosphophoryn
NCBI gene1834
HGNC3054
OMIM125485
UniProtQ9NZW4
Other data
LocusChr. 4 q22.1
Search for
StructuresSwiss-model
DomainsInterPro

It is coded by a gene of the same name (dentin sialophosphoprotein, or DSPP) present on human chromosome 4. This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.[4]

References edit

  1. ^ Yamamoto R, Oida S, Yamakoshi Y (2015). "Dentin Sialophosphoprotein–derived Proteins in the Dental Pulp". Journal of Dental Research. 94 (8): 1120–1127. doi:10.1177/0022034515585715. PMID 25951824. S2CID 24609252.
  2. ^ Letty Moss-Salentijn, Biology of Mineralized Tissue coursenotes, Columbia University College of Dental Medicine, 2009
  3. ^ Nanci, Antonio. Ten Cate's Oral Histology: Development, Structure, and Function. 7th ed. St. Louis, MO: Mosby Elsevier, 2008. Print.
  4. ^ "Entrez Gene: DSPP dentin sialophosphoprotein".

Further reading edit

  • Butler WT (1998). "Dentin matrix proteins". Eur. J. Oral Sci. 106 (Suppl 1): 204–10. doi:10.1111/j.1600-0722.1998.tb02177.x. PMID 9541227.
  • MacDougall M, Simmons D, Luan X, et al. (1997). "Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination". J. Biol. Chem. 272 (2): 835–42. doi:10.1074/jbc.272.2.835. PMID 8995371.
  • Dean JA, Hartsfield JK, Wright JT, Hart TC (1998). "Dentin dysplasia, type II linkage to chromosome 4q". J. Craniofac. Genet. Dev. Biol. 17 (4): 172–7. PMID 9493074.
  • MacDougall M, Simmons D, Luan X, et al. (1998). "Assignment of dentin sialophosphoprotein (DSPP) to the critical DGI2 locus on human chromosome 4 band q21.3 by in situ hybridization". Cytogenet. Cell Genet. 79 (1–2): 121–2. doi:10.1159/000134697. PMID 9533027.
  • MacDougall M (1998). "Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci". Eur. J. Oral Sci. 106 (Suppl 1): 227–33. doi:10.1111/j.1600-0722.1998.tb02180.x. PMID 9541230.
  • Gu K, Chang SR, Slaven MS, et al. (1999). "Human dentin phosphophoryn nucleotide and amino acid sequence" (PDF). Eur. J. Oral Sci. 106 (6): 1043–7. doi:10.1046/j.0909-8836..t01-9-.x. hdl:2027.42/75305. PMID 9879917.
  • Gu K, Chang S, Ritchie HH, et al. (2000). "Molecular cloning of a human dentin sialophosphoprotein gene" (PDF). Eur. J. Oral Sci. 108 (1): 35–42. doi:10.1034/j.1600-0722.2000.00765.x. hdl:2027.42/71920. PMID 10706475.
  • Buchaille R, Couble ML, Magloire H, Bleicher F (2000). "A substractive PCR-based cDNA library from human odontoblast cells: identification of novel genes expressed in tooth forming cells". Matrix Biol. 19 (5): 421–30. doi:10.1016/S0945-053X(00)00091-3. PMID 10980418.
  • Zhang X, Zhao J, Li C, et al. (2001). "DSPP mutation in dentinogenesis imperfecta Shields type II". Nat. Genet. 27 (2): 151–2. doi:10.1038/84765. PMID 11175779. S2CID 9692054.
  • Xiao S, Yu C, Chou X, et al. (2001). "Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP". Nat. Genet. 27 (2): 201–4. doi:10.1038/84848. PMID 11175790. S2CID 22276124.
  • Papagerakis P, Berdal A, Mesbah M, et al. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth". Bone. 30 (2): 377–85. doi:10.1016/S8756-3282(01)00683-4. PMID 11856645.
  • Qin C, Brunn JC, Cadena E, et al. (2002). "The expression of dentin sialophosphoprotein gene in bone". J. Dent. Res. 81 (6): 392–4. doi:10.1177/154405910208100607. PMID 12097430. S2CID 6384427.
  • Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
  • Jadlowiec J, Koch H, Zhang X, et al. (2005). "Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway". J. Biol. Chem. 279 (51): 53323–30. doi:10.1074/jbc.M404934200. PMID 15371433.
  • Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
  • Paine ML, Luo W, Wang HJ, et al. (2005). "Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis". J. Biol. Chem. 280 (36): 31991–8. doi:10.1074/jbc.M502991200. PMID 16014627.
  • Chaplet M, Waltregny D, Detry C, et al. (2006). "Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness". Int. J. Cancer. 118 (4): 850–6. doi:10.1002/ijc.21442. PMID 16108038. S2CID 12370385.
  • Beattie ML, Kim JW, Gong SG, et al. (2006). "Phenotypic variation in dentinogenesis imperfecta/dentin dysplasia linked to 4q21". J. Dent. Res. 85 (4): 329–33. doi:10.1177/154405910608500409. PMC 2238637. PMID 16567553.
  • Narayanan K, Gajjeraman S, Ramachandran A, et al. (2006). "Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation". J. Biol. Chem. 281 (28): 19064–71. doi:10.1074/jbc.M600714200. PMID 16679514.

January 01, 1970
dentin, sialophosphoprotein, precursor, protein, other, proteins, found, teeth, produced, cells, odontoblasts, inside, teeth, dental, pulp, smaller, quantities, bone, tissues, osteoblasts, osteocytes, required, normal, hardening, mineralisation, teeth, during,. Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth It is produced by cells odontoblasts inside the teeth dental pulp and in smaller quantities by bone tissues osteoblasts and osteocytes It is required for normal hardening mineralisation of teeth During teeth development it is broken down into three proteins such as dentin sialoprotein DSP dentin glycoprotein DGP and dentin phosphoprotein DPP 1 These proteins become the major non collagenous components of teeth Their distribution in the collagen matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein Such patients suffer dental anomalies including type III dentinogenesis imperfecta 2 3 Dentin sialophosphoproteinIdentifiersSymbolDSPPAlt namesDentin PhosphophorynNCBI gene1834HGNC3054OMIM125485UniProtQ9NZW4Other dataLocusChr 4 q22 1Search forStructuresSwiss modelDomainsInterPro It is coded by a gene of the same name dentin sialophosphoprotein or DSPP present on human chromosome 4 This gene encodes two principal proteins of the dentin extracellular matrix of the tooth The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin Mutations in this gene have been associated with dentinogenesis imperfecta 1 in some individuals dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness Allelic differences due to repeat polymorphisms have been found for this gene 4 References edit Yamamoto R Oida S Yamakoshi Y 2015 Dentin Sialophosphoprotein derived Proteins in the Dental Pulp Journal of Dental Research 94 8 1120 1127 doi 10 1177 0022034515585715 PMID 25951824 S2CID 24609252 Letty Moss Salentijn Biology of Mineralized Tissue coursenotes Columbia University College of Dental Medicine 2009 Nanci Antonio Ten Cate s Oral Histology Development Structure and Function 7th ed St Louis MO Mosby Elsevier 2008 Print Entrez Gene DSPP dentin sialophosphoprotein Further reading editButler WT 1998 Dentin matrix proteins Eur J Oral Sci 106 Suppl 1 204 10 doi 10 1111 j 1600 0722 1998 tb02177 x PMID 9541227 MacDougall M Simmons D Luan X et al 1997 Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4 Dentin phosphoprotein DNA sequence determination J Biol Chem 272 2 835 42 doi 10 1074 jbc 272 2 835 PMID 8995371 Dean JA Hartsfield JK Wright JT Hart TC 1998 Dentin dysplasia type II linkage to chromosome 4q J Craniofac Genet Dev Biol 17 4 172 7 PMID 9493074 MacDougall M Simmons D Luan X et al 1998 Assignment of dentin sialophosphoprotein DSPP to the critical DGI2 locus on human chromosome 4 band q21 3 by in situ hybridization Cytogenet Cell Genet 79 1 2 121 2 doi 10 1159 000134697 PMID 9533027 MacDougall M 1998 Refined mapping of the human dentin sialophosphoprotein DSPP gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci Eur J Oral Sci 106 Suppl 1 227 33 doi 10 1111 j 1600 0722 1998 tb02180 x PMID 9541230 Gu K Chang SR Slaven MS et al 1999 Human dentin phosphophoryn nucleotide and amino acid sequence PDF Eur J Oral Sci 106 6 1043 7 doi 10 1046 j 0909 8836 t01 9 x hdl 2027 42 75305 PMID 9879917 Gu K Chang S Ritchie HH et al 2000 Molecular cloning of a human dentin sialophosphoprotein gene PDF Eur J Oral Sci 108 1 35 42 doi 10 1034 j 1600 0722 2000 00765 x hdl 2027 42 71920 PMID 10706475 Buchaille R Couble ML Magloire H Bleicher F 2000 A substractive PCR based cDNA library from human odontoblast cells identification of novel genes expressed in tooth forming cells Matrix Biol 19 5 421 30 doi 10 1016 S0945 053X 00 00091 3 PMID 10980418 Zhang X Zhao J Li C et al 2001 DSPP mutation in dentinogenesis imperfecta Shields type II Nat Genet 27 2 151 2 doi 10 1038 84765 PMID 11175779 S2CID 9692054 Xiao S Yu C Chou X et al 2001 Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP Nat Genet 27 2 201 4 doi 10 1038 84848 PMID 11175790 S2CID 22276124 Papagerakis P Berdal A Mesbah M et al 2002 Investigation of osteocalcin osteonectin and dentin sialophosphoprotein in developing human teeth Bone 30 2 377 85 doi 10 1016 S8756 3282 01 00683 4 PMID 11856645 Qin C Brunn JC Cadena E et al 2002 The expression of dentin sialophosphoprotein gene in bone J Dent Res 81 6 392 4 doi 10 1177 154405910208100607 PMID 12097430 S2CID 6384427 Ogbureke KU Fisher LW 2004 Expression of SIBLINGs and their partner MMPs in salivary glands J Dent Res 83 9 664 70 doi 10 1177 154405910408300902 PMID 15329369 S2CID 17978869 Jadlowiec J Koch H Zhang X et al 2005 Phosphophoryn regulates the gene expression and differentiation of NIH3T3 MC3T3 E1 and human mesenchymal stem cells via the integrin MAPK signaling pathway J Biol Chem 279 51 53323 30 doi 10 1074 jbc M404934200 PMID 15371433 Ogbureke KU Fisher LW 2005 Renal expression of SIBLING proteins and their partner matrix metalloproteinases MMPs Kidney Int 68 1 155 66 doi 10 1111 j 1523 1755 2005 00389 x PMID 15954904 Paine ML Luo W Wang HJ et al 2005 Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis J Biol Chem 280 36 31991 8 doi 10 1074 jbc M502991200 PMID 16014627 Chaplet M Waltregny D Detry C et al 2006 Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness Int J Cancer 118 4 850 6 doi 10 1002 ijc 21442 PMID 16108038 S2CID 12370385 Beattie ML Kim JW Gong SG et al 2006 Phenotypic variation in dentinogenesis imperfecta dentin dysplasia linked to 4q21 J Dent Res 85 4 329 33 doi 10 1177 154405910608500409 PMC 2238637 PMID 16567553 Narayanan K Gajjeraman S Ramachandran A et al 2006 Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation J Biol Chem 281 28 19064 71 doi 10 1074 jbc M600714200 PMID 16679514 Retrieved from https en wikipedia org w index php title Dentin sialophosphoprotein amp oldid 1196783187, wikipedia, wiki, book, books, library,

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