The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000133884 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024826 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
^ ab"Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".
Further readingedit
Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. doi:10.1016/S0021-9258(18)43910-5. PMID 7961935.
Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC310681. PMID 9253601.
Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388. S2CID 22559464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
dpf2, zinc, finger, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3iufidentifiersaliases, ubid4, double, fingers, css7, smarcg2external, idsomim, 601671, 109529, homologene, 21265, genecards, gene. Zinc finger protein ubi d4 is a protein that in humans is encoded by the DPF2 gene 5 6 DPF2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3IUFIdentifiersAliasesDPF2 REQ UBID4 ubi d4 double PHD fingers 2 CSS7 SMARCG2External IDsOMIM 601671 MGI 109529 HomoloGene 21265 GeneCards DPF2Gene location Human Chr Chromosome 11 human 1 Band11q13 1Start65 333 852 bp 1 End65 354 262 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 A 19 4 34 cMStart5 946 544 bp 2 End5 963 038 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocyteAchilles tendonganglionic eminencecanal of the cervixleft uterine tubesmooth muscle tissueright uterine tubepopliteal arterygastric mucosaTop expressed ininternal carotid arteryexternal carotid arteryprimitive streaklensneural tubemolarlipsacculethymusmedial ganglionic eminenceMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding RNA polymerase II cis regulatory region sequence specific DNA binding protein binding nucleic acid binding DNA binding transcription factor activity RNA polymerase II specific transcription corepressor activity histone acetyltransferase activity histone binding H3K9me3 modified histone binding lysine acetylated histone bindingCellular componentnucleus nucleoplasm intracellular membrane bounded organelle centrosome cytoplasm cytosol histone acetyltransferase complex nBAF complexBiological processregulation of transcription DNA templated transcription DNA templated apoptotic signaling pathway apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization nervous system development histone acetylation negative regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II negative regulation of myeloid progenitor cell differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez597719708EnsemblENSG00000133884ENSMUSG00000024826UniProtQ92785Q61103RefSeq mRNA NM 006268NM 001330308NM 001291078NM 011262RefSeq protein NP 001317237NP 006259NP 006259 1NP 001278007NP 035392Location UCSC Chr 11 65 33 65 35 MbChr 19 5 95 5 96 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is a member of the d4 domain family characterized by a zinc finger like structural motif This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors It likely serves a regulatory role in rapid hematopoietic cell growth and turnover This gene is considered a candidate gene for multiple endocrine neoplasia type I an inherited cancer syndrome involving multiple parathyroid enteropancreatic and pituitary tumors 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000133884 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024826 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ninkina NN Mertsalov IB Kulikova DA Alimova Kost MV Simonova OB Korochkin LI Kiselev SL Buchman VL Feb 2002 Cerd4 third member of the d4 gene family expression and organization of genomic locus Mamm Genome 12 11 862 6 doi 10 1007 s00335 001 3039 1 PMID 11845289 S2CID 2149578 a b Entrez Gene DPF2 D4 zinc and double PHD fingers family 2 Further reading editGabig TG Mantel PL Rosli R Crean CD 1994 Requiem a novel zinc finger gene essential for apoptosis in myeloid cells J Biol Chem 269 47 29515 9 doi 10 1016 S0021 9258 18 43910 5 PMID 7961935 Chestkov AV Baka ID Kost MV et al 1997 The d4 gene family in the human genome Genomics 36 1 174 7 doi 10 1006 geno 1996 0440 PMID 8812431 Guru SC Agarwal SK Manickam P et al 1997 A Transcript Map for the 2 8 Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus Genome Res 7 7 725 35 doi 10 1101 gr 7 7 725 PMC 310681 PMID 9253601 Gabig TG Crean CD Klenk A et al 1998 Expression and chromosomal localization of the Requiem gene Mamm Genome 9 8 660 5 doi 10 1007 s003359900840 PMID 9680388 S2CID 22559464 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Bouwmeester T Bauch A Ruffner H et al 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 External links editDPF2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DPF2 amp oldid 1118749921, wikipedia, wiki, book, 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