Dock10 shares the same domain arrangement as other members of the DOCK-D/Zizimin subfamily as well as a high level of sequence similarity.[8] It contains a DHR2 domain that is involved in G protein binding and a DHR1 domain, which, in some DOCK family proteins, interacts with membrane phospholipids. Like other DOCK-D subfamily proteins Dock10 contains an N-terminalPH domain, which, in Dock9/Zizimin1, mediates recruitment to the plasma membrane.[9] The DHR2 domain of Dock10 appears to bind to the small G proteins Cdc42, TC10 and TCL although these interactions are of low affinity.[8] The physiological role of Dock10 is poorly characterised, however a study in lymphocytes has shown that Dock10 expression is upregulated in B-lymphocytes and Chronic Lymphocytic Leukemia (CLL) cells in response to the cytokineIL-4.[7] This suggests that Dock10 may have a role in B-cell activation and proliferation. Another study identified Dock10 as a protein that was overexpressed in some aggressive papillary thyroid carcinomas.[10]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000135905 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038608 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: DOCK10 dedicator of cytokinesis 10".
^Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.
^ abYelo E, Bernardo MV, Gimeno L, et al. (July 2008). "Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes". Mol. Immunol. 45 (12): 3411–18. doi:10.1016/j.molimm.2008.04.003. PMID 18499258.
^ abcNishikimi A, Meller N, Uekawa N, et al. (February 2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Letters. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388. S2CID 36721405.
^Meller N, Westbrook MJ, Shannon JD, et al. (January 2008). "Function of the N-terminus of zizimin1: autoinhibition and membrane targeting". Biochem. J. 409 (2): 525–33. doi:10.1042/BJ20071263. PMC2740492. PMID 17935486.
^Fluge Ø, Bruland O, Akslen LA, et al. (February 2006). "Gene expression in poorly differentiated papillary thyroid carcinomas". Thyroid. 16 (2): 161–75. doi:10.1089/thy.2006.16.161. PMID 16676402.
Further readingedit
Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388. S2CID 36721405.
Meller N, Merlot S, Guda C (2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241.
Côté JF, Vuori K (2006). "In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 41–57. doi:10.1016/S0076-6879(06)06004-6. ISBN9780121828110. PMID 16472648.
External linksedit
Overview of all the structural information available in the PDB for UniProt: Q96BY6 (Dedicator of cytokinesis protein 10) at the PDBe-KB.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
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Dock10 redirects here For the British television facility see Dock10 television facility Dedicator of cytokinesis protein 10 Dock10 also known as Zizimin3 is a large 240 kDa protein involved in intracellular signalling networks that in humans is encoded by the DOCK10 gene 5 It is a member of the DOCK D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins DOCK10IdentifiersAliasesDOCK10 DRIP2 Nbla10300 ZIZ3 Dock10 dedicator of cytokinesis 10External IDsOMIM 611518 MGI 2146320 HomoloGene 45952 GeneCards DOCK10 OMA DOCK10 orthologsGene location Human Chr Chromosome 2 human 1 Band2q36 2Start224 765 090 bp 1 End225 042 468 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 C5Start80 478 790 bp 2 End80 736 244 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosuminternal globus pallidusinferior ganglion of vagus nervespleensubstantia nigrabone marrow cellssubthalamic nucleuslymph nodehippocampus propermonocyteTop expressed inotolith organutriclespleenglobus pallidussciatic nervesubstantia nigrasuprachiasmatic nucleusnucleus accumbenstrigeminal ganglionsubcutaneous adipose tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding guanyl nucleotide exchange factor activity molecular functionCellular componentextracellular exosome membrane nucleus cytoplasm cell projection dendritic spine nucleoplasm cytosol intracellular anatomical structureBiological processsmall GTPase mediated signal transduction regulation of cell migration B cell homeostasis marginal zone B cell differentiation positive regulation of GTPase activity dendritic spine morphogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez55619210293EnsemblENSG00000135905ENSMUSG00000038608UniProtQ96BY6Q8BZN6RefSeq mRNA NM 001290263NM 014689NM 017718NM 001363762NM 001285927NM 175291RefSeq protein NP 001277192NP 055504NP 001350691NP 001272856NP 780500NP 001393483NP 001393484Location UCSC Chr 2 224 77 225 04 MbChr 1 80 48 80 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Discovery 2 Structure and function 3 References 4 Further reading 5 External linksDiscovery editDock10 was identified via bioinformatic approaches as one of a family of evolutionarily conserved proteins the DOCK family that share significant sequence homology 6 Dock10 is expressed in peripheral blood leukocytes 7 as well as in the brain spleen lung and thymus 8 Structure and function editDock10 shares the same domain arrangement as other members of the DOCK D Zizimin subfamily as well as a high level of sequence similarity 8 It contains a DHR2 domain that is involved in G protein binding and a DHR1 domain which in some DOCK family proteins interacts with membrane phospholipids Like other DOCK D subfamily proteins Dock10 contains an N terminal PH domain which in Dock9 Zizimin1 mediates recruitment to the plasma membrane 9 The DHR2 domain of Dock10 appears to bind to the small G proteins Cdc42 TC10 and TCL although these interactions are of low affinity 8 The physiological role of Dock10 is poorly characterised however a study in lymphocytes has shown that Dock10 expression is upregulated in B lymphocytes and Chronic Lymphocytic Leukemia CLL cells in response to the cytokine IL 4 7 This suggests that Dock10 may have a role in B cell activation and proliferation Another study identified Dock10 as a protein that was overexpressed in some aggressive papillary thyroid carcinomas 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000135905 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000038608 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene DOCK10 dedicator of cytokinesis 10 Cote JF Vuori K December 2002 Identification of an evolutionarily conserved superfamily of DOCK180 related proteins with guanine nucleotide exchange activity J Cell Sci 115 Pt 24 4901 13 doi 10 1242 jcs 00219 PMID 12432077 a b Yelo E Bernardo MV Gimeno L et al July 2008 Dock10 a novel CZH protein selectively induced by interleukin 4 in human B lymphocytes Mol Immunol 45 12 3411 18 doi 10 1016 j molimm 2008 04 003 PMID 18499258 a b c Nishikimi A Meller N Uekawa N et al February 2005 Zizimin2 a novel DOCK180 related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes FEBS Letters 579 5 1039 46 doi 10 1016 j febslet 2005 01 006 PMID 15710388 S2CID 36721405 Meller N Westbrook MJ Shannon JD et al January 2008 Function of the N terminus of zizimin1 autoinhibition and membrane targeting Biochem J 409 2 525 33 doi 10 1042 BJ20071263 PMC 2740492 PMID 17935486 Fluge O Bruland O Akslen LA et al February 2006 Gene expression in poorly differentiated papillary thyroid carcinomas Thyroid 16 2 161 75 doi 10 1089 thy 2006 16 161 PMID 16676402 Further reading editNishikimi A Meller N Uekawa N et al 2005 Zizimin2 a novel DOCK180 related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes FEBS Lett 579 5 1039 46 doi 10 1016 j febslet 2005 01 006 PMID 15710388 S2CID 36721405 Meller N Merlot S Guda C 2005 CZH proteins a new family of Rho GEFs J Cell Sci 118 Pt 21 4937 46 doi 10 1242 jcs 02671 PMID 16254241 Cote JF Vuori K 2006 In Vitro Guanine Nucleotide Exchange Activity of DHR 2 DOCKER CZH2 Domains Regulators and Effectors of Small GTPases Rho Family Methods in Enzymology Vol 406 pp 41 57 doi 10 1016 S0076 6879 06 06004 6 ISBN 9780121828110 PMID 16472648 External links editOverview of all the structural information available in the PDB for UniProt Q96BY6 Dedicator of cytokinesis protein 10 at the PDBe KB nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Dedicator of cytokinesis protein 10 amp oldid 1194506173, wikipedia, wiki, book, books, library,
