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Csaba Pal

April 10, 2024

Csaba Pal (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ]; born March 27, 1975)[6][7] is a Hungarian biologist at the Biological Research Centre (BRC)[8] in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC.[9][10] His research is at the interface of evolution, antibiotic resistance and genome engineering[11][5] and has published over 80 scientific publications in these areas.[12][13]

Csaba Pal
Pal in 2009
Born (1975-03-27) March 27, 1975 (age 49)
Budapest, Hungary
EducationEötvös Loránd Tudományegyetem (PhD)
Alma materHungarian Academy of Sciences (D.Sc.)
OccupationBiologist
EmployerBiological Research Centre
Awards
Websitehttp://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html

Education edit

Csaba Pal completed his master's in biology at Eötvös Loránd University, Budapest, in 1998.[7][14] Four years later he was awarded a Doctor of Philosophy degree from the Eötvös Loránd University, Budapest in 2002.[7][14] In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences.[7] Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,[15] Oxford, Heidelberg and Italy.[7][14] Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.[7][14] In 2023 Csaba Pál become a Corresponding member of the Hungarian Academy of Sciences.

Career and research edit

Csaba Pal works on fundamental and applied problems in the evolution of genome networks and antibiotic resistance.[11] To achieve these goals, he develops methods in systems biology, computational metabolic modelling and genome engineering.

Genome evolution edit

In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in yeast evolve slowly.[16] Later, they argued that evolutionary rate of a protein is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of protein evolution.[17][18] Balazs Papp, Csaba Pal, and Laurence Hurst studied molecular mechanisms underlying dosage sensitivity.[19] They specifically tested what is now known as the dosage balance hypothesis.[20] The hypothesis offers a synthesis on seemingly unrelated problems such as the evolution of dominance, gene duplicability and co-evolution of protein complexsubunits. In 2007, Pal and colleagues demonstrated that antagonistic co-evolution with parasites has a large impact on the evolution of bacterial mutation rate.[21] This paper showed how biotic interactions shape mutation rate evolution.

More recently, the Pal lab explored the consequences of compensatory adaptation on gene content evolution.[22] It is well known that while core cellular processes are generally conserved during evolution, the underlying genes differ somewhat between related species. They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change.[22]

Network evolution edit

The Pal lab has also contributed to the nascent field of evolutionary systems biology.[23] Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale metabolic network modelling combined with experimental tools they studied key issues in evolution, such as mutational robustness,[24] horizontal gene transfer,[25] genome reduction,[26] epistasis,[27][28] promiscuous enzyme reactions,[29] and complex adaptations.[30]

Antibiotic resistance edit

Csaba Pal's laboratory currently studies the problem of antibiotic resistance. By combining laboratory evolution, genome sequencing, and functional analysis, they charted the map of evolutionary trade-offs between antibiotics. They found that multidrug resistance mutations in bacteria simultaneously enhance sensitivity to many other unrelated drugs (collateral sensitivity), and explored the underlying molecular mechanisms.[31]

Genome engineering edit

Finally, the Pal lab is an advocate of the emerging field of evolutionary genome engineering.[32][33] Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner, and allow studying central evolutionary issues in which natural genetic variation is limited or biased. However, current tools have been optimized for a few laboratory model strains, lead to the accumulation of numerous undesired, off-target modifications, and demand extensive modification of the host genome prior to large-scale editing. The Pal laboratory presented a simple, all-in-one solution.[34][35] The method is unique as it allows systematic comparison of mutational effects and epistasis across a wide range of bacterial species.

Awards and honours edit

Csaba Pal received several domestic and international awards, including the Ignaz Lieben Award (2009),[36][circular reference][37] Szent-Györgyi Talents Award (2014),[1] and the Bolyai Prize (2015).[38][39][40][41] In 2016, Csaba Pal became member of Academia Europaea.[2] In 2017 he was selected as EMBO (European Molecular Biology Organization) member.[3][4] and in 2018, became a member of the FEMS. (Federation of European Microbiological Societies)[5] In 2021 Csaba received and Academic Award[42] and in 2023 he was elected as Corresponding member of the Hungarian Academy of Sciences[43][44]

References edit

  1. ^ a b . www.nobel-szeged.hu. Archived from the original on 29 January 2020. Retrieved 29 January 2020.
  2. ^ a b "Academy of Europe: P%C 3%A 1 l Csaba". www.ae-info.org. Retrieved 28 January 2020.
  3. ^ a b Jukic, Igor. . EMBO. Archived from the original on 19 June 2017. Retrieved 16 June 2017.
  4. ^ a b "Find people in the EMBO Communities". people.embo.org. Retrieved 28 January 2020.
  5. ^ a b c "FEMS Expert: Dr Csaba Pal". FEMS. Retrieved 29 January 2020.
  6. ^ "BRC Csaba PÁL D.Sc". www.brc.hu. Retrieved 29 January 2020.[permanent dead link]
  7. ^ a b c d e f (PDF). Archived from the original (PDF) on 29 January 2020. Retrieved 29 January 2020.
  8. ^ "BRC". www.brc.hu. Retrieved 28 January 2020.
  9. ^ . www.brc.hu. Archived from the original on 28 January 2020. Retrieved 29 January 2020.
  10. ^ "Csaba Pál Laboratory". group.szbk.u-szeged.hu. Retrieved 28 January 2020.
  11. ^ a b "New members greeted in Heidelberg". EMBO. 19 December 2018. Retrieved 19 December 2018.
  12. ^ "Magyar Tudományos Művek Tára". m2.mtmt.hu. Retrieved 31 January 2020.
  13. ^ "Csaba Pal - Google Scholar Citations". scholar.google.hu. Retrieved 31 January 2020.
  14. ^ a b c d "Academy of Europe: CV". www.ae-info.org. Retrieved 29 January 2020.
  15. ^ "Students and post-docs past and present". people.bath.ac.uk. Retrieved 28 January 2020.
  16. ^ Hurst, Laurence D.; Papp, Balázs; Pál, Csaba (June 2001). "Highly Expressed Genes in Yeast Evolve Slowly". Genetics. 158 (2): 927–931. doi:10.1093/genetics/158.2.927. PMC 1461684. PMID 11430355.
  17. ^ Zhang, Jianzhi; Yang, Jian-Rong (2015). "Determinants of the rate of protein sequence evolution". Nature Reviews Genetics. 16 (7): 409–420. doi:10.1038/nrg3950. PMC 4523088. PMID 26055156.
  18. ^ Koonin, E. V. (2011). "Are there laws of genome evolution?". PLOS Computational Biology. 7 (8): e1002173. arXiv:1108.3589. Bibcode:2011PLSCB...7E2173K. doi:10.1371/journal.pcbi.1002173. PMC 3161903. PMID 21901087.
  19. ^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194–197. Bibcode:2003Natur.424..194P. doi:10.1038/nature01771. ISSN 1476-4687. PMID 12853957. S2CID 4382441. Retrieved 10 July 2003.
  20. ^ Birchler, J. A.; Veitia, R. A. (20 August 2012). "Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines". Proceedings of the National Academy of Sciences. 109 (37): 14746–14753. doi:10.1073/pnas.1207726109. ISSN 0027-8424. PMC 3443177. PMID 22908297.
  21. ^ Pal, Csaba; Maciá, María D.; Oliver, Antonio; Schachar, Ira; Buckling, Angus (December 2007). "Coevolution with viruses drives the evolution of bacterial mutation rates". Nature. 450 (7172): 1079–1081. Bibcode:2007Natur.450.1079P. doi:10.1038/nature06350. ISSN 1476-4687. PMID 18059461. S2CID 4373536. Retrieved 2 December 2007.
  22. ^ a b Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.
  23. ^ Papp, Balázs; Notebaart, Richard A.; Pál, Csaba (September 2011). "Systems-biology approaches for predicting genomic evolution". Nature Reviews Genetics. 12 (9): 591–602. doi:10.1038/nrg3033. ISSN 1471-0064. PMID 21808261. S2CID 13965868. Retrieved 2 August 2011.
  24. ^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (June 2004). "Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast". Nature. 429 (6992): 661–664. Bibcode:2004Natur.429..661P. doi:10.1038/nature02636. ISSN 1476-4687. PMID 15190353. S2CID 492849. Retrieved 10 June 2004.
  25. ^ Pál, Csaba; Papp, Balázs; Lercher, Martin J. (December 2005). "Adaptive evolution of bacterial metabolic networks by horizontal gene transfer". Nature Genetics. 37 (12): 1372–1375. doi:10.1038/ng1686. ISSN 1546-1718. PMID 16311593. S2CID 14611750. Retrieved 20 November 2005.
  26. ^ Pál, Csaba; Papp, Balázs; Lercher, Martin J.; Csermely, Péter; Oliver, Stephen G.; Hurst, Laurence D. (March 2006). "Chance and necessity in the evolution of minimal metabolic networks". Nature. 440 (7084): 667–670. Bibcode:2006Natur.440..667P. doi:10.1038/nature04568. ISSN 1476-4687. PMID 16572170. S2CID 4424895. Retrieved 30 March 2006.
  27. ^ Harrison, Richard; Papp, Balázs; Pál, Csaba; Oliver, Stephen G.; Delneri, Daniela (13 February 2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences. 104 (7): 2307–2312. Bibcode:2007PNAS..104.2307H. doi:10.1073/pnas.0607153104. ISSN 0027-8424. PMC 1892960. PMID 17284612.
  28. ^ Szappanos, Balázs; Kovács, Károly; Szamecz, Béla; Honti, Frantisek; Costanzo, Michael; Baryshnikova, Anastasia; Gelius-Dietrich, Gabriel; Lercher, Martin J.; Jelasity, Márk; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Oliver, Stephen G.; Pál, Csaba; Papp, Balázs (July 2011). "An integrated approach to characterize genetic interaction networks in yeast metabolism". Nature Genetics. 43 (7): 656–662. doi:10.1038/ng.846. ISSN 1546-1718. PMC 3125439. PMID 21623372.
  29. ^ Notebaart, Richard A.; Szappanos, Balázs; Kintses, Bálint; Pál, Ferenc; Györkei, Ádám; Bogos, Balázs; Lázár, Viktória; Spohn, Réka; Csörgő, Bálint; Wagner, Allon; Ruppin, Eytan; Pál, Csaba; Papp, Balázs (12 August 2014). "Network-level architecture and the evolutionary potential of underground metabolism". Proceedings of the National Academy of Sciences. 111 (32): 11762–11767. Bibcode:2014PNAS..11111762N. doi:10.1073/pnas.1406102111. ISSN 0027-8424. PMC 4136603. PMID 25071190.
  30. ^ Szappanos, Balázs; Fritzemeier, Jonathan; Csörgő, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, Csaba; Papp, Balázs (20 May 2016). "Adaptive evolution of complex innovations through stepwise metabolic niche expansion". Nature Communications. 7 (1): 11607. Bibcode:2016NatCo...711607S. doi:10.1038/ncomms11607. ISSN 2041-1723. PMC 5411730. PMID 27197754.
  31. ^ Lázár, Viktória; Pal Singh, Gajinder; Spohn, Réka; Nagy, István; Horváth, Balázs; Hrtyan, Mónika; Busa-Fekete, Róbert; Bogos, Balázs; Méhi, Orsolya; Csörgő, Bálint; Pósfai, György; Fekete, Gergely; Szappanos, Balázs; Kégl, Balázs; Papp, Balázs; Pál, Csaba (2013). "Bacterial evolution of antibiotic hypersensitivity". Molecular Systems Biology. 9: 700. doi:10.1038/msb.2013.57. PMC 3817406. PMID 24169403.
  32. ^ Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance". MTA.hu (in Hungarian). Retrieved 11 June 2018.
  33. ^ Pál, Csaba; Papp, Balázs; Pósfai, György (28 May 2014). "The dawn of evolutionary genome engineering". Nature Reviews Genetics. 15 (7): 504–512. doi:10.1038/nrg3746. ISSN 1471-0056. PMID 24866756. S2CID 6854503. Retrieved 28 May 2014.
  34. ^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Latinovics, Dóra; Szamecz, Béla; Pósfai, György; Pál, Csaba (1 April 2014). "Conditional DNA repair mutants enable highly precise genome engineering". Nucleic Acids Research. 42 (8): e62. doi:10.1093/nar/gku105. ISSN 0305-1048. PMC 4005651. PMID 24500200.
  35. ^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Bálint, Balázs; Bihari, Péter; Lázár, Viktória; Apjok, Gábor; Umenhoffer, Kinga; Bogos, Balázs; Pósfai, György; Pál, Csaba (11 February 2016). "A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species". Proceedings of the National Academy of Sciences. 113 (9): 2502–2507. Bibcode:2016PNAS..113.2502N. doi:10.1073/pnas.1520040113. ISSN 0027-8424. PMC 4780621. PMID 26884157.
  36. ^ "Lieben Prize". Wikipedia. 17 January 2020. Retrieved 29 January 2020.
  37. ^ . stipendien.oeaw.ac.at. Archived from the original on 10 April 2019. Retrieved 17 November 2008.
  38. ^ "Pál Csaba biológus a Bolyai-díjas 2015-ben". Hivatalos weboldalra költözött a Bolyai-díj. Retrieved 17 May 2015.
  39. ^ "Bolyai-díj – 2015". National Geographic (in Hungarian). 18 May 2015. Retrieved 18 May 2015.
  40. ^ "Biologist Csaba Pál is awarded this year's Bolyai Prize". www.t-systems.hu. Retrieved 18 May 2015.
  41. ^ "Pál Csaba biológus kapta az idei Bolyai-díjat". hirado.hu (in Hungarian). Retrieved 17 May 2015.
  42. ^ "Akadémiai elismerések a közgyűlésen". 3 May 2021.
  43. ^ "Eseménynaptár".
  44. ^ "Antibiotikumok és ellenálló baktériumok – Pál Csaba székfoglaló előadása (2023.03.14.)". YouTube.

April 10, 2024
csaba, this, article, orphan, other, articles, link, please, introduce, links, this, page, from, related, articles, find, link, tool, suggestions, april, 2020, hungarian, pál, ˈpaːl, csaba, ʃɒbɒ, born, march, 1975, hungarian, biologist, biological, research, c. This article is an orphan as no other articles link to it Please introduce links to this page from related articles try the Find link tool for suggestions April 2020 Csaba Pal Hungarian Pal ˈpaːl Csaba ˈt ʃɒbɒ born March 27 1975 6 7 is a Hungarian biologist at the Biological Research Centre BRC 8 in Szeged Hungary His laboratory is part of the Synthetic and Systems Biology Unit at BRC 9 10 His research is at the interface of evolution antibiotic resistance and genome engineering 11 5 and has published over 80 scientific publications in these areas 12 13 Csaba PalPal in 2009Born 1975 03 27 March 27 1975 age 49 Budapest HungaryEducationEotvos Lorand Tudomanyegyetem PhD Alma materHungarian Academy of Sciences D Sc OccupationBiologistEmployerBiological Research CentreAwardsIgnaz Lieben Award 2009 Szent Gyorgyi Talents Award 2014 1 Bolyai Prize 2015 Member of the Academia Europaea 2016 2 EMBO Member 2017 3 4 Member of the Federation of European Microbiological Societies FEMS 5 Websitehttp group szbk u szeged hu sysbiol pal csaba lab index html Contents 1 Education 2 Career and research 3 Genome evolution 4 Network evolution 5 Antibiotic resistance 6 Genome engineering 7 Awards and honours 8 ReferencesEducation editCsaba Pal completed his master s in biology at Eotvos Lorand University Budapest in 1998 7 14 Four years later he was awarded a Doctor of Philosophy degree from the Eotvos Lorand University Budapest in 2002 7 14 In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences 7 Csaba Pal spent several years abroad with scholarships He had the opportunity to research in Bath 15 Oxford Heidelberg and Italy 7 14 Prior to his return to Hungary in 2008 he worked as a visiting scientist at the University of Trento 7 14 In 2023 Csaba Pal become a Corresponding member of the Hungarian Academy of Sciences Career and research editCsaba Pal works on fundamental and applied problems in the evolution of genome networks and antibiotic resistance 11 To achieve these goals he develops methods in systems biology computational metabolic modelling and genome engineering Genome evolution editIn 2001 Csaba Pal and colleagues demonstrated that highly expressed genes in yeast evolve slowly 16 Later they argued that evolutionary rate of a protein is predominantly influenced by its expression level rather than functional importance This research has contributed to a paradigmatic shift in the field of protein evolution 17 18 Balazs Papp Csaba Pal and Laurence Hurst studied molecular mechanisms underlying dosage sensitivity 19 They specifically tested what is now known as the dosage balance hypothesis 20 The hypothesis offers a synthesis on seemingly unrelated problems such as the evolution of dominance gene duplicability and co evolution of protein complexsubunits In 2007 Pal and colleagues demonstrated that antagonistic co evolution with parasites has a large impact on the evolution of bacterial mutation rate 21 This paper showed how biotic interactions shape mutation rate evolution More recently the Pal lab explored the consequences of compensatory adaptation on gene content evolution 22 It is well known that while core cellular processes are generally conserved during evolution the underlying genes differ somewhat between related species They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change 22 Network evolution editThe Pal lab has also contributed to the nascent field of evolutionary systems biology 23 Their research focused on understanding the extent to which evolution is predictable at the molecular level Using genome scale metabolic network modelling combined with experimental tools they studied key issues in evolution such as mutational robustness 24 horizontal gene transfer 25 genome reduction 26 epistasis 27 28 promiscuous enzyme reactions 29 and complex adaptations 30 Antibiotic resistance editCsaba Pal s laboratory currently studies the problem of antibiotic resistance By combining laboratory evolution genome sequencing and functional analysis they charted the map of evolutionary trade offs between antibiotics They found that multidrug resistance mutations in bacteria simultaneously enhance sensitivity to many other unrelated drugs collateral sensitivity and explored the underlying molecular mechanisms 31 Genome engineering editFinally the Pal lab is an advocate of the emerging field of evolutionary genome engineering 32 33 Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner and allow studying central evolutionary issues in which natural genetic variation is limited or biased However current tools have been optimized for a few laboratory model strains lead to the accumulation of numerous undesired off target modifications and demand extensive modification of the host genome prior to large scale editing The Pal laboratory presented a simple all in one solution 34 35 The method is unique as it allows systematic comparison of mutational effects and epistasis across a wide range of bacterial species Awards and honours editCsaba Pal received several domestic and international awards including the Ignaz Lieben Award 2009 36 circular reference 37 Szent Gyorgyi Talents Award 2014 1 and the Bolyai Prize 2015 38 39 40 41 In 2016 Csaba Pal became member of Academia Europaea 2 In 2017 he was selected as EMBO European Molecular Biology Organization member 3 4 and in 2018 became a member of the FEMS Federation of European Microbiological Societies 5 In 2021 Csaba received and Academic Award 42 and in 2023 he was elected as Corresponding member of the Hungarian Academy of Sciences 43 44 References edit a b Szent Gyorgyi Talents Award www nobel szeged hu Archived from the original on 29 January 2020 Retrieved 29 January 2020 a b Academy of Europe P C 3 A 1 l Csaba www ae info org Retrieved 28 January 2020 a b Jukic Igor EMBO welcomes 65 new members EMBO Archived from the original on 19 June 2017 Retrieved 16 June 2017 a b Find people in the EMBO Communities people embo org Retrieved 28 January 2020 a b c FEMS Expert Dr Csaba Pal FEMS Retrieved 29 January 2020 BRC Csaba PAL D Sc www brc hu Retrieved 29 January 2020 permanent dead link a b c d e f BRC Csaba PAL CV PDF Archived from the original PDF on 29 January 2020 Retrieved 29 January 2020 BRC www brc hu Retrieved 28 January 2020 BRC Synthetic and Systems Biology Unit www brc hu Archived from the original on 28 January 2020 Retrieved 29 January 2020 Csaba Pal Laboratory group szbk u szeged hu Retrieved 28 January 2020 a b New members greeted in Heidelberg EMBO 19 December 2018 Retrieved 19 December 2018 Magyar Tudomanyos Muvek Tara m2 mtmt hu Retrieved 31 January 2020 Csaba Pal Google Scholar Citations scholar google hu Retrieved 31 January 2020 a b c d Academy of Europe CV www ae info org Retrieved 29 January 2020 Students and post docs past and present people bath ac uk Retrieved 28 January 2020 Hurst Laurence D Papp Balazs Pal Csaba June 2001 Highly Expressed Genes in Yeast Evolve Slowly Genetics 158 2 927 931 doi 10 1093 genetics 158 2 927 PMC 1461684 PMID 11430355 Zhang Jianzhi Yang Jian Rong 2015 Determinants of the rate of protein sequence evolution Nature Reviews Genetics 16 7 409 420 doi 10 1038 nrg3950 PMC 4523088 PMID 26055156 Koonin E V 2011 Are there laws of genome evolution PLOS Computational Biology 7 8 e1002173 arXiv 1108 3589 Bibcode 2011PLSCB 7E2173K doi 10 1371 journal pcbi 1002173 PMC 3161903 PMID 21901087 Papp Balazs Pal Csaba Hurst Laurence D July 2003 Dosage sensitivity and the evolution of gene families in yeast Nature 424 6945 194 197 Bibcode 2003Natur 424 194P doi 10 1038 nature01771 ISSN 1476 4687 PMID 12853957 S2CID 4382441 Retrieved 10 July 2003 Birchler J A Veitia R A 20 August 2012 Gene balance hypothesis Connecting issues of dosage sensitivity across biological disciplines Proceedings of the National Academy of Sciences 109 37 14746 14753 doi 10 1073 pnas 1207726109 ISSN 0027 8424 PMC 3443177 PMID 22908297 Pal Csaba Macia Maria D Oliver Antonio Schachar Ira Buckling Angus December 2007 Coevolution with viruses drives the evolution of bacterial mutation rates Nature 450 7172 1079 1081 Bibcode 2007Natur 450 1079P doi 10 1038 nature06350 ISSN 1476 4687 PMID 18059461 S2CID 4373536 Retrieved 2 December 2007 a b Szamecz Bela Boross Gabor Kalapis Dorottya Kovacs Karoly Fekete Gergely Farkas Zoltan Lazar Viktoria Hrtyan Monika Kemmeren Patrick Groot Koerkamp Marian J A Rutkai Edit Holstege Frank C P Papp Balazs Pal Csaba 2014 The Genomic Landscape of Compensatory Evolution PLOS Biology 12 8 e1001935 doi 10 1371 journal pbio 1001935 PMC 4144845 PMID 25157590 Papp Balazs Notebaart Richard A Pal Csaba September 2011 Systems biology approaches for predicting genomic evolution Nature Reviews Genetics 12 9 591 602 doi 10 1038 nrg3033 ISSN 1471 0064 PMID 21808261 S2CID 13965868 Retrieved 2 August 2011 Papp Balazs Pal Csaba Hurst Laurence D June 2004 Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast Nature 429 6992 661 664 Bibcode 2004Natur 429 661P doi 10 1038 nature02636 ISSN 1476 4687 PMID 15190353 S2CID 492849 Retrieved 10 June 2004 Pal Csaba Papp Balazs Lercher Martin J December 2005 Adaptive evolution of bacterial metabolic networks by horizontal gene transfer Nature Genetics 37 12 1372 1375 doi 10 1038 ng1686 ISSN 1546 1718 PMID 16311593 S2CID 14611750 Retrieved 20 November 2005 Pal Csaba Papp Balazs Lercher Martin J Csermely Peter Oliver Stephen G Hurst Laurence D March 2006 Chance and necessity in the evolution of minimal metabolic networks Nature 440 7084 667 670 Bibcode 2006Natur 440 667P doi 10 1038 nature04568 ISSN 1476 4687 PMID 16572170 S2CID 4424895 Retrieved 30 March 2006 Harrison Richard Papp Balazs Pal Csaba Oliver Stephen G Delneri Daniela 13 February 2007 Plasticity of genetic interactions in metabolic networks of yeast Proceedings of the National Academy of Sciences 104 7 2307 2312 Bibcode 2007PNAS 104 2307H doi 10 1073 pnas 0607153104 ISSN 0027 8424 PMC 1892960 PMID 17284612 Szappanos Balazs Kovacs Karoly Szamecz Bela Honti Frantisek Costanzo Michael Baryshnikova Anastasia Gelius Dietrich Gabriel Lercher Martin J Jelasity Mark Myers Chad L Andrews Brenda J Boone Charles Oliver Stephen G Pal Csaba Papp Balazs July 2011 An integrated approach to characterize genetic interaction networks in yeast metabolism Nature Genetics 43 7 656 662 doi 10 1038 ng 846 ISSN 1546 1718 PMC 3125439 PMID 21623372 Notebaart Richard A Szappanos Balazs Kintses Balint Pal Ferenc Gyorkei Adam Bogos Balazs Lazar Viktoria Spohn Reka Csorgo Balint Wagner Allon Ruppin Eytan Pal Csaba Papp Balazs 12 August 2014 Network level architecture and the evolutionary potential of underground metabolism Proceedings of the National Academy of Sciences 111 32 11762 11767 Bibcode 2014PNAS 11111762N doi 10 1073 pnas 1406102111 ISSN 0027 8424 PMC 4136603 PMID 25071190 Szappanos Balazs Fritzemeier Jonathan Csorgo Balint Lazar Viktoria Lu Xiaowen Fekete Gergely Balint Balazs Herczeg Robert Nagy Istvan Notebaart Richard A Lercher Martin J Pal Csaba Papp Balazs 20 May 2016 Adaptive evolution of complex innovations through stepwise metabolic niche expansion Nature Communications 7 1 11607 Bibcode 2016NatCo 711607S doi 10 1038 ncomms11607 ISSN 2041 1723 PMC 5411730 PMID 27197754 Lazar Viktoria Pal Singh Gajinder Spohn Reka Nagy Istvan Horvath Balazs Hrtyan Monika Busa Fekete Robert Bogos Balazs Mehi Orsolya Csorgo Balint Posfai Gyorgy Fekete Gergely Szappanos Balazs Kegl Balazs Papp Balazs Pal Csaba 2013 Bacterial evolution of antibiotic hypersensitivity Molecular Systems Biology 9 700 doi 10 1038 msb 2013 57 PMC 3817406 PMID 24169403 Bokor Dora 11 June 2018 Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance MTA hu in Hungarian Retrieved 11 June 2018 Pal Csaba Papp Balazs Posfai Gyorgy 28 May 2014 The dawn of evolutionary genome engineering Nature Reviews Genetics 15 7 504 512 doi 10 1038 nrg3746 ISSN 1471 0056 PMID 24866756 S2CID 6854503 Retrieved 28 May 2014 Nyerges Akos Csorgo Balint Nagy Istvan Latinovics Dora Szamecz Bela Posfai Gyorgy Pal Csaba 1 April 2014 Conditional DNA repair mutants enable highly precise genome engineering Nucleic Acids Research 42 8 e62 doi 10 1093 nar gku105 ISSN 0305 1048 PMC 4005651 PMID 24500200 Nyerges Akos Csorgo Balint Nagy Istvan Balint Balazs Bihari Peter Lazar Viktoria Apjok Gabor Umenhoffer Kinga Bogos Balazs Posfai Gyorgy Pal Csaba 11 February 2016 A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species Proceedings of the National Academy of Sciences 113 9 2502 2507 Bibcode 2016PNAS 113 2502N doi 10 1073 pnas 1520040113 ISSN 0027 8424 PMC 4780621 PMID 26884157 Lieben Prize Wikipedia 17 January 2020 Retrieved 29 January 2020 Csaba Pal stipendien oeaw ac at Archived from the original on 10 April 2019 Retrieved 17 November 2008 Pal Csaba biologus a Bolyai dijas 2015 ben Hivatalos weboldalra koltozott a Bolyai dij Retrieved 17 May 2015 Bolyai dij 2015 National Geographic in Hungarian 18 May 2015 Retrieved 18 May 2015 Biologist Csaba Pal is awarded this year s Bolyai Prize www t systems hu Retrieved 18 May 2015 Pal Csaba biologus kapta az idei Bolyai dijat hirado hu in Hungarian Retrieved 17 May 2015 Akademiai elismeresek a kozgyulesen 3 May 2021 Esemenynaptar Antibiotikumok es ellenallo bakteriumok Pal Csaba szekfoglalo eloadasa 2023 03 14 YouTube Retrieved from https en wikipedia org w index php title Csaba Pal amp oldid 1196121364, wikipedia, wiki, book, books, library,

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