Antimalarial activity also predominates in a quinoline that bears a diaminoalkyl side chain at a rather different position from the other agents noted.
Thus, Mannich condensation of the hydroxyquinoline (1) with formaldehyde and N,N-diethylpropylenediamine affords clamoxyquin (2).
ReferencesEdit
^Burckhalter JH, Brinigar WS, Thompson PE (1961). "Antiamebic Agents. V.1Promising Basic Amebicides Derived from 5-Chloro-8-quinolinol". The Journal of Organic Chemistry. 26 (10): 4070–4078. doi:10.1021/jo01068a103.
clamoxyquine, clamoxyquin, former, pamoate, hydrochloride, salt, antiamebic, antidiarrheal, drug, clinical, dataatc, codenoneidentifiersiupac, name, chloro, diethylamino, propyl, amino, methyl, quinolin, olcas, number2545, 3pubchem, cid18029chemspider17033unii. Clamoxyquine INN or clamoxyquin former BAN as the pamoate or hydrochloride salt is an antiamebic and antidiarrheal drug ClamoxyquineClinical dataATC codenoneIdentifiersIUPAC name 5 Chloro 7 3 diethylamino propyl amino methyl quinolin 8 olCAS Number2545 39 3PubChem CID18029ChemSpider17033UNIIJUN13FZ6RFChEMBLChEMBL2106065CompTox Dashboard EPA DTXSID50180109Chemical and physical dataFormulaC 17H 24Cl N 3OMolar mass321 85 g mol 13D model JSmol Interactive imageSMILES Clc1cc c O c2ncccc12 CNCCCN CC CCIt has been used as a veterinary medicine to treat salmonids for infection with the myxozoan parasite Myxobolus cerebralis Synthesis EditAntimalarial activity also predominates in a quinoline that bears a diaminoalkyl side chain at a rather different position from the other agents noted nbsp Clamoxyquin synthesis 1 Thus Mannich condensation of the hydroxyquinoline 1 with formaldehyde and N N diethylpropylenediamine affords clamoxyquin 2 References Edit Burckhalter JH Brinigar WS Thompson PE 1961 Antiamebic Agents V 1Promising Basic Amebicides Derived from 5 Chloro 8 quinolinol The Journal of Organic Chemistry 26 10 4070 4078 doi 10 1021 jo01068a103 nbsp This antiinfective drug article is a stub You can help Wikipedia by expanding it vte nbsp This veterinary medicine related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Clamoxyquine amp oldid 1147749599, wikipedia, wiki, book, books, library,