Chrysiasis is a dermatological condition induced by the parenteral administration of gold salts, usually for the treatment of rheumatoid arthritis.[1]: 859–60 Such treatment has been superseded as the best practice for treating the disease because of "numerous side effects and monitoring requirements, their limited efficacy, and very slow onset of action".[2]
Similar to silver, a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation – especially if the skin is exposed to sunlight or artificial ultraviolet radiation.
The skin's pigmentation (in this condition) has been described as uniformly gray, grayish purple, slate gray, or grayish blue, and is usually limited to exposed portions of the body. It may involve the conjunctivae over the scleras but usually not the oral mucosa. Location of pigment predominantly in the upper dermis leads to the blue component of skin color through the scattering phenomenon. It is much less likely to be deposited in the nails and hair.
Chrysiasis was said to have been much more common when medicines containing traces of gold were used for treatment of tuberculosis (commonplace forms of treatment nearly fifty years ago). Treatments containing gold traces were also used to treat cases of rheumatoid arthritis – but because the dose used for tuberculosis was higher than for arthritis, it has not afflicted many subscribing to such treatments.
Jeghers - New England Journal of Medicine, Vol. 231: 122 & 181, 1944
Scamberg - "Chrysoderma - A permanent gold staining of the skin". Archives of Dermatology & Syphilis, Vol. 18. 862, 1928
The University of Massachusetts Online Article on Skin Pigmentation Disorders
External links
May 01, 2023
chrysiasis, dermatological, condition, induced, parenteral, administration, gold, salts, usually, treatment, rheumatoid, arthritis, such, treatment, been, superseded, best, practice, treating, disease, because, numerous, side, effects, monitoring, requirements. Chrysiasis is a dermatological condition induced by the parenteral administration of gold salts usually for the treatment of rheumatoid arthritis 1 859 60 Such treatment has been superseded as the best practice for treating the disease because of numerous side effects and monitoring requirements their limited efficacy and very slow onset of action 2 ChrysiasisSpecialtyDermatology Similar to silver a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation especially if the skin is exposed to sunlight or artificial ultraviolet radiation The skin s pigmentation in this condition has been described as uniformly gray grayish purple slate gray or grayish blue and is usually limited to exposed portions of the body It may involve the conjunctivae over the scleras but usually not the oral mucosa Location of pigment predominantly in the upper dermis leads to the blue component of skin color through the scattering phenomenon It is much less likely to be deposited in the nails and hair Chrysiasis was said to have been much more common when medicines containing traces of gold were used for treatment of tuberculosis commonplace forms of treatment nearly fifty years ago Treatments containing gold traces were also used to treat cases of rheumatoid arthritis but because the dose used for tuberculosis was higher than for arthritis it has not afflicted many subscribing to such treatments Gold can be identified in the skin chemically by light microscopy electron microscopy and spectroscopy There is no way to reverse or treat chrysiasis citation needed Contents 1 See also 2 Notes 3 References 4 External linksSee also EditColloidal gold Gold salts Gold toxicity Skin lesionNotes Edit James William Berger Timothy Elston Dirk 2005 Andrews Diseases of the Skin Clinical Dermatology 10th ed Saunders ISBN 0 7216 2921 0 Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center Retrieved 26 October 2017 References EditJeghers New England Journal of Medicine Vol 231 122 amp 181 1944 Scamberg Chrysoderma A permanent gold staining of the skin Archives of Dermatology amp Syphilis Vol 18 862 1928 The University of Massachusetts Online Article on Skin Pigmentation Disorders 1 External links Edit Retrieved from https en wikipedia org w index php title Chrysiasis amp oldid 1094623831, wikipedia, wiki, book, books, library,
