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Chemotherapy-induced nausea and vomiting

August 24, 2023

Chemotherapy-induced nausea and vomiting (CINV) is a common side-effect of many cancer treatments. Nausea and vomiting are two of the most feared cancer treatment-related side effects for cancer patients and their families. In 1983, Coates et al. found that patients receiving chemotherapy ranked nausea and vomiting as the first and second most severe side effects, respectively. Up to 20% of patients receiving highly emetogenic agents in this era postponed, or even refused, potentially curative treatments.[1] Since the 1990s, several novel classes of antiemetics have been developed and commercialized, becoming a nearly universal standard in chemotherapy regimens, and helping to better manage these symptoms in a large portion of patients. Efficient mediation of these unpleasant and sometimes debilitating symptoms results in increased quality of life for the patient, and better overall health of the patient, and, due to better patient tolerance, more effective treatment cycles.

Types

There are several subtypes of CINV. The classifications of nausea and vomiting are:[2]

  • Acute: occurring within 24 hours of chemotherapy
  • Delayed: occurring between 24 hours and 5 days after treatment
  • Breakthrough: occurring despite prophylactic treatment
  • Anticipatory: triggered by taste, odor, memories, visions, or anxiety related to chemotherapy
  • Refractory: occurring during subsequent cycles when antiemetics have failed in earlier cycles

Cause

Emesis is a defense mechanism controlled by the area postrema of the medulla oblongata. There are various sources of input to the vomiting center. Receptors on the floor of the fourth ventricle of the brain represent the chemoreceptor trigger zone. The chemoreceptor trigger zone contains dopamine D2 receptors, serotonin 5-HT3 receptors, opioid receptors, acetylcholine receptors, and receptors for substance P. Stimulation of different receptors are involved in different pathways leading to emesis. In the final common pathway, substance P, which activates the neurokinin-1 receptor, appears to be involved.[3] Additionally, the vagal and enteric nervous system inputs transmit information regarding the state of the gastrointestinal system.

Chemotherapy interferes with cell division, which particularly affects rapidly dividing cells like those of the gastrointestinal mucosa and immune cells. Irritation of the GI mucosa by chemotherapy, radiation, distention, or acute infectious gastroenteritis activates the 5-HT3 receptors of these inputs.[4] It is now widely known that cytotoxic chemotherapeutic agents cause enterochromaffin cells to produce more serotonin in response to free radical damage, leading to a detectable increase in blood levels of serotonin (5-HT) and its major metabolite, 5-Hydroxyindoleacetic acid (5-HIAA).[5] The presence of these chemicals in the blood activate 5-HT3 receptors in the chemoreceptor trigger zone, in turn releasing substance P, which activates NK1 receptors to cause an emetic response (vomiting).

Risk factors

The risk of chemotherapy-induced nausea and vomiting varies based on the type of treatment received as well as several outside factors. Some types of chemotherapy are more prone to causing nausea and vomiting than others. Some chemotherapeutic agents may not cause nausea and vomiting on their own, but may when used in combination with other agents.[6] Regimens that are linked to a high incidence (90% or higher) of nausea and vomiting are referred to as "highly emetogenic chemotherapy", and those causing a moderate incidence (30–90%) of nausea and vomiting are referred to as "moderately emetogenic chemotherapy".[7]

Some highly emetogenic agents and chemotherapy regimens include:[6][8]

Some moderately emetogenic agents and regimens include:[8]

Besides the type of treatment, personal factors may put a patient at greater risk for CINV. Other risk factors include:[2][6][9]

  • Anticipation of CINV
  • Anxiety or depression
  • Female sex
  • History of light alcohol use
  • History of motion sickness
  • History of nausea and vomiting during pregnancy
  • History of previous CINV
  • Patient age (under 55 years old)

Treatments

Several treatment methods are available to help prevent CINV. Pharmaceutical treatment is generally separated into two types: prophylactic (preventative) treatment, given before the dose of chemotherapy agents, and rescue treatment, given to treat breakthrough nausea and vomiting.

5-HT3 inhibitors

5-HT3 receptor antagonists are very effective antiemetics and constitute a great advance in the management of CINV. These drugs block one or more of the nerve signals that cause nausea and vomiting. During the first 24 hours after chemotherapy, the most effective approach appears to be blocking the 5-HT3 nerve signal.[10] Approved 5-HT3 inhibitors include dolasetron (Anzemet), granisetron (Kytril, Sancuso), and ondansetron (Zofran). Their antiemetic effect due to blockade of 5HT3 receptor on vagal afferent in the gut. in addition they also block 5-HT3 receptors in CTZ and STN. The newest 5-HT3 inhibitor, palonosetron (Aloxi), also prevents delayed nausea and vomiting, which can occur during the 2–5 days after treatment. Since some patients have trouble swallowing pills, these drugs are often available by injection, as orally disintegrating tablets, or as transdermal patches.

NK1 inhibitors

A newer class of drugs known as the NK1 antagonists are a recently developed class of very efficacious drugs for controlling CINV. These drugs are often used alongside 5HT3 inhibitors and corticosteroids to form a very potent cocktail of antiemetics that verge on achieving a nearly complete patient response (that is, completely stopping CINV).[11] The substance P inhibitor aprepitant (Emend), which became available in 2005, is highly effective in controlling nausea and vomiting associated with cancer chemotherapy.[11] Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. Indeed, positron emission tomography (PET) studies have shown that aprepitant can penetrate the brain and NK1 receptors in the brain.[12] Aprepitant has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.[11] Netupitant has recently been approved by USFDA. It has also been marketed in combination with palonosetron. Rolapitant is the newest addition in the approved NK1 antagonist list. It has advantage of a very long half life, duration of action is around 150 hours. Rolapitant got its approval by USFDA in 2015.

Other drugs

Olanzapine, as well as several other neuroleptic drugs, have also has been investigated for the control of CINV.[13] A 2007 study demonstrated Olanzapine's successful potential for this use, achieving a complete response in the acute prevention of nausea and vomiting in 100% of patients treated with moderately and highly emetogenic chemotherapy, when used in combination with palonosetron and dexamethasone.[14] Neuroleptic agents are now indicated for rescue treatment and the control of breakthrough nausea and vomiting.[13]

Some studies[15] and patient groups say that the use of cannabinoids derived from cannabis during chemotherapy greatly reduces the associated nausea and vomiting, and enables the patient to eat. Synthesized tetrahydrocannabinol (also one of the main active substances in marijuana) is marketed as Marinol and may be practical for this application. Natural medical cannabis is also used and recommended by some oncologists, though its use is regulated and it is not legal in all jurisdictions.[16] However, Marinol was less effective than megestrol acetate in helping cancer patients regain lost appetites.[17] A phase III study found no difference in effects of an oral cannabis extract or THC on appetite and quality of life (QOL) in patients with cancer-related anorexia-cachexia syndrome (CACS) to placebo.[18][third-party source needed]

Dexamethasone, a corticosteroid, is often used alongside other antiemetic drugs, as it has synergistic action with many of them, although its specific antiemetic mechanism of action is not fully understood. Metoclopramide, a dopamine D2 receptor antagonist with possible other mechanisms, is an older drug that is sometimes used, either on its own or in combination with others. Histamine blockers such as diphenhydramine or meclozine may be used in rescue treatment. Lorazepam and diazepam may sometimes be used to relieve anxiety associated with CINV before administration of chemotherapy, and are also often used in the case of rescue treatment.[13]

Alternative treatments

Ginger (Zingiber officinale)

There are several compounds that have been identified within ginger that have been shown to possess properties that are likely to be beneficial in the treatment of CINV. This includes 5-HT3 and substance P antagonism, modulation of gastrointestinal motility, and antioxidant properties.[19][20] There have been multiple clinical trials that have investigated the use of ginger supplementation as a treatment for CINV. However, due to conflicting results and methodological issues, a 2013 systematic review of seven clinical trials summarized the current evidence as stating that "Despite the widespread use of ginger in the treatment of nausea in other contexts such as gestational nausea, the current literature provides mixed support for the use of ginger as a standard part of anti-CINV control for patients undergoing chemotherapy."[21]

Other

Non-pharmacological approaches to remedy CINV typically involve small lifestyle alterations, such as using unscented deodorants and soaps, avoiding strong scents altogether, and dietary modifications such as eating several small meals throughout the day, eating high-protein, high-calorie food, drinking many clear liquids, and removing spicy, fatty, fried, or acidic foods from the diet.[22] Patients may also participate in alternative practices such as self-hypnosis, relaxation and imagery therapy, distraction, music therapy, biofeedback, desensitization, or acupressure.[2]

See also

References

  1. ^ Gill, Paula; Grothey, Axel; Loprinzi, Charles (2006). "Nausea and Vomiting in the Cancer Patient". Oncology. pp. 1482–96. doi:10.1007/0-387-31056-8_83. ISBN 978-0-387-24291-0.
  2. ^ a b c . Archived from the original on 2011-08-24. Retrieved 2011-09-02. "Chemotherapy-Induced Nausea and Vomiting"
  3. ^ Hornby, P (2001). "Central neurocircuitry associated with emesis". The American Journal of Medicine. 111 (8): 106S–112S. doi:10.1016/S0002-9343(01)00849-X. PMID 11749934.
  4. ^ Minami, Masaru; Endo, Toru; Hirafuji, Masahiko (1996). "Role of serotonin in emesis". Folia Pharmacologica Japonica. 108 (5): 233–42. doi:10.1254/fpj.108.233. PMID 8974084.
  5. ^ Minami, Masaru; Endo, Toru; Hamaue, Naoya; Hirafuji, Masahiko (2004). "Serotonin and Anticancer Drug-induced Emesis". Yakugaku Zasshi. 124 (8): 491–507. doi:10.1248/yakushi.124.491. PMID 15297719.
  6. ^ a b c "CINV Risk Factors". Cesamet Patient Education. Meda Pharmaceuticals. 2011. Retrieved 2011-09-02.
  7. ^ . Patient Education. AP Pharma. 2011. Archived from the original on 2002-04-06. Retrieved 2011-09-02.
  8. ^ a b (PDF). VHA Pharmacy Benefits Management Strategic Healthcare Group and Medical Advisory Panel. Archived from the original (PDF) on February 10, 2012. Retrieved September 2, 2011.
  9. ^ "Chemotherapy-Induced Nausea and Vomiting: Addressing the Problem of Delayed Nausea: Risk Factors for CINV". Medscape.com. Retrieved September 2, 2011.
  10. ^ Rojas, Camilo; Li, Ying; Zhang, Jie; Stathis, Marigo; Alt, Jesse; Thomas, Ajit G.; Cantoreggi, Sergio; Sebastiani, Silvia; Pietra, Claudio; Slusher, Barbara S. (November 2010). "The Antiemetic 5-HT 3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo". Journal of Pharmacology and Experimental Therapeutics. 335 (2): 362–368. doi:10.1124/jpet.110.166181. PMC 3202469.
  11. ^ a b c Gralla, Richard J.; De Wit, Ronald; Herrstedt, Jorn; Carides, Alexandra D.; Ianus, Juliana; Guoguang-Ma, Julie; Evans, Judith K.; Horgan, Kevin J. (2005). "Antiemetic efficacy of the neurokinin-1 antagonist, aprepitant, plus a 5HT3 antagonist and a corticosteroid in patients receiving anthracyclines or cyclophosphamide in addition to high-dose cisplatin". Cancer. 104 (4): 864–8. doi:10.1002/cncr.21222. PMID 15973669. S2CID 24860776.
  12. ^ Bergström, Mats; Hargreaves, Richard J; Burns, H Donald; Goldberg, Michael R; Sciberras, David; Reines, Scott A; Petty, Kevin J; Ögren, Mattias; et al. (2004). "Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant". Biological Psychiatry. 55 (10): 1007–12. doi:10.1016/j.biopsych.2004.02.007. PMID 15121485. S2CID 21071199.
  13. ^ a b c Jordan, K.; Sippel, C.; Schmoll, H.-J. (2007). "Guidelines for Antiemetic Treatment of Chemotherapy-Induced Nausea and Vomiting: Past, Present, and Future Recommendations". The Oncologist. 12 (9): 1143–50. doi:10.1634/theoncologist.12-9-1143. PMID 17914084.
  14. ^ Navari, Rudolph M.; Einhorn, Lawrence H.; Loehrer, Patrick J.; Passik, Steven D.; Vinson, Jake; McClean, John; Chowhan, Naveed; Hanna, Nasser H.; Johnson, Cynthia S. (2007). "A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting: A Hoosier oncology group study". Supportive Care in Cancer. 15 (11): 1285–91. doi:10.1007/s00520-007-0248-5. PMID 17375339. S2CID 23266144.
  15. ^ Tramer, M. R; Carroll, D; Campbell, FA; Reynolds, DJ; Moore, RA; McQuay, HJ (2001). "Cannabinoids for control of chemotherapy induced nausea and vomiting: Quantitative systematic". BMJ. 323 (7303): 16–21. doi:10.1136/bmj.323.7303.16. PMC 34325. PMID 11440936.
  16. ^ "Frequently Asked Questions - Medical Marihuana"
  17. ^ Jatoi A, Windschitl HE, Loprinzi CL, et al. (2002). "Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study". Journal of Clinical Oncology. 20 (2): 567–73. doi:10.1200/JCO.20.2.567. PMID 11786587. Retrieved 30 January 2002.
  18. ^ Strasser, F; Luftner, D; Possinger, K; Ernst, G; Ruhstaller, T; Meissner, W; Ko, YD; Schnelle, M; et al. (20 July 2006). "Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group". Journal of Clinical Oncology. 24 (21): 3394–3400. doi:10.1200/JCO.2005.05.1847. PMID 16849753.
  19. ^ Marx, Wolfgang; Kiss, Nicole; Isenring, Liz (June 2015). "Is ginger beneficial for nausea and vomiting? An update of the literature". Current Opinion in Supportive and Palliative Care. 9 (2): 189–195. doi:10.1097/SPC.0000000000000135. ISSN 1751-4266. PMID 25872115. S2CID 23359181.
  20. ^ Marx, Wolfgang; Ried, Karin; McCarthy, Alexandra L.; Vitetta, Luis; Sali, Avni; McKavanagh, Daniel; Isenring, Elisabeth (2015-04-07). "Ginger-Mechanism of Action in Chemotherapy-induced Nausea and Vomiting: A Review". Critical Reviews in Food Science and Nutrition. 57 (1): 141–146. doi:10.1080/10408398.2013.865590. ISSN 1549-7852. PMID 25848702. S2CID 24523559.
  21. ^ Marx, WM; Teleni L; McCarthy AL; Vitetta L; McKavanagh D; Thomson D; Isenring E. (2013). "Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review" (PDF). Nutr Rev. 71 (4): 245–54. doi:10.1111/nure.12016. PMID 23550785. S2CID 19187673.
  22. ^ . Archived from the original on 2012-01-13. Retrieved 2011-09-02. "How to Prevent CINV, Minimize CINV"

August 24, 2023
chemotherapy, induced, nausea, vomiting, cinv, common, side, effect, many, cancer, treatments, nausea, vomiting, most, feared, cancer, treatment, related, side, effects, cancer, patients, their, families, 1983, coates, found, that, patients, receiving, chemoth. Chemotherapy induced nausea and vomiting CINV is a common side effect of many cancer treatments Nausea and vomiting are two of the most feared cancer treatment related side effects for cancer patients and their families In 1983 Coates et al found that patients receiving chemotherapy ranked nausea and vomiting as the first and second most severe side effects respectively Up to 20 of patients receiving highly emetogenic agents in this era postponed or even refused potentially curative treatments 1 Since the 1990s several novel classes of antiemetics have been developed and commercialized becoming a nearly universal standard in chemotherapy regimens and helping to better manage these symptoms in a large portion of patients Efficient mediation of these unpleasant and sometimes debilitating symptoms results in increased quality of life for the patient and better overall health of the patient and due to better patient tolerance more effective treatment cycles Contents 1 Types 2 Cause 3 Risk factors 4 Treatments 4 1 5 HT3 inhibitors 4 2 NK1 inhibitors 4 3 Other drugs 4 4 Alternative treatments 4 4 1 Ginger Zingiber officinale 4 4 2 Other 5 See also 6 ReferencesTypes EditThere are several subtypes of CINV The classifications of nausea and vomiting are 2 Acute occurring within 24 hours of chemotherapy Delayed occurring between 24 hours and 5 days after treatment Breakthrough occurring despite prophylactic treatment Anticipatory triggered by taste odor memories visions or anxiety related to chemotherapy Refractory occurring during subsequent cycles when antiemetics have failed in earlier cyclesCause EditEmesis is a defense mechanism controlled by the area postrema of the medulla oblongata There are various sources of input to the vomiting center Receptors on the floor of the fourth ventricle of the brain represent the chemoreceptor trigger zone The chemoreceptor trigger zone contains dopamine D2 receptors serotonin 5 HT3 receptors opioid receptors acetylcholine receptors and receptors for substance P Stimulation of different receptors are involved in different pathways leading to emesis In the final common pathway substance P which activates the neurokinin 1 receptor appears to be involved 3 Additionally the vagal and enteric nervous system inputs transmit information regarding the state of the gastrointestinal system Chemotherapy interferes with cell division which particularly affects rapidly dividing cells like those of the gastrointestinal mucosa and immune cells Irritation of the GI mucosa by chemotherapy radiation distention or acute infectious gastroenteritis activates the 5 HT3 receptors of these inputs 4 It is now widely known that cytotoxic chemotherapeutic agents cause enterochromaffin cells to produce more serotonin in response to free radical damage leading to a detectable increase in blood levels of serotonin 5 HT and its major metabolite 5 Hydroxyindoleacetic acid 5 HIAA 5 The presence of these chemicals in the blood activate 5 HT3 receptors in the chemoreceptor trigger zone in turn releasing substance P which activates NK1 receptors to cause an emetic response vomiting Risk factors EditThe risk of chemotherapy induced nausea and vomiting varies based on the type of treatment received as well as several outside factors Some types of chemotherapy are more prone to causing nausea and vomiting than others Some chemotherapeutic agents may not cause nausea and vomiting on their own but may when used in combination with other agents 6 Regimens that are linked to a high incidence 90 or higher of nausea and vomiting are referred to as highly emetogenic chemotherapy and those causing a moderate incidence 30 90 of nausea and vomiting are referred to as moderately emetogenic chemotherapy 7 Some highly emetogenic agents and chemotherapy regimens include 6 8 ABVD AC BEP Cisplatin Carmustine gt 250 mg m2 CBV Cyclophosphamide gt 1500 mg m2 Dacarbazine Mechlorethamine MOPP COPP BEACOPP Streptozocin VIPSome moderately emetogenic agents and regimens include 8 Carboplatin CHOP CHOP R Cyclophosphamide 1500 mg m2 Docetaxel Doxorubicin Adriamycin Etoposide Ifosfamide Methotrexate PaclitaxelBesides the type of treatment personal factors may put a patient at greater risk for CINV Other risk factors include 2 6 9 Anticipation of CINV Anxiety or depression Female sex History of light alcohol use History of motion sickness History of nausea and vomiting during pregnancy History of previous CINV Patient age under 55 years old Treatments EditSeveral treatment methods are available to help prevent CINV Pharmaceutical treatment is generally separated into two types prophylactic preventative treatment given before the dose of chemotherapy agents and rescue treatment given to treat breakthrough nausea and vomiting 5 HT3 inhibitors Edit 5 HT3 receptor antagonists are very effective antiemetics and constitute a great advance in the management of CINV These drugs block one or more of the nerve signals that cause nausea and vomiting During the first 24 hours after chemotherapy the most effective approach appears to be blocking the 5 HT3 nerve signal 10 Approved 5 HT3 inhibitors include dolasetron Anzemet granisetron Kytril Sancuso and ondansetron Zofran Their antiemetic effect due to blockade of 5HT3 receptor on vagal afferent in the gut in addition they also block 5 HT3 receptors in CTZ and STN The newest 5 HT3 inhibitor palonosetron Aloxi also prevents delayed nausea and vomiting which can occur during the 2 5 days after treatment Since some patients have trouble swallowing pills these drugs are often available by injection as orally disintegrating tablets or as transdermal patches NK1 inhibitors Edit A newer class of drugs known as the NK1 antagonists are a recently developed class of very efficacious drugs for controlling CINV These drugs are often used alongside 5HT3 inhibitors and corticosteroids to form a very potent cocktail of antiemetics that verge on achieving a nearly complete patient response that is completely stopping CINV 11 The substance P inhibitor aprepitant Emend which became available in 2005 is highly effective in controlling nausea and vomiting associated with cancer chemotherapy 11 Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons Indeed positron emission tomography PET studies have shown that aprepitant can penetrate the brain and NK1 receptors in the brain 12 Aprepitant has also been shown to increase the activity of the 5 HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone which are also used to prevent nausea and vomiting caused by chemotherapy 11 Netupitant has recently been approved by USFDA It has also been marketed in combination with palonosetron Rolapitant is the newest addition in the approved NK1 antagonist list It has advantage of a very long half life duration of action is around 150 hours Rolapitant got its approval by USFDA in 2015 Other drugs Edit Olanzapine as well as several other neuroleptic drugs have also has been investigated for the control of CINV 13 A 2007 study demonstrated Olanzapine s successful potential for this use achieving a complete response in the acute prevention of nausea and vomiting in 100 of patients treated with moderately and highly emetogenic chemotherapy when used in combination with palonosetron and dexamethasone 14 Neuroleptic agents are now indicated for rescue treatment and the control of breakthrough nausea and vomiting 13 Some studies 15 and patient groups say that the use of cannabinoids derived from cannabis during chemotherapy greatly reduces the associated nausea and vomiting and enables the patient to eat Synthesized tetrahydrocannabinol also one of the main active substances in marijuana is marketed as Marinol and may be practical for this application Natural medical cannabis is also used and recommended by some oncologists though its use is regulated and it is not legal in all jurisdictions 16 However Marinol was less effective than megestrol acetate in helping cancer patients regain lost appetites 17 A phase III study found no difference in effects of an oral cannabis extract or THC on appetite and quality of life QOL in patients with cancer related anorexia cachexia syndrome CACS to placebo 18 third party source needed Dexamethasone a corticosteroid is often used alongside other antiemetic drugs as it has synergistic action with many of them although its specific antiemetic mechanism of action is not fully understood Metoclopramide a dopamine D2 receptor antagonist with possible other mechanisms is an older drug that is sometimes used either on its own or in combination with others Histamine blockers such as diphenhydramine or meclozine may be used in rescue treatment Lorazepam and diazepam may sometimes be used to relieve anxiety associated with CINV before administration of chemotherapy and are also often used in the case of rescue treatment 13 Alternative treatments Edit Ginger Zingiber officinale Edit There are several compounds that have been identified within ginger that have been shown to possess properties that are likely to be beneficial in the treatment of CINV This includes 5 HT3 and substance P antagonism modulation of gastrointestinal motility and antioxidant properties 19 20 There have been multiple clinical trials that have investigated the use of ginger supplementation as a treatment for CINV However due to conflicting results and methodological issues a 2013 systematic review of seven clinical trials summarized the current evidence as stating that Despite the widespread use of ginger in the treatment of nausea in other contexts such as gestational nausea the current literature provides mixed support for the use of ginger as a standard part of anti CINV control for patients undergoing chemotherapy 21 Other Edit Non pharmacological approaches to remedy CINV typically involve small lifestyle alterations such as using unscented deodorants and soaps avoiding strong scents altogether and dietary modifications such as eating several small meals throughout the day eating high protein high calorie food drinking many clear liquids and removing spicy fatty fried or acidic foods from the diet 22 Patients may also participate in alternative practices such as self hypnosis relaxation and imagery therapy distraction music therapy biofeedback desensitization or acupressure 2 See also EditCancer Cancer and nausea Chemotherapy Nausea VomitingReferences Edit Gill Paula Grothey Axel Loprinzi Charles 2006 Nausea and Vomiting in the Cancer Patient Oncology pp 1482 96 doi 10 1007 0 387 31056 8 83 ISBN 978 0 387 24291 0 a b c Chemotherapy Induced Nausea and Vomiting CINV gt OncUView gt OncUView tv Symptom Management Oncology News and Information for Healthcare Professionals Archived from the original on 2011 08 24 Retrieved 2011 09 02 Chemotherapy Induced Nausea and Vomiting Hornby P 2001 Central neurocircuitry associated with emesis The American Journal of Medicine 111 8 106S 112S doi 10 1016 S0002 9343 01 00849 X PMID 11749934 Minami Masaru Endo Toru Hirafuji Masahiko 1996 Role of serotonin in emesis Folia Pharmacologica Japonica 108 5 233 42 doi 10 1254 fpj 108 233 PMID 8974084 Minami Masaru Endo Toru Hamaue Naoya Hirafuji Masahiko 2004 Serotonin and Anticancer Drug induced Emesis Yakugaku Zasshi 124 8 491 507 doi 10 1248 yakushi 124 491 PMID 15297719 a b c CINV Risk Factors Cesamet Patient Education Meda Pharmaceuticals 2011 Retrieved 2011 09 02 Chemotherapy Induced Nausea and Vomiting CINV Patient Education AP Pharma 2011 Archived from the original on 2002 04 06 Retrieved 2011 09 02 a b PROTOCOL FOR THE USE OF ANTIEMETICS TO PREVENT CHEMOTHERAPY INDUCED NAUSEA AND VOMITING PDF VHA Pharmacy Benefits Management Strategic Healthcare Group and Medical Advisory Panel Archived from the original PDF on February 10 2012 Retrieved September 2 2011 Chemotherapy Induced Nausea and Vomiting Addressing the Problem of Delayed Nausea Risk Factors for CINV Medscape com Retrieved September 2 2011 Rojas Camilo Li Ying Zhang Jie Stathis Marigo Alt Jesse Thomas Ajit G Cantoreggi Sergio Sebastiani Silvia Pietra Claudio Slusher Barbara S November 2010 The Antiemetic 5 HT 3 Receptor Antagonist Palonosetron Inhibits Substance P Mediated Responses In Vitro and In Vivo Journal of Pharmacology and Experimental Therapeutics 335 2 362 368 doi 10 1124 jpet 110 166181 PMC 3202469 a b c Gralla Richard J De Wit Ronald Herrstedt Jorn Carides Alexandra D Ianus Juliana Guoguang Ma Julie Evans Judith K Horgan Kevin J 2005 Antiemetic efficacy of the neurokinin 1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid in patients receiving anthracyclines or cyclophosphamide in addition to high dose cisplatin Cancer 104 4 864 8 doi 10 1002 cncr 21222 PMID 15973669 S2CID 24860776 Bergstrom Mats Hargreaves Richard J Burns H Donald Goldberg Michael R Sciberras David Reines Scott A Petty Kevin J Ogren Mattias et al 2004 Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant Biological Psychiatry 55 10 1007 12 doi 10 1016 j biopsych 2004 02 007 PMID 15121485 S2CID 21071199 a b c Jordan K Sippel C Schmoll H J 2007 Guidelines for Antiemetic Treatment of Chemotherapy Induced Nausea and Vomiting Past Present and Future Recommendations The Oncologist 12 9 1143 50 doi 10 1634 theoncologist 12 9 1143 PMID 17914084 Navari Rudolph M Einhorn Lawrence H Loehrer Patrick J Passik Steven D Vinson Jake McClean John Chowhan Naveed Hanna Nasser H Johnson Cynthia S 2007 A phase II trial of olanzapine dexamethasone and palonosetron for the prevention of chemotherapy induced nausea and vomiting A Hoosier oncology group study Supportive Care in Cancer 15 11 1285 91 doi 10 1007 s00520 007 0248 5 PMID 17375339 S2CID 23266144 Tramer M R Carroll D Campbell FA Reynolds DJ Moore RA McQuay HJ 2001 Cannabinoids for control of chemotherapy induced nausea and vomiting Quantitative systematic BMJ 323 7303 16 21 doi 10 1136 bmj 323 7303 16 PMC 34325 PMID 11440936 Frequently Asked Questions Medical Marihuana Jatoi A Windschitl HE Loprinzi CL et al 2002 Dronabinol versus megestrol acetate versus combination therapy for cancer associated anorexia a North Central Cancer Treatment Group study Journal of Clinical Oncology 20 2 567 73 doi 10 1200 JCO 20 2 567 PMID 11786587 Retrieved 30 January 2002 Strasser F Luftner D Possinger K Ernst G Ruhstaller T Meissner W Ko YD Schnelle M et al 20 July 2006 Comparison of Orally Administered Cannabis Extract and Delta 9 Tetrahydrocannabinol in Treating Patients With Cancer Related Anorexia Cachexia Syndrome A Multicenter Phase III Randomized Double Blind Placebo Controlled Clinical Trial From the Cannabis In Cachexia Study Group Journal of Clinical Oncology 24 21 3394 3400 doi 10 1200 JCO 2005 05 1847 PMID 16849753 Marx Wolfgang Kiss Nicole Isenring Liz June 2015 Is ginger beneficial for nausea and vomiting An update of the literature Current Opinion in Supportive and Palliative Care 9 2 189 195 doi 10 1097 SPC 0000000000000135 ISSN 1751 4266 PMID 25872115 S2CID 23359181 Marx Wolfgang Ried Karin McCarthy Alexandra L Vitetta Luis Sali Avni McKavanagh Daniel Isenring Elisabeth 2015 04 07 Ginger Mechanism of Action in Chemotherapy induced Nausea and Vomiting A Review Critical Reviews in Food Science and Nutrition 57 1 141 146 doi 10 1080 10408398 2013 865590 ISSN 1549 7852 PMID 25848702 S2CID 24523559 Marx WM Teleni L McCarthy AL Vitetta L McKavanagh D Thomson D Isenring E 2013 Ginger Zingiber officinale and chemotherapy induced nausea and vomiting a systematic literature review PDF Nutr Rev 71 4 245 54 doi 10 1111 nure 12016 PMID 23550785 S2CID 19187673 How to Prevent CINV Minimize CINV Sancuso Archived from the original on 2012 01 13 Retrieved 2011 09 02 How to Prevent CINV Minimize CINV Retrieved from https en wikipedia org w index php title Chemotherapy induced nausea and vomiting amp oldid 1170479634, wikipedia, wiki, book, books, library,

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