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Cdx protein family

January 01, 1970

The Cdx protein family is a group of the transcription factor proteins which bind to DNA to regulate the expression of genes.[1] In particular this family of proteins can regulate the Hox genes. They are regulators of embryonic development and hematopoiesis in vertebrates, and are also involved in the development of some types of gastrointestinal cancers and leukemias.[2]

Cdx proteins edit

Humans have three genes (CDX1, CDX2, and CDX4) that encode the caudal proteins:[2]

The human Cdx2 family protein has 94% identity with the mouse Cdx2 and the hamster Cdx3.[3]

Cdx proteins and regulation of Hox gene expression edit

Cdx proteins are key regulators of Hox genes. The vertebrate Cdx proteins act upstream of Hox genes. Cdx genes integrate the posteriorizing signals from retinoic acid and Wnt canonical pathways and relay this information to Hox promoters.[4]

Expression in mouse embryo edit

Cdx2 expression begins at 3.5 days and is confined to the trophectoderm, being absent from the inner cell mass. From 8.5 days, Cdx2 begins to be expressed in embryonic tissues, principally in the posterior part of the gut from its earliest formation.[5]

See also edit

References edit

  1. ^ Béland, M.; Pilon, N.; Houle, M.; et al. (2004). "Cdx1 Autoregulation is Governed by a Novel Cdx1-LEF1 Transcription Complex". Molecular and Cellular Biology. 24 (11): 5028–5038. doi:10.1128/MCB.24.11.5028-5038.2004. PMC 416402. PMID 15143193.
  2. ^ a b Lengerke C, Daley GQ (2012). "Caudal genes in blood development and leukemia". Annals of the New York Academy of Sciences. 1266 (1): 47–54. Bibcode:2012NYASA1266...47L. doi:10.1111/j.1749-6632.2012.06625.x. PMC 3431192. PMID 22901255.
  3. ^ Mallo, G.V.; Rechreche, H.; Frigerio, J.M.; et al. (1997). "Molecular Cloning, Sequencing and Expression of the mRNA Encoding Human Cdx1 and Cdx2 Homeobox. Down-regulation of Cdx1 and Cdx2 mRNA Expression During Colorectal Carcinogenesis". International Journal of Cancer. 74 (1): 35–44. doi:10.1002/(sici)1097-0215(19970220)74:1<35::aid-ijc7>3.0.co;2-1. PMID 9036867. S2CID 46416077.
  4. ^ Lohnes, David (2003). "The Cdx1 Homeodomain Protein: An Integrator of Posterior Signaling in the Mouse". BioEssays. 25 (10): 971–980. doi:10.1002/bies.10340. PMID 14505364.
  5. ^ Beck, F.; Erler, T.; Russell, A.; et al. (1995). "Expression of Cdx-2 in the Mouse Embryo and Placenta: Possible Role in Patterning of the Extra-embryonic Membranes". Developmental Dynamics. 204 (3): 219–227. doi:10.1002/aja.1002040302. PMID 8573715. S2CID 19576530.

January 01, 1970
protein, family, group, transcription, factor, proteins, which, bind, regulate, expression, genes, particular, this, family, proteins, regulate, genes, they, regulators, embryonic, development, hematopoiesis, vertebrates, also, involved, development, some, typ. The Cdx protein family is a group of the transcription factor proteins which bind to DNA to regulate the expression of genes 1 In particular this family of proteins can regulate the Hox genes They are regulators of embryonic development and hematopoiesis in vertebrates and are also involved in the development of some types of gastrointestinal cancers and leukemias 2 Contents 1 Cdx proteins 2 Cdx proteins and regulation of Hox gene expression 3 Expression in mouse embryo 4 See also 5 ReferencesCdx proteins editHumans have three genes CDX1 CDX2 and CDX4 that encode the caudal proteins 2 Cdx1 protein Cdx2 protein Cdx4 protein The human Cdx2 family protein has 94 identity with the mouse Cdx2 and the hamster Cdx3 3 Cdx proteins and regulation of Hox gene expression editCdx proteins are key regulators of Hox genes The vertebrate Cdx proteins act upstream of Hox genes Cdx genes integrate the posteriorizing signals from retinoic acid and Wnt canonical pathways and relay this information to Hox promoters 4 Expression in mouse embryo editCdx2 expression begins at 3 5 days and is confined to the trophectoderm being absent from the inner cell mass From 8 5 days Cdx2 begins to be expressed in embryonic tissues principally in the posterior part of the gut from its earliest formation 5 See also editNeural tube Protein family Transcription factorReferences edit Beland M Pilon N Houle M et al 2004 Cdx1 Autoregulation is Governed by a Novel Cdx1 LEF1 Transcription Complex Molecular and Cellular Biology 24 11 5028 5038 doi 10 1128 MCB 24 11 5028 5038 2004 PMC 416402 PMID 15143193 a b Lengerke C Daley GQ 2012 Caudal genes in blood development and leukemia Annals of the New York Academy of Sciences 1266 1 47 54 Bibcode 2012NYASA1266 47L doi 10 1111 j 1749 6632 2012 06625 x PMC 3431192 PMID 22901255 Mallo G V Rechreche H Frigerio J M et al 1997 Molecular Cloning Sequencing and Expression of the mRNA Encoding Human Cdx1 and Cdx2 Homeobox Down regulation of Cdx1 and Cdx2 mRNA Expression During Colorectal Carcinogenesis International Journal of Cancer 74 1 35 44 doi 10 1002 sici 1097 0215 19970220 74 1 lt 35 aid ijc7 gt 3 0 co 2 1 PMID 9036867 S2CID 46416077 Lohnes David 2003 The Cdx1 Homeodomain Protein An Integrator of Posterior Signaling in the Mouse BioEssays 25 10 971 980 doi 10 1002 bies 10340 PMID 14505364 Beck F Erler T Russell A et al 1995 Expression of Cdx 2 in the Mouse Embryo and Placenta Possible Role in Patterning of the Extra embryonic Membranes Developmental Dynamics 204 3 219 227 doi 10 1002 aja 1002040302 PMID 8573715 S2CID 19576530 Retrieved from https en wikipedia org w index php title Cdx protein family amp oldid 1187411816, wikipedia, wiki, book, books, library,

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