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CXCR5

March 06, 2023

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It enables T cells to migrate to lymph node and the B cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.[5]

CXCR5
Identifiers
AliasesCXCR5, BLR1, CD185, MDR15, C-X-C motif chemokine receptor 5, C-X-C chemokine receptor type 5
External IDsOMIM: 601613 MGI: 103567 HomoloGene: 1298 GeneCards: CXCR5
Orthologs
SpeciesHumanMouse
Entrez

643

12145

Ensembl

ENSG00000160683

ENSMUSG00000047880

UniProt

P32302

Q04683

RefSeq (mRNA)

NM_032966
NM_001716

NM_007551

RefSeq (protein)

NP_001707
NP_116743

NP_031577

Location (UCSC)Chr 11: 118.88 – 118.9 MbChr 9: 44.42 – 44.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue distribution and function

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.[6] Through CXCL13 secretions B cells are able to locate the lymph node.[6]

Additionally, some recent studies have suggested that CXCL13, through CXCR5, is capable of recruiting hematopoietic precursor cells (CD3− CD4+) which would cause the development of lymph nodes and Peyer's Patches.[7][8]

Other studies highlight the role of CXCR5 in T cells, as they are unable to access B cell follicles without CXCR5 expression.[9][10] This is a key step in the production of high affinity antibodies as B cells and T cells need to interact in order to activate the Ig class switch.[9]

CXCR5 has been shown to be expressed on both CD4[11] and CD8[12] T cells, though it is often regarded as the defining marker for T Follicular Helper (Tfh) cells.[13]

Role in cancer development

Recently, it was shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases,[14] and elevated CXCR5 expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein.[15] Minor allele of SNP rs630923, located in the area of CXCR5 gene promoter and associated with the risk of multiple sclerosis, is responsible for appearance of MEF2C-binding site resulted in reduced CXCR5 gene promoter activity in B-cells during activation, that could lead to decreased autoimmune response [16]

While chemokines and chemokine receptors have been thought to be involved in cancer development and maintenance, recently CXCR5 has come under investigation for its role in metastatic progression of prostate cancer. A recent study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5.[17] Furthermore, the study found a correlation between the level of CXCR5 and Gleason score. CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers.[17]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160683 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047880 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". European Journal of Immunology. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907. S2CID 35096818.
  6. ^ a b Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (December 1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell. 87 (6): 1037–47. doi:10.1016/S0092-8674(00)81798-5. PMID 8978608. S2CID 17558174.
  7. ^ Honda, Kenya; Nakano, Hiroyasu; Yoshida, Hisahiro; Nishikawa, Satomi; Rennert, Paul; Ikuta, Koichi; Tamechika, Masakatsu; Yamaguchi, Kazuhito; Fukumoto, Tetsuo (2001-03-05). "Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis". The Journal of Experimental Medicine. 193 (5): 621–630. doi:10.1084/jem.193.5.621. ISSN 0022-1007. PMC 2193398. PMID 11238592.
  8. ^ Finke, D; Acha-Orbea, H; Mattis, A; Lipp, M; Kraehenbuhl, J.P (September 2002). "CD4+CD3− Cells Induce Peyer's Patch Development". Immunity. 17 (3): 363–373. doi:10.1016/S1074-7613(02)00395-3. PMID 12354388.
  9. ^ a b Junt, Tobias; Fink, Katja; Förster, Reinhold; Senn, Beatrice; Lipp, Martin; Muramatsu, Masamichi; Zinkernagel, Rolf M.; Ludewig, Burkhard; Hengartner, Hans (2005-12-01). "CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses". Journal of Immunology. 175 (11): 7109–7116. doi:10.4049/jimmunol.175.11.7109. ISSN 0022-1767. PMID 16301613.
  10. ^ Hardtke, S. (2005-09-15). "Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help". Blood. 106 (6): 1924–1931. doi:10.1182/blood-2004-11-4494. ISSN 0006-4971. PMID 15899919.
  11. ^ Chevalier N, Jarrossay D, Ho E, Avery DT, Ma CS, Yu D, Sallusto F, Tangye SG, Mackay CR (May 2011). "CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses". Journal of Immunology. 186 (10): 5556–68. doi:10.4049/jimmunol.1002828. PMID 21471443.
  12. ^ He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L (August 2016). "Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection". Nature. 537 (7620): 412–428. Bibcode:2016Natur.537..412H. doi:10.1038/nature19317. PMID 27501245. S2CID 4469688.
  13. ^ Moser B (2015). "CXCR5, the Defining Marker for Follicular B Helper T (TFH) Cells". Frontiers in Immunology. 6: 296. doi:10.3389/fimmu.2015.00296. PMC 4459225. PMID 26106395.
  14. ^ Biswas S, Sengupta S, Roy Chowdhury S, Jana S, Mandal G, Mandal PK, Saha N, Malhotra V, Gupta A, Kuprash DV, Bhattacharyya A (January 2014). "CXCL13-CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis". Breast Cancer Research and Treatment. 143 (2): 265–76. doi:10.1007/s10549-013-2811-8. PMID 24337540. S2CID 2937341.
  15. ^ Mitkin NA, Hook CD, Schwartz AM, Biswas S, Kochetkov DV, Muratova AM, Afanasyeva MA, Kravchenko JE, Bhattacharyya A, Kuprash DV (March 2015). "p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells". Scientific Reports. 5 (5): 9330. Bibcode:2015NatSR...5E9330M. doi:10.1038/srep09330. PMC 4365401. PMID 25786345.
  16. ^ Mitkin NA, Muratova AM, Schwartz AM, Kuprash DV (Nov 2016). "The A Allele of the Single-Nucleotide Polymorphism rs630923 Creates a Binding Site for MEF2C Resulting in Reduced CXCR5 Promoter Activity in B-Cell Lymphoblastic Cell Lines". Frontiers in Immunology. 7 (515): 515. doi:10.3389/fimmu.2016.00515. PMC 5112242. PMID 27909439.
  17. ^ a b Singh, Shailesh; Singh, Rajesh; Singh, Udai P.; Rai, Shesh N.; Novakovic, Kristian R.; Chung, Leland W.K.; Didier, Peter J.; Grizzle, William E.; Lillard, James W. (2009-11-15). "Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines". International Journal of Cancer. 125 (10): 2288–2295. doi:10.1002/ijc.24574. PMC 3600527. PMID 19610059.

External links

Further reading

  • Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking". Verhandlungen der Deutschen Gesellschaft für Pathologie. 87: 90–101. PMID 16888899.
  • Barella L, Loetscher M, Tobler A, Baggiolini M, Moser B (August 1995). "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation". The Biochemical Journal. 309 ( Pt 3) (3): 773–9. doi:10.1042/bj3090773. PMC 1135699. PMID 7639692.
  • Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". The Journal of Experimental Medicine. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
  • Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
  • Müller G, Lipp M (September 2001). "Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules". Biological Chemistry. 382 (9): 1387–97. doi:10.1515/BC.2001.171. PMID 11688722. S2CID 21366051.
  • Schaerli P, Loetscher P, Moser B (December 2001). "Cutting edge: induction of follicular homing precedes effector Th cell development". Journal of Immunology. 167 (11): 6082–6. doi:10.4049/jimmunol.167.11.6082. PMID 11714765.
  • Kim CH, Johnston B, Butcher EC (July 2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001. S2CID 37076470.
  • Carlsen HS, Baekkevold ES, Johansen FE, Haraldsen G, Brandtzaeg P (September 2002). "B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue". Gut. 51 (3): 364–71. doi:10.1136/gut.51.3.364. PMC 1773345. PMID 12171958.
  • Battle TE, Yen A (October 2002). "Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells". Experimental Biology and Medicine. 227 (9): 753–62. doi:10.1177/153537020222700906. PMID 12324654. S2CID 26070911.
  • Lisignoli G, Toneguzzi S, Piacentini A, Cattini L, Lenti A, Tschon M, Cristino S, Grassi F, Facchini A (January 2003). "Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release". Journal of Cellular Physiology. 194 (1): 71–9. doi:10.1002/jcp.10188. PMID 12447991. S2CID 8031523.
  • Chan CC, Shen D, Hackett JJ, Buggage RR, Tuaillon N (February 2003). "Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma". Ophthalmology. 110 (2): 421–6. doi:10.1016/S0161-6420(02)01737-2. PMID 12578791.
  • Flynn G, Maru S, Loughlin J, Romero IA, Male D (March 2003). "Regulation of chemokine receptor expression in human microglia and astrocytes". Journal of Neuroimmunology. 136 (1–2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646. S2CID 39725685.
  • Lisignoli G, Piacentini A, Toneguzzi S, Grassi F, Tschon M, Cristino S, Facchini A, Mariani E (2004). "Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts". Biogerontology. 4 (5): 309–17. doi:10.1023/A:1026203502385. PMID 14618028. S2CID 20511946.
  • Aust G, Sittig D, Becherer L, Anderegg U, Schütz A, Lamesch P, Schmücking E (February 2004). "The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases". European Journal of Endocrinology. 150 (2): 225–34. doi:10.1530/eje.0.1500225. PMID 14763921.
  • Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ (June 2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799.
  • Steinmetz OM, Panzer U, Kneissler U, Harendza S, Lipp M, Helmchen U, Stahl RA (April 2005). "BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection". Kidney International. 67 (4): 1616–21. doi:10.1111/j.1523-1755.2005.00244.x. PMID 15780119.
  • Hu C, Xiong J, Zhang L, Huang B, Zhang Q, Li Q, Yang M, Wu Y, Wu Q, Shen Q, Gao Q, Zhang K, Sun Z, Liu J, Jin Y, Tan J (August 2004). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia". Cellular & Molecular Immunology. 1 (4): 280–94. PMID 16225771.


 

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March 06, 2023
cxcr5, chemokine, receptor, type, also, known, cd185, cluster, differentiation, burkitt, lymphoma, receptor, blr1, protein, coupled, seven, transmembrane, receptor, chemokine, cxcl13, also, known, belongs, chemokine, receptor, family, enables, cells, migrate, . C X C chemokine receptor type 5 CXC R5 also known as CD185 cluster of differentiation 185 or Burkitt lymphoma receptor 1 BLR1 is a G protein coupled seven transmembrane receptor for chemokine CXCL13 also known as BLC and belongs to the CXC chemokine receptor family It enables T cells to migrate to lymph node and the B cell zones In humans the CXC R5 protein is encoded by the CXCR5 gene 5 CXCR5IdentifiersAliasesCXCR5 BLR1 CD185 MDR15 C X C motif chemokine receptor 5 C X C chemokine receptor type 5External IDsOMIM 601613 MGI 103567 HomoloGene 1298 GeneCards CXCR5Gene location Human Chr Chromosome 11 human 1 Band11q23 3Start118 883 892 bp 1 End118 897 787 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 A5 2 9 24 84 cMStart44 423 084 bp 2 End44 473 174 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleenlymph nodeappendixbloodascending aortaleft coronary arterystromal cell of endometriumskin of abdomencanal of the cervixganglionic eminenceTop expressed inspleenspermatidbloodsubcutaneous adipose tissuespermatocyteleft lungthymusright lung lobewhite adipose tissuemeningesMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionC X C chemokine receptor activity G protein coupled receptor activity protein binding signal transducer activity C C chemokine receptor activity chemokine binding C C chemokine bindingCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membraneBiological processpositive regulation of cytokinesis chemokine mediated signaling pathway chemotaxis B cell activation G protein coupled receptor signaling pathway lymph node development immune response signal transduction leukocyte chemotaxis positive regulation of cytosolic calcium ion concentration calcium mediated signaling cell chemotaxisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez64312145EnsemblENSG00000160683ENSMUSG00000047880UniProtP32302Q04683RefSeq mRNA NM 032966NM 001716NM 007551RefSeq protein NP 001707NP 116743NP 031577Location UCSC Chr 11 118 88 118 9 MbChr 9 44 42 44 47 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Tissue distribution and function 2 Role in cancer development 3 References 4 External links 5 Further readingTissue distribution and function EditThe BLR1 CXCR5 gene is specifically expressed in Burkitt s lymphoma and lymphatic tissues such as follicles in lymph nodes as well as in spleen The gene plays an essential role in B cell migration 6 Through CXCL13 secretions B cells are able to locate the lymph node 6 Additionally some recent studies have suggested that CXCL13 through CXCR5 is capable of recruiting hematopoietic precursor cells CD3 CD4 which would cause the development of lymph nodes and Peyer s Patches 7 8 Other studies highlight the role of CXCR5 in T cells as they are unable to access B cell follicles without CXCR5 expression 9 10 This is a key step in the production of high affinity antibodies as B cells and T cells need to interact in order to activate the Ig class switch 9 CXCR5 has been shown to be expressed on both CD4 11 and CD8 12 T cells though it is often regarded as the defining marker for T Follicular Helper Tfh cells 13 Role in cancer development EditRecently it was shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases 14 and elevated CXCR5 expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein 15 Minor allele of SNP rs630923 located in the area of CXCR5 gene promoter and associated with the risk of multiple sclerosis is responsible for appearance of MEF2C binding site resulted in reduced CXCR5 gene promoter activity in B cells during activation that could lead to decreased autoimmune response 16 While chemokines and chemokine receptors have been thought to be involved in cancer development and maintenance recently CXCR5 has come under investigation for its role in metastatic progression of prostate cancer A recent study has indicated that prostate cancer tissue as well as cell lines express higher non basal levels of CXCR5 17 Furthermore the study found a correlation between the level of CXCR5 and Gleason score CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers 17 References Edit a b c GRCh38 Ensembl release 89 ENSG00000160683 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000047880 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Dobner T Wolf I Emrich T Lipp M November 1992 Differentiation specific expression of a novel G protein coupled receptor from Burkitt s lymphoma European Journal of Immunology 22 11 2795 9 doi 10 1002 eji 1830221107 PMID 1425907 S2CID 35096818 a b Forster R Mattis AE Kremmer E Wolf E Brem G Lipp M December 1996 A putative chemokine receptor BLR1 directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen Cell 87 6 1037 47 doi 10 1016 S0092 8674 00 81798 5 PMID 8978608 S2CID 17558174 Honda Kenya Nakano Hiroyasu Yoshida Hisahiro Nishikawa Satomi Rennert Paul Ikuta Koichi Tamechika Masakatsu Yamaguchi Kazuhito Fukumoto Tetsuo 2001 03 05 Molecular Basis for Hematopoietic Mesenchymal Interaction during Initiation of Peyer s Patch Organogenesis The Journal of Experimental Medicine 193 5 621 630 doi 10 1084 jem 193 5 621 ISSN 0022 1007 PMC 2193398 PMID 11238592 Finke D Acha Orbea H Mattis A Lipp M Kraehenbuhl J P September 2002 CD4 CD3 Cells Induce Peyer s Patch Development Immunity 17 3 363 373 doi 10 1016 S1074 7613 02 00395 3 PMID 12354388 a b Junt Tobias Fink Katja Forster Reinhold Senn Beatrice Lipp Martin Muramatsu Masamichi Zinkernagel Rolf M Ludewig Burkhard Hengartner Hans 2005 12 01 CXCR5 dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses Journal of Immunology 175 11 7109 7116 doi 10 4049 jimmunol 175 11 7109 ISSN 0022 1767 PMID 16301613 Hardtke S 2005 09 15 Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B cell help Blood 106 6 1924 1931 doi 10 1182 blood 2004 11 4494 ISSN 0006 4971 PMID 15899919 Chevalier N Jarrossay D Ho E Avery DT Ma CS Yu D Sallusto F Tangye SG Mackay CR May 2011 CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses Journal of Immunology 186 10 5556 68 doi 10 4049 jimmunol 1002828 PMID 21471443 He R Hou S Liu C Zhang A Bai Q Han M Yang Y Wei G Shen T Yang X Xu L Chen X Hao Y Wang P Zhu C Ou J Liang H Ni T Zhang X Zhou X Deng K Chen Y Luo Y Xu J Qi H Wu Y Ye L August 2016 Follicular CXCR5 expressing CD8 T cells curtail chronic viral infection Nature 537 7620 412 428 Bibcode 2016Natur 537 412H doi 10 1038 nature19317 PMID 27501245 S2CID 4469688 Moser B 2015 CXCR5 the Defining Marker for Follicular B Helper T TFH Cells Frontiers in Immunology 6 296 doi 10 3389 fimmu 2015 00296 PMC 4459225 PMID 26106395 Biswas S Sengupta S Roy Chowdhury S Jana S Mandal G Mandal PK Saha N Malhotra V Gupta A Kuprash DV Bhattacharyya A January 2014 CXCL13 CXCR5 co expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis Breast Cancer Research and Treatment 143 2 265 76 doi 10 1007 s10549 013 2811 8 PMID 24337540 S2CID 2937341 Mitkin NA Hook CD Schwartz AM Biswas S Kochetkov DV Muratova AM Afanasyeva MA Kravchenko JE Bhattacharyya A Kuprash DV March 2015 p53 dependent expression of CXCR5 chemokine receptor in MCF 7 breast cancer cells Scientific Reports 5 5 9330 Bibcode 2015NatSR 5E9330M doi 10 1038 srep09330 PMC 4365401 PMID 25786345 Mitkin NA Muratova AM Schwartz AM Kuprash DV Nov 2016 The A Allele of the Single Nucleotide Polymorphism rs630923 Creates a Binding Site for MEF2C Resulting in Reduced CXCR5 Promoter Activity in B Cell Lymphoblastic Cell Lines Frontiers in Immunology 7 515 515 doi 10 3389 fimmu 2016 00515 PMC 5112242 PMID 27909439 a b Singh Shailesh Singh Rajesh Singh Udai P Rai Shesh N Novakovic Kristian R Chung Leland W K Didier Peter J Grizzle William E Lillard James W 2009 11 15 Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines International Journal of Cancer 125 10 2288 2295 doi 10 1002 ijc 24574 PMC 3600527 PMID 19610059 External links EditHuman CXCR5 genome location and CXCR5 gene details page in the UCSC Genome Browser Further reading EditLipp M Muller G 2006 Shaping up adaptive immunity the impact of CCR7 and CXCR5 on lymphocyte trafficking Verhandlungen der Deutschen Gesellschaft fur Pathologie 87 90 101 PMID 16888899 Barella L Loetscher M Tobler A Baggiolini M Moser B August 1995 Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation The Biochemical Journal 309 Pt 3 3 773 9 doi 10 1042 bj3090773 PMC 1135699 PMID 7639692 Legler DF Loetscher M Roos RS Clark Lewis I Baggiolini M Moser B February 1998 B cell attracting chemokine 1 a human CXC chemokine expressed in lymphoid tissues selectively attracts B lymphocytes via BLR1 CXCR5 The Journal of Experimental Medicine 187 4 655 60 doi 10 1084 jem 187 4 655 PMC 2212150 PMID 9463416 Gunn MD Ngo VN Ansel KM Ekland EH Cyster JG Williams LT February 1998 A B cell homing chemokine made in lymphoid follicles activates Burkitt s lymphoma receptor 1 Nature 391 6669 799 803 Bibcode 1998Natur 391 799G doi 10 1038 35876 PMID 9486651 S2CID 4373691 Muller G Lipp M September 2001 Signal transduction by the chemokine receptor CXCR5 structural requirements for G protein activation analyzed by chimeric CXCR1 CXCR5 molecules Biological Chemistry 382 9 1387 97 doi 10 1515 BC 2001 171 PMID 11688722 S2CID 21366051 Schaerli P Loetscher P Moser B December 2001 Cutting edge induction of follicular homing precedes effector Th cell development Journal of Immunology 167 11 6082 6 doi 10 4049 jimmunol 167 11 6082 PMID 11714765 Kim CH Johnston B Butcher EC July 2002 Trafficking machinery of NKT cells shared and differential chemokine receptor expression among V alpha 24 V beta 11 NKT cell subsets with distinct cytokine producing capacity Blood 100 1 11 6 doi 10 1182 blood 2001 12 0196 PMID 12070001 S2CID 37076470 Carlsen HS Baekkevold ES Johansen FE Haraldsen G Brandtzaeg P September 2002 B cell attracting chemokine 1 CXCL13 and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue Gut 51 3 364 71 doi 10 1136 gut 51 3 364 PMC 1773345 PMID 12171958 Battle TE Yen A October 2002 Ectopic expression of CXCR5 BLR1 accelerates retinoic acid and vitamin D 3 induced monocytic differentiation of U937 cells Experimental Biology and Medicine 227 9 753 62 doi 10 1177 153537020222700906 PMID 12324654 S2CID 26070911 Lisignoli G Toneguzzi S Piacentini A Cattini L Lenti A Tschon M Cristino S Grassi F Facchini A January 2003 Human osteoblasts express functional CXC chemokine receptors 3 and 5 activation by their ligands CXCL10 and CXCL13 significantly induces alkaline phosphatase and beta N acetylhexosaminidase release Journal of Cellular Physiology 194 1 71 9 doi 10 1002 jcp 10188 PMID 12447991 S2CID 8031523 Chan CC Shen D Hackett JJ Buggage RR Tuaillon N February 2003 Expression of chemokine receptors CXCR4 and CXCR5 and chemokines BLC and SDF 1 in the eyes of patients with primary intraocular lymphoma Ophthalmology 110 2 421 6 doi 10 1016 S0161 6420 02 01737 2 PMID 12578791 Flynn G Maru S Loughlin J Romero IA Male D March 2003 Regulation of chemokine receptor expression in human microglia and astrocytes Journal of Neuroimmunology 136 1 2 84 93 doi 10 1016 S0165 5728 03 00009 2 PMID 12620646 S2CID 39725685 Lisignoli G Piacentini A Toneguzzi S Grassi F Tschon M Cristino S Facchini A Mariani E 2004 Age associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts Biogerontology 4 5 309 17 doi 10 1023 A 1026203502385 PMID 14618028 S2CID 20511946 Aust G Sittig D Becherer L Anderegg U Schutz A Lamesch P Schmucking E February 2004 The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases European Journal of Endocrinology 150 2 225 34 doi 10 1530 eje 0 1500225 PMID 14763921 Howard OM Dong HF Su SB Caspi RR Chen X Plotz P Oppenheim JJ June 2005 Autoantigens signal through chemokine receptors uveitis antigens induce CXCR3 and CXCR5 expressing lymphocytes and immature dendritic cells to migrate Blood 105 11 4207 14 doi 10 1182 blood 2004 07 2697 PMC 1895027 PMID 15713799 Steinmetz OM Panzer U Kneissler U Harendza S Lipp M Helmchen U Stahl RA April 2005 BCA 1 CXCL13 expression is associated with CXCR5 positive B cell cluster formation in acute renal transplant rejection Kidney International 67 4 1616 21 doi 10 1111 j 1523 1755 2005 00244 x PMID 15780119 Hu C Xiong J Zhang L Huang B Zhang Q Li Q Yang M Wu Y Wu Q Shen Q Gao Q Zhang K Sun Z Liu J Jin Y Tan J August 2004 PEG10 activation by co stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19 CD34 B cells from patients with B cell lineage acute and chronic lymphocytic leukemia Cellular amp Molecular Immunology 1 4 280 94 PMID 16225771 This cell biology article is a stub You can help Wikipedia by expanding it vte This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CXCR5 amp oldid 1116821699, wikipedia, wiki, book, books, library,

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