Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a proteinligand that in humans is encoded by the CXCL13gene.[5][6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[9]
References
^ abcGRCh38: Ensembl release 89: ENSG00000156234 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023078 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcLegler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC2212150. PMID 9463416.
^ abGunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
^Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
^Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.
^de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.
External links
Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O43927 (C-X-C motif chemokine 13) at the PDBe-KB.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
cxcl13, chemokine, motif, ligand, also, known, lymphocyte, chemoattractant, cell, attracting, chemokine, protein, ligand, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4zai, 5cba, 5cbeidentifiersaliases, angie, ang. Chemokine C X C motif ligand 13 CXCL13 also known as B lymphocyte chemoattractant BLC or B cell attracting chemokine 1 BCA 1 is a protein ligand that in humans is encoded by the CXCL13 gene 5 6 CXCL13Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4ZAI 5CBA 5CBEIdentifiersAliasesCXCL13 ANGIE ANGIE2 BCA 1 BCA1 BLC BLR1L SCYB13 C X C motif chemokine ligand 13External IDsOMIM 605149 MGI 1888499 HomoloGene 48431 GeneCards CXCL13Gene location Human Chr Chromosome 4 human 1 Band4q21 1Start77 511 753 bp 1 End77 611 834 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 E3Start96 104 810 bp 2 End96 108 927 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleenlymph nodeappendixrectumperiodontal fiberthymussuperficial temporal arterygallbladderpylorusgumsTop expressed inspleensubmandibular glandsubcutaneous adipose tissuePaneth cellwhite adipose tissueexternal carotid arteryleft coloninternal carotid arterysecondary oocytetracheaMore reference expression dataBioGPSn aGene ontologyMolecular functionreceptor ligand activity CCR10 chemokine receptor binding cytokine activity heparin binding CXCR3 chemokine receptor binding chemokine activity protein heterodimerization activity fibroblast growth factor binding CXCR5 chemokine receptor bindingCellular componentextracellular region extracellular spaceBiological processchemokine mediated signaling pathway positive regulation of cytosolic calcium ion concentration cell cell signaling germinal center formation regulation of angiogenesis chemotaxis endothelial cell chemotaxis to fibroblast growth factor regulation of humoral immune response cell surface receptor signaling pathway response to lipopolysaccharide regulation of cell population proliferation defense response to bacterium negative regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of T cell chemotaxis immune response inflammatory response chronic inflammatory response defense response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein coupled receptor signaling pathway lymphocyte chemotaxis across high endothelial venule positive regulation of integrin activation positive regulation of cell cell adhesion mediated by integrin B cell chemotaxis activation of GTPase activity neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1056355985EnsemblENSG00000156234ENSMUSG00000023078UniProtO43927O55038RefSeq mRNA NM 006419NM 001371558NM 018866RefSeq protein NP 006410NP 001358487NP 061354Location UCSC Chr 4 77 51 77 61 MbChr 5 96 1 96 11 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction EditCXCL13 is a small chemokine belonging to the CXC chemokine family As its other names suggest this chemokine is selectively chemotactic for B cells belonging to both the B 1 and B 2 subsets and elicits its effects by interacting with chemokine receptor CXCR5 5 7 CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues 8 and is expressed highly in the liver spleen lymph nodes and gut of humans 5 The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines 6 In T lymphocytes CXCL13 expression is thought to reflect a germinal center origin of the T cell particularly a subset of T cells called follicular B helper T cells or TFH cells Hence expression of CXCL13 in T cell lymphomas such as Angioimmunoblastic T cell Lymphoma is thought to reflect a germinal center origin of the neoplastic T cells 9 References Edit a b c GRCh38 Ensembl release 89 ENSG00000156234 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000023078 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c Legler DF Loetscher M Roos RS Clark Lewis I Baggiolini M Moser B February 1998 B cell attracting chemokine 1 a human CXC chemokine expressed in lymphoid tissues selectively attracts B lymphocytes via BLR1 CXCR5 J Exp Med 187 4 655 60 doi 10 1084 jem 187 4 655 PMC 2212150 PMID 9463416 a b Gunn MD Ngo VN Ansel KM Ekland EH Cyster JG Williams LT February 1998 A B cell homing chemokine made in lymphoid follicles activates Burkitt s lymphoma receptor 1 Nature 391 6669 799 803 Bibcode 1998Natur 391 799G doi 10 1038 35876 PMID 9486651 S2CID 4373691 Ansel KM Harris RB Cyster JG January 2002 CXCL13 is required for B1 cell homing natural antibody production and body cavity immunity Immunity 16 1 67 76 doi 10 1016 S1074 7613 01 00257 6 PMID 11825566 Ansel KM Ngo VN Hyman PL Luther SA Forster R Sedgwick JD Browning JL Lipp M Cyster JG July 2000 A chemokine driven positive feedback loop organizes lymphoid follicles Nature 406 6793 309 14 doi 10 1038 35018581 PMID 10917533 S2CID 4369622 de Leval L Rickman DS Thielen C Reynies A Huang YL Delsol G Lamant L Leroy K Briere J Molina T Berger F Gisselbrecht C Xerri L Gaulard P June 2007 The gene expression profile of nodal peripheral T cell lymphoma demonstrates a molecular link between angioimmunoblastic T cell lymphoma AITL and follicular helper T TFH cells Blood 109 11 4952 63 doi 10 1182 blood 2006 10 055145 PMID 17284527 External links EditHuman CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt O43927 C X C motif chemokine 13 at the PDBe KB This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CXCL13 amp oldid 1118643958, wikipedia, wiki, book, books, library,
