Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000163624 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029330 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
^Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.
^Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
^Nowicki M (2006). (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.
Further readingedit
Liu Y, Virshup DM, White RL, Hsu LC (November 2002). "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer Research. 62 (22): 6357–61. PMID 12438214.
Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, et al. (January 1999). "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics. 55 (1): 68–77. doi:10.1006/geno.1998.5610. PMID 9889000.
Lykidis A, Jackson PD, Rock CO, Jackowski S (December 1997). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". The Journal of Biological Chemistry. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.
Heacock AM, Uhler MD, Agranoff BW (November 1996). "Cloning of CDP-diacylglycerol synthase from a human neuronal cell line" (PDF). Journal of Neurochemistry. 67 (5): 2200–3. doi:10.1046/j.1471-4159.1996.67052200.x. hdl:2027.42/65959. PMID 8863531. S2CID 2805319.
External linksedit
Human CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser.
cds1, gene, phosphatidate, cytidylyltransferase, enzyme, that, humans, encoded, cds1, gene, cds1identifiersaliasescds1, diacylglycerol, synthase, 1external, idsomim, 603548, 1921846, homologene, 68173, genecards, cds1gene, location, human, chromosome, human, b. Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene 5 6 7 CDS1IdentifiersAliasesCDS1 CDS CDP diacylglycerol synthase 1 CDS 1External IDsOMIM 603548 MGI 1921846 HomoloGene 68173 GeneCards CDS1Gene location Human Chr Chromosome 4 human 1 Band4q21 23Start84 583 127 bp 1 End84 651 334 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 E5Start101 912 996 bp 2 End101 971 724 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbronchial epithelial cellsecondary oocytecaput epididymisamniotic fluidjejunal mucosacorpus epididymismiddle temporal gyrusBrodmann area 23oral cavityduodenumTop expressed injejunumolfactory epitheliumileumretinal pigment epitheliumotolith organutriclespermatocytelipseminiferous tubuleduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity transferring phosphorus containing groups nucleotidyltransferase activity diacylglycerol cholinephosphotransferase activity transferase activity phosphatidate cytidylyltransferase activityCellular componentmembrane integral component of membrane endoplasmic reticulum endoplasmic reticulum membraneBiological processphototransduction phospholipid biosynthetic process phosphatidylglycerol biosynthetic process CDP diacylglycerol biosynthetic process lipid metabolism signal transduction phosphatidylinositol biosynthetic process CDP choline pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez104074596EnsemblENSG00000163624ENSMUSG00000029330UniProtQ92903P98191RefSeq mRNA NM 001263NM 173370RefSeq protein NP 001254NP 775546Location UCSC Chr 4 84 58 84 65 MbChr 5 101 91 101 97 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editBreakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein coupled receptors and tyrosine kinases regulating cell growth calcium metabolism and protein kinase C activity This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP diacylglycerol This enzyme is an integral membrane protein localized to two subcellular domains the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin 8 9 and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis Two genes encoding this enzyme have been identified in humans one mapping to human chromosome 4q21 this gene and a second CDS2 to 20p13 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000163624 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029330 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Halford S Dulai KS Daw SC Fitzgibbon J Hunt DM November 1998 Isolation and chromosomal localization of two human CDP diacylglycerol synthase CDS genes Genomics 54 1 140 4 doi 10 1006 geno 1998 5547 PMID 9806839 Weeks R Dowhan W Shen H Balantac N Meengs B Nudelman E Leung DW March 1997 Isolation and expression of an isoform of human CDP diacylglycerol synthase cDNA DNA and Cell Biology 16 3 281 9 doi 10 1089 dna 1997 16 281 PMID 9115637 a b Entrez Gene CDS1 CDP diacylglycerol synthase phosphatidate cytidylyltransferase 1 Nowicki M Muller F Frentzen M April 2005 Cardiolipin synthase of Arabidopsis thaliana FEBS Letters 579 10 2161 5 doi 10 1016 j febslet 2005 03 007 PMID 15811335 S2CID 21937549 Nowicki M 2006 Characterization of the Cardiolipin Synthase from Arabidopsis thaliana Ph D Thesis thesis RWTH Aachen University Archived from the original on 2011 10 05 Retrieved 2011 07 11 Further reading editLiu Y Virshup DM White RL Hsu LC November 2002 Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha Cancer Research 62 22 6357 61 PMID 12438214 Volta M Bulfone A Gattuso C Rossi E Mariani M Consalez GG et al January 1999 Identification and characterization of CDS2 a mammalian homolog of the Drosophila CDP diacylglycerol synthase gene Genomics 55 1 68 77 doi 10 1006 geno 1998 5610 PMID 9889000 Lykidis A Jackson PD Rock CO Jackowski S December 1997 The role of CDP diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content The Journal of Biological Chemistry 272 52 33402 9 doi 10 1074 jbc 272 52 33402 PMID 9407135 Heacock AM Uhler MD Agranoff BW November 1996 Cloning of CDP diacylglycerol synthase from a human neuronal cell line PDF Journal of Neurochemistry 67 5 2200 3 doi 10 1046 j 1471 4159 1996 67052200 x hdl 2027 42 65959 PMID 8863531 S2CID 2805319 External links editHuman CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDS1 gene amp oldid 1075479149, wikipedia, wiki, book, books, library,
