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Wikipedia

CDC25C

February 12, 2024

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[5]

CDC25C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDsOMIM: 157680 MGI: 88350 HomoloGene: 1356 GeneCards: CDC25C
Orthologs
SpeciesHumanMouse
Entrez

995

12532

Ensembl

ENSG00000158402

ENSMUSG00000044201

UniProt

P30307

P48967

RefSeq (mRNA)

NM_009860

RefSeq (protein)

NP_033990

Location (UCSC)Chr 5: 138.29 – 138.34 MbChr 18: 34.87 – 34.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[6]

Interactions edit

CDC25C has been shown to interact with MAPK14,[7] CHEK1,[8] PCNA,[9] PIN1,[10][11][12] PLK3[13] and NEDD4.[12]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158402 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044201 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science. 250 (4987): 1573–6. Bibcode:1990Sci...250.1573G. doi:10.1126/science.1703321. PMID 1703321. S2CID 25037148.
  6. ^ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)".
  7. ^ Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. England. 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. S2CID 4410763.
  8. ^ Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. UNITED STATES. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.
  9. ^ Kawabe T, Suganuma Masashi, Ando Tomoaki, Kimura Mayumi, Hori Haruna, Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene. England. 21 (11): 1717–26. doi:10.1038/sj.onc.1205229. ISSN 0950-9232. PMID 11896603.
  10. ^ Shen M, Stukenberg P T, Kirschner M W, Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.
  11. ^ Goldstrohm AC, Albrecht T R, Suñé C, Bedford M T, Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
  12. ^ a b Lu PJ, Zhou X Z, Shen M, Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. UNITED STATES. 283 (5406): 1325–8. Bibcode:1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. ISSN 0036-8075. PMID 10037602.
  13. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. ENGLAND. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092.

Further reading edit

  • Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53–63. doi:10.1016/S0304-419X(96)00049-2. PMID 9141461.
  • Nilsson I, Hoffmann I (2000). "Cell cycle regulation by the Cdc25 phosphatase family". Progress in Cell Cycle Research. Vol. 4. pp. 107–14. doi:10.1007/978-1-4615-4253-7_10. ISBN 978-1-4613-6909-7. PMID 10740819.
  • Amini S, Khalili K, Sawaya BE (2004). "Effect of HIV-1 Vpr on cell cycle regulators". DNA Cell Biol. 23 (4): 249–60. doi:10.1089/104454904773819833. PMID 15142382.
  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID 15265780. S2CID 23655886.
  • Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
  • Sartor H, Ehlert F, Grzeschik KH, et al. (1992). "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively". Genomics. 13 (3): 911–2. doi:10.1016/0888-7543(92)90190-4. PMID 1386342.
  • Strausfeld U, Labbé JC, Fesquet D, et al. (1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein". Nature. 351 (6323): 242–5. Bibcode:1991Natur.351..242S. doi:10.1038/351242a0. PMID 1828290. S2CID 4372756.
  • Galaktionov K, Beach D (1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. S2CID 9659637.
  • Sadhu K, Reed SI, Richardson H, Russell P (1990). "Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5139–43. Bibcode:1990PNAS...87.5139S. doi:10.1073/pnas.87.13.5139. PMC 54277. PMID 2195549.
  • Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. 69 (11): 6859–64. doi:10.1128/JVI.69.11.6859-6864.1995. PMC 189600. PMID 7474100.
  • Zwicker J, Gross C, Lucibello FC, et al. (1995). "Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1". Nucleic Acids Res. 23 (19): 3822–30. doi:10.1093/nar/23.19.3822. PMC 307297. PMID 7479023.
  • Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. doi:10.1128/JVI.69.12.7909-7916.1995. PMC 189735. PMID 7494303.
  • Strausfeld U, Fernandez A, Capony JP, et al. (1994). "Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis". J. Biol. Chem. 269 (8): 5989–6000. doi:10.1016/S0021-9258(17)37560-9. PMID 8119945.
  • Zheng XF, Ruderman JV (1993). "Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25". Cell. 75 (1): 155–64. doi:10.1016/S0092-8674(05)80092-3. PMID 8402895. S2CID 45351149.
  • Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID 8432534.
  • Honda R, Ohba Y, Nagata A, et al. (1993). "Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase". FEBS Lett. 318 (3): 331–4. doi:10.1016/0014-5793(93)80540-B. PMID 8440392. S2CID 30754963.
  • Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
  • Sanchez Y, Wong C, Thoma RS, et al. (1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. PMID 9278511.

External links edit

February 12, 2024
cdc25c, phase, inducer, phosphatase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2ojx, 3bzi, 3op3identifiersaliases, cdc25, ppp1r60, cell, division, cycle, 25cexternal, idsomim, 157680, 88350, homologene,. M phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene 5 CDC25CAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2OJX 3BZI 3OP3IdentifiersAliasesCDC25C CDC25 PPP1R60 cell division cycle 25CExternal IDsOMIM 157680 MGI 88350 HomoloGene 1356 GeneCards CDC25CGene location Human Chr Chromosome 5 human 1 Band5q31 2Start138 285 265 bp 1 End138 338 355 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 B1 18 18 71 cMStart34 866 046 bp 2 End34 884 586 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocyteganglionic eminencespermstromal cell of endometriumrectumbone marrowappendixspongy boneduodenumTop expressed incondylefossaspermatidprimitive streakmaxillary prominencemedial ganglionic eminenceyolk sachandinternal carotid arteryhair follicleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding WW domain binding protein tyrosine phosphatase activity hydrolase activity protein kinase binding phosphoprotein phosphatase activityCellular componentcytoplasm cytosol intracellular anatomical structure nucleoplasm perinuclear region of cytoplasm nucleus nuclear speckBiological processregulation of cyclin dependent protein serine threonine kinase activity protein dephosphorylation regulation of cell cycle cell division DNA replication G2 M transition of mitotic cell cycle spermatogenesis cell cycle cell population proliferation viral process regulation of mitotic nuclear division peptidyl tyrosine dephosphorylation DNA damage response signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of cell cycle G2 M phase transition positive regulation of G2 M transition of mitotic cell cycle positive regulation of mitotic cell cycle positive regulation of G2 MI transition of meiotic cell cycleSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez99512532EnsemblENSG00000158402ENSMUSG00000044201UniProtP30307P48967RefSeq mRNA NM 001287582NM 001287583NM 001790NM 022809NM 001318098NM 001364026NM 001364027NM 001364028NM 009860RefSeq protein NP 001274511NP 001274512NP 001305027NP 001781NP 073720NP 001350955NP 001350956NP 001350957NP 033990Location UCSC Chr 5 138 29 138 34 MbChr 18 34 87 34 88 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene is highly conserved during evolution and it plays a key role in the regulation of cell division The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family It directs dephosphorylation of cyclin B bound CDC2 CDK1 and triggers entry into mitosis It is also thought to suppress p53 induced growth arrest Multiple alternatively spliced transcript variants of this gene have been described however the full length nature of many of them is not known 6 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editCDC25C has been shown to interact with MAPK14 7 CHEK1 8 PCNA 9 PIN1 10 11 12 PLK3 13 and NEDD4 12 See also editCdc25References edit a b c GRCh38 Ensembl release 89 ENSG00000158402 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000044201 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Gould KL Moreno S Tonks NK Nurse P Feb 1991 Complementation of the mitotic activator p80cdc25 by a human protein tyrosine phosphatase Science 250 4987 1573 6 Bibcode 1990Sci 250 1573G doi 10 1126 science 1703321 PMID 1703321 S2CID 25037148 Entrez Gene CDC25C cell division cycle 25 homolog C S pombe Bulavin DV Higashimoto Y Popoff I J Gaarde W A Basrur V Potapova O Appella E Fornace A J May 2001 Initiation of a G2 M checkpoint after ultraviolet radiation requires p38 kinase Nature England 411 6833 102 7 doi 10 1038 35075107 ISSN 0028 0836 PMID 11333986 S2CID 4410763 Sanchez Y Wong C Thoma R S Richman R Wu Z Piwnica Worms H Elledge S J Sep 1997 Conservation of the Chk1 checkpoint pathway in mammals linkage of DNA damage to Cdk regulation through Cdc25 Science UNITED STATES 277 5331 1497 501 doi 10 1126 science 277 5331 1497 ISSN 0036 8075 PMID 9278511 Kawabe T Suganuma Masashi Ando Tomoaki Kimura Mayumi Hori Haruna Okamoto Takashi Mar 2002 Cdc25C interacts with PCNA at G2 M transition Oncogene England 21 11 1717 26 doi 10 1038 sj onc 1205229 ISSN 0950 9232 PMID 11896603 Shen M Stukenberg P T Kirschner M W Lu K P Mar 1998 The essential mitotic peptidyl prolyl isomerase Pin1 binds and regulates mitosis specific phosphoproteins Genes Dev UNITED STATES 12 5 706 20 doi 10 1101 gad 12 5 706 ISSN 0890 9369 PMC 316589 PMID 9499405 Goldstrohm AC Albrecht T R Sune C Bedford M T Garcia Blanco M A Nov 2001 The transcription elongation factor CA150 interacts with RNA polymerase II and the pre mRNA splicing factor SF1 Mol Cell Biol United States 21 22 7617 28 doi 10 1128 MCB 21 22 7617 7628 2001 ISSN 0270 7306 PMC 99933 PMID 11604498 a b Lu PJ Zhou X Z Shen M Lu K P Feb 1999 Function of WW domains as phosphoserine or phosphothreonine binding modules Science UNITED STATES 283 5406 1325 8 Bibcode 1999Sci 283 1325L doi 10 1126 science 283 5406 1325 ISSN 0036 8075 PMID 10037602 Ouyang B Li W Pan H Meadows J Hoffmann I Dai W Oct 1999 The physical association and phosphorylation of Cdc25C protein phosphatase by Prk Oncogene ENGLAND 18 44 6029 36 doi 10 1038 sj onc 1202983 ISSN 0950 9232 PMID 10557092 Further reading editDraetta G Eckstein J 1997 Cdc25 protein phosphatases in cell proliferation Biochim Biophys Acta 1332 2 M53 63 doi 10 1016 S0304 419X 96 00049 2 PMID 9141461 Nilsson I Hoffmann I 2000 Cell cycle regulation by the Cdc25 phosphatase family Progress in Cell Cycle Research Vol 4 pp 107 14 doi 10 1007 978 1 4615 4253 7 10 ISBN 978 1 4613 6909 7 PMID 10740819 Amini S Khalili K Sawaya BE 2004 Effect of HIV 1 Vpr on cell cycle regulators DNA Cell Biol 23 4 249 60 doi 10 1089 104454904773819833 PMID 15142382 Kino T Chrousos GP 2004 Human immunodeficiency virus type 1 accessory protein Vpr a causative agent of the AIDS related insulin resistance lipodystrophy syndrome Ann N Y Acad Sci 1024 1 153 67 Bibcode 2004NYASA1024 153K doi 10 1196 annals 1321 013 PMID 15265780 S2CID 23655886 Andersen JL Planelles V 2005 The role of Vpr in HIV 1 pathogenesis Curr HIV Res 3 1 43 51 doi 10 2174 1570162052772988 PMID 15638722 Sartor H Ehlert F Grzeschik KH et al 1992 Assignment of two human cell cycle genes CDC25C and CCNB1 to 5q31 and 5q12 respectively Genomics 13 3 911 2 doi 10 1016 0888 7543 92 90190 4 PMID 1386342 Strausfeld U Labbe JC Fesquet D et al 1991 Dephosphorylation and activation of a p34cdc2 cyclin B complex in vitro by human CDC25 protein Nature 351 6323 242 5 Bibcode 1991Natur 351 242S doi 10 1038 351242a0 PMID 1828290 S2CID 4372756 Galaktionov K Beach D 1992 Specific activation of cdc25 tyrosine phosphatases by B type cyclins evidence for multiple roles of mitotic cyclins Cell 67 6 1181 94 doi 10 1016 0092 8674 91 90294 9 PMID 1836978 S2CID 9659637 Sadhu K Reed SI Richardson H Russell P 1990 Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 Proc Natl Acad Sci U S A 87 13 5139 43 Bibcode 1990PNAS 87 5139S doi 10 1073 pnas 87 13 5139 PMC 54277 PMID 2195549 Re F Braaten D Franke EK Luban J 1995 Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2 cyclin B J Virol 69 11 6859 64 doi 10 1128 JVI 69 11 6859 6864 1995 PMC 189600 PMID 7474100 Zwicker J Gross C Lucibello FC et al 1995 Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine rich activators NF Y and Sp1 Nucleic Acids Res 23 19 3822 30 doi 10 1093 nar 23 19 3822 PMC 307297 PMID 7479023 Di Marzio P Choe S Ebright M et al 1996 Mutational analysis of cell cycle arrest nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr J Virol 69 12 7909 16 doi 10 1128 JVI 69 12 7909 7916 1995 PMC 189735 PMID 7494303 Strausfeld U Fernandez A Capony JP et al 1994 Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis J Biol Chem 269 8 5989 6000 doi 10 1016 S0021 9258 17 37560 9 PMID 8119945 Zheng XF Ruderman JV 1993 Functional analysis of the P box a domain in cyclin B required for the activation of Cdc25 Cell 75 1 155 64 doi 10 1016 S0092 8674 05 80092 3 PMID 8402895 S2CID 45351149 Taviaux SA Demaille JG 1993 Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15 3 11p15 1 by fluorescence in situ hybridization Genomics 15 1 194 6 doi 10 1006 geno 1993 1032 PMID 8432534 Honda R Ohba Y Nagata A et al 1993 Dephosphorylation of human p34cdc2 kinase on both Thr 14 and Tyr 15 by human cdc25B phosphatase FEBS Lett 318 3 331 4 doi 10 1016 0014 5793 93 80540 B PMID 8440392 S2CID 30754963 Booher RN Holman PS Fattaey A 1997 Human Myt1 is a cell cycle regulated kinase that inhibits Cdc2 but not Cdk2 activity J Biol Chem 272 35 22300 6 doi 10 1074 jbc 272 35 22300 PMID 9268380 Sanchez Y Wong C Thoma RS et al 1997 Conservation of the Chk1 checkpoint pathway in mammals linkage of DNA damage to Cdk regulation through Cdc25 Science 277 5331 1497 501 doi 10 1126 science 277 5331 1497 PMID 9278511 External links editHuman CDC25C genome location and CDC25C gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title CDC25C amp oldid 1199271128, wikipedia, wiki, book, books, library,

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