Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1gene.[5][6][7] CD200R1 is expressed on the surface of myeloid cells[8] and CD4+ T cells.[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[10] epithelial cells,[11] endothelial cells,[12] fibroblasts,[13] and lymphoid cells.[14]
CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[15] interferons, and inducible nitric oxide synthase (iNOS).[16]
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000163606 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022667 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
^Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.
^Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.
^Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC3322173. PMID 22496920.
^Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (October 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC3186410. PMID 21835925.
^Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.
^Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (January 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC2667927. PMID 19166481.
^Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (April 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC5399371. PMID 28429795.
^Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
^Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC3282758. PMID 22363701.
^Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.
Further readingedit
Matsue H (December 2005). "CD 200-mediated regulation of skin immunity". The Journal of Investigative Dermatology. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (October 2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH (February 2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". Journal of Immunology. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID 15661892.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN (July 2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". Journal of Virology. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC434103. PMID 15220441.
Karteris E, Chen J, Randeva HS (April 2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN (September 2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". Journal of Immunology. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A (June 2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.
cd200r1, cell, surface, transmembrane, glycoprotein, cd200, receptor, protein, that, humans, encoded, gene, expressed, surface, myeloid, cells, cells, interacts, with, cd200, transmembrane, glycoprotein, that, expressed, variety, cells, including, neurons, epi. Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene 5 6 7 CD200R1 is expressed on the surface of myeloid cells 8 and CD4 T cells 9 It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons 10 epithelial cells 11 endothelial cells 12 fibroblasts 13 and lymphoid cells 14 CD200R1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4BFG 4BFIIdentifiersAliasesCD200R1 CD200R HCRTR2 MOX2R OX2R CD200 receptor 1External IDsOMIM 607546 MGI 1889024 HomoloGene 10957 GeneCards CD200R1Gene location Human Chr Chromosome 3 human 1 Band3q13 2Start112 921 205 bp 1 End112 975 103 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 16 B4Start44 586 099 bp 2 End44 615 341 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrow cellsmonocytelymph nodeappendixspleengallbladderrectumbloodsmooth muscle tissuethymusTop expressed incalvariapharynxright lobe of liverdermisbloodspleenthymusright lung lobeyolk sacduodenumMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding immunoglobulin receptor activity signaling receptor activity glycosylated region protein bindingCellular componentintegral component of membrane extracellular region receptor complex membrane external side of plasma membrane plasma membrane cell surfaceBiological processviral process regulation of immune response signal transduction heterotypic cell cell adhesion intracellular signal transduction Fc receptor signaling pathway regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuron death negative regulation of macrophage migration negative regulation of T cell migrationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez13145057781EnsemblENSG00000163606ENSMUSG00000022667UniProtQ8TD46Q9ES57RefSeq mRNA NM 138806NM 138939NM 138940NM 170780NM 021325RefSeq protein NP 620161NP 620385NP 620386NP 740750NP 067300Location UCSC Chr 3 112 92 112 98 MbChr 16 44 59 44 62 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseCD200R1 activation regulates the expression of pro inflammatory molecules such as tumor necrosis factor TNF alpha 15 interferons and inducible nitric oxide synthase iNOS 16 Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene encodes a receptor for the OX 2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue specific manner Alternative splicing of this gene results in multiple transcript variants 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000163606 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022667 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wright GJ Puklavec MJ Willis AC Hoek RM Sedgwick JD Brown MH Barclay AN August 2000 Lymphoid neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function Immunity 13 2 233 42 doi 10 1016 S1074 7613 00 00023 6 PMID 10981966 Dick AD Broderick C Forrester JV Wright GJ January 2001 Distribution of OX2 antigen and OX2 receptor within retina Investigative Ophthalmology amp Visual Science 42 1 170 6 PMID 11133863 a b Entrez Gene CD200R1 CD200 receptor 1 Wright GJ Puklavec MJ Willis AC Hoek RM Sedgwick JD Brown MH Barclay AN August 2000 Lymphoid neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function Immunity 13 2 233 42 doi 10 1016 s1074 7613 00 00023 6 PMID 10981966 Caserta S Nausch N Sawtell A Drummond R Barr T Macdonald AS Mutapi F Zamoyska R 2012 Chronic infection drives expression of the inhibitory receptor CD200R and its ligand CD200 by mouse and human CD4 T cells PLOS ONE 7 4 e35466 Bibcode 2012PLoSO 735466C doi 10 1371 journal pone 0035466 PMC 3322173 PMID 22496920 Costello DA Lyons A Denieffe S Browne TC Cox FF Lynch MA October 2011 Long term potentiation is impaired in membrane glycoprotein CD200 deficient mice a role for Toll like receptor activation The Journal of Biological Chemistry 286 40 34722 32 doi 10 1074 jbc M111 280826 PMC 3186410 PMID 21835925 Rosenblum MD Olasz EB Yancey KB Woodliff JE Lazarova Z Gerber KA Truitt RL November 2004 Expression of CD200 on epithelial cells of the murine hair follicle a role in tissue specific immune tolerance The Journal of Investigative Dermatology 123 5 880 7 doi 10 1111 j 0022 202X 2004 23461 x PMID 15482475 Ko YC Chien HF Jiang Shieh YF Chang CY Pai MH Huang JP Chen HM Wu CH January 2009 Endothelial CD200 is heterogeneously distributed regulated and involved in immune cell endothelium interactions Journal of Anatomy 214 1 183 95 doi 10 1111 j 1469 7580 2008 00986 x PMC 2667927 PMID 19166481 Ishibashi M Neri S Hashimoto H Miyashita T Yoshida T Nakamura Y Udagawa H Kirita K Matsumoto S Umemura S Yoh K Niho S Tsuboi M Masutomi K Goto K Ochiai A Ishii G April 2017 CD200 positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors Scientific Reports 7 46662 Bibcode 2017NatSR 746662I doi 10 1038 srep46662 PMC 5399371 PMID 28429795 Gentry M Bodo J Durkin L Hsi ED February 2017 Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B Cell Lymphoma The American Journal of Surgical Pathology 41 2 189 194 doi 10 1097 PAS 0000000000000771 PMID 27879516 S2CID 25206581 Pietila M Lehtonen S Tuovinen E Lahteenmaki K Laitinen S Leskela HV Natynki A Pesala J Nordstrom K Lehenkari P 2012 CD200 positive human mesenchymal stem cells suppress TNF alpha secretion from CD200 receptor positive macrophage like cells PLOS ONE 7 2 e31671 Bibcode 2012PLoSO 731671P doi 10 1371 journal pone 0031671 PMC 3282758 PMID 22363701 Carter DA Dick AD June 2004 CD200 maintains microglial potential to migrate in adult human retinal explant model Current Eye Research 28 6 427 36 doi 10 1080 02713680490503778 PMID 15512951 S2CID 20846500 Further reading editMatsue H December 2005 CD 200 mediated regulation of skin immunity The Journal of Investigative Dermatology 125 6 x xi doi 10 1111 j 0022 202X 2005 23978 x PMID 16354172 Shiratori I Yamaguchi M Suzukawa M Yamamoto K Lanier LL Saito T Arase H October 2005 Down regulation of basophil function by human CD200 and human herpesvirus 8 CD200 Journal of Immunology 175 7 4441 9 doi 10 4049 jimmunol 175 7 4441 PMID 16177086 Cherwinski HM Murphy CA Joyce BL Bigler ME Song YS Zurawski SM Moshrefi MM Gorman DM Miller KL Zhang S Sedgwick JD Phillips JH February 2005 The CD200 receptor is a novel and potent regulator of murine and human mast cell function Journal of Immunology 174 3 1348 56 doi 10 4049 jimmunol 174 3 1348 PMID 15661892 Zhang Z Henzel WJ October 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Science 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Foster Cuevas M Wright GJ Puklavec MJ Brown MH Barclay AN July 2004 Human herpesvirus 8 K14 protein mimics CD200 in down regulating macrophage activation through CD200 receptor Journal of Virology 78 14 7667 76 doi 10 1128 JVI 78 14 7667 7676 2004 PMC 434103 PMID 15220441 Karteris E Chen J Randeva HS April 2004 Expression of human prepro orexin and signaling characteristics of orexin receptors in the male reproductive system The Journal of Clinical Endocrinology and Metabolism 89 4 1957 62 doi 10 1210 jc 2003 031778 PMID 15070969 Wright GJ Cherwinski H Foster Cuevas M Brooke G Puklavec MJ Bigler M Song Y Jenmalm M Gorman D McClanahan T Liu MR Brown MH Sedgwick JD Phillips JH Barclay AN September 2003 Characterization of the CD200 receptor family in mice and humans and their interactions with CD200 Journal of Immunology 171 6 3034 46 doi 10 4049 jimmunol 171 6 3034 PMID 12960329 Vieites JM de la Torre R Ortega MA Montero T Peco JM Sanchez Pozo A Gil A Suarez A June 2003 Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12 13 Gene 311 99 104 doi 10 1016 S0378 1119 03 00562 6 PMID 12853143 External links editCD200R1 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CD200R1 amp oldid 1142696263, wikipedia, wiki, book, books, library,
