CD1D is the humangene that encodes the proteinCD1d,[5] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.
α-galactosylceramide (α-GalCer), a compound originally derived from the marine sponge Agelas mauritanius[6] with no physiological role but great research utility.
iGb3, a self antigen which has been implied in iNKT selection.[8]
HS44, a synthetic amino cyclitolic ceramide analogue which has less contact with the TCR, activating iNKTs in a more constrained way than α-GalCer (specially in relation to Th2 cytokines production) and thus being more interesting for therapeutic use.[9]
CD1d tetramersedit
CD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. In particular, type I NKT cells and some type II NKT cells are stained by them. A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells.[10]
Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead.[10]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000158473 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028076 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"P15813 (CD1D_HUMAN)". Uniprot. Retrieved 1 March 2013.
^Franck, Richard W. (1 January 2012). "C-Galactosylceramide: Synthesis and Immunology". Comptes Rendus Chimie. 15 (1): 46–56. doi:10.1016/j.crci.2011.05.006. PMC3293403. PMID 22408579.
^Bendelac, A; Savage PB; Teyton I (2007). "The Biology of NKT Cells". Annual Review of Immunology. 25 (1): 297–336. doi:10.1146/annurev.immunol.25.022106.141711. PMID 17150027.
^Zhou, D (August 2006). "The immunological function of iGb3". Current Protein & Peptide Science. 7 (4): 325–333. doi:10.2174/138920306778018007. PMID 16918447.
^J. Kerzerho; E. Yu; C. M. Barra; E. Alari-Pahissa; E. Girardi; Y. Harrak; P. Lauzurica; A. Llebaria; D. Zajonc; O. Akbari; A. R. Castaño (2012). "Structural and functional characterization of a novel non-glycosidic iNKT agonist with immunomodulatory properties". Journal of Immunology. 188 (5): 2254–2265. doi:10.4049/jimmunol.1103049. PMC3288653. PMID 22301545.
^ abTerabe, Masaki; Berzofsky, Jay A. (2008). "The Role of NKT Cells in Tumor Immunity". Adv Cancer Res. 101: 277–348. doi:10.1016/S0065-230X(08)00408-9. PMC2693255. PMID 19055947.
Further readingedit
Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules". Curr. Opin. Immunol. 8 (1): 82–88. doi:10.1016/S0952-7915(96)80109-9. PMID 8729450.
Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system". Cell. Mol. Life Sci. 58 (3): 442–469. doi:10.1007/PL00000869. PMID 11315191. S2CID 29982004.
Sköld M, Behar SM (2003). "Role of CD1d-Restricted NKT Cells in Microbial Immunity". Infect. Immun. 71 (10): 5447–5455. doi:10.1128/IAI.71.10.5447-5455.2003. PMC201095. PMID 14500461.
Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function". Annu. Rev. Immunol. 22 (1): 817–890. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly". J. Immunol. 177 (2): 769–775. doi:10.4049/jimmunol.177.2.769. PMID 16818729.
Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells". J. Immunol. 147 (8): 2518–2524. doi:10.4049/jimmunol.147.8.2518. PMID 1717564. S2CID 33639980.
Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252–256. Bibcode:1989PNAS...86..252B. doi:10.1073/pnas.86.1.252. PMC286442. PMID 2463622.
Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes". Eur. J. Immunol. 19 (2): 285–292. doi:10.1002/eji.1830190211. PMID 2467814. S2CID 31384394.
Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): 3727–3732. doi:10.1002/j.1460-2075.1989.tb08548.x. PMC402056. PMID 2583117.
Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–9158. doi:10.1073/pnas.83.23.9154. PMC387093. PMID 3097645.
Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium". Science. 265 (5169): 259–262. Bibcode:1994Sci...265..259B. doi:10.1126/science.7517575. PMID 7517575.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides". Science. 278 (5343): 1626–1629. Bibcode:1997Sci...278.1626K. doi:10.1126/science.278.5343.1626. PMID 9374463.
Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes". Immunogenetics. 48 (1): 22–31. doi:10.1007/s002510050396. PMID 9601940. S2CID 6715203.
Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form". Int. Immunol. 11 (3): 383–392. doi:10.1093/intimm/11.3.383. PMID 10221650.
Campbell NA, Kim HS, Blumberg RS, Mayer L (1999). "The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells". J. Biol. Chem. 274 (37): 26259–26265. doi:10.1074/jbc.274.37.26259. PMID 10473580.
Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes". Tissue Antigens. 54 (2): 122–127. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738.
Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
Human CD1D genome location and CD1D gene details page in the UCSC Genome Browser.
April 16, 2024
cd1d, human, gene, that, encodes, protein, cd1d, member, cluster, differentiation, family, glycoproteins, expressed, surface, various, human, antigen, presenting, cells, they, classical, proteins, related, class, proteins, involved, presentation, lipid, antige. CD1D is the human gene that encodes the protein CD1d 5 a member of the CD1 cluster of differentiation 1 family of glycoproteins expressed on the surface of various human antigen presenting cells They are non classical MHC proteins related to the class I MHC proteins and are involved in the presentation of lipid antigens to T cells CD1d is the only member of the group 2 CD1 molecules CD1DAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4WO4 1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU 4MNG 4MQ7 4WW2IdentifiersAliasesCD1D CD1A R3 R3G1 CD1d moleculeExternal IDsOMIM 188410 MGI 107674 HomoloGene 1337 GeneCards CD1DGene location Human Chr Chromosome 1 human 1 Band1q23 1Start158 178 030 bp 1 End158 186 427 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 F1 3 37 91 cMStart86 903 141 bp 2 End86 906 748 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytethymusspleenbloodright lobe of liverappendixjejunal mucosaduodenumrectumbone marrowTop expressed inwhite adipose tissueleft lobe of liversubcutaneous adipose tissuebrown adipose tissueintercostal musclebody of femurfossaspleenmedial ganglionic eminencethymusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionbeta 2 microglobulin binding lipopeptide binding histone binding endogenous lipid antigen binding lipid antigen binding exogenous lipid antigen binding cell adhesion molecule binding protein bindingCellular componentcytoplasm integral component of membrane endosome endoplasmic reticulum membrane membrane integral component of plasma membrane cell surface lysosomal membrane basolateral plasma membrane lysosome endosome membrane plasma membrane endoplasmic reticulum extracellular space external side of plasma membraneBiological processimmune system process T cell selection heterotypic cell cell adhesion positive regulation of T cell proliferation detection of bacterium positive regulation of innate immune response antigen processing and presentation exogenous lipid antigen via MHC class Ib innate immune response viral process antigen processing and presentation endogenous lipid antigen via MHC class Ib regulation of immune response positive regulation of T cell mediated cytotoxicity immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez91212479EnsemblENSG00000158473ENSMUSG00000028076UniProtP15813P11609RefSeq mRNA NM 001766NM 001319145NM 001371761NM 001371762NM 001371763NM 007639NM 001379501NM 001379502NM 001379503RefSeq protein NP 001306074NP 001757NP 001358690NP 001358691NP 001358692NP 031665NP 001366430NP 001366431NP 001366432Location UCSC Chr 1 158 18 158 19 MbChr 3 86 9 86 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Biological significance 2 Nomenclature 3 Ligands 4 CD1d tetramers 5 References 6 Further reading 7 External linksBiological significance editCD1d presented lipid antigens activate a special class of T cells known as natural killer T NKT cells through the interaction with the T cell receptor present on NKT membranes 5 When activated NKT cells rapidly produce Th1 and Th2 cytokines typically represented by interferon gamma and interleukin 4 production Nomenclature editCD1d is also known as R3G1Ligands editSome of the known ligands for CD1d are a galactosylceramide a GalCer a compound originally derived from the marine sponge Agelas mauritanius 6 with no physiological role but great research utility a glucuronyl and a galacturonyl ceramides a family of compounds of microbial origin which can be found for example on the cell wall of Sphingomonas a ubiquitous Gram negative bacterium 7 The related b D glucopyranosylceramide is accumulated in antigen presenting cells after infection where it serves to activate invariant NKTs iNKTs a special kind of NKT iGb3 a self antigen which has been implied in iNKT selection 8 HS44 a synthetic amino cyclitolic ceramide analogue which has less contact with the TCR activating iNKTs in a more constrained way than a GalCer specially in relation to Th2 cytokines production and thus being more interesting for therapeutic use 9 CD1d tetramers editCD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled used to identify NKT cells or other CD1d reactive cells In particular type I NKT cells and some type II NKT cells are stained by them A differentiation of these two types can be obtained in human by using an antibody against the TCR Va24 chain which is specific of type I NKT cells 10 Although they are the most widely used of CD1d oligomers sometimes CD1d dimers two units or pentamers five units are used instead 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000158473 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028076 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b P15813 CD1D HUMAN Uniprot Retrieved 1 March 2013 Franck Richard W 1 January 2012 C Galactosylceramide Synthesis and Immunology Comptes Rendus Chimie 15 1 46 56 doi 10 1016 j crci 2011 05 006 PMC 3293403 PMID 22408579 Bendelac A Savage PB Teyton I 2007 The Biology of NKT Cells Annual Review of Immunology 25 1 297 336 doi 10 1146 annurev immunol 25 022106 141711 PMID 17150027 Zhou D August 2006 The immunological function of iGb3 Current Protein amp Peptide Science 7 4 325 333 doi 10 2174 138920306778018007 PMID 16918447 J Kerzerho E Yu C M Barra E Alari Pahissa E Girardi Y Harrak P Lauzurica A Llebaria D Zajonc O Akbari A R Castano 2012 Structural and functional characterization of a novel non glycosidic iNKT agonist with immunomodulatory properties Journal of Immunology 188 5 2254 2265 doi 10 4049 jimmunol 1103049 PMC 3288653 PMID 22301545 a b Terabe Masaki Berzofsky Jay A 2008 The Role of NKT Cells in Tumor Immunity Adv Cancer Res 101 277 348 doi 10 1016 S0065 230X 08 00408 9 PMC 2693255 PMID 19055947 Further reading editMelian A Beckman EM Porcelli SA Brenner MB 1996 Antigen presentation by CD1 and MHC encoded class I like molecules Curr Opin Immunol 8 1 82 88 doi 10 1016 S0952 7915 96 80109 9 PMID 8729450 Joyce S 2001 CD1d and natural T cells how their properties jump start the immune system Cell Mol Life Sci 58 3 442 469 doi 10 1007 PL00000869 PMID 11315191 S2CID 29982004 Skold M Behar SM 2003 Role of CD1d Restricted NKT Cells in Microbial Immunity Infect Immun 71 10 5447 5455 doi 10 1128 IAI 71 10 5447 5455 2003 PMC 201095 PMID 14500461 Brigl M Brenner MB 2004 CD1 antigen presentation and T cell function Annu Rev Immunol 22 1 817 890 doi 10 1146 annurev immunol 22 012703 104608 PMID 15032598 Stove V Verhasselt B 2006 Modelling thymic HIV 1 Nef effects Curr HIV Res 4 1 57 64 doi 10 2174 157016206775197583 PMID 16454711 Brutkiewicz RR 2006 CD1d ligands the good the bad and the ugly J Immunol 177 2 769 775 doi 10 4049 jimmunol 177 2 769 PMID 16818729 Blumberg RS Terhorst C Bleicher P et al 1991 Expression of a nonpolymorphic MHC class I like molecule CD1D by human intestinal epithelial cells J Immunol 147 8 2518 2524 doi 10 4049 jimmunol 147 8 2518 PMID 1717564 S2CID 33639980 Balk SP Bleicher PA Terhorst C 1989 Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule Proc Natl Acad Sci U S A 86 1 252 256 Bibcode 1989PNAS 86 252B doi 10 1073 pnas 86 1 252 PMC 286442 PMID 2463622 Calabi F Jarvis JM Martin L Milstein C 1989 Two classes of CD1 genes Eur J Immunol 19 2 285 292 doi 10 1002 eji 1830190211 PMID 2467814 S2CID 31384394 Yu CY Milstein C 1990 A physical map linking the five CD1 human thymocyte differentiation antigen genes EMBO J 8 12 3727 3732 doi 10 1002 j 1460 2075 1989 tb08548 x PMC 402056 PMID 2583117 Martin LH Calabi F Milstein C 1987 Isolation of CD1 genes a family of major histocompatibility complex related differentiation antigens Proc Natl Acad Sci U S A 83 23 9154 9158 doi 10 1073 pnas 83 23 9154 PMC 387093 PMID 3097645 Balk SP Burke S Polischuk JE et al 1994 Beta 2 microglobulin independent MHC class Ib molecule expressed by human intestinal epithelium Science 265 5169 259 262 Bibcode 1994Sci 265 259B doi 10 1126 science 7517575 PMID 7517575 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 174 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 156 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Kawano T Cui J Koezuka Y et al 1997 CD1d restricted and TCR mediated activation of valpha14 NKT cells by glycosylceramides Science 278 5343 1626 1629 Bibcode 1997Sci 278 1626K doi 10 1126 science 278 5343 1626 PMID 9374463 Katabami S Matsuura A Chen HZ et al 1998 Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes Immunogenetics 48 1 22 31 doi 10 1007 s002510050396 PMID 9601940 S2CID 6715203 Somnay Wadgaonkar K Nusrat A Kim HS et al 1999 Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2 microglobulin associated form Int Immunol 11 3 383 392 doi 10 1093 intimm 11 3 383 PMID 10221650 Campbell NA Kim HS Blumberg RS Mayer L 1999 The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells J Biol Chem 274 37 26259 26265 doi 10 1074 jbc 274 37 26259 PMID 10473580 Han M Hannick LI DiBrino M Robinson MA 2000 Polymorphism of human CD1 genes Tissue Antigens 54 2 122 127 doi 10 1034 j 1399 0039 1999 540202 x PMID 10488738 External links editCD1d antigen at the U S National Library of Medicine Medical Subject Headings MeSH Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser Human CD1D genome location and CD1D gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title CD1D amp oldid 1170118070, wikipedia, wiki, book, books, library,
