fbpx
Wikipedia

CD146

February 11, 2024

CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.[5]

MCAM
Identifiers
AliasesMCAM, CD146, MUC18, melanoma cell adhesion molecule, HEMETCAM, MelCAM
External IDsOMIM: 155735 MGI: 1933966 HomoloGene: 4742 GeneCards: MCAM
Orthologs
SpeciesHumanMouse
Entrez

4162

84004

Ensembl

ENSG00000076706

ENSMUSG00000032135

UniProt

P43121

Q8R2Y2

RefSeq (mRNA)

NM_006500

NM_023061
NM_001359530

RefSeq (protein)

NP_006491

NP_075548
NP_001346459

Location (UCSC)Chr 11: 119.31 – 119.32 MbChr 9: 44.05 – 44.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

MCAM functions as a receptor for laminin alpha 4,[6] a matrix molecule that is broadly expressed within the vascular wall. Accordingly, MCAM is highly expressed by cells that are components of the blood vessel wall, including vascular endothelial cells, smooth muscle cells and pericytes. Its function is still poorly understood, but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton. A member of the Immunoglobulin superfamily, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.

Two isoforms exist (MCAM long (MCAM-1), and MCAM short, or MCAM-s) which differ in the length of their cytoplasmic domain. Activation of these isoforms seems to produce functional differences as well. Natural killer cells transfected with MCAM-1 demonstrate decreased rolling velocity and increased cell adhesion to an endothelial cell monolayer and increased microvilli formation while cells transfected with MCAM-s showed no change in adhesion characteristics. Since these characteristics are important in leukocyte extravasation, MCAM-1 may be an important part of the inflammatory response.

CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.[7][8] CD146 T cells have been shown by Dagur and colleagues to produce IL-17.[9]

CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs,[10] and its expression may be linked to multipotency; mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface.[11]

Relevance in cancer edit

MCAM inhibits breast cancer progression.[12]

Normal melanocytes do not express MCAM and the expression of MCAM is first found in nevi and melanoma cells.[13] MCAM expression is positively correlated to melanoma progression at which the expression of MCAM is highest in metastatic melanoma cells. The significance of MCAM upregulation is evident in melanoma cells cultured in 3D skin reconstruct in which MCAM facilitates the migration of melanoma into the dermis. Without the expression of MCAM melanoma cells are controlled by keratinocytes in the epidermis that inhibit penetrance beyond the basement membrane. The control by keratinocytes are only achieved by E-cadherin expression on the surface of melanoma cells. Melanoma cells with functional E-cadherin on the surface can only exclusively grow in the epidermis as keratinocytes frequently downregulate the expression of MCAM on melanoma cells.[13]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076706 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032135 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kuske MD, Johnson JP (1999). "Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 258. doi:10.1159/000015439. PMID 10702685. S2CID 37508075.
  6. ^ Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, et al. (2012). "Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS". PLOS ONE. 7 (7): e40443. Bibcode:2012PLoSO...740443F. doi:10.1371/journal.pone.0040443. PMC 3391262. PMID 22792325.
  7. ^ Elshal MF, Khan SS, Takahashi Y, Solomon MA, McCoy JP (October 2005). "CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood". Blood. 106 (8): 2923–4. doi:10.1182/blood-2005-06-2307. PMID 16204154.
  8. ^ Elshal MF, Khan SS, Raghavachari N, Takahashi Y, Barb J, Bailey JJ, et al. (November 2007). "A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile". BMC Immunology. 8: 29. doi:10.1186/1471-2172-8-29. PMC 2248207. PMID 17999761.
  9. ^ Dagur PK, Biancotto A, Wei L, Sen HN, Yao M, Strober W, et al. (December 2011). "MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases". Journal of Autoimmunity. 37 (4): 319–27. doi:10.1016/j.jaut.2011.09.003. PMC 3223259. PMID 21959269.
  10. ^ Covas DT, Panepucci RA, Fontes AM, Silva WA, Orellana MD, Freitas MC, et al. (May 2008). "Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts". Experimental Hematology. 36 (5): 642–54. doi:10.1016/j.exphem.2007.12.015. PMID 18295964.
  11. ^ Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O'Connor KC (April 2010). "In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment". Stem Cells. 28 (4): 788–98. doi:10.1002/stem.312. PMID 20127798. S2CID 45009922.
  12. ^ Ouhtit A, Gaur RL, Abd Elmageed ZY, Fernando A, Thouta R, Trappey AK, et al. (April 2009). "Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1795 (2): 130–6. doi:10.1016/j.bbcan.2009.01.002. PMID 19356677.
  13. ^ a b Haass NK, Smalley KS, Li L, Herlyn M (June 2005). "Adhesion, migration and communication in melanocytes and melanoma". Pigment Cell Research. 18 (3): 150–9. doi:10.1111/j.1600-0749.2005.00235.x. PMID 15892711.

Further reading edit

  • Wang Z, Xu Q, Zhang N, Du X, Xu G, Yan X (August 2020). "CD146, from a melanoma cell adhesion molecule to a signaling receptor". Signal Transduction and Targeted Therapy. 5 (1): 148. doi:10.1038/s41392-020-00259-8. PMC 7421905. PMID 32782280.
  • Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D (November 2007). "Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor". Journal of Immunology. 179 (10): 6673–85. doi:10.4049/jimmunol.179.10.6673. PMID 17982057.
  • Shih IM (September 1999). "The role of CD146 (Mel-CAM) in biology and pathology". The Journal of Pathology. 189 (1): 4–11. doi:10.1002/(SICI)1096-9896(199909)189:1<4::AID-PATH332>3.0.CO;2-P. PMID 10451481. S2CID 43326956.
  • Staquicini FI, Tandle A, Libutti SK, Sun J, Zigler M, Bar-Eli M, et al. (October 2008). "A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction: evidence from mice and humans". Cancer Research. 68 (20): 8419–28. doi:10.1158/0008-5472.CAN-08-1242. PMC 2718575. PMID 18922915.
  • Johnson JP, Rothbächer U, Sers C (October 1993). "The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family". Melanoma Research. 3 (5): 337–40. doi:10.1097/00008390-199310000-00006. PMID 8292890. S2CID 43280514.
  • McGary EC, Lev DC, Bar-Eli M (2002). "Cellular adhesion pathways and metastatic potential of human melanoma". Cancer Biology & Therapy. 1 (5): 459–65. doi:10.4161/cbt.1.5.158. PMID 12496470.
  • Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
  • Wang N, Fan Y, Ni P, Wang F, Gao X, Xue Q, Tang L (2008). "High glucose effect on the role of CD146 in human proximal tubular epithelial cells in vitro". Journal of Nephrology. 21 (6): 931–40. PMID 19034879.
  • Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, et al. (February 2009). "Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma". Cancer Research. 69 (4): 1570–7. doi:10.1158/0008-5472.CAN-08-1363. PMC 2752656. PMID 19221091.
  • Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O'Connor KC (April 2010). "In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment". Stem Cells. 28 (4): 788–98. doi:10.1002/stem.312. PMID 20127798. S2CID 45009922.
  • Tripodo C, Di Bernardo A, Ternullo MP, Guarnotta C, Porcasi R, Ingrao S, et al. (January 2009). "CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis". Haematologica. 94 (1): 127–30. doi:10.3324/haematol.13598. PMC 2625423. PMID 19029148.
  • Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N (September 2008). "Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux". The Annals of Otology, Rhinology, and Laryngology. 117 (9): 688–95. doi:10.1177/000348940811700911. PMID 18834073. S2CID 23385606.
  • Bardin N, Blot-Chabaud M, Despoix N, Kebir A, Harhouri K, Arsanto JP, et al. (May 2009). "CD146 and its soluble form regulate monocyte transendothelial migration". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (5): 746–53. doi:10.1161/ATVBAHA.108.183251. PMID 19229070.
  • Fritzsche FR, Wassermann K, Rabien A, Schicktanz H, Dankof A, Loening SA, et al. (August 2008). "CD146 protein in prostate cancer: revisited with two different antibodies". Pathology. 40 (5): 457–64. doi:10.1080/00313020802197996. PMID 18604730. S2CID 205448423.
  • Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, et al. (October 2009). "Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis". The Journal of Biological Chemistry. 284 (42): 28845–55. doi:10.1074/jbc.M109.042150. PMC 2781430. PMID 19703903.
  • Chen W, Zhang HL, Jiang YG, Li JH, Liu BL, Sun MY (February 2009). "Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC-M cell". Journal of Oral Pathology & Medicine. 38 (2): 198–205. doi:10.1111/j.1600-0714.2008.00706.x. PMID 19200179.
  • Zabouo G, Imbert AM, Jacquemier J, Finetti P, Moreau T, Esterni B, et al. (2009). "CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines". Breast Cancer Research. 11 (1): R1. doi:10.1186/bcr2215. PMC 2687703. PMID 19123925.
  • Schwab KE, Gargett CE (November 2007). "Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium". Human Reproduction. 22 (11): 2903–11. doi:10.1093/humrep/dem265. PMID 17872908.
  • Malyszko J, Malyszko JS, Kozminski P, Pawlak K, Mysliwiec M (July 2008). "Adipokines, linking adipocytes and vascular function in hemodialyzed patients, may also be possibly related to CD146, a novel adhesion molecule". Clinical and Applied Thrombosis/Hemostasis. 14 (3): 338–45. doi:10.1177/1076029607305083. PMID 18160586. S2CID 43210730.
  • Zheng C, Qiu Y, Zeng Q, Zhang Y, Lu D, Yang D, et al. (November 2009). "Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization". The International Journal of Biochemistry & Cell Biology. 41 (11): 2163–72. doi:10.1016/j.biocel.2009.03.014. PMID 19782948.
  • Saito O, Saito T, Okuda K, Okuda K, Kotoda A, Akimoto T, et al. (February 2008). "Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans". Clinical and Experimental Nephrology. 12 (1): 58–64. doi:10.1007/s10157-007-0012-7. PMID 18175063. S2CID 34180131.

External links edit

February 11, 2024
cd146, cluster, differentiation, also, known, melanoma, cell, adhesion, molecule, mcam, cell, surface, glycoprotein, muc18, 113kda, cell, adhesion, molecule, currently, used, marker, endothelial, cell, lineage, humans, protein, encoded, mcam, gene, mcamidentif. CD146 cluster of differentiation 146 also known as the melanoma cell adhesion molecule MCAM or cell surface glycoprotein MUC18 is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage In humans the CD146 protein is encoded by the MCAM gene 5 MCAMIdentifiersAliasesMCAM CD146 MUC18 melanoma cell adhesion molecule HEMETCAM MelCAMExternal IDsOMIM 155735 MGI 1933966 HomoloGene 4742 GeneCards MCAMGene location Human Chr Chromosome 11 human 1 Band11q23 3Start119 308 529 bp 1 End119 321 521 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 A5 1Start44 045 766 bp 2 End44 054 024 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpopliteal arteryright coronary arterysaphenous veinleft coronary arterythoracic aortaascending aortagastric mucosasubcutaneous adipose tissueleft uterine tubenippleTop expressed inleft lung lobeatriumwhite adipose tissueascending aortabelly cordfacial motor nucleusright lung lobeuterussubcutaneous adipose tissueleft ventricleMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez416284004EnsemblENSG00000076706ENSMUSG00000032135UniProtP43121Q8R2Y2RefSeq mRNA NM 006500NM 023061NM 001359530RefSeq protein NP 006491NP 075548NP 001346459Location UCSC Chr 11 119 31 119 32 MbChr 9 44 05 44 05 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Relevance in cancer 3 References 4 Further reading 5 External linksFunction editMCAM functions as a receptor for laminin alpha 4 6 a matrix molecule that is broadly expressed within the vascular wall Accordingly MCAM is highly expressed by cells that are components of the blood vessel wall including vascular endothelial cells smooth muscle cells and pericytes Its function is still poorly understood but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton A member of the Immunoglobulin superfamily it consists of five Ig domains a transmembrane domain and a cytoplasmic region It is expressed on chicken embryonic spleen and thymus activated human T cells endothelial progenitors such as angioblasts and mesenchymal stem cells and strongly expressed on blood vessel endothelium and smooth muscle Two isoforms exist MCAM long MCAM 1 and MCAM short or MCAM s which differ in the length of their cytoplasmic domain Activation of these isoforms seems to produce functional differences as well Natural killer cells transfected with MCAM 1 demonstrate decreased rolling velocity and increased cell adhesion to an endothelial cell monolayer and increased microvilli formation while cells transfected with MCAM s showed no change in adhesion characteristics Since these characteristics are important in leukocyte extravasation MCAM 1 may be an important part of the inflammatory response CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals The CD146 T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146 T cells 7 8 CD146 T cells have been shown by Dagur and colleagues to produce IL 17 9 CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs 10 and its expression may be linked to multipotency mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface 11 Relevance in cancer editMCAM inhibits breast cancer progression 12 Normal melanocytes do not express MCAM and the expression of MCAM is first found in nevi and melanoma cells 13 MCAM expression is positively correlated to melanoma progression at which the expression of MCAM is highest in metastatic melanoma cells The significance of MCAM upregulation is evident in melanoma cells cultured in 3D skin reconstruct in which MCAM facilitates the migration of melanoma into the dermis Without the expression of MCAM melanoma cells are controlled by keratinocytes in the epidermis that inhibit penetrance beyond the basement membrane The control by keratinocytes are only achieved by E cadherin expression on the surface of melanoma cells Melanoma cells with functional E cadherin on the surface can only exclusively grow in the epidermis as keratinocytes frequently downregulate the expression of MCAM on melanoma cells 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000076706 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032135 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kuske MD Johnson JP 1999 Assignment of the human melanoma cell adhesion molecule gene MCAM to chromosome 11 band q23 3 by radiation hybrid mapping Cytogenetics and Cell Genetics 87 3 4 258 doi 10 1159 000015439 PMID 10702685 S2CID 37508075 Flanagan K Fitzgerald K Baker J Regnstrom K Gardai S Bard F et al 2012 Laminin 411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS PLOS ONE 7 7 e40443 Bibcode 2012PLoSO 740443F doi 10 1371 journal pone 0040443 PMC 3391262 PMID 22792325 Elshal MF Khan SS Takahashi Y Solomon MA McCoy JP October 2005 CD146 Mel CAM an adhesion marker of endothelial cells is a novel marker of lymphocyte subset activation in normal peripheral blood Blood 106 8 2923 4 doi 10 1182 blood 2005 06 2307 PMID 16204154 Elshal MF Khan SS Raghavachari N Takahashi Y Barb J Bailey JJ et al November 2007 A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile BMC Immunology 8 29 doi 10 1186 1471 2172 8 29 PMC 2248207 PMID 17999761 Dagur PK Biancotto A Wei L Sen HN Yao M Strober W et al December 2011 MCAM expressing CD4 T cells in peripheral blood secrete IL 17A and are significantly elevated in inflammatory autoimmune diseases Journal of Autoimmunity 37 4 319 27 doi 10 1016 j jaut 2011 09 003 PMC 3223259 PMID 21959269 Covas DT Panepucci RA Fontes AM Silva WA Orellana MD Freitas MC et al May 2008 Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene expression profile with CD146 perivascular cells and fibroblasts Experimental Hematology 36 5 642 54 doi 10 1016 j exphem 2007 12 015 PMID 18295964 Russell KC Phinney DG Lacey MR Barrilleaux BL Meyertholen KE O Connor KC April 2010 In vitro high capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment Stem Cells 28 4 788 98 doi 10 1002 stem 312 PMID 20127798 S2CID 45009922 Ouhtit A Gaur RL Abd Elmageed ZY Fernando A Thouta R Trappey AK et al April 2009 Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146 Biochimica et Biophysica Acta BBA Reviews on Cancer 1795 2 130 6 doi 10 1016 j bbcan 2009 01 002 PMID 19356677 a b Haass NK Smalley KS Li L Herlyn M June 2005 Adhesion migration and communication in melanocytes and melanoma Pigment Cell Research 18 3 150 9 doi 10 1111 j 1600 0749 2005 00235 x PMID 15892711 Further reading editWang Z Xu Q Zhang N Du X Xu G Yan X August 2020 CD146 from a melanoma cell adhesion molecule to a signaling receptor Signal Transduction and Targeted Therapy 5 1 148 doi 10 1038 s41392 020 00259 8 PMC 7421905 PMID 32782280 Guezguez B Vigneron P Lamerant N Kieda C Jaffredo T Dunon D November 2007 Dual role of melanoma cell adhesion molecule MCAM CD146 in lymphocyte endothelium interaction MCAM CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor Journal of Immunology 179 10 6673 85 doi 10 4049 jimmunol 179 10 6673 PMID 17982057 Shih IM September 1999 The role of CD146 Mel CAM in biology and pathology The Journal of Pathology 189 1 4 11 doi 10 1002 SICI 1096 9896 199909 189 1 lt 4 AID PATH332 gt 3 0 CO 2 P PMID 10451481 S2CID 43326956 Staquicini FI Tandle A Libutti SK Sun J Zigler M Bar Eli M et al October 2008 A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule MUC18 dependent interaction evidence from mice and humans Cancer Research 68 20 8419 28 doi 10 1158 0008 5472 CAN 08 1242 PMC 2718575 PMID 18922915 Johnson JP Rothbacher U Sers C October 1993 The progression associated antigen MUC18 a unique member of the immunoglobulin supergene family Melanoma Research 3 5 337 40 doi 10 1097 00008390 199310000 00006 PMID 8292890 S2CID 43280514 McGary EC Lev DC Bar Eli M 2002 Cellular adhesion pathways and metastatic potential of human melanoma Cancer Biology amp Therapy 1 5 459 65 doi 10 4161 cbt 1 5 158 PMID 12496470 Barbe L Lundberg E Oksvold P Stenius A Lewin E Bjorling E et al March 2008 Toward a confocal subcellular atlas of the human proteome Molecular amp Cellular Proteomics 7 3 499 508 doi 10 1074 mcp M700325 MCP200 PMID 18029348 Wang N Fan Y Ni P Wang F Gao X Xue Q Tang L 2008 High glucose effect on the role of CD146 in human proximal tubular epithelial cells in vitro Journal of Nephrology 21 6 931 40 PMID 19034879 Bidlingmaier S He J Wang Y An F Feng J Barbone D et al February 2009 Identification of MCAM CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma Cancer Research 69 4 1570 7 doi 10 1158 0008 5472 CAN 08 1363 PMC 2752656 PMID 19221091 Russell KC Phinney DG Lacey MR Barrilleaux BL Meyertholen KE O Connor KC April 2010 In vitro high capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment Stem Cells 28 4 788 98 doi 10 1002 stem 312 PMID 20127798 S2CID 45009922 Tripodo C Di Bernardo A Ternullo MP Guarnotta C Porcasi R Ingrao S et al January 2009 CD146 bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis Haematologica 94 1 127 30 doi 10 3324 haematol 13598 PMC 2625423 PMID 19029148 Samuels TL Handler E Syring ML Pajewski NM Blumin JH Kerschner JE Johnston N September 2008 Mucin gene expression in human laryngeal epithelia effect of laryngopharyngeal reflux The Annals of Otology Rhinology and Laryngology 117 9 688 95 doi 10 1177 000348940811700911 PMID 18834073 S2CID 23385606 Bardin N Blot Chabaud M Despoix N Kebir A Harhouri K Arsanto JP et al May 2009 CD146 and its soluble form regulate monocyte transendothelial migration Arteriosclerosis Thrombosis and Vascular Biology 29 5 746 53 doi 10 1161 ATVBAHA 108 183251 PMID 19229070 Fritzsche FR Wassermann K Rabien A Schicktanz H Dankof A Loening SA et al August 2008 CD146 protein in prostate cancer revisited with two different antibodies Pathology 40 5 457 64 doi 10 1080 00313020802197996 PMID 18604730 S2CID 205448423 Melnikova VO Balasubramanian K Villares GJ Dobroff AS Zigler M Wang H et al October 2009 Crosstalk between protease activated receptor 1 and platelet activating factor receptor regulates melanoma cell adhesion molecule MCAM MUC18 expression and melanoma metastasis The Journal of Biological Chemistry 284 42 28845 55 doi 10 1074 jbc M109 042150 PMC 2781430 PMID 19703903 Chen W Zhang HL Jiang YG Li JH Liu BL Sun MY February 2009 Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC M cell Journal of Oral Pathology amp Medicine 38 2 198 205 doi 10 1111 j 1600 0714 2008 00706 x PMID 19200179 Zabouo G Imbert AM Jacquemier J Finetti P Moreau T Esterni B et al 2009 CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines Breast Cancer Research 11 1 R1 doi 10 1186 bcr2215 PMC 2687703 PMID 19123925 Schwab KE Gargett CE November 2007 Co expression of two perivascular cell markers isolates mesenchymal stem like cells from human endometrium Human Reproduction 22 11 2903 11 doi 10 1093 humrep dem265 PMID 17872908 Malyszko J Malyszko JS Kozminski P Pawlak K Mysliwiec M July 2008 Adipokines linking adipocytes and vascular function in hemodialyzed patients may also be possibly related to CD146 a novel adhesion molecule Clinical and Applied Thrombosis Hemostasis 14 3 338 45 doi 10 1177 1076029607305083 PMID 18160586 S2CID 43210730 Zheng C Qiu Y Zeng Q Zhang Y Lu D Yang D et al November 2009 Endothelial CD146 is required for in vitro tumor induced angiogenesis the role of a disulfide bond in signaling and dimerization The International Journal of Biochemistry amp Cell Biology 41 11 2163 72 doi 10 1016 j biocel 2009 03 014 PMID 19782948 Saito O Saito T Okuda K Okuda K Kotoda A Akimoto T et al February 2008 Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans Clinical and Experimental Nephrology 12 1 58 64 doi 10 1007 s10157 007 0012 7 PMID 18175063 S2CID 34180131 External links editCD146 Antigen at the U S National Library of Medicine Medical Subject Headings MeSH Human MCAM genome location and MCAM gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title CD146 amp oldid 1188050316, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.