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Integrin alpha L

December 03, 2023

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene.[5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

ITGAL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGAL, CD11A, LFA-1, LFA1A, integrin subunit alpha L
External IDsOMIM: 153370 MGI: 96606 HomoloGene: 1666 GeneCards: ITGAL
Orthologs
SpeciesHumanMouse
Entrez

3683

16408

Ensembl

ENSG00000005844

ENSMUSG00000030830

UniProt

P20701

P24063

RefSeq (mRNA)

NM_001114380
NM_002209

NM_001253872
NM_001253873
NM_001253874
NM_008400

RefSeq (protein)

NP_001107852
NP_002200

NP_001240801
NP_001240802
NP_001240803
NP_032426

Location (UCSC)Chr 16: 30.47 – 30.52 MbChr 7: 126.9 – 126.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

ITGAL gene encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed in all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[6]

CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Efalizumab acts as an immunosuppressant by binding to CD11a but was withdrawn in 2009 because it was associated with severe side effects.

Interactions edit

CD11a has been shown to interact with ICAM-1.[7][8][9]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005844 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030830 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "NCBI".
  6. ^ "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)".
  7. ^ Lu C, Takagi J, Springer TA (May 2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. 276 (18): 14642–8. doi:10.1074/jbc.M100600200. PMID 11279101.
  8. ^ Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA (Jan 2003). "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell. 112 (1): 99–111. doi:10.1016/S0092-8674(02)01257-6. PMC 4372089. PMID 12526797.
  9. ^ Yusuf-Makagiansar H, Makagiansar IT, Hu Y, Siahaan TJ (Dec 2001). "Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction". Peptides. 22 (12): 1955–62. doi:10.1016/S0196-9781(01)00546-0. PMID 11786177. S2CID 54343441.

Further reading edit

  • Lub M, van Kooyk Y, Figdor CG (1995). "Ins and outs of LFA-1". Immunol. Today. 16 (10): 479–83. doi:10.1016/0167-5699(95)80031-X. PMID 7576051.
  • Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. doi:10.1007/s000180050184. PMID 9676575. S2CID 9775686.
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
  • Giblin PA, Lemieux RM (2006). "LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics". Curr. Pharm. Des. 12 (22): 2771–95. doi:10.2174/138161206777947731. PMID 16918410.
  • Maurer D, Holter W, Majdic O, Fischer GF, Knapp W (1991). "CD27 expression by a distinct subpopulation of human B lymphocytes". Eur. J. Immunol. 20 (12): 2679–84. doi:10.1002/eji.1830201223. PMID 1702722. S2CID 9794163.
  • Kalter DC, Gendelman HE, Meltzer MS (1992). "Inhibition of human immunodeficiency virus infection in monocytes by monoclonal antibodies against leukocyte adhesion molecules". Immunol. Lett. 30 (2): 219–27. doi:10.1016/0165-2478(91)90029-A. PMID 1757107.
  • Alvarez V, Pulido R, Campanero MR, Paraiso V, de Landázuri MO, Sánchez-Madrid F (1992). "Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils". Kidney Int. 40 (5): 899–905. doi:10.1038/ki.1991.291. PMID 1762294.
  • Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells". J. Immunol. 144 (3): 934–7. PMID 1967280.
  • Larson RS, Corbi AL, Berman L, Springer T (1989). "Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily". J. Cell Biol. 108 (2): 703–12. doi:10.1083/jcb.108.2.703. PMC 2115430. PMID 2537322.
  • Hildreth JE, Orentas RJ (1989). "Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation". Science. 244 (4908): 1075–8. Bibcode:1989Sci...244.1075H. doi:10.1126/science.2543075. PMID 2543075.
  • Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, Shaw S (1988). "Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production". J. Immunol. 140 (5): 1401–7. PMID 2894392.
  • Corbi AL, Larson RS, Kishimoto TK, Springer TA, Morton CC (1988). "Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion". J. Exp. Med. 167 (5): 1597–607. doi:10.1084/jem.167.5.1597. PMC 2188934. PMID 3284962.
  • te Velde AA, Keizer GD, Figdor CG (1987). "Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells". Immunology. 61 (3): 261–7. PMC 1453405. PMID 3301632.
  • Qu A, Leahy DJ (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10277–81. Bibcode:1995PNAS...9210277Q. doi:10.1073/pnas.92.22.10277. PMC 40779. PMID 7479767.
  • Turner ML, McIlwaine K, Anthony RS, Parker AC (1995). "Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood". Stem Cells. 13 (3): 311–6. doi:10.1002/stem.5530130312. PMID 7542116. S2CID 21373771.
  • Marzusch K, Ruck P, Geiselhart A, Handgretinger R, Dietl JA, Kaiserling E, Horny HP, Vince G, Redman CW (1993). "Distribution of cell adhesion molecules on CD56++, CD3-, CD16- large granular lymphocytes and endothelial cells in first-trimester human decidua". Hum. Reprod. 8 (8): 1203–8. doi:10.1093/oxfordjournals.humrep.a138229. PMID 7691868.
  • Capobianchi MR, Ameglio F, Cordiali Fei P, Castilletti C, Mercuri F, Fais S, Dianzani F (1994). "Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120". AIDS Res. Hum. Retroviruses. 9 (10): 957–62. doi:10.1089/aid.1993.9.957. PMID 7904170.
  • Berman PW, Nakamura GR (1994). "Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation". AIDS Res. Hum. Retroviruses. 10 (5): 585–93. doi:10.1089/aid.1994.10.585. PMID 7917519.
  • Chirmule N, Oyaizu N, Saxinger C, Pahwa S (1994). "Nef protein of HIV-1 has B-cell stimulatory activity". AIDS. 8 (6): 733–4. doi:10.1097/00002030-199406000-00002. PMID 8086129. S2CID 36774740.

External links edit


 

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

December 03, 2023
integrin, alpha, integrin, alpha, antigen, cd11a, p180, lymphocyte, function, associated, antigen, alpha, polypeptide, also, known, itgal, protein, that, humans, encoded, itgal, gene, cd11a, functions, immune, system, involved, cellular, adhesion, costimulator. Integrin alpha L antigen CD11A p180 lymphocyte function associated antigen 1 alpha polypeptide also known as ITGAL is a protein that in humans is encoded by the ITGAL gene 5 CD11a functions in the immune system It is involved in cellular adhesion and costimulatory signaling It is the target of the drug efalizumab ITGALAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4IXD 1CQP 1DGQ 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 5E6S 5E6R 5E6UIdentifiersAliasesITGAL CD11A LFA 1 LFA1A integrin subunit alpha LExternal IDsOMIM 153370 MGI 96606 HomoloGene 1666 GeneCards ITGALGene location Human Chr Chromosome 16 human 1 Band16p11 2Start30 472 658 bp 1 End30 523 567 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 F3 7 69 44 cMStart126 895 432 bp 2 End126 934 310 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodspleenlymph nodebone marrow cellsappendixthymusupper lobe of left lungthymusright lobe of liverTop expressed inthymusbloodspleensubcutaneous adipose tissuesubmandibular glandbone marrowright lung lobepharynxliverleft lung lobeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein containing complex binding metal ion binding protein binding protein heterodimerization activity ICAM 3 receptor activity cell adhesion molecule bindingCellular componentintegral component of membrane integrin alphaL beta2 complex membrane cell surface integrin complex extracellular exosome plasma membrane specific granule membraneBiological processleukocyte cell cell adhesion heterophilic cell cell adhesion via plasma membrane cell adhesion molecules T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell extracellular matrix organization receptor clustering cell adhesion regulation of immune response integrin mediated signaling pathway cell matrix adhesion inflammatory response leukocyte migration signal transduction phagocytosis neutrophil degranulation cell cell adhesionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez368316408EnsemblENSG00000005844ENSMUSG00000030830UniProtP20701P24063RefSeq mRNA NM 001114380NM 002209NM 001253872NM 001253873NM 001253874NM 008400RefSeq protein NP 001107852NP 002200NP 001240801NP 001240802NP 001240803NP 032426Location UCSC Chr 16 30 47 30 52 MbChr 7 126 9 126 93 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction editITGAL gene encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I domain containing alpha integrin combines with the beta 2 chain ITGB2 to form the integrin lymphocyte function associated antigen 1 LFA 1 which is expressed in all leukocytes LFA 1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1 3 intercellular adhesion molecules 1 through 3 and also functions in lymphocyte costimulatory signaling 6 CD11a is one of the two components along with CD18 which form lymphocyte function associated antigen 1 Efalizumab acts as an immunosuppressant by binding to CD11a but was withdrawn in 2009 because it was associated with severe side effects Interactions editCD11a has been shown to interact with ICAM 1 7 8 9 See also editCD11c integrin leukocyte adhesion deficiency Cluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000005844 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030830 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine NCBI Entrez Gene ITGAL integrin alpha L antigen CD11A p180 lymphocyte function associated antigen 1 alpha polypeptide Lu C Takagi J Springer TA May 2001 Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state J Biol Chem 276 18 14642 8 doi 10 1074 jbc M100600200 PMID 11279101 Shimaoka M Xiao T Liu JH Yang Y Dong Y Jun CD McCormack A Zhang R Joachimiak A Takagi J Wang JH Springer TA Jan 2003 Structures of the alpha L I domain and its complex with ICAM 1 reveal a shape shifting pathway for integrin regulation Cell 112 1 99 111 doi 10 1016 S0092 8674 02 01257 6 PMC 4372089 PMID 12526797 Yusuf Makagiansar H Makagiansar IT Hu Y Siahaan TJ Dec 2001 Synergistic inhibitory activity of alpha and beta LFA 1 peptides on LFA 1 ICAM 1 interaction Peptides 22 12 1955 62 doi 10 1016 S0196 9781 01 00546 0 PMID 11786177 S2CID 54343441 Further reading editLub M van Kooyk Y Figdor CG 1995 Ins and outs of LFA 1 Immunol Today 16 10 479 83 doi 10 1016 0167 5699 95 80031 X PMID 7576051 Dickeson SK Santoro SA 1998 Ligand recognition by the I domain containing integrins Cell Mol Life Sci 54 6 556 66 doi 10 1007 s000180050184 PMID 9676575 S2CID 9775686 Porter JC Hogg N 1999 Integrins take partners cross talk between integrins and other membrane receptors Trends Cell Biol 8 10 390 6 doi 10 1016 S0962 8924 98 01344 0 PMID 9789327 Giblin PA Lemieux RM 2006 LFA 1 as a key regulator of immune function approaches toward the development of LFA 1 based therapeutics Curr Pharm Des 12 22 2771 95 doi 10 2174 138161206777947731 PMID 16918410 Maurer D Holter W Majdic O Fischer GF Knapp W 1991 CD27 expression by a distinct subpopulation of human B lymphocytes Eur J Immunol 20 12 2679 84 doi 10 1002 eji 1830201223 PMID 1702722 S2CID 9794163 Kalter DC Gendelman HE Meltzer MS 1992 Inhibition of human immunodeficiency virus infection in monocytes by monoclonal antibodies against leukocyte adhesion molecules Immunol Lett 30 2 219 27 doi 10 1016 0165 2478 91 90029 A PMID 1757107 Alvarez V Pulido R Campanero MR Paraiso V de Landazuri MO Sanchez Madrid F 1992 Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils Kidney Int 40 5 899 905 doi 10 1038 ki 1991 291 PMID 1762294 Valentin A Lundin K Patarroyo M Asjo B 1990 The leukocyte adhesion glycoprotein CD18 participates in HIV 1 induced syncytia formation in monocytoid and T cells J Immunol 144 3 934 7 PMID 1967280 Larson RS Corbi AL Berman L Springer T 1989 Primary structure of the leukocyte function associated molecule 1 alpha subunit an integrin with an embedded domain defining a protein superfamily J Cell Biol 108 2 703 12 doi 10 1083 jcb 108 2 703 PMC 2115430 PMID 2537322 Hildreth JE Orentas RJ 1989 Involvement of a leukocyte adhesion receptor LFA 1 in HIV induced syncytium formation Science 244 4908 1075 8 Bibcode 1989Sci 244 1075H doi 10 1126 science 2543075 PMID 2543075 Sanders ME Makgoba MW Sharrow SO Stephany D Springer TA Young HA Shaw S 1988 Human memory T lymphocytes express increased levels of three cell adhesion molecules LFA 3 CD2 and LFA 1 and three other molecules UCHL1 CDw29 and Pgp 1 and have enhanced IFN gamma production J Immunol 140 5 1401 7 PMID 2894392 Corbi AL Larson RS Kishimoto TK Springer TA Morton CC 1988 Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA 1 Mac 1 and p150 95 Identification of a gene cluster involved in cell adhesion J Exp Med 167 5 1597 607 doi 10 1084 jem 167 5 1597 PMC 2188934 PMID 3284962 te Velde AA Keizer GD Figdor CG 1987 Differential function of LFA 1 family molecules CD11 and CD18 in adhesion of human monocytes to melanoma and endothelial cells Immunology 61 3 261 7 PMC 1453405 PMID 3301632 Qu A Leahy DJ 1995 Crystal structure of the I domain from the CD11a CD18 LFA 1 alpha L beta 2 integrin Proc Natl Acad Sci U S A 92 22 10277 81 Bibcode 1995PNAS 9210277Q doi 10 1073 pnas 92 22 10277 PMC 40779 PMID 7479767 Turner ML McIlwaine K Anthony RS Parker AC 1995 Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood Stem Cells 13 3 311 6 doi 10 1002 stem 5530130312 PMID 7542116 S2CID 21373771 Marzusch K Ruck P Geiselhart A Handgretinger R Dietl JA Kaiserling E Horny HP Vince G Redman CW 1993 Distribution of cell adhesion molecules on CD56 CD3 CD16 large granular lymphocytes and endothelial cells in first trimester human decidua Hum Reprod 8 8 1203 8 doi 10 1093 oxfordjournals humrep a138229 PMID 7691868 Capobianchi MR Ameglio F Cordiali Fei P Castilletti C Mercuri F Fais S Dianzani F 1994 Coordinate induction of interferon alpha and gamma by recombinant HIV 1 glycoprotein 120 AIDS Res Hum Retroviruses 9 10 957 62 doi 10 1089 aid 1993 9 957 PMID 7904170 Berman PW Nakamura GR 1994 Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV 1 gp160 dependent syncytium formation AIDS Res Hum Retroviruses 10 5 585 93 doi 10 1089 aid 1994 10 585 PMID 7917519 Chirmule N Oyaizu N Saxinger C Pahwa S 1994 Nef protein of HIV 1 has B cell stimulatory activity AIDS 8 6 733 4 doi 10 1097 00002030 199406000 00002 PMID 8086129 S2CID 36774740 External links editCD11a Antigen at the U S National Library of Medicine Medical Subject Headings MeSH ITGAL Info with links in the Cell Migration Gateway Archived 2014 12 11 at the Wayback Machine Human ITGAL genome location and ITGAL gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 16 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Integrin alpha L amp oldid 1145891902, wikipedia, wiki, book, books, library,

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