fbpx
Wikipedia

Howard E. Gendelman

January 31, 2023

Howard E. Gendelman (born March 18, 1954) is an American physician-scientist whose research intersects the disciplines of neuroimmunology, pharmacology, and infectious diseases. Gendelman was born in Philadelphia, Pennsylvania. His research is focused on harnessing immune responses for therapeutic gain in HIV/AIDS and Neurodegenerative disease.[1] He is the Margaret R. Larson Professor of infectious diseases and internal medicine at the University of Nebraska Medical Center (UNMC) in Omaha.[2]

Howard E. Gendelman, M.D.
BornMarch 18, 1954
Philadelphia, Pennsylvania, USA
NationalityAmerican
Alma materMuhlenberg College
Pennsylvania State University College of Medicine
Known forHIV research, Parkinson's research, neuroimmune-pharmacology
AwardsStartup of the Year 2022 UNeMed; Nebraska Coalition for Lifesaving Cures' 2022 Life Saver Award; 2018 Jewish Federation of Omaha Humanitarian of the Year Award; 2017 Society on NeuroImmune Pharmacology Lifetime Achievement Award; International Society for NeuroVirology's 2016 Pioneer in NeuroVirology; 2000 J. William Fulbright Research Scholar; and others
Scientific career
FieldsVirology, neuroimmunology, neuroscience, pharmacology, therapeutics
InstitutionsCurrent: University of Nebraska Medical Center
Previous: Henry M. Jackson Foundation for the Advancement in Military Medicine
Walter Reed Army Institute of Research
Uniformed Services University of the Health Sciences Center
Johns Hopkins University
Albert Einstein College of Medicine
Websitehttps://www.unmc.edu/pharmacology/faculty/primary-faculty/gendelman/

He is married with three children and seven grandchildren.[3]

Early life and education

Gendelman graduated with a bachelor's degree in Natural Sciences and Russian Studies from Muhlenberg College (1971-1975).[3]

He completed his doctorate of medicine at the Pennsylvania State University-Hershey Medical Center (1975-1979).[3] He then completed a residency in Internal medicine at Montefiore Hospital, Albert Einstein College of Medicine (1979-1982), and he was a Clinical and Research Fellow in Neurology and Infectious Diseases at the Johns Hopkins University Medical Center (1982-1985).[3]

Career

Gendelman worked at the National Institute of Allergy and Infectious Diseases during the height of the HIV/AIDS Pandemic.[4] Gendelman also occupied senior faculty and research positions at the Johns Hopkins Medical Institutions, the Uniformed Services University of the Health Sciences Center, the Walter Reed Army Institute of Research, and the Henry M. Jackson Foundation for the Advancement in Military Medicine before joining the faculty of UNMC in March 1993. He retired from the US Army with the rank of Lieutenant Colonel. He established the Center for Neurovirology and Neurodegenerative Disorders at UNMC in 1997,[5] which evolved into UNMC's current Department of Pharmacology and Experimental Neuroscience in 2004.[6] In 2000, he was awarded a Fulbright to do research at the Weizmann Institute of Science in Rehovot, Israel [7][8]

Research

Mononuclear phacocytes and neurodegenerative disease

Gendelman's research explores the role of mononuclear phagocytes (monocytes, macrophages, microglia, and dendritic cells) as viral reservoirs, perpetrators of disease, and depots for nanoformulated drug delivery. His work was foundational to building a field of investigation focused on lentiviral pathogenesis, diagnostics, and therapeutics. These advancements in immune transformation have led to new and effective management of neurodegenerative disease progression. Gendelman and his research team were among the first to develop laboratory assays for establishing viral tropism for mononuclear phagocytes, and they were the first to demonstrate that infected and immune activated mononuclear phagocytes release viral and cellular toxins that damage the nervous system.[9][10][11]

HIV research contributions

Gendelman's group was among the first to reverse HIV-dementia in an infected person using combination antiretroviral therapy (cART), and they developed scores of rodent models to mimic HIV/AIDS end-organ disease.[12][13][14] He coined the term long-acting slow effective release ART (LASER ART). These works led to polymer discovery, targeted drug delivery to viral reservoirs, and reduction of residual virus in lymphoid organs. His Nebraska-based research group, along with a team at Temple University, was also the first to combine HIV reservoir-targeted LASER ART and CRISPR-Cas9 to eliminate chronic viral infection from infected animals.[15] This curative approach (published in Nature Communications, 2019) received considerable attention in establishing a novel translational pathway for HIV eradication.[16][17][18] This work followed the first ultra-long acting nanocrystal prodrug and the world's first HIV vaccine mimetic[19][20] (in Nature Materials, 2020). His work with cell-based drug delivery born out of nanoparticle-mononuclear phagocyte interactions has inspired broad pharmaceutical interest; in turn, Gendelman led the establishment of the Nebraska Nanomedicine Production Plant,[21] a biotechnology good manufacturing practices (cGMP) initiative, to position research for clinical translation in the development of long acting nanoformulated ART at UNMC. He also co-founded Exavir Therapeutics, Inc.,[22] a biotechnology company developing therapies towards and cure for HIV/AIDS.

Parkinson's Disease research contributions

Gendelman was the first to pharmacologically transform effector into regulatory T cells to halt the progression of Parkinson's disease.[23][24] Phase II investigation began in early 2021 after successful phase I investigations[25]

Scientific community leadership

Gendelman has written or edited 17 books and monographs (including multiple editions of the textbooks The Neurology of AIDS[26] and Neuroimmune Pharmacology[27]). He was the founding Editor-in-Chief of the Journal of Neuroimmune Pharmacology.

Awards and honors

Research recognitions

  • Startup of the Year 2022 - Exavir Therapeutics[28]
  • Nebraska Coalition for Lifesaving Cures' 2022 Life Saver Award[29][30]
  • Lifetime Achievement Award, Contribution to the Advancement of the Mission of the Society on NeuroImmune Pharmacology, 2017[31]
  • Pioneer in NeuroVirology, International Society for NeuroVirology, 2016[8]
  • Javits Investigator Award, National Institutes of Health, 2000[32]

References

  1. ^ Johnson, Amanda McGill (2022-01-28). "2022 Luncheon Honoreers". Nebraska Cures. Retrieved 2022-10-26./
  2. ^ Temple University Health System (2019-07-02). "HIV eliminated from the genomes of living animals". Science Daily=en-US. Retrieved 2022-10-26.
  3. ^ a b c d Utesch, Margie (2018-07-03). "Humanitarian of the Year". The Jewish Community Center of Omaha. Retrieved 2021-12-16.
  4. ^ "Potential new HIV treatment developed at UNMC". KMTV. 2020-04-29. Retrieved 2021-12-16.
  5. ^ "Front Line (2009)" (PDF). University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience. Retrieved 2022-01-25.
  6. ^ "About Us". University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience. Retrieved 2022-01-25.
  7. ^ "UNMC Professor gets Fulbright to study in Israel (2001)". Daily Nebraskan. Retrieved 2022-11-04.
  8. ^ a b "The Pioneer in Neurovirology Award". International Society for NeurVirology. 2016. Retrieved 4 November 2022.
  9. ^ Adachi, A; Gendelman, H E; Koenig, S; Folks, T; Willey, R; Rabson, A; Martin, M A (August 1986). "Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone". Journal of Virology. 59 (2): 284–291. doi:10.1128/jvi.59.2.284-291.1986. ISSN 0022-538X. PMC 253077. PMID 3016298. S2CID 12551511.
  10. ^ Koenig, Scott; Gendelman, Howard E.; Orenstein, Jan M.; Dal Canto, Mauro C.; Pezeshkpour, Gholam H.; Yungbluth, Margaret; Janotta, Frank; Aksamit, Allen; Martin, Malcolm A.; Fauci, Anthony S. (1986-09-05). "Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy". Science. 233 (4768): 1089–1093. Bibcode:1986Sci...233.1089K. doi:10.1126/science.3016903. ISSN 0036-8075. PMID 3016903.
  11. ^ Gendelman, H. E.; Narayan, O.; Molineaux, S.; Clements, J. E.; Ghotbi, Z. (October 1985). "Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow". Proceedings of the National Academy of Sciences of the United States of America. 82 (20): 7086–7090. Bibcode:1985PNAS...82.7086G. doi:10.1073/pnas.82.20.7086. ISSN 0027-8424. PMC 391315. PMID 2996004.
  12. ^ Gendelman, Howard E.; Zheng, Jialin; Coulter, Cynthia L.; Ghorpade, Anuja; Che, Myhanh; Thylin, Michael; Rubocki, Ronald; Persidsky, Yuri; Hahn, Francis; Reinhard, Jr., John; Swindells, Susan (October 1998). "Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus‐Associated Dementia". The Journal of Infectious Diseases. 178 (4): 1000–1007. doi:10.1086/515693. ISSN 0022-1899. PMID 9806027. S2CID 42427863.
  13. ^ Spellman, Lisa (2019-08-09). "Science Cafe explores possibility of HIV cure". University of Nebraska Medical Center. Retrieved 2021-12-16.
  14. ^ Gendelman, Howard E. (2012). The neurology of AIDS. Oxford University Press. ISBN 978-0-19-539934-9. OCLC 828615707.
  15. ^ "Scientists say they found a cure for HIV in some mice. Humans could be next". www.washingtonpost.com. Retrieved 2022-11-23.
  16. ^ "In a first, scientists eliminate HIV from an animal's genome". www.cbsnews.com. Retrieved 2021-12-17.
  17. ^ Yancey-Bragg, N'dea. "Researchers have eliminated HIV in mice for the first time. Is a cure for humans next?". USA TODAY. Retrieved 2021-12-17.
  18. ^ Dash, Prasanta K.; Kaminski, Rafal; Bella, Ramona; Su, Hang; Mathews, Saumi; Ahooyi, Taha M.; Chen, Chen; Mancuso, Pietro; Sariyer, Rahsan; Ferrante, Pasquale; Donadoni, Martina (December 2019). "Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice". Nature Communications. 10 (1): 2753. Bibcode:2019NatCo..10.2753D. doi:10.1038/s41467-019-10366-y. ISSN 2041-1723. PMC 6606613. PMID 31266936.
  19. ^ Kulkarni, Tanmay A.; Bade, Aditya N.; Sillman, Brady; Shetty, Bhagya Laxmi Dyavar; Wojtkiewicz, Melinda S.; Gautam, Nagsen; Hilaire, James R.; Sravanam, Sruthi; Szlachetka, Adam; Lamberty, Benjamin G.; Morsey, Brenda M. (August 2020). "A year-long extended release nanoformulated cabotegravir prodrug". Nature Materials. 19 (8): 910–920. Bibcode:2020NatMa..19..910K. doi:10.1038/s41563-020-0674-z. ISSN 1476-1122. PMC 7384935. PMID 32341511.
  20. ^ Soriano, Vicente; Barreiro, Pablo; de Mendoza, Carmen (August 2020). "Long-acting antiretroviral therapy". Nature Materials. 19 (8): 826–827. Bibcode:2020NatMa..19..826S. doi:10.1038/s41563-020-0731-7. ISSN 1476-4660. PMID 32704135. S2CID 220721631.
  21. ^ "Nebraska Nanomedicine Production Plant | Pharmacology | University of Nebraska Medical Center". www.unmc.edu. Retrieved 2021-12-16.
  22. ^ "Exavir Therapeutics". exavirtherapeutics.com. 2021-02-14. Retrieved 2021-12-16.
  23. ^ Benner, Eric J.; Mosley, R. Lee; Destache, Chris J.; Lewis, Travis B.; Jackson-Lewis, Vernice; Gorantla, Santhi; Nemachek, Craig; Green, Steven R.; Przedborski, Serge; Gendelman, Howard E. (2004-06-22). "Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease". Proceedings of the National Academy of Sciences of the United States of America. 101 (25): 9435–9440. Bibcode:2004PNAS..101.9435B. doi:10.1073/pnas.0400569101. ISSN 0027-8424. PMC 438994. PMID 15197276.
  24. ^ Gendelman, Howard E.; Zhang, Yuning; Santamaria, Pamela; Olson, Katherine E.; Schutt, Charles R.; Bhatti, Danish; Shetty, Bhagya Laxmi Dyavar; Lu, Yaman; Estes, Katherine A.; Standaert, David G.; Heinrichs-Graham, Elizabeth (2017-03-23). "Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson's disease trial". npj Parkinson's Disease. 3 (1): 10. doi:10.1038/s41531-017-0013-5. ISSN 2373-8057. PMC 5445595. PMID 28649610.
  25. ^ Olson, Katherine E.; Namminga, Krista L.; Lu, Yaman; Schwab, Aaron D.; Thurston, Mackenzie J.; Abdelmoaty, Mai M.; Kumar, Vikas; Wojtkiewicz, Melinda; Obaro, Helen; Santamaria, Pamela; Mosley, R. Lee (2021-05-01). "Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease". EBioMedicine. 67: 103380. doi:10.1016/j.ebiom.2021.103380. ISSN 2352-3964. PMC 8138485. PMID 34000620.
  26. ^ Gendelman, Howard E; Grant, Igor; Everall, Ian Paul; Fox, Howard S; Gelbard, Harris A; Lipton, Stuart A; Swindells, Susan, eds. (2012). The Neurology of AIDS. Oxford University Press. doi:10.1093/med/9780195399349.001.0001. ISBN 978-0-19-996519-9.
  27. ^ Ikezu, Tsuneya; Gendelman, Howard E., eds. (2017). Neuroimmune Pharmacology. doi:10.1007/978-3-319-44022-4. ISBN 978-3-319-44020-0.
  28. ^ "Innovation Awards". UNeMed.com. 23 October 2022. Retrieved 23 November 2022.
  29. ^ "2022 Luncheon Honorees". Nebraska Cures. 28 January 2022. Retrieved 28 April 2022.
  30. ^ "Tribute to Dr. Howard Gendelman and Dr. Bonnie Bloch". YouTube. Nebraska Cures. Retrieved 28 April 2022.
  31. ^ "SNIP - Society on NeuroImmune Pharmacology". s-nip.org. Retrieved 2021-12-16.
  32. ^ "$3 Million Grant Recognizes Potential of Research at the UNMC Center for Neurovirology and Neurodegenerative Disorders". University of Nebraska Medical Center. 2001. Retrieved 4 November 2022.

January 31, 2023
howard, gendelman, born, march, 1954, american, physician, scientist, whose, research, intersects, disciplines, neuroimmunology, pharmacology, infectious, diseases, gendelman, born, philadelphia, pennsylvania, research, focused, harnessing, immune, responses, . Howard E Gendelman born March 18 1954 is an American physician scientist whose research intersects the disciplines of neuroimmunology pharmacology and infectious diseases Gendelman was born in Philadelphia Pennsylvania His research is focused on harnessing immune responses for therapeutic gain in HIV AIDS and Neurodegenerative disease 1 He is the Margaret R Larson Professor of infectious diseases and internal medicine at the University of Nebraska Medical Center UNMC in Omaha 2 Howard E Gendelman M D BornMarch 18 1954Philadelphia Pennsylvania USANationalityAmericanAlma materMuhlenberg CollegePennsylvania State University College of MedicineKnown forHIV research Parkinson s research neuroimmune pharmacologyAwardsStartup of the Year 2022 UNeMed Nebraska Coalition for Lifesaving Cures 2022 Life Saver Award 2018 Jewish Federation of Omaha Humanitarian of the Year Award 2017 Society on NeuroImmune Pharmacology Lifetime Achievement Award International Society for NeuroVirology s 2016 Pioneer in NeuroVirology 2000 J William Fulbright Research Scholar and othersScientific careerFieldsVirology neuroimmunology neuroscience pharmacology therapeuticsInstitutionsCurrent University of Nebraska Medical CenterPrevious Henry M Jackson Foundation for the Advancement in Military Medicine Walter Reed Army Institute of ResearchUniformed Services University of the Health Sciences CenterJohns Hopkins UniversityAlbert Einstein College of MedicineWebsitehttps www unmc edu pharmacology faculty primary faculty gendelman He is married with three children and seven grandchildren 3 Contents 1 Early life and education 2 Career 2 1 Research 2 2 Mononuclear phacocytes and neurodegenerative disease 2 3 HIV research contributions 2 4 Parkinson s Disease research contributions 2 5 Scientific community leadership 3 Awards and honors 3 1 Research recognitions 4 ReferencesEarly life and education EditGendelman graduated with a bachelor s degree in Natural Sciences and Russian Studies from Muhlenberg College 1971 1975 3 He completed his doctorate of medicine at the Pennsylvania State University Hershey Medical Center 1975 1979 3 He then completed a residency in Internal medicine at Montefiore Hospital Albert Einstein College of Medicine 1979 1982 and he was a Clinical and Research Fellow in Neurology and Infectious Diseases at the Johns Hopkins University Medical Center 1982 1985 3 Career EditGendelman worked at the National Institute of Allergy and Infectious Diseases during the height of the HIV AIDS Pandemic 4 Gendelman also occupied senior faculty and research positions at the Johns Hopkins Medical Institutions the Uniformed Services University of the Health Sciences Center the Walter Reed Army Institute of Research and the Henry M Jackson Foundation for the Advancement in Military Medicine before joining the faculty of UNMC in March 1993 He retired from the US Army with the rank of Lieutenant Colonel He established the Center for Neurovirology and Neurodegenerative Disorders at UNMC in 1997 5 which evolved into UNMC s current Department of Pharmacology and Experimental Neuroscience in 2004 6 In 2000 he was awarded a Fulbright to do research at the Weizmann Institute of Science in Rehovot Israel 7 8 Research Edit Mononuclear phacocytes and neurodegenerative disease Edit Gendelman s research explores the role of mononuclear phagocytes monocytes macrophages microglia and dendritic cells as viral reservoirs perpetrators of disease and depots for nanoformulated drug delivery His work was foundational to building a field of investigation focused on lentiviral pathogenesis diagnostics and therapeutics These advancements in immune transformation have led to new and effective management of neurodegenerative disease progression Gendelman and his research team were among the first to develop laboratory assays for establishing viral tropism for mononuclear phagocytes and they were the first to demonstrate that infected and immune activated mononuclear phagocytes release viral and cellular toxins that damage the nervous system 9 10 11 HIV research contributions Edit Gendelman s group was among the first to reverse HIV dementia in an infected person using combination antiretroviral therapy cART and they developed scores of rodent models to mimic HIV AIDS end organ disease 12 13 14 He coined the term long acting slow effective release ART LASER ART These works led to polymer discovery targeted drug delivery to viral reservoirs and reduction of residual virus in lymphoid organs His Nebraska based research group along with a team at Temple University was also the first to combine HIV reservoir targeted LASER ART and CRISPR Cas9 to eliminate chronic viral infection from infected animals 15 This curative approach published in Nature Communications 2019 received considerable attention in establishing a novel translational pathway for HIV eradication 16 17 18 This work followed the first ultra long acting nanocrystal prodrug and the world s first HIV vaccine mimetic 19 20 in Nature Materials 2020 His work with cell based drug delivery born out of nanoparticle mononuclear phagocyte interactions has inspired broad pharmaceutical interest in turn Gendelman led the establishment of the Nebraska Nanomedicine Production Plant 21 a biotechnology good manufacturing practices cGMP initiative to position research for clinical translation in the development of long acting nanoformulated ART at UNMC He also co founded Exavir Therapeutics Inc 22 a biotechnology company developing therapies towards and cure for HIV AIDS Parkinson s Disease research contributions Edit Gendelman was the first to pharmacologically transform effector into regulatory T cells to halt the progression of Parkinson s disease 23 24 Phase II investigation began in early 2021 after successful phase I investigations 25 Scientific community leadership Edit Gendelman has written or edited 17 books and monographs including multiple editions of the textbooks The Neurology of AIDS 26 and Neuroimmune Pharmacology 27 He was the founding Editor in Chief of the Journal of Neuroimmune Pharmacology Awards and honors EditResearch recognitions Edit Startup of the Year 2022 Exavir Therapeutics 28 Nebraska Coalition for Lifesaving Cures 2022 Life Saver Award 29 30 Lifetime Achievement Award Contribution to the Advancement of the Mission of the Society on NeuroImmune Pharmacology 2017 31 Pioneer in NeuroVirology International Society for NeuroVirology 2016 8 Javits Investigator Award National Institutes of Health 2000 32 References Edit Johnson Amanda McGill 2022 01 28 2022 Luncheon Honoreers Nebraska Cures Retrieved 2022 10 26 Temple University Health System 2019 07 02 HIV eliminated from the genomes of living animals Science Daily en US Retrieved 2022 10 26 a b c d Utesch Margie 2018 07 03 Humanitarian of the Year The Jewish Community Center of Omaha Retrieved 2021 12 16 Potential new HIV treatment developed at UNMC KMTV 2020 04 29 Retrieved 2021 12 16 Front Line 2009 PDF University of Nebraska Medical Center Department of Pharmacology and Experimental Neuroscience Retrieved 2022 01 25 About Us University of Nebraska Medical Center Department of Pharmacology and Experimental Neuroscience Retrieved 2022 01 25 UNMC Professor gets Fulbright to study in Israel 2001 Daily Nebraskan Retrieved 2022 11 04 a b The Pioneer in Neurovirology Award International Society for NeurVirology 2016 Retrieved 4 November 2022 Adachi A Gendelman H E Koenig S Folks T Willey R Rabson A Martin M A August 1986 Production of acquired immunodeficiency syndrome associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone Journal of Virology 59 2 284 291 doi 10 1128 jvi 59 2 284 291 1986 ISSN 0022 538X PMC 253077 PMID 3016298 S2CID 12551511 Koenig Scott Gendelman Howard E Orenstein Jan M Dal Canto Mauro C Pezeshkpour Gholam H Yungbluth Margaret Janotta Frank Aksamit Allen Martin Malcolm A Fauci Anthony S 1986 09 05 Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy Science 233 4768 1089 1093 Bibcode 1986Sci 233 1089K doi 10 1126 science 3016903 ISSN 0036 8075 PMID 3016903 Gendelman H E Narayan O Molineaux S Clements J E Ghotbi Z October 1985 Slow persistent replication of lentiviruses role of tissue macrophages and macrophage precursors in bone marrow Proceedings of the National Academy of Sciences of the United States of America 82 20 7086 7090 Bibcode 1985PNAS 82 7086G doi 10 1073 pnas 82 20 7086 ISSN 0027 8424 PMC 391315 PMID 2996004 Gendelman Howard E Zheng Jialin Coulter Cynthia L Ghorpade Anuja Che Myhanh Thylin Michael Rubocki Ronald Persidsky Yuri Hahn Francis Reinhard Jr John Swindells Susan October 1998 Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Associated Dementia The Journal of Infectious Diseases 178 4 1000 1007 doi 10 1086 515693 ISSN 0022 1899 PMID 9806027 S2CID 42427863 Spellman Lisa 2019 08 09 Science Cafe explores possibility of HIV cure University of Nebraska Medical Center Retrieved 2021 12 16 Gendelman Howard E 2012 The neurology of AIDS Oxford University Press ISBN 978 0 19 539934 9 OCLC 828615707 Scientists say they found a cure for HIV in some mice Humans could be next www washingtonpost com Retrieved 2022 11 23 In a first scientists eliminate HIV from an animal s genome www cbsnews com Retrieved 2021 12 17 Yancey Bragg N dea Researchers have eliminated HIV in mice for the first time Is a cure for humans next USA TODAY Retrieved 2021 12 17 Dash Prasanta K Kaminski Rafal Bella Ramona Su Hang Mathews Saumi Ahooyi Taha M Chen Chen Mancuso Pietro Sariyer Rahsan Ferrante Pasquale Donadoni Martina December 2019 Sequential LASER ART and CRISPR Treatments Eliminate HIV 1 in a Subset of Infected Humanized Mice Nature Communications 10 1 2753 Bibcode 2019NatCo 10 2753D doi 10 1038 s41467 019 10366 y ISSN 2041 1723 PMC 6606613 PMID 31266936 Kulkarni Tanmay A Bade Aditya N Sillman Brady Shetty Bhagya Laxmi Dyavar Wojtkiewicz Melinda S Gautam Nagsen Hilaire James R Sravanam Sruthi Szlachetka Adam Lamberty Benjamin G Morsey Brenda M August 2020 A year long extended release nanoformulated cabotegravir prodrug Nature Materials 19 8 910 920 Bibcode 2020NatMa 19 910K doi 10 1038 s41563 020 0674 z ISSN 1476 1122 PMC 7384935 PMID 32341511 Soriano Vicente Barreiro Pablo de Mendoza Carmen August 2020 Long acting antiretroviral therapy Nature Materials 19 8 826 827 Bibcode 2020NatMa 19 826S doi 10 1038 s41563 020 0731 7 ISSN 1476 4660 PMID 32704135 S2CID 220721631 Nebraska Nanomedicine Production Plant Pharmacology University of Nebraska Medical Center www unmc edu Retrieved 2021 12 16 Exavir Therapeutics exavirtherapeutics com 2021 02 14 Retrieved 2021 12 16 Benner Eric J Mosley R Lee Destache Chris J Lewis Travis B Jackson Lewis Vernice Gorantla Santhi Nemachek Craig Green Steven R Przedborski Serge Gendelman Howard E 2004 06 22 Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson s disease Proceedings of the National Academy of Sciences of the United States of America 101 25 9435 9440 Bibcode 2004PNAS 101 9435B doi 10 1073 pnas 0400569101 ISSN 0027 8424 PMC 438994 PMID 15197276 Gendelman Howard E Zhang Yuning Santamaria Pamela Olson Katherine E Schutt Charles R Bhatti Danish Shetty Bhagya Laxmi Dyavar Lu Yaman Estes Katherine A Standaert David G Heinrichs Graham Elizabeth 2017 03 23 Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized double blind phase 1 clinical Parkinson s disease trial npj Parkinson s Disease 3 1 10 doi 10 1038 s41531 017 0013 5 ISSN 2373 8057 PMC 5445595 PMID 28649610 Olson Katherine E Namminga Krista L Lu Yaman Schwab Aaron D Thurston Mackenzie J Abdelmoaty Mai M Kumar Vikas Wojtkiewicz Melinda Obaro Helen Santamaria Pamela Mosley R Lee 2021 05 01 Safety tolerability and immune biomarker profiling for year long sargramostim treatment of Parkinson s disease EBioMedicine 67 103380 doi 10 1016 j ebiom 2021 103380 ISSN 2352 3964 PMC 8138485 PMID 34000620 Gendelman Howard E Grant Igor Everall Ian Paul Fox Howard S Gelbard Harris A Lipton Stuart A Swindells Susan eds 2012 The Neurology of AIDS Oxford University Press doi 10 1093 med 9780195399349 001 0001 ISBN 978 0 19 996519 9 Ikezu Tsuneya Gendelman Howard E eds 2017 Neuroimmune Pharmacology doi 10 1007 978 3 319 44022 4 ISBN 978 3 319 44020 0 Innovation Awards UNeMed com 23 October 2022 Retrieved 23 November 2022 2022 Luncheon Honorees Nebraska Cures 28 January 2022 Retrieved 28 April 2022 Tribute to Dr Howard Gendelman and Dr Bonnie Bloch YouTube Nebraska Cures Retrieved 28 April 2022 SNIP Society on NeuroImmune Pharmacology s nip org Retrieved 2021 12 16 3 Million Grant Recognizes Potential of Research at the UNMC Center for Neurovirology and Neurodegenerative Disorders University of Nebraska Medical Center 2001 Retrieved 4 November 2022 Retrieved from https en wikipedia org w index php title Howard E Gendelman amp oldid 1136318489, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.