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CCHCR1

January 01, 1970

Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a protein which in humans is encoded by the CCHCR1 gene.[5][6][7]

CCHCR1
Identifiers
AliasesCCHCR1, C6orf18, HCR, SBP, coiled-coil alpha-helical rod protein 1, pg8
External IDsOMIM: 605310 MGI: 2385321 HomoloGene: 10396 GeneCards: CCHCR1
Orthologs
SpeciesHumanMouse
Entrez

54535

240084

Ensembl

ENSMUSG00000040312

UniProt

Q8TD31

Q8K2I2

RefSeq (mRNA)

NM_146248
NM_001372297
NM_001372298
NM_001372299
NM_001372300

RefSeq (protein)

NP_001099033
NP_001099034
NP_061925

NP_666360
NP_001359226
NP_001359227
NP_001359228
NP_001359229

Location (UCSC)Chr 6: 31.14 – 31.16 MbChr 17: 35.83 – 35.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene edit

The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18, Putative Gene 8 Protein, SBP, HCR (A-Helix Coiled-Coil Rod Homologue), pg8, StAR-Binding Protein, and Pg8.

Homology edit

Homologes for CCHCR1 are conserved through tetrapods.

Paralogs edit

Orthologs edit

CCHCR1 has orthologs throughout vertebrates.

Distant Homologs edit

Homologous Domains edit

Phylogeny edit

Phylogenetic analysis with ClustalW indicated that CCHCR1

The CCHCR1 gene has

Protein edit

Structure edit

The structure of CCHCR1 is primarily composed of alpha-helices, coils[clarification needed], and a small amount of beta sheets, according to PELE.[8]

Expression edit

Function edit

May be a regulator of keratinocyte proliferation or differentiation.

Interacting Proteins edit

CCHCR1 has been shown to interact with POLR2C,[9] KRT17 ,[10] TOP3B,[11] Steroidogenic acute regulatory protein,[10] TRAF4,[12] HLA-C,[13] TCF19,[13] SNX29,[14] EEF1D,[15] and EEF1B2.[15]

Clinical significance edit

In genetically engineered mice, certain CCHCR1 polymorphisms cause upregulation of the expression of cytokeratins 6 (KRT6A), 16 (KRT16) and 17 (KRT17) and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to psoriasis.[16] Defective functioning of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriasis.[17]

CCHCR1 polymorphisms have also been found to be associated with multiple sclerosis.[18]

See also edit

References edit

  1. ^ a b c ENSG00000206355, ENSG00000224180, ENSG00000206457, ENSG00000223533, ENSG00000234114 GRCh38: Ensembl release 89: ENSG00000204536, ENSG00000206355, ENSG00000224180, ENSG00000206457, ENSG00000223533, ENSG00000234114 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040312 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCHCR1 coiled-coil alpha-helical rod protein 1".
  6. ^ Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (June 2000). "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele". Hum. Mol. Genet. 9 (10): 1533–42. doi:10.1093/hmg/9.10.1533. PMID 10888604.
  7. ^ Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (November 1999). "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene". Hum. Mol. Genet. 8 (12): 2165–70. doi:10.1093/hmg/8.12.2165. PMID 10545595.
  8. ^ Boudreau, A. E. (Mar 1999). "PELE—a version of the MELTS software program for the PC platform". Comput. Geosci. 25 (2): 201–203. Bibcode:1999CG.....25..201B. doi:10.1016/S0098-3004(98)00117-4. ISSN 0098-3004.
  9. ^ Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, Di Certo MG, Spinardi L, Floridi A, Fanciulli M, Passananti C (September 2005). "RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product". J. Cell Sci. 118 (Pt 18): 4253–60. doi:10.1242/jcs.02545. PMID 16141233.
  10. ^ a b Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O (2012). "Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization". PLOS ONE. 7 (11): e49920. Bibcode:2012PLoSO...749920T. doi:10.1371/journal.pone.0049920. PMC 3506594. PMID 23189171.
  11. ^ Nicholas TJ, Baker C, Eichler EE, Akey JM (16 August 2011). "A high-resolution integrated map of copy number polymorphisms within and between breeds of the modern domesticated dog". BMC Genomics. 12: 414. doi:10.1186/1471-2164-12-414. PMC 3166287. PMID 21846351.
  12. ^ Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (Aug 2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". The Journal of Biological Chemistry. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
  13. ^ a b Petersdorf EW, Malkki M, Gooley TA, Spellman SR, Haagenson MD, Horowitz MM, Wang T (Jul 2012). "MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation". Science Translational Medicine. 4 (144): 144ra101. doi:10.1126/scitranslmed.3003974. PMC 3633562. PMID 22837536.
  14. ^ Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP (23 February 2010). "Influence of genetic background and tissue types on global DNA methylation patterns". PLOS ONE. 5 (2): e9355. Bibcode:2010PLoSO...5.9355Y. doi:10.1371/journal.pone.0009355. PMC 2826396. PMID 20186319.
  15. ^ a b Corbi N, Batassa EM, Pisani C, Onori A, Di Certo MG, Strimpakos G, Fanciulli M, Mattei E, Passananti C (31 December 2010). "The eEF1γ subunit contacts RNA polymerase II and binds vimentin promoter region". PLOS ONE. 5 (12): e14481. Bibcode:2010PLoSO...514481C. doi:10.1371/journal.pone.0014481. PMC 3013090. PMID 21217813.
  16. ^ Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (August 2004). "Transgenic mouse models support HCR as an effector gene in the PSORS1 locus". Hum. Mol. Genet. 13 (15): 1551–61. doi:10.1093/hmg/ddh178. PMID 15190014.
  17. ^ Tiala I, Wakkinen J, Suomela S, Puolakkainen P, Tammi R, Forsberg S, Rollman O, Kainu K, Rozell B, Kere J, Saarialho-Kere U, Elomaa O (April 2008). "The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice". Hum. Mol. Genet. 17 (7): 1043–51. doi:10.1093/hmg/ddm377. PMID 18174193.
  18. ^ Lin X, Deng FY, Lu X, Lei SF (2015). "Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study". Journal of Clinical Neurology. 11 (4): 311–8. doi:10.3988/jcn.2015.11.4.311. PMC 4596110. PMID 26320842.

External links edit

Further reading edit

  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  • Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (1999). "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene". Hum. Mol. Genet. 8 (12): 2165–70. doi:10.1093/hmg/8.12.2165. PMID 10545595.
  • Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000). "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele". Hum. Mol. Genet. 9 (10): 1533–42. doi:10.1093/hmg/9.10.1533. PMID 10888604.
  • O'Brien KP, Holm SJ, Nilsson S, Carlén L, Rosenmüller T, Enerbäck C, Inerot A, Ståhle-Bäckdahl M (2001). "The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene". J. Invest. Dermatol. 116 (5): 750–4. doi:10.1046/j.0022-202x.2001.01323.x. PMID 11348465.
  • Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson JA, Nakagawa H, Lazaro C, Estivill X, Capon F, Novelli G, Saarialho-Kere U, Barker J, Trembath R, Kere J (2002). "Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus". Hum. Mol. Genet. 11 (5): 589–97. doi:10.1093/hmg/11.5.589. PMID 11875053.
  • Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
  • Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (2003). "Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system". J. Biol. Chem. 278 (43): 42487–94. doi:10.1074/jbc.M302291200. PMID 12909641.
  • Suomela S, Elomaa O, Asumalahti K, Kariniemi AL, Karvonen SL, Peltonen J, Kere J, Saarialho-Kere U (2003). "HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes". J. Invest. Dermatol. 121 (6): 1360–4. doi:10.1046/j.1523-1747.2003.12642.x. PMID 14675183.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, Zaret KS, Taylor JM (2004). "miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1". RNA Biol. 1 (2): 106–13. doi:10.4161/rna.1.2.1066. PMID 17179747.
  • Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). "The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes". J. Mol. Med. 85 (6): 589–601. doi:10.1007/s00109-006-0155-0. PMID 17221218. S2CID 25864002.
  • Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U (2007). "Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis". Acta Derm. Venereol. 87 (2): 127–34. doi:10.2340/00015555-0184. PMID 17340018.
  • Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (Aug 2004). "Transgenic mouse models support HCR as an effector gene in the PSORS1 locus". Human Molecular Genetics. 13 (15): 1551–61. doi:10.1093/hmg/ddh178. PMID 15190014.

January 01, 1970
cchcr1, coiled, coil, alpha, helical, protein, also, known, protein, which, humans, encoded, gene, identifiersaliases, c6orf18, coiled, coil, alpha, helical, protein, pg8external, idsomim, 605310, 2385321, homologene, 10396, genecards, gene, location, human, c. Coiled coil alpha helical rod protein 1 also known as CCHCR1 is a protein which in humans is encoded by the CCHCR1 gene 5 6 7 CCHCR1IdentifiersAliasesCCHCR1 C6orf18 HCR SBP coiled coil alpha helical rod protein 1 pg8External IDsOMIM 605310 MGI 2385321 HomoloGene 10396 GeneCards CCHCR1Gene location Human Chr Chromosome 6 human 1 Band6p21 33Start31 142 439 bp 1 End31 158 238 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 B1Start35 827 997 bp 2 End35 841 912 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubesural nerveduodenumcanal of the cervixright lobe of thyroid glandprostategastrocnemius muscleleft uterine tubebody of stomachleft lobe of thyroid glandTop expressed inspermatocytespermatidseminiferous tubulelipyolk sacthymusesophaguslensstomachmorulaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding identical protein bindingCellular componentcentriole nucleus cytoplasm cytosolBiological processmulticellular organism development cell differentiation protein export from nucleusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez54535240084EnsemblENSG00000204536ENSG00000206355ENSG00000224180ENSG00000206457ENSG00000223533ENSG00000234114ENSMUSG00000040312UniProtQ8TD31Q8K2I2RefSeq mRNA NM 001105563NM 001105564NM 019052NM 001394641NM 001394642NM 001394643NM 001394644NM 001394646NM 001394647NM 001394648NM 001394649NM 001394645NM 146248NM 001372297NM 001372298NM 001372299NM 001372300RefSeq protein NP 001099033NP 001099034NP 061925NP 666360NP 001359226NP 001359227NP 001359228NP 001359229Location UCSC Chr 6 31 14 31 16 MbChr 17 35 83 35 84 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Gene 2 Homology 2 1 Paralogs 2 2 Orthologs 2 3 Distant Homologs 2 4 Homologous Domains 2 5 Phylogeny 3 Protein 3 1 Structure 4 Expression 5 Function 6 Interacting Proteins 7 Clinical significance 8 See also 9 References 10 External links 11 Further readingGene editThe Human CCHCR1 gene is located at 6p21 33 It is also known as Coiled Coil Alphahelical Rod Protein 1 C6orf18 Putative Gene 8 Protein SBP HCR A Helix Coiled Coil Rod Homologue pg8 StAR Binding Protein and Pg8 Homology editHomologes for CCHCR1 are conserved through tetrapods Paralogs edit Orthologs edit CCHCR1 has orthologs throughout vertebrates Distant Homologs edit Homologous Domains edit Phylogeny edit Phylogenetic analysis with ClustalW indicated that CCHCR1The CCHCR1 gene hasProtein editStructure edit The structure of CCHCR1 is primarily composed of alpha helices coils clarification needed and a small amount of beta sheets according to PELE 8 Expression editThis section is empty You can help by adding to it May 2015 Function editMay be a regulator of keratinocyte proliferation or differentiation Interacting Proteins editCCHCR1 has been shown to interact with POLR2C 9 KRT17 10 TOP3B 11 Steroidogenic acute regulatory protein 10 TRAF4 12 HLA C 13 TCF19 13 SNX29 14 EEF1D 15 and EEF1B2 15 Clinical significance editIn genetically engineered mice certain CCHCR1 polymorphisms cause upregulation of the expression of cytokeratins 6 KRT6A 16 KRT16 and 17 KRT17 and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope These CCHCR1 polymorphisms may therefore be associated with a susceptibility to psoriasis 16 Defective functioning of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriasis 17 CCHCR1 polymorphisms have also been found to be associated with multiple sclerosis 18 See also editCoiled coilReferences edit a b c ENSG00000206355 ENSG00000224180 ENSG00000206457 ENSG00000223533 ENSG00000234114 GRCh38 Ensembl release 89 ENSG00000204536 ENSG00000206355 ENSG00000224180 ENSG00000206457 ENSG00000223533 ENSG00000234114 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000040312 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene CCHCR1 coiled coil alpha helical rod protein 1 Asumalahti K Laitinen T Itkonen Vatjus R Lokki ML Suomela S Snellman E Saarialho Kere U Kere J June 2000 A candidate gene for psoriasis near HLA C HCR Pg8 is highly polymorphic with a disease associated susceptibility allele Hum Mol Genet 9 10 1533 42 doi 10 1093 hmg 9 10 1533 PMID 10888604 Oka A Tamiya G Tomizawa M Ota M Katsuyama Y Makino S Shiina T Yoshitome M Iizuka M Sasao Y Iwashita K Kawakubo Y Sugai J Ozawa A Ohkido M Kimura M Bahram S Inoko H November 1999 Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA C gene Hum Mol Genet 8 12 2165 70 doi 10 1093 hmg 8 12 2165 PMID 10545595 Boudreau A E Mar 1999 PELE a version of the MELTS software program for the PC platform Comput Geosci 25 2 201 203 Bibcode 1999CG 25 201B doi 10 1016 S0098 3004 98 00117 4 ISSN 0098 3004 Corbi N Bruno T De Angelis R Di Padova M Libri V Di Certo MG Spinardi L Floridi A Fanciulli M Passananti C September 2005 RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR the psoriasis vulgaris candidate gene product J Cell Sci 118 Pt 18 4253 60 doi 10 1242 jcs 02545 PMID 16141233 a b Tervaniemi MH Siitonen HA Soderhall C Minhas G Vuola J Tiala I Sormunen R Samuelsson L Suomela S Kere J Elomaa O 2012 Centrosomal localization of the psoriasis candidate gene product CCHCR1 supports a role in cytoskeletal organization PLOS ONE 7 11 e49920 Bibcode 2012PLoSO 749920T doi 10 1371 journal pone 0049920 PMC 3506594 PMID 23189171 Nicholas TJ Baker C Eichler EE Akey JM 16 August 2011 A high resolution integrated map of copy number polymorphisms within and between breeds of the modern domesticated dog BMC Genomics 12 414 doi 10 1186 1471 2164 12 414 PMC 3166287 PMID 21846351 Xu YC Wu RF Gu Y Yang YS Yang MC Nwariaku FE Terada LS Aug 2002 Involvement of TRAF4 in oxidative activation of c Jun N terminal kinase The Journal of Biological Chemistry 277 31 28051 7 doi 10 1074 jbc M202665200 PMID 12023963 a b Petersdorf EW Malkki M Gooley TA Spellman SR Haagenson MD Horowitz MM Wang T Jul 2012 MHC resident variation affects risks after unrelated donor hematopoietic cell transplantation Science Translational Medicine 4 144 144ra101 doi 10 1126 scitranslmed 3003974 PMC 3633562 PMID 22837536 Yang HH Hu N Wang C Ding T Dunn BK Goldstein AM Taylor PR Lee MP 23 February 2010 Influence of genetic background and tissue types on global DNA methylation patterns PLOS ONE 5 2 e9355 Bibcode 2010PLoSO 5 9355Y doi 10 1371 journal pone 0009355 PMC 2826396 PMID 20186319 a b Corbi N Batassa EM Pisani C Onori A Di Certo MG Strimpakos G Fanciulli M Mattei E Passananti C 31 December 2010 The eEF1g subunit contacts RNA polymerase II and binds vimentin promoter region PLOS ONE 5 12 e14481 Bibcode 2010PLoSO 514481C doi 10 1371 journal pone 0014481 PMC 3013090 PMID 21217813 Elomaa O Majuri I Suomela S Asumalahti K Jiao H Mirzaei Z Rozell B Dahlman Wright K Pispa J Kere J Saarialho Kere U August 2004 Transgenic mouse models support HCR as an effector gene in the PSORS1 locus Hum Mol Genet 13 15 1551 61 doi 10 1093 hmg ddh178 PMID 15190014 Tiala I Wakkinen J Suomela S Puolakkainen P Tammi R Forsberg S Rollman O Kainu K Rozell B Kere J Saarialho Kere U Elomaa O April 2008 The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice Hum Mol Genet 17 7 1043 51 doi 10 1093 hmg ddm377 PMID 18174193 Lin X Deng FY Lu X Lei SF 2015 Susceptibility Genes for Multiple Sclerosis Identified in a Gene Based Genome Wide Association Study Journal of Clinical Neurology 11 4 311 8 doi 10 3988 jcn 2015 11 4 311 PMC 4596110 PMID 26320842 External links editHuman CCHCR1 genome location and CCHCR1 gene details page in the UCSC Genome Browser Further reading editAdams MD Kerlavage AR Fleischmann RD Fuldner RA Bult CJ Lee NH Kirkness EF Weinstock KG Gocayne JD White O 1995 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence PDF Nature 377 6547 Suppl 3 174 PMID 7566098 Oka A Tamiya G Tomizawa M Ota M Katsuyama Y Makino S Shiina T Yoshitome M Iizuka M Sasao Y Iwashita K Kawakubo Y Sugai J Ozawa A Ohkido M Kimura M Bahram S Inoko H 1999 Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA C gene Hum Mol Genet 8 12 2165 70 doi 10 1093 hmg 8 12 2165 PMID 10545595 Asumalahti K Laitinen T Itkonen Vatjus R Lokki ML Suomela S Snellman E Saarialho Kere U Kere J 2000 A candidate gene for psoriasis near HLA C HCR Pg8 is highly polymorphic with a disease associated susceptibility allele Hum Mol Genet 9 10 1533 42 doi 10 1093 hmg 9 10 1533 PMID 10888604 O Brien KP Holm SJ Nilsson S Carlen L Rosenmuller T Enerback C Inerot A Stahle Backdahl M 2001 The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene J Invest Dermatol 116 5 750 4 doi 10 1046 j 0022 202x 2001 01323 x PMID 11348465 Asumalahti K Veal C Laitinen T Suomela S Allen M Elomaa O Moser M de Cid R Ripatti S Vorechovsky I Marcusson JA Nakagawa H Lazaro C Estivill X Capon F Novelli G Saarialho Kere U Barker J Trembath R Kere J 2002 Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus Hum Mol Genet 11 5 589 97 doi 10 1093 hmg 11 5 589 PMID 11875053 Xu YC Wu RF Gu Y Yang YS Yang MC Nwariaku FE Terada LS 2002 Involvement of TRAF4 in oxidative activation of c Jun N terminal kinase J Biol Chem 277 31 28051 7 doi 10 1074 jbc M202665200 PMID 12023963 Sugawara T Shimizu H Hoshi N Nakajima A Fujimoto S 2003 Steroidogenic acute regulatory protein binding protein cloned by a yeast two hybrid system J Biol Chem 278 43 42487 94 doi 10 1074 jbc M302291200 PMID 12909641 Suomela S Elomaa O Asumalahti K Kariniemi AL Karvonen SL Peltonen J Kere J Saarialho Kere U 2003 HCR a candidate gene for psoriasis is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon gamma in keratinocytes J Invest Dermatol 121 6 1360 4 doi 10 1046 j 1523 1747 2003 12642 x PMID 14675183 Brandenberger R Wei H Zhang S Lei S Murage J Fisk GJ Li Y Xu C Fang R Guegler K Rao MS Mandalam R Lebkowski J Stanton LW 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Lim J Hao T Shaw C Patel AJ Szabo G Rual JF Fisk CJ Li N Smolyar A Hill DE Barabasi AL Vidal M Zoghbi HY 2006 A protein protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration Cell 125 4 801 14 doi 10 1016 j cell 2006 03 032 PMID 16713569 S2CID 13709685 Chang J Nicolas E Marks D Sander C Lerro A Buendia MA Xu C Mason WS Moloshok T Bort R Zaret KS Taylor JM 2004 miR 122 a mammalian liver specific microRNA is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT 1 RNA Biol 1 2 106 13 doi 10 4161 rna 1 2 1066 PMID 17179747 Tiala I Suomela S Huuhtanen J Wakkinen J Holtta Vuori M Kainu K Ranta S Turpeinen U Hamalainen E Jiao H Karvonen SL Ikonen E Kere J Saarialho Kere U Elomaa O 2007 The CCHCR1 HCR gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes J Mol Med 85 6 589 601 doi 10 1007 s00109 006 0155 0 PMID 17221218 S2CID 25864002 Suomela S Kainu K Onkamo P Tiala I Himberg J Koskinen L Snellman E Karvonen SL Karvonen J Uurasmaa T Reunala T Kivikas K Jansen CT Holopainen P Elomaa O Kere J Saarialho Kere U 2007 Clinical associations of the risk alleles of HLA Cw6 and CCHCR1 WWCC in psoriasis Acta Derm Venereol 87 2 127 34 doi 10 2340 00015555 0184 PMID 17340018 Elomaa O Majuri I Suomela S Asumalahti K Jiao H Mirzaei Z Rozell B Dahlman Wright K Pispa J Kere J Saarialho Kere U Aug 2004 Transgenic mouse models support HCR as an effector gene in the PSORS1 locus Human Molecular Genetics 13 15 1551 61 doi 10 1093 hmg ddh178 PMID 15190014 Retrieved from https en wikipedia org w index php title CCHCR1 amp oldid 1188049533, wikipedia, wiki, book, books, library,

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