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Wikipedia

Keratin 16

December 15, 2023

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.[5][6][7]

KRT16
Identifiers
AliasesKRT16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1, keratin 16
External IDsOMIM: 148067 MGI: 96690 HomoloGene: 21145 GeneCards: KRT16
Orthologs
SpeciesHumanMouse
Entrez

3868

16666

Ensembl

ENSG00000186832

ENSMUSG00000053797

UniProt

P08779

Q9Z2K1

RefSeq (mRNA)

NM_005557

NM_008470
NM_001313958

RefSeq (protein)

NP_005548

NP_001300887
NP_032496

Location (UCSC)Chr 17: 41.61 – 41.62 MbChr 11: 100.14 – 100.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186832 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053797 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rosenberg M, RayChaudhury A, Shows TB, Le Beau MM, Fuchs E (February 1988). "A group of type I keratin genes on human chromosome 17: characterization and expression". Mol. Cell. Biol. 8 (2): 722–36. doi:10.1128/mcb.8.2.722. PMC 363198. PMID 2451124.
  6. ^ Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenet. Cell Genet. 57 (1): 33–8. doi:10.1159/000133109. PMID 1713141.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ Shamsher MK, Navsaria HA, Stevens HP, Ratnavel RC, Purkis PE, Kelsell DP, McLean WH, Cook LJ, Griffiths WA, Gschmeissner S (October 1995). "Novel mutations in keratin 16 gene underlie focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families". Hum. Mol. Genet. 4 (10): 1875–81. doi:10.1093/hmg/4.10.1875. PMID 8595410.

External links edit

  • GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita

Further reading edit

  • Liao H, Sayers JM, Wilson NJ, et al. (2007). "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita". J. Dermatol. Sci. 48 (3): 199–205. doi:10.1016/j.jdermsci.2007.07.003. PMID 17719747.
  • Barcelos AC, Sotto MN (2009). "Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions". J. Cutan. Pathol. 36 (6): 647–54. doi:10.1111/j.1600-0560.2008.01127.x. PMID 19515043. S2CID 205816580.
  • Wang YN, Chang WC (2003). "Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun". J. Biol. Chem. 278 (46): 45848–57. doi:10.1074/jbc.M302630200. PMID 12954631.
  • Bai ZL, Feng YG, Tan SS, et al. (2008). "Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families". Br. J. Dermatol. 159 (1): 238–40. doi:10.1111/j.1365-2133.2008.08603.x. PMID 18489596. S2CID 32875094.
  • Harris RA, Yang A, Stein RC, et al. (2002). "Cluster analysis of an extensive human breast cancer cell line protein expression map database". Proteomics. 2 (2): 212–23. doi:10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H. PMID 11840567. S2CID 44946014.
  • van Lingen RG, Poll MK, Seyger MM, et al. (2008). "Distribution of dipeptidyl-peptidase IV on keratinocytes in the margin zone of a psoriatic lesion: a comparison with hyperproliferation and aberrant differentiation markers". Arch. Dermatol. Res. 300 (10): 561–7. doi:10.1007/s00403-008-0862-1. PMID 18496701.
  • Nishizawa M, Izawa I, Inoko A, et al. (2005). "Identification of trichoplein, a novel keratin filament-binding protein". J. Cell Sci. 118 (Pt 5): 1081–90. doi:10.1242/jcs.01667. PMID 15731013.
  • Bhawan J, Bansal C, Whren K, et al. (2004). "K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis". J. Cutan. Pathol. 31 (7): 471–6. doi:10.1111/j.0303-6987.2004.0220.x. PMID 15239676. S2CID 20099397.
  • Terrinoni A, Puddu P, Didona B, et al. (2000). "A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus". J. Invest. Dermatol. 114 (6): 1136–40. doi:10.1046/j.1523-1747.2000.00983.x. PMID 10844556.
  • Ito Y, Kurokawa I, Nishimura K, et al. (2008). "Keratin and filaggrin expression in keratoacanthoma". J Eur Acad Dermatol Venereol. 22 (3): 353–5. doi:10.1111/j.1468-3083.2007.02440.x. PMID 18005116. S2CID 37712127.
  • Smith FJ, Fisher MP, Healy E, et al. (2000). "Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma". Exp. Dermatol. 9 (3): 170–7. doi:10.1034/j.1600-0625.2000.009003170.x. PMID 10839714. S2CID 44384231.
  • Yu JQ, Zhuang H, Xiu Y, et al. (2005). "Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report". J Nucl Med Technol. 33 (1): 31–3. PMID 15731018.
  • Wu C, Li C, Wei L, Zheng Z (2008). "Innate immune modulation of keratinocytes by antikeratin 16 antibodies". Exp. Dermatol. 17 (8): 645–52. doi:10.1111/j.1600-0625.2007.00682.x. PMID 18557933. S2CID 21212353.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Terrinoni A, Smith FJ, Didona B, et al. (2001). "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita". J. Invest. Dermatol. 117 (6): 1391–6. doi:10.1046/j.0022-202x.2001.01565.x. PMID 11886499.
  • Chen YJ, Wang YN, Chang WC (2007). "ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression". J. Biol. Chem. 282 (37): 27215–28. doi:10.1074/jbc.M700264200. PMID 17623675.
  • Connors JB, Rahil AK, Smith FJ, et al. (2001). "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16". Br. J. Dermatol. 144 (5): 1058–62. doi:10.1046/j.1365-2133.2001.04199.x. PMID 11359398. S2CID 22597662.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

December 15, 2023
keratin, protein, that, humans, encoded, krt16, gene, krt16identifiersaliaseskrt16, ck16, fneppk, k1cp, krt16a, neppk, keratin, 16external, idsomim, 148067, 96690, homologene, 21145, genecards, krt16gene, location, human, chromosome, human, band17q21, 2start41. Keratin 16 is a protein that in humans is encoded by the KRT16 gene 5 6 7 KRT16IdentifiersAliasesKRT16 CK16 FNEPPK K16 K1CP KRT16A NEPPK PC1 keratin 16External IDsOMIM 148067 MGI 96690 HomoloGene 21145 GeneCards KRT16Gene location Human Chr Chromosome 17 human 1 Band17q21 2Start41 609 778 bp 1 End41 615 899 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 DStart100 136 917 bp 2 End100 139 728 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inhair follicleamniotic fluidskin of abdomenperiodontal fibercervix epitheliumbody of tongueepithelium of esophagushuman penisvulvacavity of mouthTop expressed inlipmiddle earepidermisEustachian tubezone of skincorneal epitheliumurethravaginarespiratory epitheliumolfactory epitheliumMore reference expression dataBioGPSn aGene ontologyMolecular functionstructural constituent of cytoskeleton protein binding structural molecule activityCellular componentextracellular exosome cytoskeleton intermediate filament nucleus cytosolBiological processmorphogenesis of an epithelium hair cycle keratinocyte migration human ageing cell population proliferation inflammatory response negative regulation of cell migration innate immune response cytoskeleton organization keratinocyte differentiation epidermis development intermediate filament cytoskeleton organization establishment of skin barrier keratinization cornificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez386816666EnsemblENSG00000186832ENSMUSG00000053797UniProtP08779Q9Z2K1RefSeq mRNA NM 005557NM 008470NM 001313958RefSeq protein NP 005548NP 001300887NP 032496Location UCSC Chr 17 41 61 41 62 MbChr 11 100 14 100 14 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseKeratin 16 is a type I cytokeratin It is paired with keratin 6 in a number of epithelial tissues including nail bed esophagus tongue and hair follicles Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita non epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000186832 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000053797 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rosenberg M RayChaudhury A Shows TB Le Beau MM Fuchs E February 1988 A group of type I keratin genes on human chromosome 17 characterization and expression Mol Cell Biol 8 2 722 36 doi 10 1128 mcb 8 2 722 PMC 363198 PMID 2451124 Rosenberg M Fuchs E Le Beau MM Eddy RL Shows TB 1991 Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12 Cytogenet Cell Genet 57 1 33 8 doi 10 1159 000133109 PMID 1713141 Schweizer J Bowden PE Coulombe PA Langbein L Lane EB Magin TM Maltais L Omary MB Parry DA Rogers MA Wright MW July 2006 New consensus nomenclature for mammalian keratins J Cell Biol 174 2 169 74 doi 10 1083 jcb 200603161 PMC 2064177 PMID 16831889 Shamsher MK Navsaria HA Stevens HP Ratnavel RC Purkis PE Kelsell DP McLean WH Cook LJ Griffiths WA Gschmeissner S October 1995 Novel mutations in keratin 16 gene underlie focal non epidermolytic palmoplantar keratoderma NEPPK in two families Hum Mol Genet 4 10 1875 81 doi 10 1093 hmg 4 10 1875 PMID 8595410 External links editGeneReviews NCBI NIH UW entry on Pachyonychia CongenitaFurther reading editLiao H Sayers JM Wilson NJ et al 2007 A spectrum of mutations in keratins K6a K16 and K17 causing pachyonychia congenita J Dermatol Sci 48 3 199 205 doi 10 1016 j jdermsci 2007 07 003 PMID 17719747 Barcelos AC Sotto MN 2009 Comparative analysis of the expression of cytokeratins 1 10 14 16 4 involucrin filaggrin and e cadherin in plane warts and epidermodysplasia verruciformis plane wart type lesions J Cutan Pathol 36 6 647 54 doi 10 1111 j 1600 0560 2008 01127 x PMID 19515043 S2CID 205816580 Wang YN Chang WC 2003 Induction of disease associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c Jun J Biol Chem 278 46 45848 57 doi 10 1074 jbc M302630200 PMID 12954631 Bai ZL Feng YG Tan SS et al 2008 Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1 report of a novel and a recently reported mutation in two unrelated Chinese families Br J Dermatol 159 1 238 40 doi 10 1111 j 1365 2133 2008 08603 x PMID 18489596 S2CID 32875094 Harris RA Yang A Stein RC et al 2002 Cluster analysis of an extensive human breast cancer cell line protein expression map database Proteomics 2 2 212 23 doi 10 1002 1615 9861 200202 2 2 lt 212 AID PROT212 gt 3 0 CO 2 H PMID 11840567 S2CID 44946014 van Lingen RG Poll MK Seyger MM et al 2008 Distribution of dipeptidyl peptidase IV on keratinocytes in the margin zone of a psoriatic lesion a comparison with hyperproliferation and aberrant differentiation markers Arch Dermatol Res 300 10 561 7 doi 10 1007 s00403 008 0862 1 PMID 18496701 Nishizawa M Izawa I Inoko A et al 2005 Identification of trichoplein a novel keratin filament binding protein J Cell Sci 118 Pt 5 1081 90 doi 10 1242 jcs 01667 PMID 15731013 Bhawan J Bansal C Whren K et al 2004 K16 expression in uninvolved psoriatic skin a possible marker of pre clinical psoriasis J Cutan Pathol 31 7 471 6 doi 10 1111 j 0303 6987 2004 0220 x PMID 15239676 S2CID 20099397 Terrinoni A Puddu P Didona B et al 2000 A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus J Invest Dermatol 114 6 1136 40 doi 10 1046 j 1523 1747 2000 00983 x PMID 10844556 Ito Y Kurokawa I Nishimura K et al 2008 Keratin and filaggrin expression in keratoacanthoma J Eur Acad Dermatol Venereol 22 3 353 5 doi 10 1111 j 1468 3083 2007 02440 x PMID 18005116 S2CID 37712127 Smith FJ Fisher MP Healy E et al 2000 Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma Exp Dermatol 9 3 170 7 doi 10 1034 j 1600 0625 2000 009003170 x PMID 10839714 S2CID 44384231 Yu JQ Zhuang H Xiu Y et al 2005 Small urine leak after renal transplantation detection by delayed 99mTc DTPA renography a case report J Nucl Med Technol 33 1 31 3 PMID 15731018 Wu C Li C Wei L Zheng Z 2008 Innate immune modulation of keratinocytes by antikeratin 16 antibodies Exp Dermatol 17 8 645 52 doi 10 1111 j 1600 0625 2007 00682 x PMID 18557933 S2CID 21212353 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Terrinoni A Smith FJ Didona B et al 2001 Novel and recurrent mutations in the genes encoding keratins K6a K16 and K17 in 13 cases of pachyonychia congenita J Invest Dermatol 117 6 1391 6 doi 10 1046 j 0022 202x 2001 01565 x PMID 11886499 Chen YJ Wang YN Chang WC 2007 ERK2 mediated C terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor induced keratin 16 gene expression J Biol Chem 282 37 27215 28 doi 10 1074 jbc M700264200 PMID 17623675 Connors JB Rahil AK Smith FJ et al 2001 Delayed onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16 Br J Dermatol 144 5 1058 62 doi 10 1046 j 1365 2133 2001 04199 x PMID 11359398 S2CID 22597662 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Keratin 16 amp oldid 1115907276, wikipedia, wiki, book, books, library,

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