Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000100211 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022428 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699.
^Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. Bibcode:2003Natur.422..905T. doi:10.1038/nature01570. PMID 12712206. S2CID 4418716.
^Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI (November 2016). "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis". Molecular and Cellular Biology. 36 (21): 2668–2680. doi:10.1128/MCB.00160-16. PMC5064215. PMID 27528616.
External linksEdit
Human CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser.
Further readingEdit
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC311086. PMID 11337467.
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC430954. PMID 12529303.
Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. Bibcode:2003Natur.422..905T. doi:10.1038/nature01570. PMID 12712206. S2CID 4418716.
Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?". BMC Cancer. 4: 31. doi:10.1186/1471-2407-4-31. PMC471554. PMID 15245581.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC545604. PMID 15461802.
Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines". World J. Gastroenterol. 12 (10): 1529–35. doi:10.3748/wjg.v12.i10.1529. PMC4124284. PMID 16570344.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K (2007). "Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling". Mol. Cell. Biol. 27 (12): 4347–54. doi:10.1128/MCB.01640-06. PMC1900052. PMID 17403895.
This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.
protein, chibby, homolog, protein, that, humans, encoded, cby1, gene, cby1available, structurespdbortholog, search, pdbe, rcsblist, codes4wrqidentifiersaliasescby1, c22orf2, hs508i15a, pgea1, pigea, pigea14, arb1, chibby, homolog, drosophila, chibby, family, m. Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene 5 6 7 CBY1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4WRQIdentifiersAliasesCBY1 C22orf2 CBY HS508I15A PGEA1 PIGEA 14 PIGEA14 arb1 chibby homolog 1 Drosophila chibby family member 1 beta catenin antagonist Chibby1External IDsOMIM 607757 MGI 1920989 HomoloGene 12514 GeneCards CBY1Gene location Human Chr Chromosome 22 human 1 Band22q13 1Start38 656 636 bp 1 End38 673 854 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 E1 15Start79 543 400 bp 2 End79 551 861 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocyteright uterine tubebronchial epithelial cellright coronary arterypopliteal arteryleft ventricleleft coronary arteryanterior pituitarycanal of the cervixTop expressed inspermatocyteinterventricular septummedial ganglionic eminenceseminiferous tubuleneural tubevisual cortexsuperior frontal gyrusolfactory bulbspermatidRegion I of hippocampus properMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionbeta catenin binding protein binding identical protein binding protein homodimerization activityCellular componentcytosol trans Golgi network Golgi apparatus nuclear speck nucleus nucleoplasm cytoplasm centriole cytoskeleton cell projection ciliary basal bodyBiological processprotein localization cardiac muscle cell differentiation negative regulation of Wnt signaling pathway cell differentiation negative regulation of transcription DNA templated fat cell differentiation cell projection organization protein homotetramerization cilium assembly ciliary transition zone assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2577673739EnsemblENSG00000100211ENSMUSG00000022428UniProtQ9Y3M2Q9D1C2RefSeq mRNA NM 015373NM 001002880NM 028634RefSeq protein NP 001002880NP 056188NP 082910Location UCSC Chr 22 38 66 38 67 MbChr 15 79 54 79 55 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 External links 5 Further readingFunction EditBeta catenin is a transcriptional activator and oncoprotein involved in the development of several cancers The protein encoded by this gene interacts directly with the C terminal region of beta catenin inhibiting oncogenic beta catenin mediated transcriptional activation by competing with transcription factors for binding to beta catenin Two transcript variants encoding different isoforms have been found for this gene 7 Interactions EditCBY1 has been shown to interact with Beta catenin 8 CBY1 has also been shown to interact with CEP164 CIBAR1 FAM92A1 and RAB8A 9 References Edit a b c GRCh38 Ensembl release 89 ENSG00000100211 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022428 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Dunham I Shimizu N Roe BA Chissoe S Hunt AR Collins JE Bruskiewich R Beare DM Clamp M Smink LJ Ainscough R Almeida JP Babbage A Bagguley C Bailey J Barlow K Bates KN Beasley O Bird CP Blakey S Bridgeman AM Buck D Burgess J Burrill WD O Brien KP Dec 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Hidaka S Konecke V Osten L Witzgall R Aug 2004 PIGEA 14 a novel coiled coil protein affecting the intracellular distribution of polycystin 2 J Biol Chem 279 33 35009 16 doi 10 1074 jbc M314206200 PMID 15194699 a b Entrez Gene CBY1 chibby homolog 1 Drosophila Takemaru K Yamaguchi S Lee YS Zhang Y Carthew RW Moon RT Apr 2003 Chibby a nuclear beta catenin associated antagonist of the Wnt Wingless pathway Nature 422 6934 905 9 Bibcode 2003Natur 422 905T doi 10 1038 nature01570 PMID 12712206 S2CID 4418716 Li FQ Chen X Fisher C Siller SS Zelikman K Kuriyama R Takemaru KI November 2016 BAR Domain Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis Molecular and Cellular Biology 36 21 2668 2680 doi 10 1128 MCB 00160 16 PMC 5064215 PMID 27528616 External links EditHuman CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser Further reading EditWiemann S Weil B Wellenreuther R Gassenhuber J Glassl S Ansorge W Bocher M Blocker H Bauersachs S Blum H Lauber J Dusterhoft A Beyer A Kohrer K Strack N Mewes HW Ottenwalder B Obermaier B Tampe J Heubner D Wambutt R Korn B Klein M Poustka A 2001 Toward a Catalog of Human Genes and Proteins Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Suzuki Y Tsunoda T Sese J Taira H Mizushima Sugano J Hata H Ota T Isogai T Tanaka T Nakamura Y Suyama A Sakaki Y Morishita S Okubo K Sugano S 2001 Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes Genome Res 11 5 677 84 doi 10 1101 gr gr 1640r PMC 311086 PMID 11337467 Collins JE Goward ME Cole CG Smink LJ Huckle EJ Knowles S Bye JM Beare DM Dunham I 2003 Reevaluating Human Gene Annotation A Second Generation Analysis of Chromosome 22 Genome Res 13 1 27 36 doi 10 1101 gr 695703 PMC 430954 PMID 12529303 Takemaru K Yamaguchi S Lee YS Zhang Y Carthew RW Moon RT 2003 Chibby a nuclear beta catenin associated antagonist of the Wnt Wingless pathway Nature 422 6934 905 9 Bibcode 2003Natur 422 905T doi 10 1038 nature01570 PMID 12712206 S2CID 4418716 Gad S Teboul D Lievre A Goasguen N Berger A Beaune P Laurent Puig P 2004 Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer BMC Cancer 4 31 doi 10 1186 1471 2407 4 31 PMC 471554 PMID 15245581 Collins JE Wright CL Edwards CA Davis MP Grinham JA Cole CG Goward ME Aguado B Mallya M Mokrab Y Huckle EJ Beare DM Dunham I 2005 A genome annotation driven approach to cloning the human ORFeome Genome Biol 5 10 R84 doi 10 1186 gb 2004 5 10 r84 PMC 545604 PMID 15461802 Schuierer MM Graf E Takemaru K Dietmaier W Bosserhoff AK 2006 Reduced expression of beta catenin inhibitor Chibby in colon carcinoma cell lines World J Gastroenterol 12 10 1529 35 doi 10 3748 wjg v12 i10 1529 PMC 4124284 PMID 16570344 Lim J Hao T Shaw C Patel AJ Szabo G Rual JF Fisk CJ Li N Smolyar A Hill DE Barabasi AL Vidal M Zoghbi HY 2006 A protein protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration Cell 125 4 801 14 doi 10 1016 j cell 2006 03 032 PMID 16713569 Li FQ Singh AM Mofunanya A Love D Terada N Moon RT Takemaru K 2007 Chibby Promotes Adipocyte Differentiation through Inhibition of b Catenin Signaling Mol Cell Biol 27 12 4347 54 doi 10 1128 MCB 01640 06 PMC 1900052 PMID 17403895 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Protein chibby homolog 1 amp oldid 1174268150, wikipedia, wiki, book, books, library,
