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Wikipedia

CBX3

January 01, 1970

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.[5][6]

CBX3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
External IDsOMIM: 604477; MGI: 108515; HomoloGene: 40583; GeneCards: CBX3; OMA:CBX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

11335

12417

Ensembl

ENSG00000122565

ENSMUSG00000029836

UniProt

Q13185

P23198

RefSeq (mRNA)

NM_007276
NM_016587

NM_001037798
NM_007624
NM_001355002

RefSeq (protein)

NP_009207
NP_057671

n/a

Location (UCSC)Chr 7: 26.2 – 26.21 MbChr 6: 51.45 – 51.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[6]

Interactions edit

CBX3 has been shown to interact with PIM1,[7] Ki-67,[8] Lamin B receptor,[9] CBX5[10] and CBX1.[10]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122565 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029836 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
  6. ^ a b "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
  7. ^ Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi:10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. S2CID 29392124.
  8. ^ Kametaka A, Takagi Masatoshi, Hayakawa Tomohiro, Haraguchi Tokuko, Hiraoka Yasushi, Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. S2CID 6802841.
  9. ^ Ye Q, Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349.
  10. ^ a b Nielsen AL, Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. hdl:10261/308369. ISSN 1097-2765. PMID 11336697.

Further reading edit

  • Ye Q, Callebaut I, Pezhman A, et al. (1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". J. Biol. Chem. 272 (23): 14983–9. doi:10.1074/jbc.272.23.14983. PMID 9169472.
  • Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. doi:10.1182/blood.V91.4.1216. PMID 9454751.
  • Seeler JS, Marchio A, Sitterlin D, et al. (1998). "Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7316–21. Bibcode:1998PNAS...95.7316S. doi:10.1073/pnas.95.13.7316. PMC 22602. PMID 9636146.
  • Lehming N, Le Saux A, Schüller J, Ptashne M (1998). "Chromatin components as part of a putative transcriptional repressing complex". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7322–6. Bibcode:1998PNAS...95.7322L. doi:10.1073/pnas.95.13.7322. PMC 22604. PMID 9636147.
  • Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1". J. Cell Biol. 143 (7): 1763–74. doi:10.1083/jcb.143.7.1763. PMC 2175214. PMID 9864353.
  • Ryan RF, Schultz DC, Ayyanathan K, et al. (1999). "KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing". Mol. Cell. Biol. 19 (6): 4366–78. doi:10.1128/mcb.19.6.4366. PMC 104396. PMID 10330177.
  • Minc E, Allory Y, Worman HJ, et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. doi:10.1007/s004120050372. PMID 10460410. S2CID 12381860.
  • Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
  • Koike N, Maita H, Taira T, et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi:10.1016/S0014-5793(00)01105-4. PMID 10664448. S2CID 29392124.
  • Minc E, Courvalin JC, Buendia B (2001). "HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes". Cytogenet. Cell Genet. 90 (3–4): 279–84. doi:10.1159/000056789. PMID 11124534. S2CID 24349769.
  • Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. Bibcode:2001Natur.410..116L. doi:10.1038/35065132. PMID 11242053. S2CID 4331863.
  • Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. hdl:10261/308369. PMID 11336697.
  • Scholzen T, Endl E, Wohlenberg C, et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364. S2CID 36130549.
  • Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. Bibcode:2002PNAS...99.5919V. doi:10.1073/pnas.092025499. PMC 122877. PMID 11959914.
  • Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135. S2CID 34863978.
  • Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kametaka A, Takagi M, Hayakawa T, et al. (2003). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi:10.1046/j.1365-2443.2002.00596.x. PMID 12485163. S2CID 6802841.
  • Cheutin T, McNairn AJ, Jenuwein T, et al. (2003). "Maintenance of stable heterochromatin domains by dynamic HP1 binding". Science. 299 (5607): 721–5. Bibcode:2003Sci...299..721C. doi:10.1126/science.1078572. PMID 12560555. S2CID 32776616.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
cbx3, chromobox, protein, homolog, protein, that, encoded, gene, humans, available, structurespdbortholog, search, pdbe, rcsblist, codes3tzd, 2l11, 3dm1, 3kupidentifiersaliases, hech, gamma, hp1hs, gamma, chromobox, 3external, idsomim, 604477, 108515, homologe. Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans 5 6 CBX3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3TZD 2L11 3DM1 3KUPIdentifiersAliasesCBX3 HECH HP1 GAMMA HP1Hs gamma chromobox 3External IDsOMIM 604477 MGI 108515 HomoloGene 40583 GeneCards CBX3 OMA CBX3 orthologsGene location Human Chr Chromosome 7 human 1 Band7p15 2Start26 201 162 bp 1 End26 213 607 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 B3 6 24 89 cMStart51 447 340 bp 2 End51 460 684 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellganglionic eminencevisceral pleuraparietal pleuragerminal epitheliumtibiatrabecular boneendometriumpalpebral conjunctivaBrodmann area 23Top expressed inmorulayolk sacsuperior frontal gyruslipspermatidspermatocytethymuscerebellar cortexneural tubeesophagusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein domain specific binding histone methyltransferase binding protein binding identical protein binding enzyme bindingCellular componentnuclear envelope spindle nuclear inner membrane chromatin chromosome centromeric region nucleus condensed chromosome centromeric region nucleoplasm site of DNA damage senescence associated heterochromatin focusBiological processchromatin remodeling regulation of transcription DNA templated rhythmic process transcription DNA templated negative regulation of transcription DNA templated negative regulation of G0 to G1 transition chromatin organization cellular response to DNA damage stimulus cellular response to dexamethasone stimulusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1133512417EnsemblENSG00000122565ENSMUSG00000029836UniProtQ13185P23198RefSeq mRNA NM 007276NM 016587NM 001037798NM 007624NM 001355002RefSeq protein NP 009207NP 057671n aLocation UCSC Chr 7 26 2 26 21 MbChr 6 51 45 51 46 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse At the nuclear envelope the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane The protein encoded by this gene binds DNA and is a component of heterochromatin This protein also can bind lamin B receptor an integral membrane protein found in the inner nuclear membrane The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane Two transcript variants encoding the same protein but differing in the 5 UTR have been found for this gene 6 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editCBX3 has been shown to interact with PIM1 7 Ki 67 8 Lamin B receptor 9 CBX5 10 and CBX1 10 See also editHeterochromatin protein 1References edit a b c GRCh38 Ensembl release 89 ENSG00000122565 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029836 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ye Q Worman HJ August 1996 Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 J Biol Chem 271 25 14653 6 doi 10 1074 jbc 271 25 14653 PMID 8663349 a b Entrez Gene CBX3 chromobox homolog 3 HP1 gamma homolog Drosophila Koike N Maita H Taira T Ariga H Iguchi Ariga S M February 2000 Identification of heterochromatin protein 1 HP1 as a phosphorylation target by Pim 1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1 1 FEBS Lett 467 1 17 21 doi 10 1016 S0014 5793 00 01105 4 ISSN 0014 5793 PMID 10664448 S2CID 29392124 Kametaka A Takagi Masatoshi Hayakawa Tomohiro Haraguchi Tokuko Hiraoka Yasushi Yoneda Yoshihiro December 2002 Interaction of the chromatin compaction inducing domain LR domain of Ki 67 antigen with HP1 proteins Genes Cells 7 12 1231 42 doi 10 1046 j 1365 2443 2002 00596 x ISSN 1356 9597 PMID 12485163 S2CID 6802841 Ye Q Worman H J June 1996 Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 J Biol Chem 271 25 14653 6 doi 10 1074 jbc 271 25 14653 ISSN 0021 9258 PMID 8663349 a b Nielsen AL Oulad Abdelghani M Ortiz J A Remboutsika E Chambon P Losson R April 2001 Heterochromatin formation in mammalian cells interaction between histones and HP1 proteins Mol Cell 7 4 729 39 doi 10 1016 S1097 2765 01 00218 0 hdl 10261 308369 ISSN 1097 2765 PMID 11336697 Further reading editYe Q Callebaut I Pezhman A et al 1997 Domain specific interactions of human HP1 type chromodomain proteins and inner nuclear membrane protein LBR J Biol Chem 272 23 14983 9 doi 10 1074 jbc 272 23 14983 PMID 9169472 Lessard J Baban S Sauvageau G 1998 Stage specific expression of polycomb group genes in human bone marrow cells Blood 91 4 1216 24 doi 10 1182 blood V91 4 1216 PMID 9454751 Seeler JS Marchio A Sitterlin D et al 1998 Interaction of SP100 with HP1 proteins A link between the promyelocytic leukemia associated nuclear bodies and the chromatin compartment Proc Natl Acad Sci U S A 95 13 7316 21 Bibcode 1998PNAS 95 7316S doi 10 1073 pnas 95 13 7316 PMC 22602 PMID 9636146 Lehming N Le Saux A Schuller J Ptashne M 1998 Chromatin components as part of a putative transcriptional repressing complex Proc Natl Acad Sci U S A 95 13 7322 6 Bibcode 1998PNAS 95 7322L doi 10 1073 pnas 95 13 7322 PMC 22604 PMID 9636147 Ainsztein AM Kandels Lewis SE Mackay AM Earnshaw WC 1999 INCENP Centromere and Spindle Targeting Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1 J Cell Biol 143 7 1763 74 doi 10 1083 jcb 143 7 1763 PMC 2175214 PMID 9864353 Ryan RF Schultz DC Ayyanathan K et al 1999 KAP 1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins a Potential Role for Kruppel Associated Box Zinc Finger Proteins in Heterochromatin Mediated Gene Silencing Mol Cell Biol 19 6 4366 78 doi 10 1128 mcb 19 6 4366 PMC 104396 PMID 10330177 Minc E Allory Y Worman HJ et al 1999 Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells Chromosoma 108 4 220 34 doi 10 1007 s004120050372 PMID 10460410 S2CID 12381860 Nielsen AL Ortiz JA You J et al 2000 Interaction with members of the heterochromatin protein 1 HP1 family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family EMBO J 18 22 6385 95 doi 10 1093 emboj 18 22 6385 PMC 1171701 PMID 10562550 Koike N Maita H Taira T et al 2000 Identification of heterochromatin protein 1 HP1 as a phosphorylation target by Pim 1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1 1 FEBS Lett 467 1 17 21 doi 10 1016 S0014 5793 00 01105 4 PMID 10664448 S2CID 29392124 Minc E Courvalin JC Buendia B 2001 HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes Cytogenet Cell Genet 90 3 4 279 84 doi 10 1159 000056789 PMID 11124534 S2CID 24349769 Lachner M O Carroll D Rea S et al 2001 Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins Nature 410 6824 116 20 Bibcode 2001Natur 410 116L doi 10 1038 35065132 PMID 11242053 S2CID 4331863 Nielsen AL Oulad Abdelghani M Ortiz JA et al 2001 Heterochromatin formation in mammalian cells interaction between histones and HP1 proteins Mol Cell 7 4 729 39 doi 10 1016 S1097 2765 01 00218 0 hdl 10261 308369 PMID 11336697 Scholzen T Endl E Wohlenberg C et al 2002 The Ki 67 protein interacts with members of the heterochromatin protein 1 HP1 family a potential role in the regulation of higher order chromatin structure J Pathol 196 2 135 44 doi 10 1002 path 1016 PMID 11793364 S2CID 36130549 Vassallo MF Tanese N 2002 Isoform specific interaction of HP1 with human TAFII130 Proc Natl Acad Sci U S A 99 9 5919 24 Bibcode 2002PNAS 99 5919V doi 10 1073 pnas 092025499 PMC 122877 PMID 11959914 Ogawa H Ishiguro K Gaubatz S et al 2002 A complex with chromatin modifiers that occupies E2F and Myc responsive genes in G0 cells Science 296 5570 1132 6 Bibcode 2002Sci 296 1132O doi 10 1126 science 1069861 PMID 12004135 S2CID 34863978 Hwang KK Worman HJ 2002 Gene regulation by human orthologs of Drosophila heterochromatin protein 1 Biochem Biophys Res Commun 293 4 1217 22 doi 10 1016 S0006 291X 02 00377 7 PMID 12054505 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kametaka A Takagi M Hayakawa T et al 2003 Interaction of the chromatin compaction inducing domain LR domain of Ki 67 antigen with HP1 proteins Genes Cells 7 12 1231 42 doi 10 1046 j 1365 2443 2002 00596 x PMID 12485163 S2CID 6802841 Cheutin T McNairn AJ Jenuwein T et al 2003 Maintenance of stable heterochromatin domains by dynamic HP1 binding Science 299 5607 721 5 Bibcode 2003Sci 299 721C doi 10 1126 science 1078572 PMID 12560555 S2CID 32776616 External links editCBX3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CBX3 genome location and CBX3 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title CBX3 amp oldid 1191214563, wikipedia, wiki, book, books, library,

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