CatSper4, is a protein which in humans is encoded by the CATSPER4gene.[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000188782 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000048003 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC184451. PMID 12932298.
^Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC1770895. PMID 17227845.
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
^*"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
catsper4, protein, which, humans, encoded, catsper4, gene, catsper1, member, cation, channels, sperm, family, protein, four, proteins, this, family, together, form, permeant, channel, specific, essential, correct, function, sperm, cells, catsper4identifiersali. CatSper4 is a protein which in humans is encoded by the CATSPER4 gene 5 6 7 CatSper1 is a member of the cation channels of sperm family of protein The four proteins in this family together form a Ca2 permeant ion channel specific essential for the correct function of sperm cells 8 CATSPER4IdentifiersAliasesCATSPER4 CatSper4 cation channel sperm associated 4External IDsOMIM 609121 MGI 3043288 HomoloGene 18638 GeneCards CATSPER4Gene location Human Chr Chromosome 1 human 1 Band1p36 11Start26 190 561 bp 1 End26 202 968 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D2 3Start133 939 281 bp 2 End133 954 694 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleskeletal muscle tissueright uterine tubelobe of thyroid glandleft lobe of thyroid glandtibial nerveTop expressed inspermatidtesticlespermatocytemuscle tissuequadriceps femoris musclejejunumskeletal muscle tissueislet of LangerhansduodenumileumMore reference expression dataBioGPSn aGene ontologyMolecular functionvoltage gated calcium channel activity calcium activated cation channel activity calcium channel activity voltage gated ion channel activity ion channel activity NAADP sensitive calcium release channel activityCellular componentintegral component of membrane CatSper complex cell projection membrane plasma membrane cilium sperm principal piece acrosomal vesicle motile ciliumBiological processflagellated sperm motility cell differentiation membrane depolarization during action potential sodium ion transport regulation of ion transmembrane transport ion transport multicellular organism development calcium ion transmembrane transport transmembrane transport spermatogenesis sperm egg recognition sperm capacitation release of sequestered calcium ion into cytosol calcium ion transport response to progesteroneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez378807329954EnsemblENSG00000188782ENSMUSG00000048003UniProtQ7RTX7Q8BVN3RefSeq mRNA NM 198137NM 001130030NM 177866RefSeq protein NP 937770NP 001123502NP 808534Location UCSC Chr 1 26 19 26 2 MbChr 4 133 94 133 95 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000188782 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000048003 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lobley A Pierron V Reynolds L Allen L Michalovich D August 2003 Identification of human and mouse CatSper3 and CatSper4 genes characterisation of a common interaction domain and evidence for expression in testis Reprod Biol Endocrinol 1 53 doi 10 1186 1477 7827 1 53 PMC 184451 PMID 12932298 Qi H Moran MM Navarro B Chong JA Krapivinsky G Krapivinsky L Kirichok Y Ramsey IS Quill TA Clapham DE January 2007 All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility Proc Natl Acad Sci U S A 104 4 1219 23 doi 10 1073 pnas 0610286104 PMC 1770895 PMID 17227845 Clapham DE Garbers DL December 2005 International Union of Pharmacology L Nomenclature and structure function relationships of CatSper and two pore channels Pharmacol Rev 57 4 451 4 doi 10 1124 pr 57 4 7 PMID 16382101 S2CID 35096827 CatSper and Two Pore Channels Introduction IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CatSper4 amp oldid 1081534881, wikipedia, wiki, book, books, library,
