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Wikipedia

CAMKK1

January 01, 1970

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.[5][6]

CAMKK1
Identifiers
AliasesCAMKK1, CAMKKA, calcium/calmodulin-dependent protein kinase kinase 1, calcium/calmodulin dependent protein kinase kinase 1
External IDsOMIM: 611411 MGI: 1891766 HomoloGene: 10327 GeneCards: CAMKK1
Orthologs
SpeciesHumanMouse
Entrez

84254

55984

Ensembl

ENSG00000004660

ENSMUSG00000020785

UniProt

Q8N5S9

Q8VBY2

RefSeq (mRNA)

NM_032294
NM_172206
NM_172207

NM_018883
NM_001362841

RefSeq (protein)

NP_115670
NP_757343
NP_757344

NP_061371
NP_001349770

Location (UCSC)Chr 17: 3.86 – 3.89 MbChr 11: 72.91 – 72.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.[6]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020785 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ a b "Entrez Gene: CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha".

External links edit

Further reading edit

  • Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. doi:10.1074/jbc.270.29.17616. PMID 7615569.
  • Tokumitsu H, Enslen H, Soderling TR (1995). "Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 270 (33): 19320–4. doi:10.1074/jbc.270.33.19320. PMID 7642608.
  • Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. doi:10.1074/jbc.271.10.5617. PMID 8621423.
  • Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
  • Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase". J. Biol. Chem. 274 (15): 10086–93. doi:10.1074/jbc.274.15.10086. PMID 10187789.
  • Lawson ND, Zain M, Zibello T, et al. (1999). "Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation". Exp. Hematol. 27 (11): 1682–90. doi:10.1016/S0301-472X(99)00108-3. PMID 10560916.
  • Okuno S, Kitani T, Matsuzaki H, et al. (2000). "Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases". J. Biochem. 127 (6): 965–70. doi:10.1093/oxfordjournals.jbchem.a022712. PMID 10833263.
  • Okuno S, Kitani T, Fujisawa H (2002). "Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis". J. Biochem. 130 (4): 503–13. doi:10.1093/oxfordjournals.jbchem.a003013. PMID 11574070.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Imai S, Okayama N, Shimizu M, Itoh M (2003). "Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells". Life Sci. 72 (20): 2199–209. doi:10.1016/S0024-3205(03)00092-4. PMID 12628440.
  • Ishikawa Y, Tokumitsu H, Inuzuka H, et al. (2003). "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells". FEBS Lett. 550 (1–3): 57–63. doi:10.1016/S0014-5793(03)00817-2. PMID 12935886. S2CID 22116744.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
camkk1, calcium, calmodulin, dependent, protein, kinase, kinase, enzyme, that, humans, encoded, gene, identifiersaliases, camkka, calcium, calmodulin, dependent, protein, kinase, kinase, calcium, calmodulin, dependent, protein, kinase, kinase, 1external, idsom. Calcium calmodulin dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene 5 6 CAMKK1IdentifiersAliasesCAMKK1 CAMKKA calcium calmodulin dependent protein kinase kinase 1 calcium calmodulin dependent protein kinase kinase 1External IDsOMIM 611411 MGI 1891766 HomoloGene 10327 GeneCards CAMKK1Gene location Human Chr Chromosome 17 human 1 Band17p13 2Start3 860 315 bp 1 End3 894 891 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B4Start72 909 834 bp 2 End72 932 899 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellBrodmann area 9prefrontal cortexmiddle temporal gyrusendothelial cellcingulate gyrusputamennucleus accumbenscaudate nucleusBrodmann area 23Top expressed insuperior frontal gyrushippocampus properfacial motor nucleusanterior horn of spinal cordprimary motor cortexcerebellar cortexsubiculummotor neuronprefrontal cortexpontine nucleiMore reference expression dataBioGPSn aGene ontologyMolecular functionkinase activity transferase activity nucleotide binding protein kinase activity protein serine threonine kinase activity protein binding ATP binding calmodulin dependent protein kinase activity calmodulin bindingCellular componentcytosol nucleus cytoplasm nucleoplasmBiological processprotein phosphorylation phosphorylation peptidyl serine phosphorylation peptidyl threonine phosphorylation intracellular signal transduction positive regulation of protein kinase activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8425455984EnsemblENSG00000004660ENSMUSG00000020785UniProtQ8N5S9Q8VBY2RefSeq mRNA NM 032294NM 172206NM 172207NM 018883NM 001362841RefSeq protein NP 115670NP 757343NP 757344NP 061371NP 001349770Location UCSC Chr 17 3 86 3 89 MbChr 11 72 91 72 93 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The product of this gene belongs to the serine threonine protein kinase family and to the Ca 2 calmodulin dependent protein kinase CAMK subfamily This protein plays a role in the calcium calmodulin dependent CaM kinase cascade Three transcript variants encoding two distinct isoforms have been identified for this gene 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000004660 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020785 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wiemann S Weil B Wellenreuther R Gassenhuber J Glassl S Ansorge W Bocher M Blocker H Bauersachs S Blum H Lauber J Dusterhoft A Beyer A Kohrer K Strack N Mewes HW Ottenwalder B Obermaier B Tampe J Heubner D Wambutt R Korn B Klein M Poustka A Mar 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 a b Entrez Gene CAMKK1 calcium calmodulin dependent protein kinase kinase 1 alpha External links editHuman CAMKK1 genome location and CAMKK1 gene details page in the UCSC Genome Browser Further reading editSelbert MA Anderson KA Huang QH et al 1995 Phosphorylation and activation of Ca 2 calmodulin dependent protein kinase IV by Ca 2 calmodulin dependent protein kinase Ia kinase Phosphorylation of threonine 196 is essential for activation J Biol Chem 270 29 17616 21 doi 10 1074 jbc 270 29 17616 PMID 7615569 Tokumitsu H Enslen H Soderling TR 1995 Characterization of a Ca2 calmodulin dependent protein kinase cascade Molecular cloning and expression of calcium calmodulin dependent protein kinase kinase J Biol Chem 270 33 19320 4 doi 10 1074 jbc 270 33 19320 PMID 7642608 Tokumitsu H Soderling TR 1996 Requirements for calcium and calmodulin in the calmodulin kinase activation cascade J Biol Chem 271 10 5617 22 doi 10 1074 jbc 271 10 5617 PMID 8621423 Matsushita M Nairn AC 1998 Characterization of the mechanism of regulation of Ca2 calmodulin dependent protein kinase I by calmodulin and by Ca2 calmodulin dependent protein kinase kinase J Biol Chem 273 34 21473 81 doi 10 1074 jbc 273 34 21473 PMID 9705275 Matsushita M Nairn AC 1999 Inhibition of the Ca2 calmodulin dependent protein kinase I cascade by cAMP dependent protein kinase J Biol Chem 274 15 10086 93 doi 10 1074 jbc 274 15 10086 PMID 10187789 Lawson ND Zain M Zibello T et al 1999 Modulation of a calcium calmodulin dependent protein kinase cascade by retinoic acid during neutrophil maturation Exp Hematol 27 11 1682 90 doi 10 1016 S0301 472X 99 00108 3 PMID 10560916 Okuno S Kitani T Matsuzaki H et al 2000 Studies on the phosphorylation of protein kinase B by Ca 2 calmodulin dependent protein kinases J Biochem 127 6 965 70 doi 10 1093 oxfordjournals jbchem a022712 PMID 10833263 Okuno S Kitani T Fujisawa H 2002 Regulation of Ca 2 calmodulin dependent protein kinase kinase alpha by cAMP dependent protein kinase I Biochemical analysis J Biochem 130 4 503 13 doi 10 1093 oxfordjournals jbchem a003013 PMID 11574070 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Imai S Okayama N Shimizu M Itoh M 2003 Increased intracellular calcium activates serum and glucocorticoid inducible kinase 1 SGK1 through a calmodulin calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells Life Sci 72 20 2199 209 doi 10 1016 S0024 3205 03 00092 4 PMID 12628440 Ishikawa Y Tokumitsu H Inuzuka H et al 2003 Identification and characterization of novel components of a Ca2 calmodulin dependent protein kinase cascade in HeLa cells FEBS Lett 550 1 3 57 63 doi 10 1016 S0014 5793 03 00817 2 PMID 12935886 S2CID 22116744 Jin J Smith FD Stark C et al 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization Curr Biol 14 16 1436 50 Bibcode 2004CBio 14 1436J doi 10 1016 j cub 2004 07 051 PMID 15324660 S2CID 2371325 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CAMKK1 amp oldid 1214948282, wikipedia, wiki, book, books, library,

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