Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel and a voltage-gated ATP channel that in humans is encoded by the CALHM1gene.[5][6]
CALHM1 was identified by a tissue-specific gene expression profiling approach[7] that screened for genes located on susceptibility loci for late-onset Alzheimer's disease (AD) and that are preferentially expressed in the hippocampus,[5] a brain region affected early in AD. CALHM1 is a plasma membrane calcium-permeable ion channel regulated by voltage and extracellular calcium levels.[8] The exact function of CALHM1 in the brain is not completely understood, but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling, as well as calcium-dependent neuronal excitability and memory in mouse models.[8][9][10] Recent data have also shown that CALHM1 might facilitate the proteolytic degradation of the cerebral amyloid beta peptide, a culprit in AD pathogenesis.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000185933 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000079258 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abDreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P (Jun 2008). "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk". Cell. 133 (7): 1149–61. doi:10.1016/j.cell.2008.05.048. PMC2577842. PMID 18585350.
^Taruno A, Matsumoto I, Ma Z, Marambaud P, Foskett JK (December 2013). "How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel". BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology. 35 (12): 1111–8. doi:10.1002/bies.201300077. PMC3981604. PMID 24105910.
^Skrabanek L, Campagne F (Nov 2001). "TissueInfo: high-throughput identification of tissue expression profiles and specificity". Nucleic Acids Research. 29 (21): E102-2. doi:10.1093/nar/29.21.e102. PMC60201. PMID 11691939.
^ abMa Z, Siebert AP, Cheung KH, Lee RJ, Johnson B, Cohen AS, Vingtdeux V, Marambaud P, Foskett JK (Jul 2012). "Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability". Proceedings of the National Academy of Sciences of the United States of America. 109 (28): E1963-71. Bibcode:2012PNAS..109E1963M. doi:10.1073/pnas.1204023109. PMC3396471. PMID 22711817.
^Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P (Mar 2013). "CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons". J Cell Sci. 126 (Pt 5): 1199–206. doi:10.1242/jcs.117135. PMC4481642. PMID 23345406.
^Vingtdeux V, Chang EH, Frattini SA, Zhao H, Chandakkar P, Adrien L, Strohl JJ, Gibson EL, Ohmoto M, Matsumoto I, Huerta PT, Marambaud P (Apr 2016). "CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice". Sci Rep. 6 (24250): 24250. Bibcode:2016NatSR...624250V. doi:10.1038/srep24250. PMC4828655. PMID 27066908.
^Vingtdeux V, Chandakkar P, Zhao H, Blanc L, Ruiz S, Marambaud P (May 2015). "CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain". J Cell Sci. 128 (13): 2330–8. doi:10.1242/jcs.167270. PMC4524106. PMID 25999473.
^Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan MM, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK (Mar 2013). "CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes". Nature. 495 (7440): 223–6. Bibcode:2013Natur.495..223T. doi:10.1038/nature11906. PMC3600154. PMID 23467090.
^Kinnamon SC, Finger TE (Dec 2013). "A taste for ATP: neurotransmission in taste buds". Front Cell Neurosci. 7: 264. doi:10.3389/fncel.2013.00264. PMC3866518. PMID 24385952.
External linksedit
Human CALHM1 genome location and CALHM1 gene details page in the UCSC Genome Browser.
Further readingedit
Moyer BD, Hevezi P, Gao N, Lu M, Kalabat D, Soto H, Echeverri F, Laita B, Yeh SA, Zoller M, Zlotnik A (Dec 2009). "Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations". PLOS ONE. 4 (12): e7682. Bibcode:2009PLoSO...4.7682M. doi:10.1371/journal.pone.0007682. PMC2780358. PMID 19997627.
Moreno-Ortega AJ, Ruiz-Nuño A, García AG, Cano-Abad MF (Jan 2010). "Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1". Biochemical and Biophysical Research Communications. 391 (1): 722–6. doi:10.1016/j.bbrc.2009.11.127. PMID 19944073.
Desharnais R, Godin G, Jobin J, Valois P, Ross A (Dec 1990). "Optimism and health-relevant cognitions after a myocardial infarction". Psychological Reports. 67 (3 Pt 2): 1131–1135. doi:10.2466/pr0.1990.67.3f.1131. PMID 2084739. S2CID 46335269.
Lv RJ, He JS, Fu YH, Shao XQ, Wu LW, Lu Q, Jin LR, Liu H (Apr 2011). "A polymorphism in CALHM1 is associated with temporal lobe epilepsy". Epilepsy & Behavior. 20 (4): 681–5. doi:10.1016/j.yebeh.2011.02.007. PMID 21439911. S2CID 45287698.
January 01, 1970
calhm1, calcium, homeostasis, modulator, pore, forming, subunit, voltage, gated, channel, voltage, gated, channel, that, humans, encoded, gene, identifiersaliases, fam26c, calcium, homeostasis, modulator, 1external, idsomim, 612234, 3643383, homologene, 55508,. Calcium homeostasis modulator 1 CALHM1 is a pore forming subunit of a voltage gated ion channel and a voltage gated ATP channel that in humans is encoded by the CALHM1 gene 5 6 CALHM1IdentifiersAliasesCALHM1 FAM26C calcium homeostasis modulator 1External IDsOMIM 612234 MGI 3643383 HomoloGene 55508 GeneCards CALHM1Gene location Human Chr Chromosome 10 human 1 Band10q24 33Start103 453 240 bp 1 End103 458 900 bp 1 Gene location Mouse Chr Chromosome 19 mouse 2 Band19 19 C3Start47 129 348 bp 2 End47 132 693 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellprefrontal cortexexternal globus pallidussuperior vestibular nucleusBrodmann area 9occipital lobeBrodmann area 23superior frontal gyrusmetencephaloncerebellumn aMore reference expression dataBioGPSn aGene ontologyMolecular functionvoltage gated calcium channel activity calcium activated cation channel activity calcium channel activity voltage gated ion channel activity identical protein bindingCellular componentintegral component of membrane endoplasmic reticulum membrane membrane plasma membrane integral component of plasma membrane endoplasmic reticulumBiological processsensory perception of umami taste ATP transport regulation of ion transmembrane transport cation transport ion transport sensory perception of bitter taste calcium ion transmembrane transport sensory perception of sweet taste protein homooligomerization sensory perception of taste calcium ion transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez255022546729EnsemblENSG00000185933ENSMUSG00000079258UniProtQ8IU99D3Z291RefSeq mRNA NM 001001412NM 001081271RefSeq protein NP 001001412NP 001074740Location UCSC Chr 10 103 45 103 46 MbChr 19 47 13 47 13 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 1 1 Central nervous system 1 2 Peripheral taste system 2 See also 3 References 4 External links 5 Further readingFunction editCentral nervous system edit CALHM1 was identified by a tissue specific gene expression profiling approach 7 that screened for genes located on susceptibility loci for late onset Alzheimer s disease AD and that are preferentially expressed in the hippocampus 5 a brain region affected early in AD CALHM1 is a plasma membrane calcium permeable ion channel regulated by voltage and extracellular calcium levels 8 The exact function of CALHM1 in the brain is not completely understood but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling as well as calcium dependent neuronal excitability and memory in mouse models 8 9 10 Recent data have also shown that CALHM1 might facilitate the proteolytic degradation of the cerebral amyloid beta peptide a culprit in AD pathogenesis 11 Peripheral taste system edit CALHM1 is expressed in taste bud cells where it controls purinergic receptor mediated taste transduction in the gustatory system 12 13 See also editRuthenium redReferences edit a b c GRCh38 Ensembl release 89 ENSG00000185933 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000079258 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Dreses Werringloer U Lambert JC Vingtdeux V Zhao H Vais H Siebert A Jain A Koppel J Rovelet Lecrux A Hannequin D Pasquier F Galimberti D Scarpini E Mann D Lendon C Campion D Amouyel P Davies P Foskett JK Campagne F Marambaud P Jun 2008 A polymorphism in CALHM1 influences Ca2 homeostasis Abeta levels and Alzheimer s disease risk Cell 133 7 1149 61 doi 10 1016 j cell 2008 05 048 PMC 2577842 PMID 18585350 Taruno A Matsumoto I Ma Z Marambaud P Foskett JK December 2013 How do taste cells lacking synapses mediate neurotransmission CALHM1 a voltage gated ATP channel BioEssays News and Reviews in Molecular Cellular and Developmental Biology 35 12 1111 8 doi 10 1002 bies 201300077 PMC 3981604 PMID 24105910 Skrabanek L Campagne F Nov 2001 TissueInfo high throughput identification of tissue expression profiles and specificity Nucleic Acids Research 29 21 E102 2 doi 10 1093 nar 29 21 e102 PMC 60201 PMID 11691939 a b Ma Z Siebert AP Cheung KH Lee RJ Johnson B Cohen AS Vingtdeux V Marambaud P Foskett JK Jul 2012 Calcium homeostasis modulator 1 CALHM1 is the pore forming subunit of an ion channel that mediates extracellular Ca2 regulation of neuronal excitability Proceedings of the National Academy of Sciences of the United States of America 109 28 E1963 71 Bibcode 2012PNAS 109E1963M doi 10 1073 pnas 1204023109 PMC 3396471 PMID 22711817 Dreses Werringloer U Vingtdeux V Zhao H Chandakkar P Davies P Marambaud P Mar 2013 CALHM1 controls the Ca dependent MEK ERK RSK and MSK signaling cascade in neurons J Cell Sci 126 Pt 5 1199 206 doi 10 1242 jcs 117135 PMC 4481642 PMID 23345406 Vingtdeux V Chang EH Frattini SA Zhao H Chandakkar P Adrien L Strohl JJ Gibson EL Ohmoto M Matsumoto I Huerta PT Marambaud P Apr 2016 CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice Sci Rep 6 24250 24250 Bibcode 2016NatSR 624250V doi 10 1038 srep24250 PMC 4828655 PMID 27066908 Vingtdeux V Chandakkar P Zhao H Blanc L Ruiz S Marambaud P May 2015 CALHM1 ion channel elicits amyloid b clearance by insulin degrading enzyme in cell lines and in vivo in the mouse brain J Cell Sci 128 13 2330 8 doi 10 1242 jcs 167270 PMC 4524106 PMID 25999473 Taruno A Vingtdeux V Ohmoto M Ma Z Dvoryanchikov G Li A Adrien L Zhao H Leung S Abernethy M Koppel J Davies P Civan MM Chaudhari N Matsumoto I Hellekant G Tordoff MG Marambaud P Foskett JK Mar 2013 CALHM1 ion channel mediates purinergic neurotransmission of sweet bitter and umami tastes Nature 495 7440 223 6 Bibcode 2013Natur 495 223T doi 10 1038 nature11906 PMC 3600154 PMID 23467090 Kinnamon SC Finger TE Dec 2013 A taste for ATP neurotransmission in taste buds Front Cell Neurosci 7 264 doi 10 3389 fncel 2013 00264 PMC 3866518 PMID 24385952 External links editHuman CALHM1 genome location and CALHM1 gene details page in the UCSC Genome Browser Further reading editMoyer BD Hevezi P Gao N Lu M Kalabat D Soto H Echeverri F Laita B Yeh SA Zoller M Zlotnik A Dec 2009 Expression of genes encoding multi transmembrane proteins in specific primate taste cell populations PLOS ONE 4 12 e7682 Bibcode 2009PLoSO 4 7682M doi 10 1371 journal pone 0007682 PMC 2780358 PMID 19997627 Moreno Ortega AJ Ruiz Nuno A Garcia AG Cano Abad MF Jan 2010 Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L CALHM1 Biochemical and Biophysical Research Communications 391 1 722 6 doi 10 1016 j bbrc 2009 11 127 PMID 19944073 Desharnais R Godin G Jobin J Valois P Ross A Dec 1990 Optimism and health relevant cognitions after a myocardial infarction Psychological Reports 67 3 Pt 2 1131 1135 doi 10 2466 pr0 1990 67 3f 1131 PMID 2084739 S2CID 46335269 Lv RJ He JS Fu YH Shao XQ Wu LW Lu Q Jin LR Liu H Apr 2011 A polymorphism in CALHM1 is associated with temporal lobe epilepsy Epilepsy amp Behavior 20 4 681 5 doi 10 1016 j yebeh 2011 02 007 PMID 21439911 S2CID 45287698 Retrieved from https en wikipedia org w index php title CALHM1 amp oldid 1116596934, wikipedia, wiki, book, books, library,
