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Borrelia lusitaniae

January 01, 1970

Borrelia lusitaniae is a bacterium of the spirochete class of the genus Borrelia, which has a diderm (double-membrane) envelope.[1] It is a part of the Borrelia burgdorferi sensu lato genospecies[2] and is a Gram-negative bacterium. B. lusitaniae is tick-borne; he type strain is PotiB2.[1] It can be pathogenic, being involved in cases of Lyme borreliosis.[3][4][5] A species of tick, Ixodes ricinus, is the host of B. lusitaniae. It is thought to have originated from Portugal and has since spread to parts of Europe and North Africa. Lizards of the family Lacertidae are now believed to be important reservoir hosts of this bacterium.[2]

Borrelia lusitaniae
Scientific classification
Domain: Bacteria
Phylum: Spirochaetota
Class: Spirochaetia
Order: Spirochaetales
Family: Borreliaceae
Genus: Borrelia
Species:
B. lusitaniae
Binomial name
Borrelia lusitaniae
Le Fleche et al., 1997

Origin and distribution edit

While B. lusitaniae is distributed throughout countries in Europe and North Africa, it is the sole species of the Lyme borreliosis group in southern Portugal. Lizards of the family Lacertidae are believed to be important reservoir hosts of B. lusitaniae.[2] They were first isolated in Portugal in 1993.[3] These lizards that include the sand lizard and common wall lizard[6] are known to be highly structured phylogeographically. Migration is very limited between the lizard populations from different localities and it has shed light into the evolution and epidemiology of B. lusitaniae. The pronounced population structure of B. lusitaniae over a short geographic distance (southern Portugal) by housekeeping genes indicates that the migration rates of B. lusitaniae are rather low, because the distribution of Mediterranean lizard populations is highly parapatric.[2]

Different populations of B. lusitaniae are known. Seven strains of B. lusitaniae sp. nov. have been isolated from Ixodes ricinus ticks in Portugal, the Czech Republic, Moldavia, Ukraine, and Belarus.[1][7] Local populations have diverged through vicariance, because climate change after the last ice age generated ecological barriers between Mafra and Grândola. In more northern or eastern countries, B. lusitaniae has been detected at only a few sites, at which it infects ticks less frequently than it does on the Mediterranean coast,[6] although in Morocco and Tunisia, 96.6-100% of the Borrelia species present were B. lusitaniae.[7]

In lizards edit

Because lizards are considered important reservoir hosts of B. lusitaniae, their limited dispersal affects the migration rates of B. lusitaniae. This results in the fine-scale geographic structure of this tick-borne bacterium. Although I. ricinus ticks infected with B. lusitaniae may be dispersed rapidly over long distances when feeding on mobile hosts, such as migratory birds, this is unlikely to be an important process in the effective dispersal of B. lusitaniae.[8] Feeding tick larvae apparently do not acquire B. lusitaniae from vertebrate species other than lizards. However, B. lusitaniae-infected nymphs that feed on long-distance migrants give rise to hunting adult ticks that subsequently feed on larger animals, such as deer, which are not reservoir-competent for any of the species of the Lyme borreliosis group of spirochetes. Therefore, only larvae and nymphs that feed on lizards maintain the cycles of B. lusitaniae. So, the migration rates of B. lusitaniae are determined by those of lizards.[8]

In humans edit

To date, the reservoir of B. lusitaniae has not been fully defined, and little is known about the ecology of this genospecies. It is known to cause experimental disease in mouse models, suggesting that some strains could also be connected with human Lyme borreliosis. The first known isolate of Borrelia was in Portugal. A 46-year-old woman from the Lisbon area presented with skin lesions on her left thigh that had persisted about 10 years.[3][7] Molecular analysis of the patient isolate allowed the classification of the strain to B. lusitaniae, a genospecies previously thought to be nonpathogenic in humans[7] The woman had a weak serological response, which is present in a high percentage of patients with unspecific and long-lasting skin manifestations. This suggests a clinical pattern for B. lusitaniae different from those for other Borrelia spp. in the Portuguese population compared to date .[3]

Plasmids edit

The plasmid profiles of B. lusitaniae strains usually range from 19 to 76 kb.[8] In the case of B. lusitaniae, the number of plasmids is quite low and the species lacks all the small plasmids described for the other Borrelia species with medical importance in Lyme borreliosis. Because most of the Borrelia virulence genes are located on plasmids, including genes that encode for OspC, Erps, and CRASP proteins, the low number of these genetic elements in B. lusitaniae strains could be associated with the lower infectivity reported for this species since only two human isolates have been found so far. Furthermore, the number (0.04/100,000 inhabitants) of reported cases in Portugal is not as high as in other European countries despite a high reported infection prevalence of B. lusitaniae in ticks.[8]

References edit

  1. ^ a b c Fleche, A.L.; Postic, D.; Girardet, K.; Peter, O.; Baranton, G. (1997). "Characterization of Borrelia lusitaniae sp. nov. by 16S Ribosomal DNA Sequence Analysis". International Journal of Systematic Bacteriology. 47 (4): 921–925. doi:10.1099/00207713-47-4-921. ISSN 0020-7713. PMID 9336887.
  2. ^ a b c d Vitorino, L. L.; Margos, G.; Feil, E.; Collares-Pereira, M.; Ze-Ze, L. (2008). "Fine-Scale Phylogeographic Structure of Borrelia lusitaniae Revealed by Multilocus Sequence Typing". PLOS ONE. 3 (12): 1–13. Bibcode:2008PLoSO...3.4002V. doi:10.1371/journal.pone.0004002. PMC 2602731. PMID 19104655.
  3. ^ a b c d Collares-Pereira, M.; Couceiro, S.; Franca, I.; Kurtenbach, K.; Schafer, S. M.; Vitorino, L.; Goncalves, L.; Baptista, S.; Vieira, M. L.; Cunha, C. (2004). "First Isolation of Borrelia lusitaniae from a Human Patient". Journal of Clinical Microbiology. 42 (3): 1316–1318. doi:10.1128/JCM.42.3.1316-1318.2004. ISSN 0095-1137. PMC 356816. PMID 15004107.
  4. ^ da Franca I, Santos L, Mesquita T, et al. (June 2005). "Lyme borreliosis in Portugal caused by Borrelia lusitaniae? Clinical report on the first patient with a positive skin isolate". Wiener Klinische Wochenschrift. 117 (11–12): 429–32. doi:10.1007/s00508-005-0386-z. PMID 16053200. S2CID 9870590.
  5. ^ Lopes de Carvalho, I.; Fonseca, J. E.; Marques, J. G.; Ullmann, A.; Hojgaard, A.; Zeidner, N.; Núncio, M. S. (2008). "Vasculitis-like syndrome associated with Borrelia lusitaniae infection". Clinical Rheumatology. 27 (12): 1587–1591. doi:10.1007/s10067-008-1012-z. ISSN 0770-3198. PMID 18795392. S2CID 2329665.
  6. ^ a b Richter, D.; Matuschka, F. (2006). "Perpetuation of the Lyme Disease Spirochete Borrelia lusitaniae by Lizards". Applied and Environmental Microbiology. 72 (7): 4627–4632. Bibcode:2006ApEnM..72.4627R. doi:10.1128/aem.00285-06. ISSN 0099-2240. PMC 1489336. PMID 16820453.
  7. ^ a b c d Younsi, H. L.; Sarih, M.; Jouda, F.; Godfroid, E.; Gern, L.; Bouattour, A.; Baranton, G.; Postic, D. (2005). "Characterization of Borrelia lusitaniae Isolates Collected in Tunisia and Morocco". Journal of Clinical Microbiology. 43 (4): 1587–1593. doi:10.1128/jcm.43.4.1587-1593.2005. PMC 1081310. PMID 15814970.
  8. ^ a b c d Vitorino, L. L.; Margos, G.; Zé-Zé, L.; Kurtenbach, K.; Collares-Pereira n, M. (2010). "Plasmid profile analysis of Portuguese Borrelia lusitaniae strains". Ticks and Tick-Borne Diseases. 1 (3): 125–126. doi:10.1016/j.ttbdis.2010.07.001. PMID 21771519.

Further reading edit

  • Ishii N, Isogai E, Isogai H, et al. (1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". Microbiology and Immunology. 39 (12): 929–35. doi:10.1111/j.1348-0421.1995.tb03295.x. PMID 8789051.
  • Richter, D.; Matuschka, F.-R. (2006). "Perpetuation of the Lyme Disease Spirochete Borrelia lusitaniae by Lizards". Applied and Environmental Microbiology. 72 (7): 4627–4632. Bibcode:2006ApEnM..72.4627R. doi:10.1128/AEM.00285-06. ISSN 0099-2240. PMC 1489336. PMID 16820453.
  • Kurtenback, K. L.; Hanincová, K.; Tsao, J.; Margos, G.; Fish, D.; Ogden, N. (2006). "Fundamental processes in the evolutionary ecology of Lyme borreliosis". Nature Reviews Microbiology. 4 (9): 660–669. doi:10.1038/nrmicro1475. ISSN 1740-1526. PMID 16894341. S2CID 10877654.

External links edit

  • NCBI Taxonomy Browser - Borrelia
  • UniProct Identification
  • Type strain of Borrelia lusitaniae at BacDive - the Bacterial Diversity Metadatabase

January 01, 1970
borrelia, lusitaniae, bacterium, spirochete, class, genusborrelia, which, diderm, double, membrane, envelope, part, borrelia, burgdorferi, sensu, lato, genospecies, gram, negative, bacterium, lusitaniae, tick, borne, type, strain, potib2, pathogenic, being, in. Borrelia lusitaniae is a bacterium of the spirochete class of the genusBorrelia which has a diderm double membrane envelope 1 It is a part of the Borrelia burgdorferi sensu lato genospecies 2 and is a Gram negative bacterium B lusitaniae is tick borne he type strain is PotiB2 1 It can be pathogenic being involved in cases of Lyme borreliosis 3 4 5 A species of tick Ixodes ricinus is the host of B lusitaniae It is thought to have originated from Portugal and has since spread to parts of Europe and North Africa Lizards of the family Lacertidae are now believed to be important reservoir hosts of this bacterium 2 Borrelia lusitaniae Scientific classification Domain Bacteria Phylum Spirochaetota Class Spirochaetia Order Spirochaetales Family Borreliaceae Genus Borrelia Species B lusitaniae Binomial name Borrelia lusitaniaeLe Fleche et al 1997 Contents 1 Origin and distribution 2 In lizards 3 In humans 4 Plasmids 5 References 6 Further reading 7 External linksOrigin and distribution editWhile B lusitaniae is distributed throughout countries in Europe and North Africa it is the sole species of the Lyme borreliosis group in southern Portugal Lizards of the family Lacertidae are believed to be important reservoir hosts of B lusitaniae 2 They were first isolated in Portugal in 1993 3 These lizards that include the sand lizard and common wall lizard 6 are known to be highly structured phylogeographically Migration is very limited between the lizard populations from different localities and it has shed light into the evolution and epidemiology of B lusitaniae The pronounced population structure of B lusitaniae over a short geographic distance southern Portugal by housekeeping genes indicates that the migration rates of B lusitaniae are rather low because the distribution of Mediterranean lizard populations is highly parapatric 2 Different populations of B lusitaniae are known Seven strains of B lusitaniae sp nov have been isolated from Ixodes ricinus ticks in Portugal the Czech Republic Moldavia Ukraine and Belarus 1 7 Local populations have diverged through vicariance because climate change after the last ice age generated ecological barriers between Mafra and Grandola In more northern or eastern countries B lusitaniae has been detected at only a few sites at which it infects ticks less frequently than it does on the Mediterranean coast 6 although in Morocco and Tunisia 96 6 100 of the Borrelia species present were B lusitaniae 7 In lizards editBecause lizards are considered important reservoir hosts of B lusitaniae their limited dispersal affects the migration rates of B lusitaniae This results in the fine scale geographic structure of this tick borne bacterium Although I ricinus ticks infected with B lusitaniae may be dispersed rapidly over long distances when feeding on mobile hosts such as migratory birds this is unlikely to be an important process in the effective dispersal of B lusitaniae 8 Feeding tick larvae apparently do not acquire B lusitaniae from vertebrate species other than lizards However B lusitaniae infected nymphs that feed on long distance migrants give rise to hunting adult ticks that subsequently feed on larger animals such as deer which are not reservoir competent for any of the species of the Lyme borreliosis group of spirochetes Therefore only larvae and nymphs that feed on lizards maintain the cycles ofB lusitaniae So the migration rates of B lusitaniae are determined by those of lizards 8 In humans editTo date the reservoir ofB lusitaniae has not been fully defined and little is known about the ecology of this genospecies It is known to cause experimental disease in mouse models suggesting that some strains could also be connected with human Lyme borreliosis The first known isolate of Borrelia was in Portugal A 46 year old woman from the Lisbon area presented with skin lesions on her left thigh that had persisted about 10 years 3 7 Molecular analysis of the patient isolate allowed the classification of the strain to B lusitaniae a genospecies previously thought to be nonpathogenic in humans 7 The woman had a weak serological response which is present in a high percentage of patients with unspecific and long lasting skin manifestations This suggests a clinical pattern for B lusitaniae different from those for other Borrelia spp in the Portuguese population compared to date 3 Plasmids editThe plasmid profiles of B lusitaniae strains usually range from 19 to 76 kb 8 In the case of B lusitaniae the number of plasmids is quite low and the species lacks all the small plasmids described for the otherBorrelia species with medical importance in Lyme borreliosis Because most of theBorreliavirulence genes are located on plasmids including genes that encode for OspC Erps and CRASP proteins the low number of these genetic elements in B lusitaniae strains could be associated with the lower infectivity reported for this species since only two human isolates have been found so far Furthermore the number 0 04 100 000 inhabitants of reported cases in Portugal is not as high as in other European countries despite a high reported infection prevalence of B lusitaniae in ticks 8 References edit a b c Fleche A L Postic D Girardet K Peter O Baranton G 1997 Characterization of Borrelia lusitaniae sp nov by 16S Ribosomal DNA Sequence Analysis International Journal of Systematic Bacteriology 47 4 921 925 doi 10 1099 00207713 47 4 921 ISSN 0020 7713 PMID 9336887 a b c d Vitorino L L Margos G Feil E Collares Pereira M Ze Ze L 2008 Fine Scale Phylogeographic Structure of Borrelia lusitaniae Revealed by Multilocus Sequence Typing PLOS ONE 3 12 1 13 Bibcode 2008PLoSO 3 4002V doi 10 1371 journal pone 0004002 PMC 2602731 PMID 19104655 a b c d Collares Pereira M Couceiro S Franca I Kurtenbach K Schafer S M Vitorino L Goncalves L Baptista S Vieira M L Cunha C 2004 First Isolation of Borrelia lusitaniae from a Human Patient Journal of Clinical Microbiology 42 3 1316 1318 doi 10 1128 JCM 42 3 1316 1318 2004 ISSN 0095 1137 PMC 356816 PMID 15004107 da Franca I Santos L Mesquita T et al June 2005 Lyme borreliosis in Portugal caused by Borrelia lusitaniae Clinical report on the first patient with a positive skin isolate Wiener Klinische Wochenschrift 117 11 12 429 32 doi 10 1007 s00508 005 0386 z PMID 16053200 S2CID 9870590 Lopes de Carvalho I Fonseca J E Marques J G Ullmann A Hojgaard A Zeidner N Nuncio M S 2008 Vasculitis like syndrome associated with Borrelia lusitaniae infection Clinical Rheumatology 27 12 1587 1591 doi 10 1007 s10067 008 1012 z ISSN 0770 3198 PMID 18795392 S2CID 2329665 a b Richter D Matuschka F 2006 Perpetuation of the Lyme Disease Spirochete Borrelia lusitaniae by Lizards Applied and Environmental Microbiology 72 7 4627 4632 Bibcode 2006ApEnM 72 4627R doi 10 1128 aem 00285 06 ISSN 0099 2240 PMC 1489336 PMID 16820453 a b c d Younsi H L Sarih M Jouda F Godfroid E Gern L Bouattour A Baranton G Postic D 2005 Characterization of Borrelia lusitaniae Isolates Collected in Tunisia and Morocco Journal of Clinical Microbiology 43 4 1587 1593 doi 10 1128 jcm 43 4 1587 1593 2005 PMC 1081310 PMID 15814970 a b c d Vitorino L L Margos G Ze Ze L Kurtenbach K Collares Pereira n M 2010 Plasmid profile analysis of Portuguese Borrelia lusitaniae strains Ticks and Tick Borne Diseases 1 3 125 126 doi 10 1016 j ttbdis 2010 07 001 PMID 21771519 Further reading editIshii N Isogai E Isogai H et al 1995 T cell response to Borrelia garinii Borrelia afzelii and Borrelia japonica in various congenic mouse strains Microbiology and Immunology 39 12 929 35 doi 10 1111 j 1348 0421 1995 tb03295 x PMID 8789051 Richter D Matuschka F R 2006 Perpetuation of the Lyme Disease Spirochete Borrelia lusitaniae by Lizards Applied and Environmental Microbiology 72 7 4627 4632 Bibcode 2006ApEnM 72 4627R doi 10 1128 AEM 00285 06 ISSN 0099 2240 PMC 1489336 PMID 16820453 Kurtenback K L Hanincova K Tsao J Margos G Fish D Ogden N 2006 Fundamental processes in the evolutionary ecology of Lyme borreliosis Nature Reviews Microbiology 4 9 660 669 doi 10 1038 nrmicro1475 ISSN 1740 1526 PMID 16894341 S2CID 10877654 External links editNCBI Taxonomy Browser Borrelia UniProct Identification Type strain of Borrelia lusitaniae at BacDive the Bacterial Diversity Metadatabase Retrieved from https en wikipedia org w index php title Borrelia lusitaniae amp oldid 1136304977, wikipedia, wiki, book, books, library,

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