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Wikipedia

BRD7

April 15, 2024

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.[5][6][7]

BRD7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRD7, BP75, CELTIX1, NAG4, bromodomain containing 7, SMARCI1
External IDsOMIM: 618489 MGI: 1349766 HomoloGene: 8085 GeneCards: BRD7
Orthologs
SpeciesHumanMouse
Entrez

29117

26992

Ensembl

ENSG00000166164

ENSMUSG00000031660

UniProt

Q9NPI1

O88665

RefSeq (mRNA)

NM_001173984
NM_013263

NM_012047

RefSeq (protein)

NP_001167455
NP_037395

Location (UCSC)Chr 16: 50.31 – 50.37 MbChr 8: 88.33 – 88.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions edit

BRD7 has been shown to interact with IRF2[8] and HNRPUL1.[9]

Azoospermia edit

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.[10]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166164 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031660 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152. S2CID 41216030.
  6. ^ Kaeser MD, Aslanian A, Dong MQ, Yates JR III, Emerson BM (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem. 283 (47): 32254–32263. doi:10.1074/jbc.M806061200. PMC 2583284. PMID 18809673.
  7. ^ "Entrez Gene: BRD7 bromodomain containing 7".
  8. ^ Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2). UNITED STATES: 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449. S2CID 22932901.
  9. ^ Kzhyshkowska, Julia; Rusch Andre; Wolf Hans; Dobner Thomas (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2). England: 385–93. doi:10.1042/BJ20021281. ISSN 0264-6021. PMC 1223277. PMID 12489984.
  10. ^ a b Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M (2016). "Knockout of BRD7 results in impaired spermatogenesis and male infertility". Sci Rep. 6: 21776. Bibcode:2016NatSR...621776W. doi:10.1038/srep21776. PMC 4754950. PMID 26878912.

External links edit

Further reading edit

  • Staal A, Enserink JM, Stein JL, et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449. S2CID 22932901.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kzhyshkowska J, Rusch A, Wolf H, Dobner T (2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277. PMID 12489984.
  • Zhou M, Peng C, Nie XM, et al. (2003). "[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]". AI Zheng. 22 (2): 123–7. PMID 12600283.
  • Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–2596. doi:10.1167/iovs.02-1099. PMID 12766061.
  • Zhang XM, Wang XY, Sheng SR, et al. (2003). "Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer". World J. Gastroenterol. 9 (8): 1729–33. doi:10.3748/wjg.v9.i8.1729. PMC 4611532. PMID 12918109.
  • Kim S, Lee J, Park J, Chung J (2003). "BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta". Cancer Res. 63 (16): 4792–5. PMID 12941796.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Zhou J, Ma J, Zhang BC, et al. (2004). "BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways". J. Cell. Physiol. 200 (1): 89–98. doi:10.1002/jcp.20013. PMID 15137061. S2CID 10383569.
  • Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Peng C, Zhou J, Liu HY, et al. (2006). "The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain". J. Cell. Biochem. 97 (4): 882–892. doi:10.1002/jcb.20645. PMID 16265664. S2CID 25852399.
  • Zhou M, Liu H, Xu X, et al. (2006). "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression". J. Cell. Biochem. 98 (4): 920–930. doi:10.1002/jcb.20788. PMID 16475162. S2CID 23757847.
  • Zhou M, Xu XJ, Zhou HD, et al. (2007). "BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis". Mol. Cell. Biochem. 292 (1–2): 205–212. doi:10.1007/s11010-006-9233-4. PMID 16786191. S2CID 5979230.
  • Liu H, Peng C, Zhou M, et al. (2006). "Cloning and characterization of the BRD7 gene promoter". DNA Cell Biol. 25 (6): 346–358. doi:10.1089/dna.2006.25.346. PMID 16792505.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


April 15, 2024
brd7, bromodomain, containing, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2i7kidentifiersaliases, bp75, celtix1, nag4, bromodomain, containing, smarci1external, idsomim, 618489, 1349766, homolo. Bromodomain containing protein 7 is a protein that in humans is encoded by the BRD7 gene 5 6 7 BRD7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2I7KIdentifiersAliasesBRD7 BP75 CELTIX1 NAG4 bromodomain containing 7 SMARCI1External IDsOMIM 618489 MGI 1349766 HomoloGene 8085 GeneCards BRD7Gene location Human Chr Chromosome 16 human 1 Band16q12 1Start50 313 487 bp 1 End50 368 988 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C3Start88 331 039 bp 2 End88 362 194 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveganglionic eminenceislet of LangerhansAchilles tendonpopliteal arteryascending aortasmooth muscle tissueright coronary arterybody of pancreasskin of abdomenTop expressed ininterventricular septumsecondary oocytelenscondyleplantaris muscleextensor digitorum longus muscleganglionic eminenceyolk sacsuperior surface of tonguethymusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontranscription coactivator activity histone binding p53 binding transcription factor binding protein binding transcription corepressor activity lysine acetylated histone bindingCellular componentnucleus nucleoplasm cytoplasm cytosolBiological processregulation of transcription by RNA polymerase II positive regulation of transcription DNA templated negative regulation of G1 S transition of mitotic cell cycle cell cycle negative regulation of transcription DNA templated regulation of transcription DNA templated Wnt signaling pathway transcription DNA templated negative regulation of cell population proliferation positive regulation of histone acetylation regulation of signal transduction by p53 class mediatorSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2911726992EnsemblENSG00000166164ENSMUSG00000031660UniProtQ9NPI1O88665RefSeq mRNA NM 001173984NM 013263NM 012047RefSeq protein NP 001167455NP 037395NP 036177NP 001363942NP 001363943NP 001363944NP 001363945NP 001363946Location UCSC Chr 16 50 31 50 37 MbChr 8 88 33 88 36 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 Azoospermia 3 References 4 External links 5 Further readingInteractions editBRD7 has been shown to interact with IRF2 8 and HNRPUL1 9 Azoospermia editBRD7 protein is a transcription regulator that is normally highly expressed in the testis particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids However in the testes of patients exhibiting spermatogenesis arrest and azoospermia BRD7 protein expression is observed to be absent or reduced 10 Homozygous knockout mice BRD7 are infertile and have increased DNA damage and apoptosis in their germline 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000166164 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031660 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cuppen E van Ham M Pepers B Wieringa B Hendriks W November 1999 Identification and molecular characterization of BP75 a novel bromodomain containing protein FEBS Lett 459 3 291 298 doi 10 1016 S0014 5793 99 01191 6 PMID 10526152 S2CID 41216030 Kaeser MD Aslanian A Dong MQ Yates JR III Emerson BM November 2008 BRD7 a novel PBAF specific SWI SNF subunit is required for target gene activation and repression in embryonic stem cells J Biol Chem 283 47 32254 32263 doi 10 1074 jbc M806061200 PMC 2583284 PMID 18809673 Entrez Gene BRD7 bromodomain containing 7 Staal A Enserink J M Stein J L Stein G S van Wijnen A J November 2000 Molecular characterization of celtix 1 a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 J Cell Physiol 185 2 UNITED STATES 269 279 doi 10 1002 1097 4652 200011 185 2 lt 269 AID JCP12 gt 3 0 CO 2 L ISSN 0021 9541 PMID 11025449 S2CID 22932901 Kzhyshkowska Julia Rusch Andre Wolf Hans Dobner Thomas April 2003 Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B AP5 is mediated by complex formation with the novel bromodomain containing protein BRD7 Biochem J 371 Pt 2 England 385 93 doi 10 1042 BJ20021281 ISSN 0264 6021 PMC 1223277 PMID 12489984 a b Wang H Zhao R Guo C Jiang S Yang J Xu Y Liu Y Fan L Xiong W Ma J Peng S Zeng Z Zhou Y Li X Li Z Li X Schmitt DC Tan M Li G Zhou M 2016 Knockout of BRD7 results in impaired spermatogenesis and male infertility Sci Rep 6 21776 Bibcode 2016NatSR 621776W doi 10 1038 srep21776 PMC 4754950 PMID 26878912 External links editHuman BRD7 genome location and BRD7 gene details page in the UCSC Genome Browser Further reading editStaal A Enserink JM Stein JL et al 2000 Molecular characterization of celtix 1 a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 J Cell Physiol 185 2 269 279 doi 10 1002 1097 4652 200011 185 2 lt 269 AID JCP12 gt 3 0 CO 2 L PMID 11025449 S2CID 22932901 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kzhyshkowska J Rusch A Wolf H Dobner T 2003 Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B AP5 is mediated by complex formation with the novel bromodomain containing protein BRD7 Biochem J 371 Pt 2 385 93 doi 10 1042 BJ20021281 PMC 1223277 PMID 12489984 Zhou M Peng C Nie XM et al 2003 Expression of BRD7 interacting proteins BRD2 and BRD3 in nasopharyngeal carcinoma tissues AI Zheng 22 2 123 7 PMID 12600283 Tomarev SI Wistow G Raymond V et al 2003 Gene expression profile of the human trabecular meshwork NEIBank sequence tag analysis Invest Ophthalmol Vis Sci 44 6 2588 2596 doi 10 1167 iovs 02 1099 PMID 12766061 Zhang XM Wang XY Sheng SR et al 2003 Expression of tumor related genes NGX6 NAG 7 BRD7 in gastric and colorectal cancer World J Gastroenterol 9 8 1729 33 doi 10 3748 wjg v9 i8 1729 PMC 4611532 PMID 12918109 Kim S Lee J Park J Chung J 2003 BP75 bromodomain containing M r 75 000 protein binds dishevelled 1 and enhances Wnt signaling by inactivating glycogen synthase kinase 3 beta Cancer Res 63 16 4792 5 PMID 12941796 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 45 doi 10 1038 ng1285 PMID 14702039 Zhou J Ma J Zhang BC et al 2004 BRD7 a novel bromodomain gene inhibits G1 S progression by transcriptionally regulating some important molecules involved in ras MEK ERK and Rb E2F pathways J Cell Physiol 200 1 89 98 doi 10 1002 jcp 20013 PMID 15137061 S2CID 10383569 Goehler H Lalowski M Stelzl U et al 2004 A protein interaction network links GIT1 an enhancer of huntingtin aggregation to Huntington s disease Mol Cell 15 6 853 865 doi 10 1016 j molcel 2004 09 016 PMID 15383276 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 2127 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Peng C Zhou J Liu HY et al 2006 The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain J Cell Biochem 97 4 882 892 doi 10 1002 jcb 20645 PMID 16265664 S2CID 25852399 Zhou M Liu H Xu X et al 2006 Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression J Cell Biochem 98 4 920 930 doi 10 1002 jcb 20788 PMID 16475162 S2CID 23757847 Zhou M Xu XJ Zhou HD et al 2007 BRD2 is one of BRD7 interacting proteins and its over expression could initiate apoptosis Mol Cell Biochem 292 1 2 205 212 doi 10 1007 s11010 006 9233 4 PMID 16786191 S2CID 5979230 Liu H Peng C Zhou M et al 2006 Cloning and characterization of the BRD7 gene promoter DNA Cell Biol 25 6 346 358 doi 10 1089 dna 2006 25 346 PMID 16792505 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 648 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Retrieved from https en wikipedia org w index php title BRD7 amp oldid 1174054090, wikipedia, wiki, book, books, library,

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