BEX4

Brain expressed, X-linked 4 is a protein that in humans is encoded by the BEX4 gene.^[5]

BEX4
Identifiers
Aliases	BEX4, BEXL1, brain expressed X-linked 4
External IDs	OMIM: 300692 MGI: 3606746 HomoloGene: 18948 GeneCards: BEX4
Gene location (Human) Chr. X chromosome (human)^[1] Band Xq22.1 Start 103,215,108 bp^[1] End 103,217,246 bp^[1]
Gene location (Mouse) Chr. X chromosome (mouse)^[2] Band X F1|X Start 135,039,745 bp^[2] End 135,041,192 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 frontal pole nucleus accumbens hypothalamus caudate nucleus pons amygdala cingulate gyrus cerebellar cortex Top expressed in yolk sac ovary lens mesencephalon neural tube islet of Langerhans ganglionic eminence lung hypothalamus rhombencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function histone deacetylase binding alpha-tubulin binding Cellular component nucleus cytoplasm microtubule spindle pole cytoskeleton Biological process chromosome segregation regulation of cell migration regulation of cell population proliferation negative regulation of tubulin deacetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56271 406217 Ensembl ENSG00000102409 ENSMUSG00000047844 UniProt Q9NWD9 Q9CWT2 RefSeq (mRNA) NM_001127688 NM_001080425 NM_212457 NM_001359569 NM_001359570 RefSeq (protein) NP_001073894 NP_001121160 NP_997622 NP_001346498 NP_001346499 Location (UCSC) Chr X: 103.22 – 103.22 Mb Chr X: 135.04 – 135.04 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the brain expressed X-linked gene family. Proteins encoded by other members of this family act as transcription elongation factors that allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants encoding the same protein have been identified.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000102409 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047844 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Brain expressed, X-linked 4". Retrieved 2013-04-04.

Further reading

• Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, et al. (July 2005). "Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer". Oncogene. 24 (32): 5089–5100. doi:10.1038/sj.onc.1208700. PMID 15870691. S2CID 34533769.
• Gao W, Li JZ, Chen SQ, Chu CY, Chan JY, Wong TS (June 2016). "Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma". Journal of Experimental & Clinical Cancer Research. 35 (1): 92. doi:10.1186/s13046-016-0355-6. PMC 4906687. PMID 27297407.
• Lee JK, Lee J, Go H, Lee CG, Kim S, Kim HS, et al. (August 2016). "Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition". Cell Death & Disease. 7 (8): e2336. doi:10.1038/cddis.2016.240. PMC 5108325. PMID 27512957.
• Yu W, Yaping L, Mingjun W, Jie H, Xiaogang L, Gang L (July 2017). "BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury". Journal of Biochemical and Molecular Toxicology. 31 (7): e21908. doi:10.1002/jbt.21908. PMID 28295929. S2CID 27130849.
• Zhao Z, Li J, Tan F, Gao S, He J (June 2018). "mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4". Biochemical and Biophysical Research Communications. 500 (2): 302–309. doi:10.1016/j.bbrc.2018.04.064. PMID 29660335. S2CID 5045928.
• Lee JK, Ha GH, Kim HS, Lee CW (October 2018). "Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation". Experimental & Molecular Medicine. 50 (10): 1–12. doi:10.1038/s12276-018-0168-0. PMC 6203768. PMID 30367032.
• Zhu C, Xiao D (November 2020). "Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer". Medicine. 99 (47): e23133. doi:10.1097/MD.0000000000023133. PMC 7676604. PMID 33217815.
• Lee S, Kang H, Shin E, Jeon J, Youn H, Youn B (September 2021). "BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling". International Journal of Molecular Sciences. 22 (18): 9845. doi:10.3390/ijms22189845. PMC 8471324. PMID 34576008.