BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBIgene.[5][6]
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000095739 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024232 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.
Further readingedit
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling". J. Biol. Chem. 283 (48): 33053–8. doi:10.1074/jbc.M804039200. PMC2662247. PMID 18838381.
Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling". Biochem. Biophys. Res. Commun. 320 (3): 680–4. doi:10.1016/j.bbrc.2004.06.017. PMID 15240101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential". Gastroenterology. 137 (1): 165–75. doi:10.1053/j.gastro.2009.03.041. PMID 19328798.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer". Int. J. Cancer. 125 (2): 328–38. doi:10.1002/ijc.24318. PMID 19326429. S2CID 32084443.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells". J. Biol. Chem. 279 (8): 6840–6. doi:10.1074/jbc.M310876200. PMID 14660579.
Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer". World J. Gastroenterol. 14 (31): 4880–8. doi:10.3748/wjg.14.4880. PMC2739940. PMID 18756595.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC2286551. PMID 15340161.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.
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This article is about the human gene For the German media award see Bambi award For other uses see BAMBI disambiguation BMP and activin membrane bound inhibitor homolog Xenopus laevis also known as BAMBI is a protein which in humans is encoded by the BAMBI gene 5 6 BAMBIIdentifiersAliasesBAMBI NMA BMP and activin membrane bound inhibitor BMP and activin membrane bound inhibitorExternal IDsOMIM 604444 MGI 1915260 HomoloGene 8215 GeneCards BAMBI OMA BAMBI orthologsGene location Human Chr Chromosome 10 human 1 Band10p12 1Start28 677 510 bp 1 End28 682 932 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 18 A1Start3 507 923 bp 2 End3 516 404 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed intibiaperiodontal fiberglomerulusadrenal cortexleft adrenal glandmetanephric glomerulusascending aortaplacentaseminal vesiculaurinary bladderTop expressed inmolarendocardial cushionMeckel s cartilageclaviclehair follicleupper lipatrioventricular valvebody of femurcrypt of lieberkuhn of small intestineabdominal wallMore reference expression dataBioGPSn aGene ontologyMolecular functiontype II transforming growth factor beta receptor binding frizzled bindingCellular componentcytoplasm integral component of membrane plasma membrane membraneBiological processpositive regulation of transcription DNA templated positive regulation of protein binding negative regulation of transforming growth factor beta receptor signaling pathway cell migration positive regulation of epithelial to mesenchymal transition positive regulation of cell population proliferation regulation of cell shape positive regulation of canonical Wnt signaling pathway transforming growth factor beta receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2580568010EnsemblENSG00000095739ENSMUSG00000024232UniProtQ13145Q9D0L6RefSeq mRNA NM 012342NM 026505RefSeq protein NP 036474NP 080781Location UCSC Chr 10 28 68 28 68 MbChr 18 3 51 3 52 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor beta TGF beta family whose members play important roles in signal transduction in many developmental and pathological processes The encoded protein however is a pseudoreceptor lacking an intracellular serine threonine kinase domain required for signaling Similar proteins in frog mouse and zebrafish function as negative regulators of TGF beta which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF beta family during early embryogenesis 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000095739 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024232 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene BMP and activin membrane bound inhibitor homolog Xenopus laevis Degen WG Weterman MA van Groningen JJ Cornelissen IM Lemmers JP Agterbos MA Geurts van Kessel A Swart GW Bloemers HP February 1996 Expression of nma a novel gene inversely correlates with the metastatic potential of human melanoma cell lines and xenografts Int J Cancer 65 4 460 5 doi 10 1002 SICI 1097 0215 19960208 65 4 lt 460 AID IJC12 gt 3 0 CO 2 E PMID 8621228 Further reading editRual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Lin Z Gao C Ning Y et al 2008 The pseudoreceptor BMP and activin membrane bound inhibitor positively modulates Wnt beta catenin signaling J Biol Chem 283 48 33053 8 doi 10 1074 jbc M804039200 PMC 2662247 PMID 18838381 Sekiya T Oda T Matsuura K Akiyama T 2004 Transcriptional regulation of the TGF beta pseudoreceptor BAMBI by TGF beta signaling Biochem Biophys Res Commun 320 3 680 4 doi 10 1016 j bbrc 2004 06 017 PMID 15240101 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Fritzmann J Morkel M Besser D et al 2009 A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential Gastroenterology 137 1 165 75 doi 10 1053 j gastro 2009 03 041 PMID 19328798 Hoja MR Wahlestedt C Hoog C 2000 A visual intracellular classification strategy for uncharacterized human proteins Exp Cell Res 259 1 239 46 doi 10 1006 excr 2000 4948 PMID 10942595 Khin SS Kitazawa R Win N et al 2009 BAMBI gene is epigenetically silenced in subset of high grade bladder cancer Int J Cancer 125 2 328 38 doi 10 1002 ijc 24318 PMID 19326429 S2CID 32084443 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Wistow G Bernstein SL Wyatt MK et al 2002 Expressed sequence tag analysis of human retina for the NEIBank Project retbindin an abundant novel retinal cDNA and alternative splicing of other retina preferred gene transcripts Mol Vis 8 196 204 PMID 12107411 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Sekiya T Adachi S Kohu K et al 2004 Identification of BMP and activin membrane bound inhibitor BAMBI an inhibitor of transforming growth factor beta signaling as a target of the beta catenin pathway in colorectal tumor cells J Biol Chem 279 8 6840 6 doi 10 1074 jbc M310876200 PMID 14660579 Togo N Ohwada S Sakurai S et al 2008 Prognostic significance of BMP and activin membrane bound inhibitor in colorectal cancer World J Gastroenterol 14 31 4880 8 doi 10 3748 wjg 14 4880 PMC 2739940 PMID 18756595 Deloukas P Earthrowl ME Grafham DV et al 2004 The DNA sequence and comparative analysis of human chromosome 10 Nature 429 6990 375 81 Bibcode 2004Natur 429 375D doi 10 1038 nature02462 PMID 15164054 Zhang Z Henzel WJ 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites Protein Sci 13 10 2819 24 doi 10 1110 ps 04682504 PMC 2286551 PMID 15340161 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Degen WG Weterman MA van Groningen JJ et al 1996 Expression of nma a novel gene inversely correlates with the metastatic potential of human melanoma cell lines and xenografts Int J Cancer 65 4 460 5 doi 10 1002 SICI 1097 0215 19960208 65 4 lt 460 AID IJC12 gt 3 0 CO 2 E PMID 8621228 External links editBAMBI protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human BAMBI genome location and BAMBI gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title BAMBI amp oldid 1174053618, wikipedia, wiki, book, books, library,
