Atypical Solute Carrier Families (Atypical SLCs) are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families.[1][2]
Atypical major facilitator superfamily transport familiesedit
Most atypical SLCs are families within the major facilitator superfamily (MFS).[3] These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers.[1][2][4] They are, however, not named according to the SLC root system, or classified into any of the existing SLC families.[1] ATMFs are categorised based on their sequence similarity and phylogenetic closeness.[3]
Although most atypical SLCs are from the major facilitator superfamily, there are exceptions: TMEM104 (APC superfamily), OCA2 (IT superfamily) and CLN3 (unknown superfamily).[1]
Referencesedit
^ abcdPerland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
^ abSreedharan S, Stephansson O, Schiöth HB, Fredriksson R (June 2011). "Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters". Gene. 478 (1–2): 11–18. doi:10.1016/j.gene.2010.10.011. PMID 21044875.
^ abPerland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC5627054. PMID 28878041.
^Höglund PJ, Nordström KJ, Schiöth HB, Fredriksson R (April 2011). "The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species". Molecular Biology and Evolution. 28 (4): 1531–1541. doi:10.1093/molbev/msq350. PMC3058773. PMID 21186191.
^ abPerland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC5648162. PMID 29049335.
^Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC5671512. PMID 29163028.
atypical, slcs, this, article, technical, most, readers, understand, please, help, improve, make, understandable, experts, without, removing, technical, details, august, 2017, learn, when, remove, this, template, message, atypical, solute, carrier, families, n. This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details August 2017 Learn how and when to remove this template message Atypical Solute Carrier Families Atypical SLCs are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families SLCs However they have not been assigned a name according to the SLC root system or been classified into any of the existing SLC families 1 2 Atypical major facilitator superfamily transport families editMost atypical SLCs are families within the major facilitator superfamily MFS 3 These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers 1 2 4 They are however not named according to the SLC root system or classified into any of the existing SLC families 1 ATMFs are categorised based on their sequence similarity and phylogenetic closeness 3 AMTF Family members SLC family AMTF1 MFSD9 MFSD10 MFSD14A MFSD14B SLC46 AMTF2 MFSD8 AMTF3 MFSD4A MFSD4B AMTF4 CLN3 AMTF5 MFSD7 SLC49 AMTF6 MFSD1 MFSD5 AMTF7 MFSD12 AMTF8 MFSD2A MFSD2B AMTF9 SV2A SV2B SV2C SVOP SVOPL SLC22 AMTF10 MFSD11 UNC93A UNC93B1 AMTF11 SPNS1 SPNS2 SPNS3 AMTF12 MFSD13A AMTF13 MFSD6 AMTF14 MFSD6L AMTF15 MFSD3 Some Atypical SLC of MFS type are OCA2 CLN3 SPNS1 SPNS2 SPNS3 SV2A SV2B SV2C SVOP SVOPL MFSD1 MFSD2A MFSD2B MFSD3 MFSD4A 5 MFSD4B MFSD5 MFSD6 MFSD6L MFSD8 MFSD9 5 MFSD10 MFSD11 MFSD12 MFSD13A MFSD14A MFSD14B UNC93A 6 and UNC93B1 All these are atypical SLCs found within the Major facilitator superfamily Also TMEM104 APC clan OCA2 IT clan and CLN3 having no clan are atypical SLCs in humans 7 8 9 Non MFS transport families editAlthough most atypical SLCs are from the major facilitator superfamily there are exceptions TMEM104 APC superfamily OCA2 IT superfamily and CLN3 unknown superfamily 1 References edit a b c d Perland E Fredriksson R March 2017 Classification Systems of Secondary Active Transporters Trends in Pharmacological Sciences 38 3 305 315 doi 10 1016 j tips 2016 11 008 PMID 27939446 a b Sreedharan S Stephansson O Schioth HB Fredriksson R June 2011 Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters Gene 478 1 2 11 18 doi 10 1016 j gene 2010 10 011 PMID 21044875 a b Perland E Bagchi S Klaesson A Fredriksson R September 2017 Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type evolutionary conservation predicted structure and neuronal co expression Open Biology 7 9 170142 doi 10 1098 rsob 170142 PMC 5627054 PMID 28878041 Hoglund PJ Nordstrom KJ Schioth HB Fredriksson R April 2011 The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species Molecular Biology and Evolution 28 4 1531 1541 doi 10 1093 molbev msq350 PMC 3058773 PMID 21186191 a b Perland E Hellsten SV Schweizer N Arapi V Rezayee F Bushra M Fredriksson R 2017 Structural prediction of two novel human atypical SLC transporters MFSD4A and MFSD9 and their neuroanatomical distribution in mice PLOS ONE 12 10 e0186325 Bibcode 2017PLoSO 1286325P doi 10 1371 journal pone 0186325 PMC 5648162 PMID 29049335 Ceder MM Lekholm E Hellsten SV Perland E Fredriksson R 2017 The Neuronal and Peripheral Expressed Membrane Bound UNC93A Respond to Nutrient Availability in Mice Frontiers in Molecular Neuroscience 10 351 doi 10 3389 fnmol 2017 00351 PMC 5671512 PMID 29163028 TMEM104 transmembrane protein 104 Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2022 03 14 OCA2 OCA2 melanosomal transmembrane protein Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2022 03 14 CLN3 CLN3 lysosomal endosomal transmembrane protein battenin Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2022 03 14 nbsp This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Atypical SLCs amp oldid 1078859801 Atypical major facilitator superfamily transport families, wikipedia, wiki, book, books, library,
