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Amino acid transporter

January 01, 1970

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.

Transmembrane amino acid transporter protein
Identifiers
SymbolAa_trans
PfamPF01490
InterProIPR013057
TCDB2.A.18
Membranome228
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Families edit

There are several families that function in amino acid transport, some of these include:

Solute carrier family examples edit

VIAAT edit

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]

Human proteins containing this domain edit

SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.

See also edit

References edit

  1. ^ Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflügers Arch. 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974. S2CID 21564906.
  2. ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309. S2CID 25808108.
  3. ^ Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science. 322 (5908): 1655–1661. Bibcode:2008Sci...322.1655S. doi:10.1126/science.1166777. PMC 2832577. PMID 19074341.
  4. ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310. S2CID 11670040.
  5. ^ Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflügers Arch. 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028. S2CID 22369521.
  6. ^ Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Arch. 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560. S2CID 9680597.
  7. ^ Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.
  8. ^ Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Arch. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172. S2CID 25304722.
  9. ^ Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflügers Arch. 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755. S2CID 20302398.
  10. ^ Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers Arch. 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892. S2CID 24669893.
  11. ^ Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflügers Arch. 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860. S2CID 25655241.
  12. ^ Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflügers Arch. 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534. S2CID 35457147.
  13. ^ [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003

January 01, 1970
amino, acid, transporter, amino, acid, transporter, membrane, transport, protein, that, transports, amino, acids, they, mainly, solute, carrier, family, transmembrane, amino, acid, transporter, proteinidentifierssymbolaa, transpfampf01490interproipr013057tcdb2. An amino acid transporter is a membrane transport protein that transports amino acids They are mainly of the solute carrier family Transmembrane amino acid transporter proteinIdentifiersSymbolAa transPfamPF01490InterProIPR013057TCDB2 A 18Membranome228Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Families 2 Solute carrier family examples 2 1 VIAAT 3 Human proteins containing this domain 4 See also 5 ReferencesFamilies editThere are several families that function in amino acid transport some of these include TC 2 A 3 Amino Acid Polyamine Organocation APC Superfamily TC 2 A 18 Amino Acid Auxin Permease AAAP Family TC 2 A 23 Dicarboxylate Amino Acid Cation Na or H Symporter DAACS Family TC 2 A 26 Branched Chain Amino Acid Cation Symporter LIVCS Family TC 2 A 42 Hydroxy Aromatic Amino Acid Permease HAAAP Family TC 2 A 78 Branched Chain Amino Acid Exporter LIV E Family TC 2 A 95 6TMS Neutral Amino Acid Transporter NAAT Family TC 2 A 118 Basic Amino Acid Antiporter ArcD Family TC 2 A 120 Putative Amino Acid Permease PAAP FamilySolute carrier family examples edit 1 high affinity glutamate and neutral amino acid transporter 1 3 heavy subunits of heteromeric amino acid transporters 2 6 Bacterial Leucine Transporter LeuT 3 7 cationic amino acid transporter glycoprotein associated 4 15 proton oligopeptide cotransporter 5 17 vesicular glutamate transporter 6 18 vesicular amine transporter 7 25 some mitochondrial carriers 8 26 multifunctional anion exchanger 9 32 vesicular inhibitory amino acid transporter 10 36 proton coupled amino acid transporter 11 38 System A amp N sodium coupled neutral amino acid transporter 12 VIAAT edit Vesicular inhibitory amino acid transporter VIAAT is responsible for the storage of GABA and glycine in neuronal synaptic vesicles 13 Human proteins containing this domain editSLC32A1 SLC36A1 SLC36A2 SLC36A3 SLC36A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 See also editSolute carrier family Amino acid transport Amino acid transport acidic Amino acid transport basic Amino acid transport disorder Amino acid Transporter Classification DatabaseReferences edit Kanai Y Hediger MA 2004 The glutamate neutral amino acid transporter family SLC1 molecular physiological and pharmacological aspects Pflugers Arch 447 5 469 479 doi 10 1007 s00424 003 1146 4 PMID 14530974 S2CID 21564906 Palacin M Kanai Y 2004 The ancillary proteins of HATs SLC3 family of amino acid transporters Pflugers Arch 447 5 490 494 doi 10 1007 s00424 003 1062 7 PMID 14770309 S2CID 25808108 Singh SK Piscitelli CL Yamashita A Gouaux E 2008 A competitive inhibitor traps LeuT in an open to out conformation Science 322 5908 1655 1661 Bibcode 2008Sci 322 1655S doi 10 1126 science 1166777 PMC 2832577 PMID 19074341 Verrey F Closs EI Wagner CA Palacin M Endou H Kanai Y 2004 CATs and HATs the SLC7 family of amino acid transporters PDF Pflugers Arch 447 5 532 542 doi 10 1007 s00424 003 1086 z PMID 14770310 S2CID 11670040 Daniel H Kottra G 2004 The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology Pflugers Arch 447 5 610 618 doi 10 1007 s00424 003 1101 4 PMID 12905028 S2CID 22369521 Reimer RJ Edwards RH 2004 Organic anion transport is the primary function of the SLC17 type I phosphate transporter family Pflugers Arch 447 5 629 635 doi 10 1007 s00424 003 1087 y PMID 12811560 S2CID 9680597 Eiden LE Schafer MK Weihe E Schutz B 2004 The vesicular amine transporter family SLC18 amine proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine Pflugers Arch 447 5 636 640 doi 10 1007 s00424 003 1100 5 PMID 12827358 S2CID 20764857 Palmieri F 2004 The mitochondrial transporter family SLC25 physiological and pathological implications Pflugers Arch 447 5 689 709 doi 10 1007 s00424 003 1099 7 PMID 14598172 S2CID 25304722 Mount DB Romero MF 2004 The SLC26 gene family of multifunctional anion exchangers Pflugers Arch 447 5 710 721 doi 10 1007 s00424 003 1090 3 PMID 12759755 S2CID 20302398 Gasnier B 2004 The SLC32 transporter a key protein for the synaptic release of inhibitory amino acids Pflugers Arch 447 5 752 755 doi 10 1007 s00424 003 1091 2 PMID 12750892 S2CID 24669893 Boll M Daniel H Gasnier B 2004 The SLC36 family proton coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family Pflugers Arch 447 5 776 779 doi 10 1007 s00424 003 1073 4 PMID 12748860 S2CID 25655241 Mackenzie B Erickson JD 2004 Sodium coupled neutral amino acid System N A transporters of the SLC38 gene family Pflugers Arch 447 5 784 795 doi 10 1007 s00424 003 1117 9 PMID 12845534 S2CID 35457147 Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon Containing Secretory Granules in alpha TC6 Cells Mouse Clonal alpha Cells and alpha Cells of Islets of Langerhans Diabetes 52 2066 2074 2003 Retrieved from https en wikipedia org w index php title Amino acid transporter 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