Amine oxidase

An amine oxidase is an enzyme that catalyzes the oxidative cleavage of alkylamines into aldehydes and ammonia:^[1]

RCH₂NH₂ + H₂O + O₂ ${\displaystyle \rightleftharpoons }$ RCHO + NH₃ + H₂O₂

Amine oxidases are divided into two subfamilies based on the cofactor they contain:

Class	Cofactor	Subclass	Enzyme Commission number	Human genes
Amine oxidase (formerly EC 1.4.3.6)	copper	lysyl oxidase	EC 1.4.3.13	LOX
		primary-amine oxidase	EC 1.4.3.21	AOC2, AOC3
		diamine oxidase	EC 1.4.3.22	AOC1
Monoamine oxidase	flavin	N/A	EC 1.4.3.4	MAOA, MAOB

References

1. Mondovì B, Finazzi Agrò A (1982). "Structure and Function of Amine Oxidases". Structure and Function Relationships in Biochemical Systems. Advances in Experimental Medicine and Biology. Vol. 148. pp. 141–53. doi:10.1007/978-1-4615-9281-5_12. ISBN 978-1-4615-9283-9. PMID 7124512.

External links

• Amine+Oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)