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α-Difluoromethyl-DOPA

α-Difluoromethyl-3,4-dihydroxyphenylalanine (DFMD, DFM-DOPA) is a DOPA decarboxylase inhibitor.[1]

α-Difluoromethyl-DOPA
Names
Systematic IUPAC name
(2S)-2-Amino-2-[(3,4-dihydroxyphenyl)methyl]-3,3-difluoropropanoic acid
Other names
α-(Difluoromethyl)-3-hydroxy-L-tyrosine
Identifiers
  • 160401-53-6 Y
3D model (JSmol)
  • Interactive image
  • Interactive image
ChemSpider
  • 114812 Y
MeSH alpha-difluoromethyl-DOPA
  • 129677
UNII
  • 4FX102BRL6 Y
  • DTXSID70220233
  • InChI=1S/C10H11F2NO4/c11-8(12)10(13,9(16)17)4-5-1-2-6(14)7(15)3-5/h1-3,8,14-15H,4,13H2,(H,16,17)/t10-/m1/s1 Y
    Key: XZVHHLNLLVICFA-SNVBAGLBSA-N Y
  • InChI=1/C10H11F2NO4/c11-8(12)10(13,9(16)17)4-5-1-2-6(14)7(15)3-5/h1-3,8,14-15H,4,13H2,(H,16,17)/t10-/m1/s1
    Key: XZVHHLNLLVICFA-SNVBAGLBBM
  • C1=CC(=C(C=C1C[C@@](C(F)F)(C(=O)O)N)O)O
  • FC(F)[C@](C(=O)O)(N)Cc1cc(O)c(O)cc1
Properties
C10H11F2NO4
Molar mass 247.20 g/mol
Density 1.528 g/mL
Boiling point 479 °C (894 °F; 752 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

See also edit

References edit

  1. ^ Zbinden G, Brändle E (February 1980). "Inhibition of 5-hydroxytryptophan nephrotoxicity by alpha-difluoromethyl-dopa, an inhibitor or L-amino acid decarboxylase". Toxicology Letters. 5 (2): 125–9. doi:10.1016/0378-4274(80)90161-7. PMID 6781106.


difluoromethyl, dopa, difluoromethyl, dihydroxyphenylalanine, dfmd, dopa, dopa, decarboxylase, inhibitor, namessystematic, iupac, name, amino, dihydroxyphenyl, methyl, difluoropropanoic, acidother, names, difluoromethyl, hydroxy, tyrosineidentifierscas, number. a Difluoromethyl 3 4 dihydroxyphenylalanine DFMD DFM DOPA is a DOPA decarboxylase inhibitor 1 a Difluoromethyl DOPA NamesSystematic IUPAC name 2S 2 Amino 2 3 4 dihydroxyphenyl methyl 3 3 difluoropropanoic acidOther names a Difluoromethyl 3 hydroxy L tyrosineIdentifiersCAS Number 160401 53 6 Y3D model JSmol Interactive imageInteractive imageChemSpider 114812 YMeSH alpha difluoromethyl DOPAPubChem CID 129677UNII 4FX102BRL6 YCompTox Dashboard EPA DTXSID70220233InChI InChI 1S C10H11F2NO4 c11 8 12 10 13 9 16 17 4 5 1 2 6 14 7 15 3 5 h1 3 8 14 15H 4 13H2 H 16 17 t10 m1 s1 YKey XZVHHLNLLVICFA SNVBAGLBSA N YInChI 1 C10H11F2NO4 c11 8 12 10 13 9 16 17 4 5 1 2 6 14 7 15 3 5 h1 3 8 14 15H 4 13H2 H 16 17 t10 m1 s1Key XZVHHLNLLVICFA SNVBAGLBBMSMILES C1 CC C C C1C C C F F C O O N O OFC F C C O O N Cc1cc O c O cc1PropertiesChemical formula C10H11F2NO4Molar mass 247 20 g molDensity 1 528 g mLBoiling point 479 C 894 F 752 K Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox referencesSee also editCarbidopa MethyldopaReferences edit Zbinden G Brandle E February 1980 Inhibition of 5 hydroxytryptophan nephrotoxicity by alpha difluoromethyl dopa an inhibitor or L amino acid decarboxylase Toxicology Letters 5 2 125 9 doi 10 1016 0378 4274 80 90161 7 PMID 6781106 Retrieved from https en wikipedia org w index php title A Difluoromethyl DOPA amp oldid 1175820068, wikipedia, wiki, book, books, library,

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