^ abcGRCh38: Ensembl release 89: ENSG00000106927 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028356 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Vetr H, Gebhard W (1990). "Structure of the human alpha 1-microglobulin-bikunin gene". Biol. Chem. Hoppe-Seyler. 371 (12): 1185–96. doi:10.1515/bchm3.1990.371.2.1185. PMID 1708673.
^Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
^Grubb AO, López C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. 258 (23): 14698–707. doi:10.1016/S0021-9258(17)43919-6. PMID 6196366.
^Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. 245 (3): 676–83. doi:10.1111/j.1432-1033.1997.00676.x. PMID 9183005.
Kobayashi H, Suzuki M, Hirashima Y, Terao T (2003). "The protease inhibitor bikunin, a novel anti-metastatic agent". Biol. Chem. 384 (5): 749–54. doi:10.1515/BC.2003.083. PMID 12817471. S2CID 38608465.
Ekström B, Berggård I (1977). "Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties". J. Biol. Chem. 252 (22): 8048–57. doi:10.1016/S0021-9258(17)40934-3. PMID 72071.
Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E (1990). "Location and characterization of the three carbohydrate prosthetic groups of human protein HC". FEBS Lett. 266 (1–2): 167–70. doi:10.1016/0014-5793(90)81531-R. PMID 1694784. S2CID 36320110.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, Salier JP, Léveillard T, Martin JP (1990). "Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene". Eur. J. Biochem. 191 (1): 131–9. doi:10.1111/j.1432-1033.1990.tb19102.x. PMID 1696200.
Gebhard W, Schreitmüller T, Vetr H, Wachter E, Hochstrasser K (1990). "Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin". FEBS Lett. 269 (1): 32–6. doi:10.1016/0014-5793(90)81112-2. PMID 1696914. S2CID 84271910.
Falkenberg C, Grubb A, Akerström B (1990). "Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue". J. Biol. Chem. 265 (27): 16150–7. doi:10.1016/S0021-9258(17)46201-6. PMID 1697852.
Nazimova SV, Akulenko IV, Zaĭtseva IV, Zaraĭskiĭ EI, Posiseeva LV (1990). "[Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy]". Akush Ginekol (Mosk) (7): 70–2. PMID 1700638.
Escribano J, Grubb A, Calero M, Méndez E (1991). "The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC". J. Biol. Chem. 266 (24): 15758–63. doi:10.1016/S0021-9258(18)98474-7. PMID 1714898.
Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. doi:10.1016/S0021-9258(17)35235-3. PMID 1898736.
Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP (1985). "Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase". Biol. Chem. Hoppe-Seyler. 366 (5): 479–83. doi:10.1515/bchm3.1985.366.1.479. PMID 2408638.
Bourguignon J, Diarra-Mehrpour M, Sesboüé R, Frain M, Sala-Trepat JM, Martin JP, Salier JP (1985). "Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA". Biochem. Biophys. Res. Commun. 131 (3): 1146–53. doi:10.1016/0006-291X(85)90210-4. PMID 2413856.
Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F (1986). "Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1472–5. Bibcode:1986PNAS...83.1472M. doi:10.1073/pnas.83.5.1472. PMC323098. PMID 2419908.
Traboni C, Cortese R (1986). "Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin)". Nucleic Acids Res. 14 (15): 6340. doi:10.1093/nar/14.15.6340. PMC311643. PMID 2428011.
Kaumeyer JF, Polazzi JO, Kotick MP (1986). "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)". Nucleic Acids Res. 14 (20): 7839–50. doi:10.1093/nar/14.20.7839. PMC311818. PMID 2430261.
Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, Tatarinov IuS, Fuks BB (1990). "[Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors]". Vopr. Med. Khim. 35 (5): 130–2. PMID 2482577.
Schreitmüller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
Morii M, Travis J (1985). "The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein". Biol. Chem. Hoppe-Seyler. 366 (1): 19–21. doi:10.1515/bchm3.1985.366.1.19. PMID 3890890.
External links
The MEROPS online database for peptidases and their inhibitors: LI02-001
This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.
alpha, microglobulin, bikunin, precursor, protein, ambp, protein, that, humans, encoded, ambp, gene, ambpavailable, structurespdbortholog, search, pdbe, rcsblist, codes1bik, 3qkg, 4es7, 4u30identifiersaliasesambp, edc1, hi30, iatil, itil, itilc, alpha, microgl. Protein AMBP is a protein that in humans is encoded by the AMBP gene 5 6 7 AMBPAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1BIK 3QKG 4ES7 4U30IdentifiersAliasesAMBP A1M EDC1 HCP HI30 IATIL ITI ITIL ITILC UTI alpha 1 microglobulin bikunin precursorExternal IDsOMIM 176870 MGI 88002 HomoloGene 1234 GeneCards AMBPGene location Human Chr Chromosome 9 human 1 Band9q32Start114 060 127 bp 1 End114 078 328 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 B3 4 33 96 cMStart63 061 512 bp 2 End63 073 036 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of livergallbladderbody of pancreasislet of Langerhansoocytepancreatic epithelial cellsecondary oocytekidneykidney tubulebody of stomachTop expressed inleft lobe of livergallbladderyolk sacabdominal wallright lobe of liverislet of Langerhanssexually immature organismliver parenchymapyloric antrumveinMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionpeptidase inhibitor activity calcium channel inhibitor activity protein homodimerization activity calcium oxalate binding protein binding heme binding serine type endopeptidase inhibitor activity small molecule binding IgA bindingCellular componentblood microparticle intracellular membrane bounded organelle plasma membrane extracellular region cell surface extracellular exosome extracellular space extracellular matrix collagen containing extracellular matrixBiological processnegative regulation of peptidase activity female pregnancy receptor mediated endocytosis negative regulation of JNK cascade heme catabolic process negative regulation of immune response cell adhesion protein catabolic process viral process negative regulation of endopeptidase activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez25911699EnsemblENSG00000106927ENSMUSG00000028356UniProtP02760Q07456RefSeq mRNA NM 001633NM 007443RefSeq protein NP 001624NP 031469Location UCSC Chr 9 114 06 114 08 MbChr 4 63 06 63 07 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions EditAlpha 1 microglobulin bikunin precursor has been shown to interact with CD79A 8 9 See also EditInter alpha trypsin inhibitor Alpha 1 microglobulinReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000106927 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028356 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Vetr H Gebhard W 1990 Structure of the human alpha 1 microglobulin bikunin gene Biol Chem Hoppe Seyler 371 12 1185 96 doi 10 1515 bchm3 1990 371 2 1185 PMID 1708673 Salier JP Simon D Rouet P Raguenez G Muscatelli F Gebhard W Guenet JL Mattei MG Dec 1992 Homologous chromosomal locations of the four genes for inter alpha inhibitor and pre alpha inhibitor family in human and mouse assignment of the ancestral gene for the lipocalin superfamily Genomics 14 1 83 8 doi 10 1016 S0888 7543 05 80287 3 PMID 1385302 Entrez Gene AMBP alpha 1 microglobulin bikunin precursor Grubb AO Lopez C Tejler L Mendez E December 1983 Isolation of human complex forming glycoprotein heterogeneous in charge protein HC and its IgA complex from plasma Physiochemical and immunochemical properties normal plasma concentration J Biol Chem 258 23 14698 707 doi 10 1016 S0021 9258 17 43919 6 PMID 6196366 Berggard T Thelin N Falkenberg C Enghild JJ Akerstrom B May 1997 Prothrombin albumin and immunoglobulin A form covalent complexes with alpha1 microglobulin in human plasma Eur J Biochem 245 3 676 83 doi 10 1111 j 1432 1033 1997 00676 x PMID 9183005 Further reading EditAkerstrom B Logdberg L Berggard T Osmark P Lindqvist A 2000 alpha 1 Microglobulin a yellow brown lipocalin Biochim Biophys Acta 1482 1 2 172 84 doi 10 1016 S0167 4838 00 00157 6 PMID 11058759 Kobayashi H Suzuki M Hirashima Y Terao T 2003 The protease inhibitor bikunin a novel anti metastatic agent Biol Chem 384 5 749 54 doi 10 1515 BC 2003 083 PMID 12817471 S2CID 38608465 Ekstrom B Berggard I 1977 Human alpha1 microglobulin Purification procedure chemical and physiochemical properties J Biol Chem 252 22 8048 57 doi 10 1016 S0021 9258 17 40934 3 PMID 72071 Escribano J Lopex Otin C Hjerpe A Grubb A Mendez E 1990 Location and characterization of the three carbohydrate prosthetic groups of human protein HC FEBS Lett 266 1 2 167 70 doi 10 1016 0014 5793 90 81531 R PMID 1694784 S2CID 36320110 Diarra Mehrpour M Bourguignon J Sesboue R Salier JP Leveillard T Martin JP 1990 Structural analysis of the human inter alpha trypsin inhibitor light chain gene Eur J Biochem 191 1 131 9 doi 10 1111 j 1432 1033 1990 tb19102 x PMID 1696200 Gebhard W Schreitmuller T Vetr H Wachter E Hochstrasser K 1990 Complementary DNA and deduced amino acid sequences of procine alpha 1 microglobulin and bikunin FEBS Lett 269 1 32 6 doi 10 1016 0014 5793 90 81112 2 PMID 1696914 S2CID 84271910 Falkenberg C Grubb A Akerstrom B 1990 Isolation of rat serum alpha 1 microglobulin Identification of a complex with alpha 1 inhibitor 3 a rat alpha 2 macroglobulin homologue J Biol Chem 265 27 16150 7 doi 10 1016 S0021 9258 17 46201 6 PMID 1697852 Nazimova SV Akulenko IV Zaĭtseva IV Zaraĭskiĭ EI Posiseeva LV 1990 Immunoenzyme analysis of placenta specific alpha 1 microglobulin in the blood serum in normal and pathological pregnancy Akush Ginekol Mosk 7 70 2 PMID 1700638 Escribano J Grubb A Calero M Mendez E 1991 The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction resistant bond and causes the charge heterogeneity of protein HC J Biol Chem 266 24 15758 63 doi 10 1016 S0021 9258 18 98474 7 PMID 1714898 Enghild JJ Salvesen G Hefta SA Thogersen IB Rutherfurd S Pizzo SV 1991 Chondroitin 4 sulfate covalently cross links the chains of the human blood protein pre alpha inhibitor J Biol Chem 266 2 747 51 doi 10 1016 S0021 9258 17 35235 3 PMID 1898736 Reisinger P Hochstrasser K Albrecht GJ Lempart K Salier JP 1985 Human inter alpha trypsin inhibitor localization of the Kunitz type domains in the N terminal part of the molecule and their release by a trypsin like proteinase Biol Chem Hoppe Seyler 366 5 479 83 doi 10 1515 bchm3 1985 366 1 479 PMID 2408638 Bourguignon J Diarra Mehrpour M Sesboue R Frain M Sala Trepat JM Martin JP Salier JP 1985 Human inter alpha trypsin inhibitor characterization and partial nucleotide sequencing of a light chain encoding cDNA Biochem Biophys Res Commun 131 3 1146 53 doi 10 1016 0006 291X 85 90210 4 PMID 2413856 Mendez E Fernandez Luna JL Grubb A Leyva Cobian F 1986 Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis Proc Natl Acad Sci U S A 83 5 1472 5 Bibcode 1986PNAS 83 1472M doi 10 1073 pnas 83 5 1472 PMC 323098 PMID 2419908 Traboni C Cortese R 1986 Sequence of a full length cDNA coding for human protein HC alpha 1 microglobulin Nucleic Acids Res 14 15 6340 doi 10 1093 nar 14 15 6340 PMC 311643 PMID 2428011 Kaumeyer JF Polazzi JO Kotick MP 1986 The mRNA for a proteinase inhibitor related to the HI 30 domain of inter alpha trypsin inhibitor also encodes alpha 1 microglobulin protein HC Nucleic Acids Res 14 20 7839 50 doi 10 1093 nar 14 20 7839 PMC 311818 PMID 2430261 Zaraĭskiĭ EI Nazimova SV Olefirenko GA Pchelkina ZM Petrunin DD Tatarinov IuS Fuks BB 1990 Immunoenzyme analysis of placenta specific alpha 1 microglobulin in the serum of blood donors Vopr Med Khim 35 5 130 2 PMID 2482577 Schreitmuller T Hochstrasser K Reisinger PW Wachter E Gebhard W 1987 cDNA cloning of human inter alpha trypsin inhibitor discloses three different proteins Biol Chem Hoppe Seyler 368 8 963 70 doi 10 1515 bchm3 1987 368 2 963 PMID 3663330 Morii M Travis J 1985 The reactive site of human inter alpha trypsin inhibitor is in the amino terminal half of the protein Biol Chem Hoppe Seyler 366 1 19 21 doi 10 1515 bchm3 1985 366 1 19 PMID 3890890 External links EditThe MEROPS online database for peptidases and their inhibitors LI02 001 This article on a gene on human chromosome 9 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Alpha 1 microglobulin bikunin precursor amp oldid 1079671870, wikipedia, wiki, book, books, library,
