Genetic admixture occurs when previously isolated populations interbreed resulting in a population that is descended from multiple sources. It can occur between species, such as with hybrids, or within species, such as when geographically distant individuals migrate to new regions. It results in gene pool that is a mix of the source populations.[1][2][3]
Climatic cycles facilitate genetic admixture in cold periods and genetic diversification in warm periods.[4] Natural flooding can cause genetic admixture within populations of migrating fish species.[5] Genetic admixture may have an important role for the success of populations that colonise a new area and interbreed with individuals of native populations.[6]
Mappingedit
Admixture mapping is a method of gene mapping that uses a population of mixed ancestry (an admixed population) to find the genetic loci that contribute to differences in diseases or other phenotypes found between the different ancestral populations. The method is best applied to populations with recent admixture from two populations that were previously genetically isolated. The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest. Genetic markers that differ in frequency between the ancestral populations are needed across the genome.[7]
Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease-causing or phenotype-causing genetic variants between populations. In an admixed population, these causal variants occur more frequently on chromosomal segments inherited from one or another ancestral population. The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped.[8] By 2010, high-density mapping panels had been constructed for African Americans, Latino/Hispanics, and Uyghurs.
^Rius, M.; Darling, J.A. (2014). "How important is intraspecific genetic admixture to the success of colonising populations?". Trends in Ecology & Evolution. 29 (4): 233−242. doi:10.1016/j.tree.2014.02.003. PMID 24636862.
^Yang, Melinda A.; Fu, Qiaomei (March 2018). "Insights into Modern Human Prehistory Using Ancient Genomes". Trends in Genetics. 34 (3): 184–196 6y. doi:10.1016/j.tig.2017.11.008. PMID 29395378.
^Lv X, Cheng J, Meng Y, Chang Y, Xia L, Wen Z, Ge D, Liu S, Yang Q (2018). "Disjunct distribution and distinct intraspecific diversification of Eothenomys melanogaster in South China". BMC Evolutionary Biology. 18 (1): 50. doi:10.1186/s12862-018-1168-3. PMC5894153. PMID 29636000.
^Jaisuk, C.; Senanan, W. (2018). "Effects of landscape features on population genetic variation of a tropical stream fish, Stone lapping minnow, Garra cambodgiensis, in the upper Nan River drainage basin, northern Thailand". PeerJ. 6: e4487. doi:10.7717/peerj.4487. PMC5845392. PMID 29568710.
^Kolbe JJ, Larson A, Losos JB, de Queiroz K (2008). "Admixture determines genetic diversity and population differentiation in the biological invasion of a lizard species". Biology Letters. 4 (4): 434−437. doi:10.1098/rsbl.2008.0205. PMC2610154. PMID 18492644.
^Shriver, MD; et al. (April 2003). "Skin pigmentation, biogeographical ancestry and admixture mapping". Human Genetics. 112 (4): 387–99. doi:10.1007/s00439-002-0896-y. PMID 12579416. S2CID 7877572.
^Winkler, C. A.; Nelson, G. W.; Smith, M. W. (2010). "Admixture mapping comes of age". Annu Rev Genom Hum Genet. 11: 65–89. doi:10.1146/annurev-genom-082509-141523. PMC7454031. PMID 20594047.
Further readingedit
Balding (2007). "Glossary of Genetic Terms". Handbook of statistical genetics, Volume 1. John Wiley & Sons. ISBN978-0-470-05830-5.
Foulkes (28 April 2009). "Glossary of Terms". Applied Statistical Genetics With R: For Population-based Association Studies. Springer. p. 250. ISBN978-0-387-89553-6.
Stone; et al. (2007). "Glossary of Terms". Genes, culture, and human evolution: a synthesis. Wiley. ISBN978-1-4051-5089-7.
Kolbe JJ, Glor RE, Schettino LR, Lara AC, Losos AL, Losos JB (2004) Genetic Variation Increases during Biological Invasion by a Cuban Lizard. Nature 431: 171-181
Lenormand T (2002). Gene flow and the limits to natural selection. Trends in Ecology and Evolution. 17:183-189
Shriner 2013, "Overview of Admixture Mapping"
January 01, 1970
genetic, admixture, this, article, technical, most, readers, understand, please, help, improve, make, understandable, experts, without, removing, technical, details, january, 2023, learn, when, remove, this, message, occurs, when, previously, isolated, populat. This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details January 2023 Learn how and when to remove this message Genetic admixture occurs when previously isolated populations interbreed resulting in a population that is descended from multiple sources It can occur between species such as with hybrids or within species such as when geographically distant individuals migrate to new regions It results in gene pool that is a mix of the source populations 1 2 3 Contents 1 Examples 2 Mapping 3 See also 4 References 5 Further readingExamples editClimatic cycles facilitate genetic admixture in cold periods and genetic diversification in warm periods 4 Natural flooding can cause genetic admixture within populations of migrating fish species 5 Genetic admixture may have an important role for the success of populations that colonise a new area and interbreed with individuals of native populations 6 Mapping editAdmixture mapping is a method of gene mapping that uses a population of mixed ancestry an admixed population to find the genetic loci that contribute to differences in diseases or other phenotypes found between the different ancestral populations The method is best applied to populations with recent admixture from two populations that were previously genetically isolated The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest Genetic markers that differ in frequency between the ancestral populations are needed across the genome 7 Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease causing or phenotype causing genetic variants between populations In an admixed population these causal variants occur more frequently on chromosomal segments inherited from one or another ancestral population The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped 8 By 2010 high density mapping panels had been constructed for African Americans Latino Hispanics and Uyghurs See also editChloroplast capture Gene cluster Gene flow Haplogroup Human genetic variation Hybrid Hybrid vigor Interbreeding between archaic and modern humans Introgression Population groups in biomedicineReferences edit Korunes Katharine L Goldberg Amy 2021 03 11 Human genetic admixture PLOS Genetics 17 3 Public Library of Science PLoS e1009374 doi 10 1371 journal pgen 1009374 ISSN 1553 7404 PMC 7951803 Rius M Darling J A 2014 How important is intraspecific genetic admixture to the success of colonising populations Trends in Ecology amp Evolution 29 4 233 242 doi 10 1016 j tree 2014 02 003 PMID 24636862 Yang Melinda A Fu Qiaomei March 2018 Insights into Modern Human Prehistory Using Ancient Genomes Trends in Genetics 34 3 184 196 6y doi 10 1016 j tig 2017 11 008 PMID 29395378 Lv X Cheng J Meng Y Chang Y Xia L Wen Z Ge D Liu S Yang Q 2018 Disjunct distribution and distinct intraspecific diversification of Eothenomys melanogaster in South China BMC Evolutionary Biology 18 1 50 doi 10 1186 s12862 018 1168 3 PMC 5894153 PMID 29636000 Jaisuk C Senanan W 2018 Effects of landscape features on population genetic variation of a tropical stream fish Stone lapping minnow Garra cambodgiensis in the upper Nan River drainage basin northern Thailand PeerJ 6 e4487 doi 10 7717 peerj 4487 PMC 5845392 PMID 29568710 Kolbe JJ Larson A Losos JB de Queiroz K 2008 Admixture determines genetic diversity and population differentiation in the biological invasion of a lizard species Biology Letters 4 4 434 437 doi 10 1098 rsbl 2008 0205 PMC 2610154 PMID 18492644 Shriver MD et al April 2003 Skin pigmentation biogeographical ancestry and admixture mapping Human Genetics 112 4 387 99 doi 10 1007 s00439 002 0896 y PMID 12579416 S2CID 7877572 Winkler C A Nelson G W Smith M W 2010 Admixture mapping comes of age Annu Rev Genom Hum Genet 11 65 89 doi 10 1146 annurev genom 082509 141523 PMC 7454031 PMID 20594047 Further reading editBalding 2007 Glossary of Genetic Terms Handbook of statistical genetics Volume 1 John Wiley amp Sons ISBN 978 0 470 05830 5 Foulkes 28 April 2009 Glossary of Terms Applied Statistical Genetics With R For Population based Association Studies Springer p 250 ISBN 978 0 387 89553 6 Stone et al 2007 Glossary of Terms Genes culture and human evolution a synthesis Wiley ISBN 978 1 4051 5089 7 Kolbe JJ Glor RE Schettino LR Lara AC Losos AL Losos JB 2004 Genetic Variation Increases during Biological Invasion by a Cuban Lizard Nature 431 171 181 Lenormand T 2002 Gene flow and the limits to natural selection Trends in Ecology and Evolution 17 183 189 Shriner 2013 Overview of Admixture Mapping Retrieved from https en wikipedia org w index php title Genetic admixture amp oldid 1193477152, wikipedia, wiki, book, books, library,
