Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[6]
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[7]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030168 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcYamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
^University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
^ abcOtvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC4201147. PMID 25368867.
^Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
^ abcdSun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC3653934. PMID 23691032.
External linksedit
Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
adiponectin, receptor, adipor2, protein, which, humans, encoded, adipor2, gene, member, progestin, adipoq, receptor, paqr, family, also, known, paqr2, adipor2available, structurespdbortholog, search, pdbe, rcsblist, codes3wxwidentifiersaliasesadipor2, adiponec. Adiponectin receptor 2 AdipoR2 is a protein which in humans is encoded by the ADIPOR2 gene 5 It is a member of the progestin and adipoQ receptor PAQR family and is also known as PAQR2 6 ADIPOR2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3WXWIdentifiersAliasesADIPOR2 adiponectin receptor 2 ACDCR2 PAQR2External IDsOMIM 607946 MGI 93830 HomoloGene 56119 GeneCards ADIPOR2Gene location Human Chr Chromosome 12 human 1 Band12p13 33Start1 688 574 bp 1 End1 788 674 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 F1 6 56 78 cMStart119 330 111 bp 2 End119 394 665 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosumright lungleft adrenal glandsubstantia nigraliverhippocampus properduodenumtibial nerveright lobe of liversubcutaneous adipose tissueTop expressed inbrown adipose tissueepithelium of stomachpyloric antrumleft lobe of liverwhite adipose tissueduodenumsubcutaneous adipose tissuemucous cell of stomachstria vascularisjejunumMore reference expression dataBioGPSn aGene ontologyMolecular functionadipokinetic hormone receptor activity adiponectin binding metal ion binding identical protein binding protein heterodimerization activity signaling receptor activityCellular componentintegral component of membrane membrane intrinsic component of plasma membrane plasma membraneBiological processpositive regulation of glucose import glucose homeostasis response to nutrient lipid metabolism female pregnancy adiponectin activated signaling pathway fatty acid metabolic process vascular wound healing heart development negative regulation of cell growth fatty acid oxidation hormone mediated signaling pathway regulation of fatty acid biosynthetic process positive regulation of cold induced thermogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez7960268465EnsemblENSG00000006831ENSG00000285070ENSMUSG00000030168UniProtQ86V24Q8BQS5RefSeq mRNA NM 024551NM 001375363NM 001375364NM 001375365NM 197985NM 001355692RefSeq protein NP 078827NP 001362292NP 001362293NP 001362294NP 932102NP 001342621Location UCSC Chr 12 1 69 1 79 MbChr 6 119 33 119 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Structure 2 Function 3 Ligands 3 1 Agonists 3 1 1 Peptide 3 1 2 Non peptide 3 2 Antagonists 3 2 1 Peptide 4 See also 5 References 6 External linksStructure editSimilar to G protein coupled receptors GPCRs AdipoR2 also possesses 7 transmembrane domains However AdipoR2 is orientated oppositely to GPCRs in the membrane i e cytoplasmic N terminus extracellular C terminus and does not associate with G proteins 5 Function editThe adiponectin receptors AdipoR1 and AdipoR2 serve as receptors for globular and full length adiponectin and mediate increased AMPK and PPAR a ligand activities as well as fatty acid oxidation and glucose uptake by adiponectin 5 In 2016 the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data as accused by an anonymous person group called Ordinary researchers 7 Ligands editAgonists edit Peptide edit Adiponectin ADP 355 8 ADP 399 8 Non peptide edit AdipoRon 9 Deoxyschizandrin 10 Parthenolide 10 Syringing 10 Taxifoliol 10 Antagonists edit Peptide edit ADP 400 8 See also editAdiponectin receptor Adiponectin receptor 1References edit a b c ENSG00000285070 GRCh38 Ensembl release 89 ENSG00000006831 ENSG00000285070 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000030168 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c Yamauchi T Kamon J Ito Y Tsuchida A Yokomizo T Kita S Sugiyama T Miyagishi M Hara K Tsunoda M Murakami K Ohteki T Uchida S Takekawa S Waki H Tsuno NH Shibata Y Terauchi Y Froguel P Tobe K Koyasu S Taira K Kitamura T Shimizu T Nagai R Kadowaki T June 2003 Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 6941 762 9 Bibcode 2003Natur 423 762Y doi 10 1038 nature01705 PMID 12802337 S2CID 52860797 Tang YT Hu T Arterburn M Boyle B Bright JM Emtage PC Funk WD September 2005 PAQR proteins a novel membrane receptor family defined by an ancient 7 transmembrane pass motif Journal of Molecular Evolution 61 3 372 80 Bibcode 2005JMolE 61 372T doi 10 1007 s00239 004 0375 2 PMID 16044242 S2CID 31473802 University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider Dennis Normile Sep 20 2016 a b c Otvos L Knappe D Hoffmann R Kovalszky I Olah J Hewitson TD Stawikowska R Stawikowski M Cudic P Lin F Wade JD Surmacz E Lovas S 2014 Development of second generation peptides modulating cellular adiponectin receptor responses Frontiers in Chemistry 2 93 Bibcode 2014FrCh 2 93O doi 10 3389 fchem 2014 00093 PMC 4201147 PMID 25368867 Okada Iwabu M Yamauchi T Iwabu M Honma T Hamagami K Matsuda K Yamaguchi M Tanabe H Kimura Someya T Shirouzu M Ogata H Tokuyama K Ueki K Nagano T Tanaka A Yokoyama S Kadowaki T November 2013 A small molecule AdipoR agonist for type 2 diabetes and short life in obesity Nature 503 7477 493 9 Bibcode 2013Natur 503 493O doi 10 1038 nature12656 PMID 24172895 S2CID 4447039 a b c d Sun Y Zang Z Zhong L Wu M Su Q Gao X Zan W Lin D Zhao Y Zhang Z 2013 Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay PLOS ONE 8 5 e63354 Bibcode 2013PLoSO 863354S doi 10 1371 journal pone 0063354 PMC 3653934 PMID 23691032 External links editHuman ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Adiponectin receptor 2 amp oldid 1142721486, wikipedia, wiki, book, books, library,
