The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000115239 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020305 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II". Mol Cell Biol. 25 (11): 4716–26. doi:10.1128/MCB.25.11.4716-4726.2005. PMC1140645. PMID 15899873.
^ ab"Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3".
External linksedit
Human ASB3 genome location and ASB3 gene details page in the UCSC Genome Browser.
Further readingedit
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC87336. PMID 11509662.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
asb3, ankyrin, repeat, socs, protein, protein, that, humans, encoded, gene, identifiersaliases, ankyrin, repeat, socs, containing, 3external, idsomim, 605760, 1929749, homologene, 9391, genecards, gene, location, human, chromosome, human, band2p16, 2start53, e. Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene 5 6 ASB3IdentifiersAliasesASB3 ASB 3 ankyrin repeat and SOCS box containing 3External IDsOMIM 605760 MGI 1929749 HomoloGene 9391 GeneCards ASB3Gene location Human Chr Chromosome 2 human 1 Band2p16 2Start53 532 672 bp 1 End53 860 160 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 A4 11 18 19 cMStart30 835 416 bp 2 End31 052 704 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocyteganglionic eminencemiddle temporal gyrusendothelial celltibiacorpus callosumentorhinal cortexpostcentral gyrussuperior frontal gyrusAchilles tendonTop expressed inspermatocyteendocardial cushionmedial ganglionic eminencespermatidcumulus cellotic placodebloodatrioventricular valvecalvariathymusMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding ubiquitin protein ligase binding ubiquitin protein transferase activityCellular componentcytoplasm nucleus ubiquitin ligase complex cytosolBiological processprotein ubiquitination intracellular signal transduction post translational protein modificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5113065257EnsemblENSG00000115239ENSMUSG00000020305UniProtQ9Y575Q9WV72RefSeq mRNA NM 145863NM 001201965NM 016115NM 023906RefSeq protein NP 001157637NP 076395Location UCSC Chr 2 53 53 53 86 MbChr 11 30 84 31 05 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a member of the ankyrin repeat and SOCS box containing ASB family of proteins They contain ankyrin repeat sequence and SOCS box domain The SOCS box serves to couple suppressor of cytokine signalling SOCS proteins and their binding partners with the elongin B and C complex possibly targeting them for degradation Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000115239 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020305 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chung AS Guan YJ Yuan ZL Albina JE Chin YE May 2005 Ankyrin repeat and SOCS box 3 ASB3 mediates ubiquitination and degradation of tumor necrosis factor receptor II Mol Cell Biol 25 11 4716 26 doi 10 1128 MCB 25 11 4716 4726 2005 PMC 1140645 PMID 15899873 a b Entrez Gene ASB3 ankyrin repeat and SOCS box containing 3 External links editHuman ASB3 genome location and ASB3 gene details page in the UCSC Genome Browser Further reading editKile BT Schulman BA Alexander WS et al 2002 The SOCS box a tale of destruction and degradation Trends Biochem Sci 27 5 235 41 doi 10 1016 S0968 0004 02 02085 6 PMID 12076535 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Kile BT Viney EM Willson TA et al 2001 Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box containing proteins Asb 1 Asb 2 Asb 3 and Asb 4 Gene 258 1 2 31 41 doi 10 1016 S0378 1119 00 00402 9 PMID 11111040 Kile BT Metcalf D Mifsud S et al 2001 Functional analysis of Asb 1 using genetic modification in mice Mol Cell Biol 21 18 6189 97 doi 10 1128 MCB 21 18 6189 6197 2001 PMC 87336 PMID 11509662 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ASB3 amp oldid 1115514300, wikipedia, wiki, book, books, library,
