All SOCS have certain structures in common. This includes a varying N-terminal domain involved in protein-protein interactions, a central SH2 domain, which can bind to molecules that have been phosphorylated by tyrosine kinases, and a SOCS box located at the C-terminal that enables recruitment of E3 ligases and ubiquitin signaling molecules.[1]
Discoveryedit
The first protein to be classified as a suppressor of cytokine signaling, CIS (cytokine-inducible SH2), was discovered in 1995, when it was found to have a unique ability to regulate cytokine signal transduction.[2]
Functionedit
SOCS are negative regulators of the JAK-STAT signaling pathway. SOCS have also been implicated in the regulation of cytokines, growth factors, and tumor suppression.[3]
Role in Diseaseedit
It has been suggested that SOCS can help prevent cytokine-mediated apoptosis in diabetes through negative regulation of pro-inflammatory cytokines secreted by immune cells, such as IFNγ, TNFα and IL-15. Improper functioning of one specific SOCS, SOCS3 may lead to type 2 diabetes, as it has been found that SOCS3 plays an important role in proper leptin signaling.[4]
Referencesedit
^Babon, Jeffrey; Nicola, Nicos A (August 2012). "The biology and mechanism of action of Suppressor of Cytokine Signaling 3 (SOCS3)". Growth Factors. 30 (4): 207–219. doi:10.3109/08977194.2012.687375. ISSN 0897-7194. PMC3757090. PMID 22574771.
^Yoshimura, A.; Ohkubo, T.; Kiguchi, T.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Hara, T.; Miyajima, A. (1995). "A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors". The EMBO Journal. 14 (12): 2816–2826. doi:10.1002/j.1460-2075.1995.tb07281.x. PMC398400. PMID 7796808. S2CID 22563011.
^Sasi, Walid; Sharma, Anup K.; Mokbel, Kefah (2014-03-16). "The Role of Suppressors of Cytokine Signalling in Human Neoplasms". Molecular Biology International. 2014: 630797. doi:10.1155/2014/630797. PMC3976820. PMID 24757565.
^Ye, Cheng; Driver, John P. (2016). "Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells". Frontiers in Immunology. 7: 169. doi:10.3389/fimmu.2016.00169. ISSN 1664-3224. PMC4860527. PMID 27242781. S2CID 15424776.
External linksedit
Suppressor+of+Cytokine+Signaling+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This biochemistry article is a stub. You can help Wikipedia by expanding it.
suppressor, cytokine, signalling, socs, suppressor, cytokine, signaling, proteins, refers, family, genes, involved, inhibiting, stat, signaling, pathway, suppressor, cytokine, signaling, socs, redirects, here, other, uses, socs, contents, genes, structure, dis. SOCS suppressor of cytokine signaling proteins refers to a family of genes involved in inhibiting the JAK STAT signaling pathway Suppressor of Cytokine Signaling 2 SOCS redirects here For other uses see Socs Contents 1 Genes 2 Structure 3 Discovery 4 Function 5 Role in Disease 6 References 7 External linksGenes editCISH SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7Structure editAll SOCS have certain structures in common This includes a varying N terminal domain involved in protein protein interactions a central SH2 domain which can bind to molecules that have been phosphorylated by tyrosine kinases and a SOCS box located at the C terminal that enables recruitment of E3 ligases and ubiquitin signaling molecules 1 Discovery editThe first protein to be classified as a suppressor of cytokine signaling CIS cytokine inducible SH2 was discovered in 1995 when it was found to have a unique ability to regulate cytokine signal transduction 2 Function editSOCS are negative regulators of the JAK STAT signaling pathway SOCS have also been implicated in the regulation of cytokines growth factors and tumor suppression 3 Role in Disease editIt has been suggested that SOCS can help prevent cytokine mediated apoptosis in diabetes through negative regulation of pro inflammatory cytokines secreted by immune cells such as IFNg TNFa and IL 15 Improper functioning of one specific SOCS SOCS3 may lead to type 2 diabetes as it has been found that SOCS3 plays an important role in proper leptin signaling 4 References edit Babon Jeffrey Nicola Nicos A August 2012 The biology and mechanism of action of Suppressor of Cytokine Signaling 3 SOCS3 Growth Factors 30 4 207 219 doi 10 3109 08977194 2012 687375 ISSN 0897 7194 PMC 3757090 PMID 22574771 Yoshimura A Ohkubo T Kiguchi T Jenkins N A Gilbert D J Copeland N G Hara T Miyajima A 1995 A novel cytokine inducible gene CIS encodes an SH2 containing protein that binds to tyrosine phosphorylated interleukin 3 and erythropoietin receptors The EMBO Journal 14 12 2816 2826 doi 10 1002 j 1460 2075 1995 tb07281 x PMC 398400 PMID 7796808 S2CID 22563011 Sasi Walid Sharma Anup K Mokbel Kefah 2014 03 16 The Role of Suppressors of Cytokine Signalling in Human Neoplasms Molecular Biology International 2014 630797 doi 10 1155 2014 630797 PMC 3976820 PMID 24757565 Ye Cheng Driver John P 2016 Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic b Cells Frontiers in Immunology 7 169 doi 10 3389 fimmu 2016 00169 ISSN 1664 3224 PMC 4860527 PMID 27242781 S2CID 15424776 External links editSuppressor of Cytokine Signaling Proteins at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Suppressor of cytokine signalling amp oldid 1140865392, wikipedia, wiki, book, books, library,
