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Wikipedia

AP2A2

January 01, 1970

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.[5][6][7]

AP2A2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
External IDsOMIM: 607242; MGI: 101920; HomoloGene: 5335; GeneCards: AP2A2; OMA:AP2A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

161

11772

Ensembl

ENSG00000281385
ENSG00000280759
ENSG00000183020

ENSMUSG00000002957

UniProt

O94973

P17427

RefSeq (mRNA)

NM_001242837
NM_012305

NM_007459
NM_001357068

RefSeq (protein)

NP_001229766
NP_036437

NP_031485
NP_001343997

Location (UCSC)Chr 11: 0.92 – 1.01 MbChr 7: 141.14 – 141.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

AP2A2 has been shown to interact with EPN1[8] and SHC1.[9]

References edit

  1. ^ a b c ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002957 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
  6. ^ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
  7. ^ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".
  8. ^ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
  9. ^ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.

Further reading edit

  • Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 331–5. Bibcode:1996PNAS...93..331D. doi:10.1073/pnas.93.1.331. PMC 40232. PMID 8552632.
  • Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.
  • Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". The Journal of Biological Chemistry. 271 (20): 12111–6. doi:10.1074/jbc.271.20.12111. PMID 8662627.
  • van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (Feb 1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". The Journal of Cell Biology. 136 (4): 811–21. doi:10.1083/jcb.136.4.811. PMC 2132490. PMID 9049247.
  • Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (Jun 1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". The Journal of Biological Chemistry. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
  • Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. Bibcode:1999PNAS...96.8907T. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
  • Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
  • Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
  • Slepnev VI, Ochoa GC, Butler MH, De Camilli P (Jun 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
  • Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (Aug 2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis" (PDF). Journal of Cell Science. 113 (16): 2837–44. doi:10.1242/jcs.113.16.2837. PMID 10910768.

External links edit


 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
ap2a2, complex, subunit, alpha, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1b9k, 1ky6, 1ky7, 1kyd, 1kyf, 1kyu, 1qtp, 1qts, 1w80, 2jkr, 2jkt, 2vj0, 3hs8identifiersaliases, adtab, clapa2, hip9, hypj, adap. AP 2 complex subunit alpha 2 is a protein that in humans is encoded by the AP2A2 gene 5 6 7 AP2A2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1B9K 1KY6 1KY7 1KYD 1KYF 1KYU 1QTP 1QTS 1W80 2JKR 2JKT 2VJ0 3HS8IdentifiersAliasesAP2A2 ADTAB CLAPA2 HIP 9 HIP9 HYPJ adaptor related protein complex 2 alpha 2 subunit adaptor related protein complex 2 subunit alpha 2External IDsOMIM 607242 MGI 101920 HomoloGene 5335 GeneCards AP2A2 OMA AP2A2 orthologsGene location Human Chr Chromosome 11 human 1 Band11p15 5Start924 881 bp 1 End1 012 245 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 F5Start141 142 086 bp 2 End141 212 924 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleensuperior frontal gyrussural nervesubcutaneous adipose tissueprefrontal cortexcanal of the cervixpituitary glandganglionic eminenceupper lobe of left lungkidneyTop expressed inentorhinal cortexmedullary collecting ductsuperior frontal gyruscerebellar cortexhabenulahippocampus propersupraoptic nucleusRegion I of hippocampus properamygdaladorsomedial hypothalamic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionclathrin adaptor activity protein binding protein kinase binding lipid binding protein domain specific binding disordered domain specific binding molecular functionCellular componentendocytic vesicle membrane cytosol clathrin coated endocytic vesicle membrane membrane plasma membrane endolysosome membrane membrane coat clathrin coated pit AP 2 adaptor complex clathrin adaptor complex secretory granule membrane cytoplasmic vesicle ficolin 1 rich granule membrane clathrin coated endocytic vesicleBiological processendocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus clathrin dependent endocytosis protein transport intracellular protein transport vesicle mediated transport microtubule based movement Wnt signaling pathway planar cell polarity pathway neutrophil degranulation membrane organization low density lipoprotein particle receptor catabolic process low density lipoprotein particle clearance transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez16111772EnsemblENSG00000281385ENSG00000280759ENSG00000183020ENSMUSG00000002957UniProtO94973P17427RefSeq mRNA NM 001242837NM 012305NM 007459NM 001357068RefSeq protein NP 001229766NP 036437NP 031485NP 001343997Location UCSC Chr 11 0 92 1 01 MbChr 7 141 14 141 21 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editAP2A2 has been shown to interact with EPN1 8 and SHC1 9 References edit a b c ENSG00000280759 ENSG00000183020 GRCh38 Ensembl release 89 ENSG00000281385 ENSG00000280759 ENSG00000183020 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000002957 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Faber PW Barnes GT Srinidhi J Chen J Gusella JF MacDonald ME Sep 1998 Huntingtin interacts with a family of WW domain proteins Human Molecular Genetics 7 9 1463 74 doi 10 1093 hmg 7 9 1463 PMID 9700202 Robinson MS Mar 1989 Cloning of cDNAs encoding two related 100 kD coated vesicle proteins alpha adaptins The Journal of Cell Biology 108 3 833 42 doi 10 1083 jcb 108 3 833 PMC 2115374 PMID 2564002 Entrez Gene AP2A2 adaptor related protein complex 2 alpha 2 subunit Chen H Fre S Slepnev VI Capua MR Takei K Butler MH Di Fiore PP De Camilli P Aug 1998 Epsin is an EH domain binding protein implicated in clathrin mediated endocytosis Nature 394 6695 793 7 Bibcode 1998Natur 394 793C doi 10 1038 29555 PMID 9723620 S2CID 4430975 Okabayashi Y Sugimoto Y Totty NF Hsuan J Kido Y Sakaguchi K Gout I Waterfield MD Kasuga M Mar 1996 Interaction of Shc with adaptor protein adaptins The Journal of Biological Chemistry 271 9 5265 9 doi 10 1074 jbc 271 9 5265 PMID 8617812 Further reading editKirchhausen T 2000 Clathrin Annual Review of Biochemistry 69 699 727 doi 10 1146 annurev biochem 69 1 699 PMID 10966473 Nakajima D Okazaki N Yamakawa H Kikuno R Ohara O Nagase T Jun 2002 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Research 9 3 99 106 CiteSeerX 10 1 1 500 923 doi 10 1093 dnares 9 3 99 PMID 12168954 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 David C McPherson PS Mundigl O de Camilli P Jan 1996 A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals Proceedings of the National Academy of Sciences of the United States of America 93 1 331 5 Bibcode 1996PNAS 93 331D doi 10 1073 pnas 93 1 331 PMC 40232 PMID 8552632 Okabayashi Y Sugimoto Y Totty NF Hsuan J Kido Y Sakaguchi K Gout I Waterfield MD Kasuga M Mar 1996 Interaction of Shc with adaptor protein adaptins The Journal of Biological Chemistry 271 9 5265 9 doi 10 1074 jbc 271 9 5265 PMID 8617812 Benmerah A Begue B Dautry Varsat A Cerf Bensussan N May 1996 The ear of alpha adaptin interacts with the COOH terminal domain of the Eps 15 protein The Journal of Biological Chemistry 271 20 12111 6 doi 10 1074 jbc 271 20 12111 PMID 8662627 van Delft S Schumacher C Hage W Verkleij AJ van Bergen en Henegouwen PM Feb 1997 Association and colocalization of Eps15 with adaptor protein 2 and clathrin The Journal of Cell Biology 136 4 811 21 doi 10 1083 jcb 136 4 811 PMC 2132490 PMID 9049247 Ramjaun AR Micheva KD Bouchelet I McPherson PS Jun 1997 Identification and characterization of a nerve terminal enriched amphiphysin isoform The Journal of Biological Chemistry 272 26 16700 6 doi 10 1074 jbc 272 26 16700 PMID 9195986 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Chen H Fre S Slepnev VI Capua MR Takei K Butler MH Di Fiore PP De Camilli P Aug 1998 Epsin is an EH domain binding protein implicated in clathrin mediated endocytosis Nature 394 6695 793 7 Bibcode 1998Natur 394 793C doi 10 1038 29555 PMID 9723620 S2CID 4430975 Berlioz Torrent C Shacklett BL Erdtmann L Delamarre L Bouchaert I Sonigo P Dokhelar MC Benarous R Feb 1999 Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins Journal of Virology 73 2 1350 61 doi 10 1128 JVI 73 2 1350 1361 1999 PMC 103959 PMID 9882340 Nagase T Ishikawa K Suyama M Kikuno R Hirosawa M Miyajima N Tanaka A Kotani H Nomura N Ohara O Dec 1998 Prediction of the coding sequences of unidentified human genes XII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Research 5 6 355 64 doi 10 1093 dnares 5 6 355 PMID 10048485 Traub LM Downs MA Westrich JL Fremont DH Aug 1999 Crystal structure of the alpha appendage of AP 2 reveals a recruitment platform for clathrin coat assembly Proceedings of the National Academy of Sciences of the United States of America 96 16 8907 12 Bibcode 1999PNAS 96 8907T doi 10 1073 pnas 96 16 8907 PMC 17706 PMID 10430869 Page LJ Sowerby PJ Lui WW Robinson MS Sep 1999 Gamma synergin an EH domain containing protein that interacts with gamma adaptin The Journal of Cell Biology 146 5 993 1004 doi 10 1083 jcb 146 5 993 PMC 2169493 PMID 10477754 Kim ST Lim DS Canman CE Kastan MB Dec 1999 Substrate specificities and identification of putative substrates of ATM kinase family members The Journal of Biological Chemistry 274 53 37538 43 doi 10 1074 jbc 274 53 37538 PMID 10608806 Slepnev VI Ochoa GC Butler MH De Camilli P Jun 2000 Tandem arrangement of the clathrin and AP 2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites The Journal of Biological Chemistry 275 23 17583 9 doi 10 1074 jbc M910430199 PMID 10748223 Jullien Flores V Mahe Y Mirey G Leprince C Meunier Bisceuil B Sorkin A Camonis JH Aug 2000 RLIP76 an effector of the GTPase Ral interacts with the AP2 complex involvement of the Ral pathway in receptor endocytosis PDF Journal of Cell Science 113 16 2837 44 doi 10 1242 jcs 113 16 2837 PMID 10910768 External links editHuman AP2A2 genome location and AP2A2 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AP2A2 amp oldid 1198641525, wikipedia, wiki, book, books, library,

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