The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell.[1][2] At least 20 AKAPs have been cloned.[3] There are at least 50 members, often named after their molecular mass.
Functionedit
AKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi-protein complexes to specific locations, such as the nucleus, in cells.[2] This allows specific targeting of substrates to be regulated by phosphorylation (by PKA) and dephosphorylation (by phosphatases).[2] The dimerization and docking (D/D) domain of the regulatory subunit dimer of PKA binds with the A-kinase binding (AKB) domain (an amphipathic helix) of AKAP. The AKAPs also bind other components, including; phosphodiesterases (PDEs) which break down cAMP, phosphatases which dephosphorylate downstream PKA targets and also other kinases (PKC and MAPK). Some AKAPs are able to bind both regulatory subunits (RI & RII) of PKA and are dual-specific AKAPs (D-AKAP1 and D-AKAP2).
^ abcMarin, Wenwen (January 2020). "A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases". Journal of Molecular and Cellular Cardiology. 138: 99–109. doi:10.1016/j.yjmcc.2019.11.154. ISSN 0022-2828. PMID 31783032. S2CID 208499003.
^Schwartz JH (November 2001). "The many dimensions of cAMP signaling". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13482–4. Bibcode:2001PNAS...9813482S. doi:10.1073/pnas.251533998. PMC61065. PMID 11717418.
January 01, 1970
kinase, anchoring, protein, kinase, anchoring, proteins, kinase, anchor, proteins, akaps, group, structurally, diverse, proteins, which, have, common, function, binding, regulatory, subunit, protein, kinase, confining, holoenzyme, discrete, locations, within, . The A kinase anchoring proteins or A kinase anchor proteins AKAPs are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A PKA and confining the holoenzyme to discrete locations within the cell 1 2 At least 20 AKAPs have been cloned 3 There are at least 50 members often named after their molecular mass Function editAKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi protein complexes to specific locations such as the nucleus in cells 2 This allows specific targeting of substrates to be regulated by phosphorylation by PKA and dephosphorylation by phosphatases 2 The dimerization and docking D D domain of the regulatory subunit dimer of PKA binds with the A kinase binding AKB domain an amphipathic helix of AKAP The AKAPs also bind other components including phosphodiesterases PDEs which break down cAMP phosphatases which dephosphorylate downstream PKA targets and also other kinases PKC and MAPK Some AKAPs are able to bind both regulatory subunits RI amp RII of PKA and are dual specific AKAPs D AKAP1 and D AKAP2 List of AKAPs editAKAP1 AKAP2 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 AKAP10 AKAP11 AKAP12 AKAP13References edit Langeberg LK Scott JD 1 August 2005 A kinase anchoring proteins Journal of Cell Science 118 15 3217 3220 CiteSeerX 10 1 1 621 7853 doi 10 1242 jcs 02416 PMID 16079273 S2CID 19917481 a b c Marin Wenwen January 2020 A kinase anchoring protein 1 AKAP1 and its role in some cardiovascular diseases Journal of Molecular and Cellular Cardiology 138 99 109 doi 10 1016 j yjmcc 2019 11 154 ISSN 0022 2828 PMID 31783032 S2CID 208499003 Schwartz JH November 2001 The many dimensions of cAMP signaling Proc Natl Acad Sci U S A 98 24 13482 4 Bibcode 2001PNAS 9813482S doi 10 1073 pnas 251533998 PMC 61065 PMID 11717418 Retrieved from https en wikipedia org w index php title A kinase anchoring protein amp oldid 1209506891, wikipedia, wiki, book, books, library,
